کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9956883 1576428 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure
چکیده انگلیسی
Evidence suggests that vascular endothelium plays key role in the regulation of vascular tone, in the process of inflammation and in the thrombotic mechanisms. Recent studies indicate that it is an important component of the pathophysiological mechanisms of heart failure. Heart failure may induce endothelial dysfunction by different mechanisms, such as reduced synthesis and release of nitric oxide (NO), increased degradation of NO or by increased production of endothelin-1. In addition, endothelial dysfunction has been associated with the progression of heart failure. Alterations in neurotransmitters, hormones and also in physiological stimuli are present in heart failure and affect the vascular endothelium. Treatments with beneficial effects on endothelial dysfunction may also improve prognosis in patients with heart failure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 100, Issue 3, 28 April 2005, Pages 347-353
نویسندگان
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