Keywords: 6-OHDA; 6-hydroxydopamine; L-DOPA; L-3,4-dihydroxyphenylalanine; MB; methylene blue; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; OD; optical density; p; probenecid; PD; Parkinson's disease; SNpc; substantia nig
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Keywords: AD; Alzheimer's disease; DA; dopamine; DAergic; dopaminergic; hMAO-A; human monoamine oxidase A; hMAO-B; human monoamine oxidase B; HRP; horseradish peroxidase; IC50; the half maximal inhibitory concentration; i.p.; intraperitoneal; Ki; inhibition const
Keywords: AcH; acetaldehyde; CTIQs; catechol isoquinolines; DA; dopamine; DMDHIQ+; 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion; ISOP; isoproterenol; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-Methyl-4-phenylpyridinium; N-Me-Sal; N-methyl-salsolino
Keywords: OS; oxidative stress; ROS; reactive oxygen species; MG; methylglyoxal; glo 1; glyoxalase-1; glo 2; glyoxalase-2; AGEs; advanced glycation end products; ASD; autism spectrum disorder; GSH; reduced glutathione; cas-3; caspase-3; NeuN; neuronal specific nucl
Keywords: PC12 cells; Rat adrenal pheochromocytoma cells; SNCA; α-synuclein; pDNA; plasmid DNA; BBB; blood-brain barrier; GNP; gold nanoparticles; CTS; chitosan; DTPA; 3,3â²-dithiodipropionic acid; NHS; N-hydroxysuccinimide; DTSP; dithiobis-(succinimidyl propio
Keywords: Dopaminergic (DA) neurons; Inflammatory mediators; Mast cells; Parkinson's disease; Substantia nigra; Transglutaminase 2; BMMCs; Bone marrow-derived mast cells; DA neurons; Dopaminergic neurons; DAT; dopamine transporter; LTs; Leukotrienes; MAOB; Monoamin
Keywords: AA; Arachidonic acid; AhR; Aryl hydrocarbon receptor; BBB; Blood-brain barrier; cDNA; Complementary DNA, deoxyribonucleic acid; CNS; Central nervous system; CP; Chlorpyrifos; CPO; Chlorpyrifos-oxon; CPR; Cytochrome p450 reductase; CYP; Cytochrome P450; EE
Keywords: 3-HK; 3-hydroxykynurenine; 6-OHDA; 6-hydroxydopamine; A; Amygdala; ACMSD; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; AD; Alzheimer's disease; AD; Anterodorsal nucleus (Thalamus); α-syn; Alpha-synuclein; CCL2; Chemokine (CC motif) ligand 2;
Keywords: 1-methyl-4-phenylpyridinium; blood-retinal barrier; organic cation; efflux;
Keywords: α-syn; α-synuclein; AD; Alzheimer's Disease; Al; aluminum; C. elegans; Caenorhabditis elegans; CPF; chlorpyrifos; DA; dopamine; DDE; dichlorodiphenyldichloroethylene; DDT; dichlorodiphenyltrichloroethane; ETC; electron transport chain; FAO; fatty acid
Keywords: organic cation transporters (OCTs); renal clearance; hepatic transport; hepatocytes; elderly; AUC; area under the curve; CKD; chronic kidney disease; CVD; cardiovascular disease; FMO3; flavin-containing monooxigenase 3; HEK; human embryonic kidney; HK; h
Keywords: Polyphenols; Antibiotics; Antioxidants; PACAP; Aβ; β-amyloid; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; BBB; blood-brain barrier; BDNF; brain-derived neurotrophic factor; CAT; catalase; CNS; central nervous system; COX-2; cyclooxyge
Keywords: pulmonary; tissue partition; pharmacokinetics; pulmonary drug delivery; distribution; Cu,cell; intracellular unbound drug concentration; Cu,lungISF; unbound drug concentration in the lung interstitial fluid; fu,lung; fraction of unbound drug in diluted lu
Keywords: DA; dopaminergic; MPP+; 1-methyl-4-phenylpyridinium; PD; Parkinson's disease; TH; tyrosine hydroxylase; Drosophila; Mitochondria; drp1; opa1; Parkinson;
Keywords: α-Syn; alpha-synuclein; CBE; conduritol-B-epoxide; CCCP; carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; CS; citrate synthase; Cx I; mitochondrial respiratory chain complex I; DA; dopaminergic; DIV; day in vitro; DMSO; dimethyl sulfoxide; EDTA; eth
Keywords: ANOVA; analysis of variance; BBB; blood-brain barrier; GDNF; glia-derived neurotrophic factor; GLP-1; glucagon-like peptide 1; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD; Parkinson's disease; TH; tyrosine
Keywords: PD; Parkinson's disease; ASYN; alpha-synuclein; CT cybrids; (control cybrids); sPD cybrids; (sporadic Parkinson's disease cybrids); mtDNA; mitochondrial DNA; MPP+; 1-methyl-4-phenylpyridinium; NAP; Mitochondria dynamics; Microtubule network;
Keywords: PAs; pyrrolizidine alkaloids; MCT; monocrotaline; OCT1; organic cation transporter 1; MDCK; Madin-Darby canine kidney; MPP+; 1-methyl-4-phenylpyridinium; d-THP; d-tetrahydropalmatine; DHM; dehydromonocrotaline; CYP; cytochrome P450; ASP+; 4-(4-(dimethyl
Keywords: ABC; ATP-binding cassette; ANPs; acyclic nucleoside phosphonates; BCRP/ABCG2; breast cancer resistance protein; CNTs; concentrative nucleoside transporters; DMEM; Dulbecco's modified Eagle's medium; EMEM; Eagle's minimum essential medium; hCNT2; human con
Keywords: SNc; substantia nigra pars compacta; PD; Parkinson disease; NMS; nonmotor symptoms; MAO-B; monoamine oxidase-B; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 6-OHDA; 6-hydroxy dopamine; GBA; glucocerebrosidase; STN
Keywords: ABC; ATP-binding cassette transporter; ASK1; apoptosis signal-regulating kinase 1; BBB; blood-brain barrier; BSO; l-buthionine-(S,R)-sulfoximine; COMT; catechol-O-methyltransferase; DA; dopamine; DAT; dopamine transporter; DHBT-1; 7-(2-aminoethyl)-3,4-d
Keywords: APC; apparent partition coefficient; BCRP; breast cancer resistance protein; CH; cholate; cLPM; canalicular liver plasma membrane; DC; deoxycholate; GC; glycocholate; GDC; glycodeoxycholate; HNAP; hydroxy-2-naphthoic acid; Mw; molecular weight; MATE; mult
Keywords: PD; Parkinson's disease; AD; Alzheimer's disease; HD; Huntington's Disease; ALS; Amyotrophic Lateral Sclerosis; TAR DNA; binding protein TDP-43; TCA; tricarboxylic acid cycle; ROS; reactive oxygen species; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydrod
Fluorinated phenmetrazine “legal highs” act as substrates for high-affinity monoamine transporters of the SLC6 family
Keywords: New psychoactive substances; Legal high; Phenmetrazine; Monoamine transporter; Amphetamine; 5-HT; 5-hydroxytryptamine; DA; dopamine; DAT; dopamine transporter; FPM; fluorophenmetrazine; HEK293Â cells; human embryonic kidney cells; KHB; Krebs-HEPES-buffer;
miR-494-3p modulates the progression of in vitro and in vivo Parkinson's disease models by targeting SIRT3
Keywords: PD; Parkinson's disease; SOD; superoxide dismutase; LDH; lactate dehydrogenase; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; ROS; reactive oxygen species; SNpc; substantia nigra pars compacta; DA; dopaminergic; miRNAs; microRNAs; snRNA; sm
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway
Keywords: Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test
Astaxanthin: A mechanistic review on its biological activities and health benefits
Keywords: Astaxanthin (PubChem CID: 5368397); Beta-Carotene (PubChem CID: 5280489); Beta-Cryptoxanthin (PubChem CID: 5281235); Canthaxanthin (PubChem CID: 5281227); Lutein (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); Alpha-Tocopherol (PubChem CID: 149
Differential expression of miR-34a, miR-141, and miR-9 in MPP+-treated differentiated PC12 cells as a model of Parkinson's disease
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; BCL2; B-cell lymphoma 2; BDNF; brain-derived neurotrophic factor; DAVID; database annotation, visualization, and integrated discovery; DCF; 2â²,7â²-dichlorofluorescin; GAPDH; glyceraldehyde 3-
Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel
Keywords: OCT1; Organic Cation Transporter 1; hOCT1; human OCT1; HEK; Human Embryonic Kidney; EV; empty vector; MPP+; 1-methyl-4-phenylpyridinium; TEA; tetraethylammonium; CCF; competitive counter flow; TMD; transmembrane domains; CHARMm; Chemistry at Harvard Macro
Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease
Keywords: Parkinson's disease; Ginsenoside Rb1; Glutamatergic transmission; Glutamate transporters; EAAC1; excitatory amino acid carrier-1; EAATs; excitatory amino acid transporters; GLAST; glutamate/aspartate transporter; GLT-1; glutamate transporter-1; mEPSCs; mi
Mitochondrial ROS-mediated post-transcriptional regulation of α-synuclein through miR-7 and miR-153
Keywords: α-SYN; alpha-synuclein; ROS; reactive oxygen species; 3â²-UTR; 3â²-untranslated region; DAT; dopamine transporter; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; α-synuclein; microRNA; 3â²-UTR; Mitochondria; Pa
Redox signaling in acute oxygen sensing
Keywords: AM; adrenal medulla; CB; carotid body; ETC; electron transport chain; H2O2; hydrogen peroxide; MCI; mitochondrial complex I; MCII; mitochondrial complex II; MCIII; mitochondrial complex III; MCIV; Mitochondrial complex IV; MPP+; 1-methyl-4-phenylpyridiniu
Interspecies comparison of the functional characteristics of plasma membrane monoamine transporter (PMAT) between human, rat and mouse
Keywords: DA; dopamine; DAT; dopamine transporter; ENT; equilibrative nucleoside transporters; EPI; epinephrine; 5-HT; serotonin; MDCK; Madin-Darby canine kidney; MPP+; 1-methyl-4-phenylpyridinium; NE; norepinephrine; NBMPR; S-(4-nitrobenzyl)-6-thioinosine; NET; th
CpG demethylation in the neurotoxicity of 1-methyl-4-phenylpyridinium might mediate transcriptional up-regulation of α-synuclein in SH-SY5Y cells
Keywords: Parkinson's disease; α-synuclein; 6-hydroxydopamine; 1-methyl-4-phenylpyridinium; CpG demethylation;
Interaction between the zebrafish (Danio rerio) organic cation transporter 1 (Oct1) and endo- and xenobiotics
Keywords: ADME; absorption, distribution, metabolism and excretion; ASP+; 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide; DAPI; 4â²,6-diamidino-2-phenylindole; DBT; dibutyltin chloride; DMEM; Dulbecco's modified eagle's medium; HEK239; human embryonic kid
Photoactivation of ERK/CREB/VMAT2 pathway attenuates MPP+-induced neuronal injury in a cellular model of Parkinson's disease
Keywords: PD; Parkinson's disease; SNpc; substantia nigra pars compacta; DA; dopamine; MPTP; 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium; VMAT2; vesicular monoamine transporter 2; LPLI; low-power laser irradiation; Aβ; amyloi
Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban
Keywords: drug interactions; solute transporters; organic anion transporters (OAT); pharmacokinetics/pharmacodynamics; renal transport; BCRP; breast cancer resistance protein; CCK8; cholecystokinin-8; E217βG; estradiol 17β-D-glucuronide; E-sul; estrone 3-sulfate;
Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
Keywords: COR; C-terminal of Ras; CSF; cerebral spinal fluid; DAT-1; dopamine transporter-1; ERK5; extracellular-signal-regulated kinase 5; ExAC; Exome Aggregation Consortium; GTPase; Guanosine Triphosphate Hydrolase; LoF; loss of function; LRRK2; leucine-rich repe
Targeted methylation sequencing reveals dysregulated Wnt signaling in Parkinson disease
Keywords: Epigenetic regulation; Neurodegenerative diseases; Environmental toxins; Neurogenesis; PD; Parkinson disease; DA; dopaminergic; CGIs; CpG islands; T-DMRs; tissue differential methylation regions; TSS; transcription start sites; MPP+; 1-methyl-4-phenylpyri
Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway
Keywords: ERα; estrogen receptor alpha; GSH; glutathione; IGF-1; insulin-like growth factor 1; TGF-β1; transforming growth factor beta 1; ApoE; apolipoprotein; GDNF; glial cell line-derived neurotrophic factor; MPP+; 1-methyl-4-phenylpyridinium; Estrogen; Neuropr
Alteration of nuclear factor-kappaB pathway promote neuroinflammation depending on the functions of estrogen receptors in substantia nigra after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment
Keywords: PD; Parkinson's disease; SN; substantia nigra; Iba1; ionized calcium binding adaptor molecule 1; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; TNF-α; tumor necrosis factor-alpha; b.w.; body weight; GFAP; glial fib
Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model
Keywords: Neurodegeneration; Neurodegenerative disorders; PACAP; Dopaminergic neuron survival; SH-SY5Y neuroblastoma cell survival; Vasodilation; Cq; quantification cycle; Eu3; europium(III) cryptate; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3
Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease
Keywords: Abdil solution; antibody dilution solution; A.U.; arbitrary units; BBB; blood brain barrier; BSA; bovine serum albumin; DCPIP; 2,6-dichlorophenolindophenol; DD; deacetylase domain; dpf; days post fertilization; DMB; dynein motor binding; HAD; HDAC associa
Increased neurotrophic factor levels in ventral mesencephalic cultures do not explain the protective effect of osteopontin and the synthetic 15-mer RGD domain against MPPÂ + toxicity
Keywords: 6-OHDA; 6-hydroxydopamine; BDNF; brain-derived neurotrophic factor; ED-1; ectodermal dysplasia 1; GDNF; glial-derived neurotrophic factor; GFAP; glial fibrillary acidic protein; MPPÂ +; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahyd
Differential regulation of caspase-2 in MPP+-induced apoptosis in primary cortical neurons
Keywords: PD; Parkinson׳s disease; MPTP; 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium; MOMP; mitochondrial outer membrane permeabilization; PCD; programmed cell death pathway; Bax; Bcl-2 associated protein X; JNK; stress-activ
The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease
Keywords: 6-OHDA; 6-hydroxydopamine; ANOVA; analysis of variance; DOPAC; 3,4-dihydrophenylacetic acid; HPLC; high-performance liquid chromatography; IL; interleukin; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; MPP; 1-methyl-4-phenylpyridinium; M
Basic neuroscienceA quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections
Keywords: Parkinson's disease; Non-human primate animal model; Intracerebroventricular administration; MPP+; Dopaminergic cell loss; PD; Parkinson's disease; MPTP; 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium; i.c.v.; intracerebr
Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson׳s disease
Keywords: DG; modified Chungsimyeolda-tang; MYH; modified Youldahanso-tang; SCM; Sasang Constitutional Medicine; PD; Parkinson׳s disease; UPS; ubiquitin-proteasome system; ALP; autophagy-lysosomal pathway; MPP+; 1-methyl-4-phenylpyridinium; NGF; nerve growth facto
Anti-apoptotic effect of modified Chunsimyeolda-tang, a traditional Korean herbal formula, on MPTP-induced neuronal cell death in a Parkinson's disease mouse model
Keywords: ABC; avidin-biotin peroxidase complex; DG; modified Chungsimyeolda-tang; FBS; fetal bovine serum; MYH; modified Youldahanso-tang; PD; Parkinson's disease; MEM; minimal essential medium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-methyl-4-
MicroRNA-7: A miRNA with expanding roles in development and disease
Keywords: ACK1; activated CDC42 kinase 1; BASP1; brain abundant, membrane attached signal protein 1; c-Myc; v-Myc avian myelocytomatosis viral oncogene homolog; CD57; cluster of differentiation 57; CD44; cluster of differentiation 44; ciRS-7; circular RNA sponge fo