کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10739785 | 1046889 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of peroxidases in Parkinson disease: a hypothesis
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کلمات کلیدی
LPSMAO-B1-methyl-4-phenylpyridiniumIFN-γCOX-2COX-1MPTPIL-1β1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridineMPP+ - MPP +interferon-γ - اینترفرون-γInterleukin-β - اینترلوکین-بتاParkinson disease - بیماری پارکینسونtumor necrosis factor-α - تومور نکروز عامل αFree radicals - رادیکال آزادCytotoxicity - سمیت سلولیcytochrome c - سیتوکروم سیcyclooxygenase-1 - سیکلوکوکسیژناز 1Cyclooxygenase-2 - سیکلوکوکسیژناز2TNF-α - فاکتور نکروز توموری آلفاlipopolysaccharide - لیپوپلی ساکاریدmonoamine oxidase B - مونوآمین اکسیداز Bmyeloperoxidase - میلوپراکسیداز Nitric oxide - نیتریک اکسیدPeroxidase - پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Extensive research has been done to elucidate the underlying molecular events causing neurodegenerative diseases such as Parkinson disease, yet the cause and the individual steps in the progression of such diseases are still unknown. Here we advance the hypothesis that, rather than or in addition to inorganic radical molecules, heme-containing peroxidase enzymes may play a major role in the etiology of Parkinson disease. This hypothesis is based on the following considerations: (1) several heme-containing enzymes with peroxidase activity are present in the substantia nigra pars compacta; (2) these peroxidases have the ability to catalyze the oxidation of proteins and lipids; (3) certain heme peroxidases are known to destroy cells in vivo; (4) heme peroxidases have the stability and specificity that could account for the fact that specific molecules and cells are subject to damage in Parkinson disease, rather than a random destruction; (5) heme peroxidase activity could account for certain reactions in connection with parkinsonism that thus far have not been adequately explained; and (6) the participation of a heme peroxidase could explain some recent observations that are inconsistent with the oxyradical theory. The peroxidase-catalyzed oxidative pathway proposed here does not preclude the participation of apoptosis as an additional mechanism for cell destruction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 38, Issue 10, 15 May 2005, Pages 1296-1310
Journal: Free Radical Biology and Medicine - Volume 38, Issue 10, 15 May 2005, Pages 1296-1310
نویسندگان
Johannes Everse, Penelope W. Coates,