کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841585 | 1615026 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in salsolinol production and salsolinol synthase activity in Parkinson's disease model
ترجمه فارسی عنوان
تغییرات در تولید ساسولینول و فعالیت سدازالسالینول در مدل بیماری پارکینسون
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کلمات کلیدی
Sal, salsolinolSalsolinol1-methyl-4-phenylpyridinium6-OHDAMPTP1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine6-hydroxy-dopamine - 6-هیدروکسی دپامینMPP+ - MPP +PCA - PCASNpc - SNPCACh - آهacetaldehyde - استالدهید Perchloric acid - اسید پرکلریکisoproterenol - ایزوپروترنولIsop - ایسپParkinson’s disease - بیماری پارکینسونsubstantia nigra pars compacta - توده سیاه پارس متراکمtyrosine hydroxylase - تیروزین هیدروکسیلازDopamine - دوپامینsham-operated - شام کار می کندEnzyme activity - فعالیت آنزیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Salsolinol is an endogenous neurotoxin derived from dopamine, and has been proved to cause the apoptosis of the dopaminergic neurons involved in the pathogenesis of Parkinson's disease (PD). Salsolinol synthase is the key enzyme in the biosynthesis of salsolinol, and its activity exists in most regions of rat brain. However, the activity distribution and its catalyzed function in vivo are still unknown. On the basis of the chromatographic assay established previously, we investigated the activity of salsolinol synthase and salsolinol production in both cell and rat model of PD induced by 6-hydroxydopamine (6-OHDA). The results show that the enzymatic activity increases in cell model and in the striatum region of PD rat brain. Nevertheless, there is a reduction of activity in hippocampus, cortex, and midbrain of PD model when compared with control. Conversely, the level of salsolinol was significantly increased in the midbrain region. Together, these results indicate the relationship between the oxidative stress induced by 6-OHDA and the activity of salsolinol synthase, suggesting the correlation of the endogenous neurotoxin and Parkinson's disease. Further research will provide more evidence and clarity on the function of Sal synthase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 673, 23 April 2018, Pages 39-43
Journal: Neuroscience Letters - Volume 673, 23 April 2018, Pages 39-43
نویسندگان
Xiaotong Zheng, Xuechai Chen, Minjun Guo, Sakhawat Ali, Yinghui Huang, Feiyi Sun, Kefu Liu, Zixuan Chen, Yulin Deng, Rugang Zhong,