The discovery of a selective, high affinity A2B adenosine receptor antagonist for the potential treatment of asthma Fulltext Access 4 Pages 2005
1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors Fulltext Access 4 Pages 2005
Active site directed inhibitors of replication-specific bacterial DNA polymerases Fulltext Access 4 Pages 2005
Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans Fulltext Access 4 Pages 2005
Pyrenyldiazomethane, a versatile reagent for nucleotide phosphate alkylation Fulltext Access 4 Pages 2005
Synthesis and antifungal activity of noble 5-arylamino- and 6-arylthio-4,7-dioxobenzoselenazoles Fulltext Access 4 Pages 2005
Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase Fulltext Access 4 Pages 2005
Cleavage at 5-methylcytosine in DNA by photosensitized oxidation with 2-methyl-1,4-naphthoquinone tethered oligodeoxynucleotides Fulltext Access 4 Pages 2005
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold Fulltext Access 4 Pages 2005
Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands Fulltext Access 4 Pages 2005
Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells Fulltext Access 4 Pages 2005
Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives Fulltext Access 4 Pages 2005
Design and synthesis of macrocycles active against vancomycin-resistant enterococci (VRE): the interplay between d-Ala-d-Lac binding and hydrophobic effect Fulltext Access 4 Pages 2005
Studies on the structure-activity relationship of 2â²,6â²-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH3 Fulltext Access 4 Pages 2005
Generation of a new class of hNK2 receptor ligands using the 'fragment approach' Fulltext Access 4 Pages 2005
Synthesis of modified proanthocyanidins: easy and general introduction of a hydroxy group at C-6 of catechin; efficient synthesis of elephantorrhizol Fulltext Access 4 Pages 2005
Synthesis of modified proanthocyanidins: introduction of acyl substituents at C-8 of catechin. Selective synthesis of a C-4 â O â C-3 ether-linked procyanidin-like dimer Fulltext Access 4 Pages 2005
Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists Fulltext Access 4 Pages 2005
Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B Fulltext Access 4 Pages 2005
Enantiomerical excess determination, purification and biological evaluation of (3S) and (3R) α,β-butenolide analogues of isobenzofuranone Fulltext Access 4 Pages 2005
Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups Fulltext Access 4 Pages 2005
Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme Fulltext Access 4 Pages 2005
Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists Fulltext Access 4 Pages 2005
Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis Fulltext Access 4 Pages 2005
Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors Fulltext Access 4 Pages 2005
(S,E)-N-[1-(3-Heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity Fulltext Access 4 Pages 2005
Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus Fulltext Access 4 Pages 2005
Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier Fulltext Access 4 Pages 2005
Structure-antioxidant activity relationships of flavonoids isolated from the resinous exudate of Heliotropium sinuatum Fulltext Access 4 Pages 2005
Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers Fulltext Access 4 Pages 2005
A new ligand binding to G-G mismatch having improved thermal and alkaline stability Fulltext Access 4 Pages 2005
Discovery of a novel, potent and selective human β3-adrenergic receptor agonist Fulltext Access 4 Pages 2005
Crystallographic determination of stereochemistry of biologically active 2â³,3â³-dibromo-7-epi-10-deacetylcephalomannine Fulltext Access 4 Pages 2005
Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies Fulltext Access 4 Pages 2005
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors Fulltext Access 4 Pages 2005
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships Fulltext Access 4 Pages 2005
Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT7 receptor Fulltext Access 4 Pages 2005
Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp. Fulltext Access 4 Pages 2005
Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA Fulltext Access 4 Pages 2005
Efficient cleavage of RNA, enhanced cellular uptake, and controlled intracellular localization of conjugate DNAzymes Fulltext Access 4 Pages 2005
Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase Fulltext Access 4 Pages 2005
Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2 Fulltext Access 4 Pages 2005
New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties Fulltext Access 4 Pages 2005
Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core Fulltext Access 4 Pages 2005
Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase Fulltext Access 4 Pages 2005
Amide derivatives of 9,11-seco-estra-1,3,5(10)-trien-11-oic acid as modified orally active estrogen agonists with moderate antagonistic activity Fulltext Access 4 Pages 2005
Characterization of l-glutamine:2-deoxy-scyllo-inosose aminotransferase (tbmB) from Streptomyces tenebrarius Fulltext Access 4 Pages 2005
A new class of androgen receptor antagonists bearing carborane in place of a steroidal skeleton Fulltext Access 4 Pages 2005
Design, synthesis and evaluation of 5-substituted amino-2,4-diamino-8-chloropyrimido-[4,5-b]quinolines as novel antimalarials Fulltext Access 4 Pages 2005
2,3-Ethylene- and 2,3-trimethylene-bridged analogues of the group III metabotropic glutamate receptor ligand 2-amino-4-phosphonobutanoic acid Fulltext Access 4 Pages 2005
Syntheses of 2,4,6-trisubstituted pyrimidine derivatives as a new class of antifilarial topoisomerase II inhibitors Fulltext Access 4 Pages 2005
Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas Fulltext Access 4 Pages 2005
A new strategy to combat Alzheimer's disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule Fulltext Access 4 Pages 2005
From a total synthesis of cepabactin and its 3:1 ferric complex to the isolation of a 1:1:1 mixed complex between iron (III), cepabactin and pyochelin Fulltext Access 4 Pages 2005
Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification Fulltext Access 4 Pages 2005
Glycosylation of allyl 2-acetamido-4,6-O-benzylidene-2-deoxy-α-d-glucopyranoside with bulky substituted glycosyl donors Fulltext Access 4 Pages 2005
Synthesis of the β anomer of the spacer-equipped tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium Fulltext Access 4 Pages 2005
Interaction of dopamine and acetylcholine with an amphiphilic resorcinarene receptor in aqueous micelle system Fulltext Access 4 Pages 2005
Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T Fulltext Access 4 Pages 2005
2-Substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-one as a structurally new NK1 antagonist Fulltext Access 4 Pages 2005
Crystal structures of human HSP90α-complexed with dihydroxyphenylpyrazoles Fulltext Access 4 Pages 2005
Electronic structure calculations on the thiazole-containing antibiotic thiostrepton: molecular mechanics, semi-empirical and ab initio analyses Fulltext Access 4 Pages 2005
Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity Fulltext Access 4 Pages 2005
Structure-activity relationships and sub-type selectivity in an oxabicyclic estrogen receptor α/β agonist scaffold Fulltext Access 4 Pages 2005
4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands Fulltext Access 4 Pages 2005
Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors Fulltext Access 4 Pages 2005
Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic Fulltext Access 4 Pages 2005
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists Fulltext Access 4 Pages 2005
Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol Fulltext Access 4 Pages 2005
Biaryls and heterobiaryls as α-glucosidase and protein tyrosine phosphatase inhibitors Fulltext Access 4 Pages 2005
Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors Fulltext Access 4 Pages 2005
The discovery and synthesis of novel adenosine receptor (A2A) antagonists Fulltext Access 4 Pages 2005
Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics Fulltext Access 4 Pages 2005
Synthesis and radiopharmacological evaluation of 2â²-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole as potential glucocorticoid receptor ligand for positron emission tomography (PET) Fulltext Access 4 Pages 2005
Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives Fulltext Access 4 Pages 2005
Novel 1β-methylcarbapenems with isoxazoloethenyl moieties containing carboxylic acid sodium salt Fulltext Access 4 Pages 2005