Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility Fulltext Access 7 Pages 2007
Discovery and structure–activity relationship studies of indole derivatives as liver X receptor (LXR) agonists Fulltext Access 7 Pages 2007
Development of carboxylic acid replacements in indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase Fulltext Access 7 Pages 2007
Identification of dissociated non-steroidal glucocorticoid receptor agonists Fulltext Access 7 Pages 2007
Design, synthesis, and structure–activity relationship studies of new phenolic DNA gyrase inhibitors Fulltext Access 7 Pages 2007
Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2) Fulltext Access 7 Pages 2007
Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity Fulltext Access 7 Pages 2007
Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa Fulltext Access 7 Pages 2007
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors Fulltext Access 7 Pages 2007
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors Fulltext Access 7 Pages 2007
Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor Fulltext Access 7 Pages 2007
Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor Fulltext Access 7 Pages 2007
RXR–LXR heterodimer modulators for the potential treatment of dyslipidemia Fulltext Access 7 Pages 2007
Synthesis and structure–activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor Fulltext Access 7 Pages 2007
Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis Fulltext Access 7 Pages 2007
Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors Fulltext Access 7 Pages 2007
Synthesis of pseudopeptides based l-tryptophan as a potential antimicrobial agent Fulltext Access 7 Pages 2007
Pharmacophore mapping of diverse classes of farnesyltransferase inhibitors Fulltext Access 7 Pages 2007
Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells Fulltext Access 7 Pages 2007
Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor Fulltext Access 7 Pages 2007
Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid as anti-inflammatory agents free of ulcerogenic liability Fulltext Access 7 Pages 2007
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors Fulltext Access 7 Pages 2007
Farnesyltransferase pharmacophore model derived from diverse classes of inhibitors Fulltext Access 7 Pages 2007
Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin Fulltext Access 7 Pages 2007
Inhibition of peritoneal dissemination of tumor cells by cationized catalase in mice Fulltext Access 7 Pages 2007
New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity Fulltext Access 7 Pages 2007
Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents Fulltext Access 7 Pages 2007
Novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41 as catalyst, and their biological evaluation as human platelet aggregation inhibitors Fulltext Access 7 Pages 2007
Synthesis and antibacterial activity of oxazolidinones containing triazolyl group Fulltext Access 7 Pages 2007
Structure-based discovery of new small molecule inhibitors of low molecular weight protein tyrosine phosphatase Fulltext Access 7 Pages 2007
Convenient one pot synthesis and antimicrobial evaluation of some new Mannich bases carrying 4-methylthiobenzyl moiety Fulltext Access 7 Pages 2007
Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[μ2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(μ2-CH2CH2NHNCC6H4)PdCl]2·C2H5OH complex Fulltext Access 7 Pages 2007
Glutamine vinyl ester proteasome inhibitors selective for trypsin-like (β2) subunit Fulltext Access 7 Pages 2007
Chemotherapy of leishmaniasis. Part VII: Synthesis and bioevaluation of substituted terpenyl pyrimidines Fulltext Access 7 Pages 2007
N- and S-α-l-Arabinopyranosyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. First synthesis and biological evaluation Fulltext Access 7 Pages 2007
N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated γ-secretase Fulltext Access 7 Pages 2007
Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine—a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays Fulltext Access 7 Pages 2007
1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors Fulltext Access 7 Pages 2007
1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists Fulltext Access 7 Pages 2007
Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability Fulltext Access 7 Pages 2007
ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2 Fulltext Access 7 Pages 2007
Synthesis and HIV-1 integrase inhibitory activity of spiroundecane(ene) derivatives Fulltext Access 7 Pages 2007
Simple criterion for selection of flavonoid compounds with anti-HIV activity Fulltext Access 7 Pages 2007
New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases Fulltext Access 7 Pages 2007
Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors Fulltext Access 7 Pages 2007
Metallocene-based antimalarials: An exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum Fulltext Access 7 Pages 2007
Effect of indole ethyl isothiocyanates on proliferation, apoptosis, and MAPK signaling in neuroblastoma cell lines Fulltext Access 7 Pages 2007
The design and preliminary structure–activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes Fulltext Access 7 Pages 2007
N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease Fulltext Access 7 Pages 2007
Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA Fulltext Access 7 Pages 2007
In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors Fulltext Access 7 Pages 2007
Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents Fulltext Access 7 Pages 2007
2,3,5-Substituted tetrahydrofurans as cancer chemopreventives. Part 1: Synthesis and anti-cancer activities of 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols Fulltext Access 7 Pages 2007
Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer Fulltext Access 7 Pages 2007
Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of a series of substituted benzylic ketones derived from histidine Fulltext Access 7 Pages 2007
High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors Fulltext Access 7 Pages 2007
Synthesis and potent antitumor activity of new arylamino derivatives of nor-β-lapachone and nor-α-lapachone Fulltext Access 7 Pages 2007
Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups Fulltext Access 7 Pages 2007
Synthesis and structure–activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells Fulltext Access 7 Pages 2007
In vitro free radical scavenging activities and effect of synthetic oligosaccharides on antioxidant enzymes and lipid peroxidation in aged mice Fulltext Access 7 Pages 2007
Determination of Cu, Fe, Mn and Zn by flame atomic absorption spectrometry in multivitamin/multimineral dosage forms or tablets after an acidic extraction Fulltext Access 7 Pages 2007
Performance characteristics of two immunoassays for the measurement of urinary luteinizing hormone Fulltext Access 7 Pages 2007
Determination of doxorubicin in rabbit ocular tissues and pharmacokinetics after intravitreal injection of a single dose of doxorubicin-loaded poly-β-hydroxybutyrate microspheres Fulltext Access 7 Pages 2007
Anion-exchange chromatography using short monolithic columns as a complementary technique for human serum albumin depletion prior to human plasma proteome analysis Fulltext Access 7 Pages 2007
Development and validation of a stability-indicating analytical method for the quantitation of oxytocin in pharmaceutical dosage forms Fulltext Access 7 Pages 2007
Screening and analysis of bioactive compounds in traditional Chinese medicines using cell extract and gas chromatography–mass spectrometry Fulltext Access 7 Pages 2007
Simultaneous determination of eight active components in Chinese medicine ‘YIQING’ capsule using high-performance liquid chromatography Fulltext Access 7 Pages 2007
Synthesis and structure–activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells Fulltext Access 7 Pages 2007
Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors Fulltext Access 7 Pages 2007
Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity Fulltext Access 7 Pages 2007
Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα Fulltext Access 7 Pages 2007
Design, synthesis, and evaluation of phenanthridine derivatives targeting the telomerase RNA/DNA heteroduplex Fulltext Access 7 Pages 2007
Quantitative structure-selectivity relationship for M2 selectivity between M1 and M2 of piperidinyl piperidine derivatives as muscarinic antagonists Fulltext Access 7 Pages 2007
Synthesis and herbicidal activity of novel pyrazolo[3,4-d]pyrimidin-4-one derivatives containing aryloxyphenoxypropionate moieties Fulltext Access 7 Pages 2007
A new platinum complex of triazine demonstrates G1 arrest with novel biological profile in human breast cancer cell line, MDA-MB-468 Fulltext Access 7 Pages 2007
4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV Fulltext Access 7 Pages 2007
Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors Fulltext Access 7 Pages 2007
Synthesis and evaluation of Novel Benzimidazole derivative [Bz-Im] and its radio/biological studies Fulltext Access 7 Pages 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose–thioureido tails Fulltext Access 7 Pages 2007
A novel class of selective anti-Helicobacter pylori agents 2-oxo-2H-chromene-3-carboxamide derivatives Fulltext Access 7 Pages 2007
Skin penetration behaviour of sesquiterpene lactones from different Arnica preparations using a validated GC-MSD method Fulltext Access 7 Pages 2007
Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARδ-selective agonists Fulltext Access 7 Pages 2007
Arylpropanolamines: Selective β3 agonists arising from strategies to mitigate phase I metabolic transformations Fulltext Access 7 Pages 2007
Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides—Solution and crystallographic studies Fulltext Access 7 Pages 2007
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: Kinetic and X-ray crystallographic studies Fulltext Access 7 Pages 2007
Respiratory syncytial virus fusion inhibitors. Part 6: An examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety Fulltext Access 7 Pages 2007
Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects Fulltext Access 7 Pages 2007
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor Fulltext Access 7 Pages 2007
Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors Fulltext Access 7 Pages 2007
Capped diaminopropionamide–glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2) Fulltext Access 7 Pages 2007