Insecticidal activity of proteinous venom from tentacle of jellyfish Rhopilema esculentum Kishinouye Fulltext Access 4 Pages 2005
3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists Fulltext Access 4 Pages 2005
Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells Fulltext Access 4 Pages 2005
Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis Fulltext Access 4 Pages 2005
Synthesis of a novel prodrug of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid for colon delivery Fulltext Access 4 Pages 2005
Polymer supported carbodiimide strategy for the synthesis of N-acylated derivatives of deoxy- and ribo purinenucleosides using active esters Fulltext Access 4 Pages 2005
Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists Fulltext Access 4 Pages 2005
Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides Fulltext Access 4 Pages 2005
(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators Fulltext Access 4 Pages 2005
Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain Fulltext Access 4 Pages 2005
Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2 Fulltext Access 4 Pages 2005
Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents Fulltext Access 4 Pages 2005
Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol Fulltext Access 4 Pages 2005
Synthesis of (2R,3S) 3-amino-4-mercapto-2-butanol, a threonine analogue for covalent inhibition of sortases Fulltext Access 4 Pages 2005
Design, synthesis, and enzymatic property of a sulfur-substituted analogue of trigalacturonic acid Fulltext Access 4 Pages 2005
Solid support synthesis of 6-aryl-2-substituted pyrimidin-4-yl phenols as anti-infective agents Fulltext Access 4 Pages 2005
The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides Fulltext Access 4 Pages 2005
The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines Fulltext Access 4 Pages 2005
Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin Fulltext Access 4 Pages 2005
Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucose-dependent insulinotropic polypeptide Fulltext Access 4 Pages 2005
Controllable selective synthesis of a polymerizable prodrug of cytarabine by enzymatic and chemical methods Fulltext Access 4 Pages 2005
Utilizing the intramolecular Fukuyama–Mitsunobu reaction for a flexible synthesis of novel heterocyclic scaffolds for peptidomimetic drug design Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists Fulltext Access 4 Pages 2005
Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents Fulltext Access 4 Pages 2005
Chemical characteristics of a polysaccharide from Porphyra capensis (Rhodophyta) Fulltext Access 4 Pages 2005
Glycosylation of acid sensitive acceptors. Synthesis of (2,3-epoxy-1-propyl) glycosides Fulltext Access 4 Pages 2005
Identification of bound water molecules in the cyclic tetrasaccharide, cyclo-{â6}-α-d-Glcp-(1â3)-α-d-Glcp-(1â6)-α-d-Glcp-(1â3)-α-d-Glcp-(1â) Fulltext Access 4 Pages 2005
Observations on the reactivity of thiyl radicals derived from 3,6-epidithiodiketopiperazine-2,5-diones and related congeners Fulltext Access 4 Pages 2005
Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase Fulltext Access 4 Pages 2005
NMDA-NR2B subtype selectivity of stereoisomeric 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives Fulltext Access 4 Pages 2005
3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation Fulltext Access 4 Pages 2005
Synthesis and assay of isoquinoline derivatives as HIV-1 Tat–TAR interaction inhibitors Fulltext Access 4 Pages 2005
A colorimetric titration method for quantification of millimolar glucose in a pH 7.4 aqueous phosphate buffer Fulltext Access 4 Pages 2005
Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists Fulltext Access 4 Pages 2005
New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: Synthesis and biological activity Fulltext Access 4 Pages 2005
In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I Fulltext Access 4 Pages 2005
Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments Fulltext Access 4 Pages 2005
Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists Fulltext Access 4 Pages 2005
Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1 Fulltext Access 4 Pages 2005
Structure–activity relationship studies of salubrinal lead to its active biotinylated derivative Fulltext Access 4 Pages 2005
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors Fulltext Access 4 Pages 2005
Toward high yield synthesis of peptide–oligonucleotide chimera through a disulfide bridge: A simplified method for oligonucleotide activation Fulltext Access 4 Pages 2005
Synthesis of desthio prenylcysteine analogs: Sulfur is important for biological activity Fulltext Access 4 Pages 2005
A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor Fulltext Access 4 Pages 2005
Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents Fulltext Access 4 Pages 2005
Metabolism investigation leading to novel drug design: Orally active prostacyclin mimetics. Part 4 Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro Fulltext Access 4 Pages 2005
6-(2-Phenylethyl)nicotine: A novel nicotinic cholinergic receptor ligand Fulltext Access 4 Pages 2005
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives Fulltext Access 4 Pages 2005
Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists Fulltext Access 4 Pages 2005
Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells Fulltext Access 4 Pages 2005
Pharmacophore-based design, synthesis, biological evaluation, and 3D-QSAR studies of aryl-piperazines as α1-adrenoceptor antagonists Fulltext Access 4 Pages 2005
Discovery of non-steroidal mifepristone mimetics: Pyrazoline-based PR antagonists Fulltext Access 4 Pages 2005
Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia Fulltext Access 4 Pages 2005
Discovery and synthesis of a novel and selective drug-like P2X1 antagonist Fulltext Access 4 Pages 2005
Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy Fulltext Access 4 Pages 2005
New series of potent δ-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif Fulltext Access 4 Pages 2005
Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases Fulltext Access 4 Pages 2005
A thiolate ligand on a cytochrome P-450 mimic permits the use of simple environmentally benign oxidants for biomimetic steroid hydroxylation in water Fulltext Access 4 Pages 2005
New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors Fulltext Access 4 Pages 2005
Efficient synthesis of C-terminal modified peptide ketones for chemical ligations Fulltext Access 4 Pages 2005
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416 Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors Fulltext Access 4 Pages 2005
SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: A novel class of cytotoxic agents for prostate cancer Fulltext Access 4 Pages 2005
O-Methylglucogalloyl esters: Synthesis and evaluation of their antimycotic activity Fulltext Access 4 Pages 2005
Novel peptide derivatives of bleomycin A5: Synthesis, antitumor activity and interaction with DNA Fulltext Access 4 Pages 2005
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists Fulltext Access 4 Pages 2005
Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism Fulltext Access 4 Pages 2005
Synthesis, in vivo and in vitro biological activity of novel azaline B analogs Fulltext Access 4 Pages 2005
Azinomycin inspired bisepoxides: influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking Fulltext Access 4 Pages 2005
Anti-malarial activity of Baylis–Hillman adducts from substituted 2-chloronicotinaldehydes Fulltext Access 4 Pages 2005
Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13 Fulltext Access 4 Pages 2005
A micromethod for the stereochemical analysis of fatty acid desaturase-mediated sulfoxidation reactions Fulltext Access 4 Pages 2005
The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents Fulltext Access 4 Pages 2005
Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants Fulltext Access 4 Pages 2005
Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase Fulltext Access 4 Pages 2005
Chiral discrimination in binding of enantiomers of 2-(aminoalkoxy)-substituted 4-(2-thienyl)pyrimidines and 4,6-bis(2-thienyl)pyrimidines with duplex DNA Fulltext Access 4 Pages 2005
Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives Fulltext Access 4 Pages 2005
Redox-responsive and calcium-dependent switching of glycosyldisulfide interactions with Concanavalin A Fulltext Access 4 Pages 2005