دانلود مقالات ISI درباره 1-Methyl-4-Phenylpyridinium + ترجمه فارسی

Functional characterization of the organic cation transporters (OCTs) in human airway pulmonary epithelial cells

Keywords: ALI; air-liquid interface culture; EBSS; Earle's Balanced Salt Solution; MPP+; 1-methyl-4-phenylpyridinium; OCT; organic cation transporter; PBS; phosphate-buffered saline solution; PGE2; prostaglandine E2; TEER; transepithelial electrical resistance; P

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8+ T cells in the nigra of hemiparkinsonian monkey

Keywords: DA; dopaminergic; ELISA; enzyme-linked immuno assay; IKK; IκB kinase; MPP+; 1-methyl-4-phenylpyridinium; NBD; NEMO-binding domain; NEMO; NF-κB essential modifier; RT-PCR; real-time polymerase chain reaction; TH; tyrosine hydroxylase; wt; wild type; Park

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo

Keywords: 6-OHDA; 6-hydroxydopamine; AAV; adeno-associated viral vector; Bcl-2; B-cell lymphoma 2; CNS; central nervous system; ctl; contralateral; DAPI; 4′,6-diamidino-2-phenylindole; DIV; day in vitro; DOPAC; 3,4-dihydroxyphenylacetic acid; EGFP; enhanced green

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression

Keywords: ARE; antioxidant response elements; CNC; Cap 'n' Collar; CBA; coumarin boronic acid; GCLM; glutamate-cysteine ligase modifier subunit; eGFP; enhanced green fluorescent protein; HO-1; heme oxygenase 1; iTRAQ; Isobaric tags for relative and absolute qua

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2015 سفارش ترجمه

Edaravone protected PC12 cells against MPP(+)-cytoxicity via inhibiting oxidative stress and up-regulating heme oxygenase-1 expression

Keywords: Parkinson's disease; Edaravone; PC12; 1-Methyl-4-phenylpyridinium; Oxidative stress; Heme oxygenase-1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson's disease

Keywords: Naringin; Parkinson's disease; GDNF; 1-Methyl-4-phenylpyridinium; Neuroprotection;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death

Keywords: Dopamine; Neuroprotection; Neuroinflammation; Microglia; Parkinson; Rho; LME; l-leucine methyl ester; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-metil-4-fenil-1,2,3,6 tetrahidropiridine; PD; Parkinson's disease; ROCK; Rho-associated Kinase; TH; tyrosine h

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons

Keywords: Dopamine; D2 autoreceptors; KATP channels; HCN channels; Brain slice; ACSF; artificial cerebrospinal fluid; ATP; adenosine triphosphate; DA; dopamine; DAT; dopamine transporter; GIRK; G protein-coupled inwardly rectifying potassium channels; HCN; hyperpol

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease

Keywords: PD; Parkinson disease; SNPc; substantia nigra pars compacta; α-syn; α-synuclein; GTPCH; GTP cyclohydrolase I; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium; NOS; nitric oxide synthase; DAT; dopamine transporter; B

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2014 سفارش ترجمه

AIF, reactive oxygen species, and neurodegeneration: A “complex” problem

Keywords: AIF; apoptosis inducing factor; DCFH-DA; dichlorodihydrofluorescein; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NMDA; N-methyl d-aspartate; ROS; reactive oxygen species; Mitochondria; Electron transport; Complex

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Compartmentalized oxidative stress in dopaminergic cell death induced by pesticides and complex I inhibitors: Distinct roles of superoxide anion and superoxide dismutases

Keywords: ARE; antioxidant response elements; DHE; dihydroethidium; ETC; electron transport chain; CuZnSOD; copper/zinc SOD; IMS; intermembrane space; MnSOD; manganese SOD; MPP+; 1-methyl-4-phenylpyridinium; ΔΨm; mitochondrial membrane potential; MnTBAP; Mn(III)t

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2013 سفارش ترجمه

Residue Ile89 in human plasma membrane monoamine transporter influences its organic cation transport activity and sensitivity to inhibition by dilazep

Keywords: PMAT; plasma membrane monoamine transporter; SLC29; solute carrier 29; SLC22; solute carrier 22; MPP+; 1-methyl-4-phenylpyridinium; ENT; equilibrative nucleoside transporter; Vmax; maximal transport velocity; Km; apparent binding affinity; OCT; organic ca

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The power of life-Cytochrome c oxidase takes center stage in metabolic control, cell signalling and survival

Keywords: ATP; adenosine 5′-triphosphate; COX; cytochrome c oxidase; Δpm; proton motive force; ΔΨm; mitochondrial membrane potential; H2S; hydrogen sulphur; MPP+; 1-methyl-4-phenylpyridinium; NO; nitric oxide; NPA; 3-nitropropionic acid; 6-OHDA; 6-hydroxydopam

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse

Keywords: α-syn; α-synuclein; ASK1; Apoptosis signaling-regulating kinase 1; CMA; Chaperone-mediated autophagy; DAT; Dopamine transporter; ETC; Electron transport chain; iPS; Induced pluripotent stem; LAMP-2A; Lysosome-associated membrane protein 2A; LB; Lewy bod

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Long-lasting transcriptional refractoriness triggered by a single exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine

Keywords: Cdkn1a; cyclin-dependent kinase inhibitor 1a; CDS; coding sequence; DA; dopamine; DOPAC; 3-4-dihydroxphenylacetic acid; EDTA; ethylenediaminetetraacetic acid; Edg3; endothelial differentiation, sphingolipid G-protein-coupled receptor 3; Fosb; FBJ murine o

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2012 سفارش ترجمه

Protective effect of Zhen-Wu-Tang (ZWT) through keeping DA stable and VMAT 2/DAT mRNA in balance in rats with striatal lesions induced by MPTP

Keywords: PD; Parkinson's disease; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine; MPP+; 1-methyl-4-phenylpyridinium; ZWT; Zhen-Wu-Tang; DA; dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; HVA; homovanillic acid; DHBA; 3,4-dihydroxybenzylamine; TH; tyrosine h

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice

Keywords: Parkinson's disease; 1-methyl-4-phenylpyridinium; S-Allylcysteine; Dopamine; Neuroprotection; Antioxidant defense

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects

Keywords: CNS; central nervous system; MPP+; 1-methyl-4-phenylpyridinium; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PACAP; Structure-activity; PAC1/VPAC1 selectivity; Neuroprotection; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease

Keywords: Modified Youldahanso-tang (MYH); Neuroprotection; Autophagy; Parkinson's disease; 1-Methyl-4-phenyl-1,2,3,6-tetrahydrophenylpyridine (MPTP); Lactacystin; MYH; Modified Youldahanso-tang; PD; Parkinson's disease; UPS; ubiquitin-proteasome system; ALP; autop

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Functional characterization of Rat Plasma Membrane Monoamine Transporter in the Blood–Brain and Blood–Cerebrospinal Fluid Barriers

Keywords: blood–brain barrier; blood–cerebrospinal fluid barrier; in vitro models; transporters; CNS; plasma membrane monoamine transporter; 1-methyl-4-phenylpyridinium; TR-BBB13 cells; TR-CSFB3 cells

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

l-DOPA: A scapegoat for accelerated neurodegeneration in Parkinson's disease?

Keywords: AADC; aromatic l-amino acid decarboxylase; ALDH; aldehyde dehydrogenase; AMPA; α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; AR; aldehyde reeductase; ATP; adenosine triphosphate; Bax; Bcl-2-associated X protein; BDNF; brain-derived neurotrophic fac

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2011 سفارش ترجمه

Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases

Keywords: ACE2; angiotensin-converting enzyme 2; ADP; adenosine diphosphate; AGE; advanced glycation end-products; APV; DL-2-amino-5-phosphonovaleric acid; AT1; angiotensin II type I receptor; Aβ25-35; β-amyloid; Bcl-2; B-cell leukemia/lymphoma-2; BKCa; large-con

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2011 سفارش ترجمه

Differential effect of platelet activating factor on 1-methyl-4-phenylpyridinium-induced cell death through regulation of apoptosis-related protein activation

Keywords: Platelet activating factor; 1-Methyl-4-phenylpyridinium; PC12 cells; Apoptosis-related protein activation; Differential effect;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

The dopamine transporter is differentially regulated after dopaminergic lesion

Keywords: DA; domanine; dSt; dorsal striatum; glyco-DAT; glycosylated DAT form; MPP+; 1-methyl-4-phenylpyridinium; non-glyco-DAT; non-glcyosylated DAT form; SNcv; substantia nigra, caudoventral and lateral region; SNrm; substantia nigra, rostromedial and dorsal reg

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Effect of EGb761 supplementation on the content of copper in mouse brain in an animal model of Parkinson's disease

Keywords: Copper content; 1-Methyl-4-phenylpyridinium; Animal model of Parkinson's disease; Ginkgo biloba extract; Striatum

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease

Keywords: 6-OHDA; 6-hydroxydopamine; CHAPS; 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonic acid; CoQ1; ubiquinone; DTT; dithiotreitol; ER; endoplasmic reticulum; FCCP; carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone; LBs; Lewy bodies; LC; locus coe

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Antidepressants reveal differential effect against 1-methyl-4-phenylpyridinium toxicity in differentiated PC12 cells

Keywords: Antidepressant; 1-Methyl-4-phenylpyridinium; Mitochondrial membrane permeability change; Cell death; Different effect

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults

Keywords: AA; arachidonic acid; AIPH; 2,2′-azobis[2-(2-imidazolin-2-yl)-propane] dihydrochloride; COX; cyclooxygenase; HpETE; hydroperoxyeicosatetraenoic acid; HpODE; hydroperoxyloctadecadienoic acid; IL; interleukin; LA; linoleic acid; LOX; lipoxygenase; LPS; li

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Prostaglandin analogue misoprostol attenuates neurotoxin 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells

Keywords: Misoprostol; 1-Methyl-4-phenylpyridinium; PC12 cells; Mitochondrial membrane permeability change; Cell death; Protection;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in dopaminergic neurons

Keywords: Mg, magnesium; MPP+, 1-methyl-4-phenylpyridinium; PD, Parkinson disease; TH, tyrosine hydroxylaseMagnesium; 1-methyl-4-phenylpyridinium; Dopaminergic neuron; Ventral mesencephalic–striatal co-culture; Parkinson disease

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

N-Methyltetrahydro-β-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic β-carbolinium cations by heme peroxidases

Keywords: MPTP; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-Methyl-4-phenylpyridinium; β-Carbolinium; N-Methyltetrahydro-β-carbolines; Myeloperoxidase; Lactoperoxidase; Horseradish peroxidase; Cytochrome P450; CYP2D6; Monoamine oxidase (MAO); Parkinson’s

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Biphasic mechanism of the toxicity induced by 1-methyl-4-phenylpyridinium ion (MPP+) as revealed by dynamic changes in glucose metabolism in rat brain slices

Keywords: 1-Methyl-4-phenylpyridinium; Neurotoxicity; GBR 12909; α-Phenyl-N-tert-butylnitrone; [18F]2-fluoro-2-deoxy-d-glucose; Brain slice

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Lamotrigine inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death

Keywords: Rotenone; 1-Methyl-4-phenylpyridinium; Lamotrigine; PC12 cells; Mitochondrial permeability transition; Protection

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells

Keywords: 1-methyl-4-phenylpyridinium; PC12 cells; Erythropoietin; Oxidative stress; Apoptosis

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Econazole attenuates cytotoxicity of 1-methyl-4-phenylpyridinium by suppressing mitochondrial membrane permeability transition

Keywords: 1-Methyl-4-phenylpyridinium; Econazole; PC12 cells; Mitochondrial membrane permeability; Cell injury

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Piperine inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells

Keywords: 1-Methyl-4-phenylpyridinium; Piperine; PC12 cells; Mitochondrial membrane permeability; Cell injury

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Acute intranigral homocysteine administration produces stereotypic behavioral changes and striatal dopamine depletion in Sprague-Dawley rats

Keywords: AD; Alzheimer's disease; COMT; catechol-O-methyl transferase; DA; dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; 5-HIAA; 5-hydroxyindolecaetic acid; 5-HT; 5-hydroxytryptamine; HVA; homovanillic acid; l-DOPA; levodopa; MPP+; 1-methyl-4-phenylpyridinium;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Granulocyte colony-stimulating factor is not protective against selective dopaminergic cell death in vitro

Keywords: Parkinson's disease; Granulocyte colony-stimulating factor; 1-Methyl-4-phenylpyridinium;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Sulfiredoxin: a potential therapeutic agent?

Keywords: Glutathione; Glutathionylation; Sulfiredoxin; Reactive oxygen/nitrogen species; Oxidative stress; GST; ALS; amylotrophic lateral sclerosis; ER; endoplasmic reticulum; FRDA; Friedrich's ataxia; Grx; glutaredoxin; GSH; glutathione; GSSG; glutathione disul

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Interleukin-6 induces glutathione in hippocampal cells

Keywords: BSA; bovine serum albumin; BSO; buthionine sulfoximine; CNS; central nervous system; DTNB; 5,5′-dithio-bis(2-nitrobenzoic acid); DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; GSH; glutathione; GSSG; glutathione disulfide; GR; glutathi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Synergistic effects of hydrogen peroxide and ethanol on cell viability loss in PC12 cells by increase in mitochondrial permeability transition

Keywords: carboxy-PTIO; 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; DCFH2-DA; 2′,7′-dichlorofluorescin diacetate; DiOC6(3); 3,3′-dihexyloxacarbocyanine iodide; DTNB; 5,5′-dithio-bis-(2-nitrobenzoic acid); Mn-TBAP; Mn(III) tetrakis(4-b

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Reduction of Zinc-Positive Terminal Fields in Striatum of Mouse after 1-Methyl-4-Phenylpyridinium Neurotoxicity

Keywords: Zinc; 1-Methyl-4-phenylpyridinium; Striatum; Histochemistry; Timm's method;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Therapeutic role of coenzyme Q10 in Parkinson's disease

Keywords: AIF; apoptosis-inducing factor; ATP; adenosine 5′ triphosphate; C. elegans; Caenorhabditis elegans; CoA; coenzyme A; ETC; electron transport chain; FADH2; flavin adenine dinucleotide; IAP; inhibitors of apoptosis proteins; MOMP; mitochondrial outer memb

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Role of peroxidases in Parkinson disease: a hypothesis

Keywords: COX-1; cyclooxygenase-1; COX-2; cyclooxygenase-2; IFN-γ; interferon-γ; IL-1β; interleukin-β; LPS; lipopolysaccharide; MAO-B; monoamine oxidase B; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPDP; 1-methyl-4-phenyl-1,2-dihydropyridine; MPP+; 1-

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه

Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease

Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; AIF; apoptosis-inducing factor; ALS; amyotrophic lateral sclerosis; Apaf-1; apoptotic protease-activating factor; APC; adenomatous polyposis coli; APP; amyloid precursor protein; BrdU; bromodeoxyuridine; CARD; cas

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2005 سفارش ترجمه

Therapeutic potential of adenosine A2A receptor antagonists in Parkinson's disease

Keywords: Adenosine A2A receptor; Caffeine; Dyskinesia; Neuroprotection; Parkinson's disease; Striatum; 6-OHDA; 6-hydroxydopamine; ACh; acetylcholine; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APEC; 2-[(2-aminoethylamino)carbonylethyl-phenylethyl

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2005 سفارش ترجمه