A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Adenosine as an Adjunct to Reperfusion in the Treatment of Acute Myocardial Infarction (AMISTAD-II)

Clinical outcomes in patients with STEMI undergoing reperfusion therapy were not significantly improved with adenosine, although infarct size was reduced with the 70-μg/kg/min adenosine infusion, a finding that correlated with fewer adverse clinical events. A larger study limited to the 70-μg/kg/min dose is, therefore, warranted.