Discodermolide analogues as the chemical component of combination bacteriolytic therapy Fulltext Access 4 Pages 2005
Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor Fulltext Access 4 Pages 2005
Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 Fulltext Access 4 Pages 2005
Dipyridyl amines: Potent metabotropic glutamate subtype 5 receptor antagonists Fulltext Access 4 Pages 2005
Molecular design, chemical synthesis, and evaluation of cytosine–carbohydrate hybrids for selective recognition of a single guanine bulged duplex DNA Fulltext Access 4 Pages 2005
A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin Fulltext Access 4 Pages 2005
Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies Fulltext Access 4 Pages 2005
Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents Fulltext Access 4 Pages 2005
Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis Fulltext Access 4 Pages 2005
A general method for the synthesis of aryl [11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression Fulltext Access 4 Pages 2005
Epibatidine analogues as selective ligands for the αxβ2-containing subtypes of nicotinic acetylcholine receptors Fulltext Access 4 Pages 2005
Synthesis of multitopic neoglycopeptides displaying recognition and detection motifs Fulltext Access 4 Pages 2005
SAR studies of 6-aryl-1,3-dihydrobenzimidazol-2-ones as progesterone receptor antagonists Fulltext Access 4 Pages 2005
Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of novel angularly fused polycyclic coumarins Fulltext Access 4 Pages 2005
Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol Fulltext Access 4 Pages 2005
A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide Fulltext Access 4 Pages 2005
Synthesis and biological activity of mustard derivatives of combretastatins Fulltext Access 4 Pages 2005
Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives Fulltext Access 4 Pages 2005
An efficient asymmetric synthesis of (S)-atenolol: using hydrolytic kinetic resolution Fulltext Access 4 Pages 2005
The dinuclear iron-oxo ferroxidase center of Pyrococcus furiosus ferritin is a stable prosthetic group with unexpectedly high reduction potentials Fulltext Access 4 Pages 2005
Oxygenated complex of cytochrome bd from Escherichia coli: Stability and photolability Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents Fulltext Access 4 Pages 2005
Synthesis, antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains Fulltext Access 4 Pages 2005
Synthesis of substituted indole derivatives as a new class of antimalarial agents Fulltext Access 4 Pages 2005
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists Fulltext Access 4 Pages 2005
Synthesis and characterization of the monomer ruthenium complex of hypocrellin B Fulltext Access 4 Pages 2005
Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics Fulltext Access 4 Pages 2005
Gastric cytoprotective activity of ilicic aldehyde: Structure–activity relationships Fulltext Access 4 Pages 2005
The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: Antagonists versus agonists Fulltext Access 4 Pages 2005
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs Fulltext Access 4 Pages 2005
Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives Fulltext Access 4 Pages 2005
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors Fulltext Access 4 Pages 2005
Three-dimensional structure of Plasmodium falciparum Ca2+-ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6 Fulltext Access 4 Pages 2005
New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects Fulltext Access 4 Pages 2005
Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by α-aminoxy acids Fulltext Access 4 Pages 2005
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-α converting enzyme Fulltext Access 4 Pages 2005
Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II Fulltext Access 4 Pages 2005
DNA binding specificity and cytotoxicity of novel antitumor agent Ge132 derivatives Fulltext Access 4 Pages 2005
N-[(3S)-1-Benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: Human dopamine D4 ligands with high affinity for the 5-HT2A receptor Fulltext Access 4 Pages 2005
A synthesis of 3-deoxydihydrolycoricidine: Refinement of a structurally minimum pancratistatin pharmacophore Fulltext Access 4 Pages 2005
Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus Fulltext Access 4 Pages 2005
Inhibitors of the serotonin transporter protein (SERT): The design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots Fulltext Access 4 Pages 2005
Photoregulation of DNA polymerase I (Klenow) with caged fluorescent oligodeoxynucleotides Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents Fulltext Access 4 Pages 2005
Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): A radiolabelled glycogen synthase kinase-3β specific inhibitor for PET studies Fulltext Access 4 Pages 2005
Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome Fulltext Access 4 Pages 2005
Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals Fulltext Access 4 Pages 2005
Privileged structure-based ligands for melanocortin receptors—tetrahydroquinolines, indoles, and aminotetralines Fulltext Access 4 Pages 2005
Structure–activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor Fulltext Access 4 Pages 2005
Self-complementary peptides for the formation of collagen-like triple helical supramolecules Fulltext Access 4 Pages 2005
Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes Fulltext Access 4 Pages 2005
A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents Fulltext Access 4 Pages 2005
In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors Fulltext Access 4 Pages 2005
Phosphinate, sulfonate, and sulfonamidate dipeptides as potential inhibitors of Escherichia coli aminopeptidase N Fulltext Access 4 Pages 2005
Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase Fulltext Access 4 Pages 2005
Highly sensitive peptide-based probes for protein tyrosine phosphatase activity utilizing a fluorogenic mimic of phosphotyrosine Fulltext Access 4 Pages 2005
Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide–protein interactions Fulltext Access 4 Pages 2005
Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors Fulltext Access 4 Pages 2005
Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold Fulltext Access 4 Pages 2005
The tert-butyl dimethyl silyl group as an enhancer of drug cytotoxicity against human tumor cells Fulltext Access 4 Pages 2005
Design, synthesis and evaluation of racemic 1-(4-hydroxyphenyl)-2-[3-(substituted phenoxy)-2-hydroxy-1-propyl]amino-1-propanol hydrochlorides as novel uterine relaxants Fulltext Access 4 Pages 2005
Investigation of glycine α-ketoamide HCV NS3 protease inhibitors: Effect of carboxylic acid isosteres Fulltext Access 4 Pages 2005
Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein Fulltext Access 4 Pages 2005
9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers Fulltext Access 4 Pages 2005
Optimization of piperazinebenzylamines with a N-(1-methoxy-2-propyl) side chain as potent and selective antagonists of the human melanocortin-4 receptor Fulltext Access 4 Pages 2005
Calorimetric and computational study of enthalpy of formation of 3,6-dibutanoic-1,2,4,5-tetroxane Fulltext Access 4 Pages 2005
The synthesis and antioxidant activity of the Schiff bases of chitosan and carboxymethyl chitosan Fulltext Access 4 Pages 2005
The hydrogen peroxide induced enhancement of DNA cleavage in the ambient light photolysis of CpFe(CO)2Ph: A potential strategy for targeting cancer cells Fulltext Access 4 Pages 2005
Hydroxylated N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives as potent broad-spectrum anticoccidial agents Fulltext Access 4 Pages 2005
8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity Fulltext Access 4 Pages 2005
Glycolipids and other constituents from Desmodium gangeticum with antileishmanial and immunomodulatory activities Fulltext Access 4 Pages 2005
Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones Fulltext Access 4 Pages 2005
The enigma of coproporphyrinogen oxidase: How does this unusual enzyme carry out oxidative decarboxylations to afford vinyl groups? Fulltext Access 4 Pages 2005
Synthesis and in vitro and in vivo antimycobacterial activity of isonicotinoyl hydrazones Fulltext Access 4 Pages 2005
Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease Fulltext Access 4 Pages 2005
Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands Fulltext Access 4 Pages 2005