Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity Fulltext Access 4 Pages 2005
Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities Fulltext Access 4 Pages 2005
Design and synthesis of novel diphenacoum-derived, conformation-restricted vitamin K 2,3-epoxide reductase inhibitors Fulltext Access 4 Pages 2005
Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf Fulltext Access 4 Pages 2005
A divergent chemoenzymatic route to an intermediate for nucleoside analogues Fulltext Access 4 Pages 2005
Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b]thiophenes Fulltext Access 4 Pages 2005
Optimization of isotope-labeling conditions for lambertellin based on isotope patterns observed by mass spectrometry Fulltext Access 4 Pages 2005
Lambertellol C, a labile and novel biosynthetic congener of lambertellols A and B Fulltext Access 4 Pages 2005
2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR Fulltext Access 4 Pages 2005
Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-heteroaryl-thieno[3,2-b]pyridine-6-carbonitriles Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of gemcitabine–lipid conjugate (NEO6002) Fulltext Access 4 Pages 2005
Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones Fulltext Access 4 Pages 2005
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors Fulltext Access 4 Pages 2005
Lactams as prostanoid receptor ligands. Part 4: 2-Piperidones as selective EP4 receptor agonists Fulltext Access 4 Pages 2005
Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers Fulltext Access 4 Pages 2005
EB1627: a soluble prodrug of the potent anticancer cyanoguanidine CHS828 Fulltext Access 4 Pages 2005
Antiproliferative activity in HL60 cells by tetrasubstituted pyrroles: a structure–activity relationship study Fulltext Access 4 Pages 2005
Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases Fulltext Access 4 Pages 2005
Reactions of α-hydroxyethyl radicals with flavonoids of various structures Fulltext Access 4 Pages 2005
Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat–TAR interactions: Squaryldiamide as a new potential bioisostere of unsubstituted guanidine Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7 Fulltext Access 4 Pages 2005
Structure–activity relationships of Erwinia carotovora quorum sensing signaling molecules Fulltext Access 4 Pages 2005
5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase Fulltext Access 4 Pages 2005
Design, synthesis and structure-activity relationship of a series of fragment analogues of antistasin (ATS) and ghilantens (GLS) Fulltext Access 4 Pages 2005
Characterisation and biodistribution of two neutral 99mTc(CO)3 complexes with a tridentate ligand Fulltext Access 4 Pages 2005
Isolation, structure elucidation, preparation, and biological properties of neolambertellin Fulltext Access 4 Pages 2005
SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors Fulltext Access 4 Pages 2005
Camptothecin binds to a synthetic peptide identified by a T7 phage display screen Fulltext Access 4 Pages 2005
Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents Fulltext Access 4 Pages 2005
Investigation of factor Xa inhibitors containing non-amidine S1 elements Fulltext Access 4 Pages 2005
A fluorogenic and chromogenic probe that detects the esterase activity of trace copper(II) Fulltext Access 4 Pages 2005
Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases Fulltext Access 4 Pages 2005
Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors Fulltext Access 4 Pages 2005
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors Fulltext Access 4 Pages 2005
Potential antitumor agents: Flavones and their derivatives from Linaria reflexa Desf. Fulltext Access 4 Pages 2005
High affinity ligands for the α7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor Fulltext Access 4 Pages 2005
Benzyl ether structure–activity relationships in a series of ketopiperazine-based renin inhibitors Fulltext Access 4 Pages 2005
Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography Fulltext Access 4 Pages 2005
Quorum sensing in Vibrio harveyi: probing the specificity of the LuxP binding site Fulltext Access 4 Pages 2005
Effects of B group vitamins on reactions of various α-hydroxyl-containing organic radicals Fulltext Access 4 Pages 2005
Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors Fulltext Access 4 Pages 2005
Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1â²,2â²:1,5]pyrazolo[3,4-d]pyrimidines Fulltext Access 4 Pages 2005
Synthesis and structural modeling of the amphiphilic siderophore rhizobactin-1021 and its analogs Fulltext Access 4 Pages 2005
Hydrophobicity in the design of P2/P2â² tetrahydropyrimidinone HIV protease inhibitors Fulltext Access 4 Pages 2005
Inhibition of tumor cell proliferation by thieno[2,3-d]pyrimidin-4(1H)-one-based analogs Fulltext Access 4 Pages 2005
Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues Fulltext Access 4 Pages 2005
Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety Fulltext Access 4 Pages 2005
2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs as adenosine A2A antagonists: The successful reduction of hERG activity. Part 2 Fulltext Access 4 Pages 2005
QSAR for phospholipase A2 inhibitions by 1-acyloxy-3-N-n-octylcarbamyl-benzenes Fulltext Access 4 Pages 2005
2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists Fulltext Access 4 Pages 2005
New pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors Fulltext Access 4 Pages 2005
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors Fulltext Access 4 Pages 2005
Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase Fulltext Access 4 Pages 2005
N-DEVD-N′-morpholinecarbonyl-rhodamine 110: novel caspase-3 fluorogenic substrates for cell-based apoptosis assay Fulltext Access 4 Pages 2005
Hypoxia-selective activation of 5-fluorodeoxyuridine prodrug possessing indolequinone structure: radiolytic reduction and cytotoxicity characteristics Fulltext Access 4 Pages 2005
A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs Fulltext Access 4 Pages 2005
Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones Fulltext Access 4 Pages 2005
Reduction of a 4-pyrrole phenylacyl-containing peptide with trifluoroacetic acid–triisopropylsilane–phenol–H2O during solid-phase peptide synthesis and its protein kinase C α inhibitory activity Fulltext Access 4 Pages 2005
A proof of the specificity of kanamycin-ribosomal RNA interaction with designed synthetic analogs and the antibacterial activity Fulltext Access 4 Pages 2005
Structure-driven HtL: Design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity Fulltext Access 4 Pages 2005
Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor Fulltext Access 4 Pages 2005
1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists Fulltext Access 4 Pages 2005
4,4′-Dimethoxytrityl group derived from secondary alcohols: Are they removed slowly under acidic conditions? Fulltext Access 4 Pages 2005
A novel [99mTcN]2+ complex of metronidazole xanthate as a potential agent for targeting hypoxia Fulltext Access 4 Pages 2005
Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors Fulltext Access 4 Pages 2005
Discovery of 3-OH-3-methylpipecolic hydroxamates: Potent orally active inhibitors of aggrecanase and MMP-13 Fulltext Access 4 Pages 2005
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886 Fulltext Access 4 Pages 2005
Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP Fulltext Access 4 Pages 2005
Fluorescence resonance energy transfer studies of aminoglycoside binding to a T box antiterminator RNA Fulltext Access 4 Pages 2005
Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors Fulltext Access 4 Pages 2005
Quinazolines revisited: search for novel anxiolytic and GABAergic agents Fulltext Access 4 Pages 2005
Synthesis of sphingomyelin sulfur analogue and its behavior toward sphingomyelinase Fulltext Access 4 Pages 2005
Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone Fulltext Access 4 Pages 2005
Discovery, synthesis and biological evaluation of novel glucokinase activators Fulltext Access 4 Pages 2005
Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine Fulltext Access 4 Pages 2005
Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts Fulltext Access 4 Pages 2005
Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure–activity relationships Fulltext Access 4 Pages 2005
Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design Fulltext Access 4 Pages 2005
A general carbometalation, three component coupling strategy for the synthesis of α,β-unsaturated γ-sultines including thio-rofecoxib, a selective COX-2 inhibitor Fulltext Access 4 Pages 2005
Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium Fulltext Access 4 Pages 2005