Keywords: 3-اسید نیتروپروپیونیک; 3-HK; 3-hydroxykynurenine; 3-NP; 3-nitropropionic acid; 6âOHDA; 6-hydroxidopamine; AADC; aromatic amino acid decarboxylase; ACA; anterior cerebral artery; ADP; adenosine-5â²-diphosphate; ALDH; aldehyde dehydrogenases; ALS; amyotrophic lateral sclerosis
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Keywords: 3-اسید نیتروپروپیونیک; Aging; Nrf2 signaling; Tert-Buthylhydroquinone; Oxidative stress; 3-Nitropropionic acid;
Keywords: 3-اسید نیتروپروپیونیک; Estrogen; Neuroprotection; Aging; Cognition; Stroke; Traumatic brain injury; 3NPA; 3-nitropropionic acid; 17αE2; 17 alpha-estradiol; 17βE2; 17 beta-estradiol; ATP; adenosine triphosphate; BBB; blood brain barrier; BDNF; brain-derived neurotrophic factor
Keywords: 3-اسید نیتروپروپیونیک; Mitochondria; Antioxidants; Polyphenols; Caffeoyl; Neurotoxins; Micronuclei; ANOVA; Analysis of Variance; CGA; Chlorogenic acid; HD; Huntington Disease; i.p.; Intraperitoneal; MNC; Micronuclei cells; 3-NP; 3-nitropropionic acid; NC; Normochromatic; PC; Po
Keywords: 3-اسید نیتروپروپیونیک; 2,4-D; dichlorophenoxyacetic acid; [35S]TBPS; [35S]tertiary-butylbicyclophosphorothionate; 3-NP; 3-nitropropionic acid; 4CL; 4-coumarate: CoA ligase; 4-O-MH; 4-O-methylhonokiol; 6-OHDA; 6-hydroxydopamine; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; AChE; acetylc
Keywords: 3-اسید نیتروپروپیونیک; Neurodegeneration; Flavonoids; Antioxidant; Signalling pathways; Neuroinflammation; AD; Alzheimer's disease; PD; Parkinson's disease; HD; Huntington's disease; ALS; amyotrophic lateral sclerosis; MS; multiple sclerosis; DA; dopamine agonist; IFN; interfer
Keywords: 3-اسید نیتروپروپیونیک; Rh123; Rhodamine 123; HMG-CoA reductase; 3-hydroxy-3-methyl-glutaryl-CoA reductase; ROS; reactive oxygen species; DMSO; dimethylsulphoxide; FCCP; Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; DETCA; diethylthiocarbamate; TEA; tetraethylammonium; 3
Keywords: 3-اسید نیتروپروپیونیک; 3-NPA; 3-nitropropionic acid; 6-OHDA; 6-hydroxy dopamine; AD; Alzheimer's disease; AIF; apoptosis inducing factor; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; AÃ; β-amyloid peptide; CA; trans-cinnamaldehyde; Cat; catalase; CBP;
Keywords: 3-اسید نیتروپروپیونیک; EMF; electromagnetic fields; IARC; International Research Center on Cancer; VLF; very low frequency; ELF; extremely low frequency; SAR; specific absorption rate; RF; radio frequency; CNS; central nervous system; MMP; matrix metalloproteinases; BBB; bloodâ
Keywords: 3-اسید نیتروپروپیونیک; 3-Nitropropionic acid; Apoptosis signal-regulating kinase 1; siRNA; Caspase-6; Caspase-3;
Keywords: 3-اسید نیتروپروپیونیک; Huntington's disease; 3-Nitropropionic acid; Tryptophan metabolism; HPLC; Behavioral alterations
Keywords: 3-اسید نیتروپروپیونیک; Alpha-lipoic acid; Acetyl-L-carnitine; Huntington's disease; 3-Nitropropionic acid; Mitochondria; Oxidative stress;
Keywords: 3-اسید نیتروپروپیونیک; Huntington's disease; Herbal medicines; Formulations; 3-Nitropropionic acid; Neurodegenerative
Keywords: 3-اسید نیتروپروپیونیک; 3-Nitropropionic acid; Huntington's disease; Renin angiotensin system (RAS); Trandolapril; Mitochondrial stress;
Keywords: 3-اسید نیتروپروپیونیک; ALA; alpha-lipoic acid; ALCAR; acetyl-l-carnitine; DAB; 3,3â²-di-aminobenzidine; 3-NP; 3-nitropropionic acid; GFAP; glial fibrillary acidic protein; GSH; glutathione; HD; Huntington's disease; MDA; malondialdehyde; TTC; 2,3,5-triphenyltetrazolium chlorid
Keywords: 3-اسید نیتروپروپیونیک; Ethyl pyruvate; 3-Nitropropionic acid; Huntington’s disease; Microglia; Mitogen-activated protein kinases; Nuclear factor-kappa B
Keywords: 3-اسید نیتروپروپیونیک; Antioxidant gene therapy; Brain ischemia; Neurodegenerative disorders; Oxidative stress; Virus-mediated gene delivery; ROS; ÎΨm; mitochondrial membrane potential; 3-NP; 3-nitropropionic acid; 6-OHDA; 6-hydroxydopamine; AADC; aromatic-l-amino decarboxyla
Keywords: 3-اسید نیتروپروپیونیک; 3-NP; 3-nitropropionic acid; ADAM; a disintegrin and metalloprotease; DIV; days in vitro; ES; ectodomain shedding; GAD-67; gamma-amino butyric acid decarboxilase-67; GFAP; glial fibillary acidic protein; GM6001; Ilomastat; MMP; matrix metalloprotease; MTT
Keywords: 3-اسید نیتروپروپیونیک; 2DG; 2-Deoxy-D-glucose; 2-ME; 2-methoxyestradiol; 3NP; 3-nitropropionic acid; ASK1; apoptosis signal-regulating kinase 1; Atg; autophagy-related gene; ATM; ataxia-telangiectasia mutated; Bif-1; Bax-interacting factor-1; BNIP3; Bcl-2/E1B interacting protei
Keywords: 3-اسید نیتروپروپیونیک; Cochlea; Fibrocyte; Spiral ligament; Spiral ganglion cell; Korean red ginseng; 3-Nitropropionic acid;
Keywords: 3-اسید نیتروپروپیونیک; 3-NP; 3-nitropropionic acid; CAT; catalase; DTNB; 5,5-dithiobis-2-nitrobenzoic acid; ETC; electron transport chain; HD; Huntington's disease; LMW-SH; low molecular weight thiols; MDA; malondialdehyde; NBT; nitroblue tetrazolium; PSH; protein thiols; ROS/R
Keywords: 3-اسید نیتروپروپیونیک; 1,3-Dinitrobenzene; 3-Nitropropionic acid; 3-Chloropropanediol; Oxidative stress; Carbonylation; Mitochondria;
Keywords: 3-اسید نیتروپروپیونیک; CI; cerebral ischemia; PD; Parkinson's disease; HD; Huntington's disease; SN; substancia nigra; DA; dopamine; GABA; gamma-aminobutyric acid; MSN; medium spiny neuron; CNS; central nervous system; NSC; neural stem cells; ES; embryonic stem; MSC; mesenchyma
Comparison of quantitative T2 and ADC mapping in the assessment of 3-nitropropionic acid-induced neurotoxicity in rats
Keywords: 3-اسید نیتروپروپیونیک; MRI; Neurotoxicity; T2 Relaxation; Apparent diffusion coefficient; 3-Nitropropionic acid; Rat;
Topiramate mitigates 3-nitropropionic acid-induced striatal neurotoxicity via modulation of AMPA receptors
Keywords: 3-اسید نیتروپروپیونیک; GluR2; AMPA; Topiramate; 3-Nitropropionic acid; Excitotoxicity; Huntington's disease;
Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: Implication of an antioxidation-independent mechanism
Keywords: 3-اسید نیتروپروپیونیک; Ac; acetylated; ADA; the 3 AKT phosphorylation sites of FOXO1 are mutated; AKT; thymoma viral proto-oncogene; ATG; autophagy-related; AVOs; acidic vesicular organelles; AOI; antioxidant inhibitors; BECN1; beclin 1; BP; blank plasmid; CAT; catalase; CCK-8;
Research articleMice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity
Keywords: 3-اسید نیتروپروپیونیک; Huntington's disease; Oxidative stress; 3-Nitropropionic acid; Striatal injury; L-12/15- lipoxygenase;
Protective effect of Yerba mate (Ilex paraguariensis St. Hill.) against oxidative damage in vitro in rat brain synaptosomal/mitochondrial P2 fractions
Keywords: 3-اسید نیتروپروپیونیک; Antioxidant defense; Rat brain; Mitochondrial dysfunction; Neuroprotection; Yerba mate extract; Chlorogenic acid; 5-CQA; 5-cafeoilquinic acid; CGA; chlorogenic acid; DCF; dichlorofluorescein; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; MTT; 3-(4,5-d
Effect of Praeruptorin C on 3-nitropropionic acid induced Huntington's disease-like symptoms in mice
Keywords: 3-اسید نیتروپروپیونیک; 3-NP; 3-nitropropionic acid; Pra-C; Praeruptorin C; OFT; open field test; FST; forced swimming test; TST; tail suspension test; MSNs; medium spiny neurons; BDNF; brain derived neurotrophic factor; HPLC; high performance liquid chromatography; GABA; γ-ami
Desmin expression profile in reactive astrocytes in the 3-nitropropionic acid-lesioned striatum of rat: Characterization and comparison with glial fibrillary acidic protein and nestin
Keywords: 3-اسید نیتروپروپیونیک; 3-NP; 3-nitropropionic acid; ANOVA; analysis of variance; CNS; central nervous system; DAB; 3,3â²-diaminobenzidine tetrahydrochloride; DAPI; 4â²,6-diamidino-2â²-phenylindole; GFAP; glial fibrillary acidic protein; i.p.; intraperitoneally; LV; lateral v
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
Keywords: 3-اسید نیتروپروپیونیک; 3-NPA; 3-nitropropionic acid; Co; complex; FH; fumarate hydratase; PC; pyruvate carboxylase; TCA cycle; tricarboxylic acid cycle; SDH; succinate dehydrogenase; 3-nitropropionic acid (PubChem CID: 1678); Atpenin A5 (PubChem CID: 54676868); rotenone (PubChe
3-NP-induced Huntington's-like disease impairs Nrf2 activation without loss of cardiac function in aged rats
Keywords: 3-اسید نیتروپروپیونیک; Aging; Nrf2 signaling; 3-Nitropropionic acid; Cardiac function; Hormesis;
Chrysin exerts neuroprotective effects against 3-Nitropropionic acid induced behavioral despair-Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulating Bax-Bad genes in male wistar rats
Keywords: 3-اسید نیتروپروپیونیک; 3-Nitropropionic acid; Huntington's disease; Chrysin; Apoptotic markers; Mitochondrial dysfunction; Histopathology;
Genistein improves sensorimotor gating: Mechanisms related to its neuroprotective effects on the striatum
Keywords: 3-اسید نیتروپروپیونیک; Huntington's disease; 3-Nitropropionic acid; Prepulse inhibition; Genistein; 17β-estradiol;
A novel therapeutic application of solid lipid nanoparticles encapsulated thymoquinone (TQ-SLNs) on 3-nitroproponic acid induced Huntington’s disease-like symptoms in wistar rats
Keywords: 3-اسید نیتروپروپیونیک; Huntington’s disease; 3-Nitropropionic acid; Solid lipid nanoparticle; Thymoquinone; Oxidative stress; Histopathology
Neuroprotective effect of hemeoxygenase-1/glycogen synthase kinase-3β modulators in 3-nitropropionic acid-induced neurotoxicity in rats
Keywords: 3-اسید نیتروپروپیونیک; 3-NP; 3-nitropropionic acid; ANOVA; analysis of variance; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ARE; Antioxidant-responsive element; BDNF; Brain-derived neurotrophic factor; ELISA; Enzyme-linked immunosorbent assay; GABA; gamma am
Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons
Keywords: 3-اسید نیتروپروپیونیک; BH domain; Bcl-2 homology domain; CBP; CREB-binding protein; ChIP; chromatin immunoprecipitation; CHX; cycloheximide; CREB; cAMP-response element-binding protein; DIV; days-in-vitro; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FC
Behavioural pharmacologyProtective effects of phosphodiesterase-1 (PDE1) and ATP sensitive potassium (KATP) channel modulators against 3-nitropropionic acid induced behavioral and biochemical toxicities in experimental Huntington׳s disease
Keywords: 3-اسید نیتروپروپیونیک; 3-Nitropropionic acid; Vinpocetine; Nicorandil; Mitochondrial enzyme complexes; Myeloperoxidase; Acetylcholinesterase;
Profilin-2 increased expression and its altered interaction with β-actin in the striatum of 3-nitropropionic acid-induced Huntington's disease in rats
Keywords: 3-اسید نیتروپروپیونیک; 3-NP; 3-nitropropionic acid; BLAST; basic local alignment search tool; CT; cycles of threshold; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; FITC; fluorescein isothiocyanate; GAD; glutamic acid decarboxylase; HD; Huntington's disease
Pharmacological benefits of agomelatine and vanillin in experimental model of Huntington's disease
Keywords: 3-اسید نیتروپروپیونیک; 3-Nitropropionic acid; Acetylcholinesterase; Morris water maze; Mitochondrial enzyme complex; Oxidative stress; Tetrabenazine
In vivo mitochondrial inhibition alters corticostriatal synaptic function and the modulatory effects of neurotrophins
Keywords: 3-اسید نیتروپروپیونیک; 3-NP; 3-nitropropionic acid; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; EGTA; ethylene glycol tetraacetic acid; HD; Huntington's disease; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; IHC; immunohistochemistry; MS
Preconditioning provides neuroprotection in models of CNS disease: Paradigms and clinical significance
Keywords: 3-اسید نیتروپروپیونیک; Preconditioning; Neuroprotection; Ischemia; Traumatic brain injury; MCAO; middle cerebral artery occlusion; 2VO; two vessel occlusion; 3-NPA; 3-Nitropropionic acid; 4VO; four vessel occlusion; BCCAO; bilateral common carotid artery occlusion; CSD; cortica
Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal degeneration in 3-nitropropionic acid-infused mice
Keywords: 3-اسید نیتروپروپیونیک; Apoptosis signal-regulating kinase 1; 3-Nitropropionic acid; siRNA; Superoxide dismutase;
Neuroprotective role of PDE4 and PDE5 inhibitors in 3-nitropropionic acid induced behavioral and biochemical toxicities in rats
Keywords: 3-اسید نیتروپروپیونیک; PDE inhibitor; Motor disorder; Oxidative stress; 3-Nitropropionic acid; Huntington's disease;
Type II Fp of human mitochondrial respiratory complex II and its role in adaptation to hypoxia and nutrition-deprived conditions
Keywords: 3-اسید نیتروپروپیونیک; Fp; flavoprotein; SQR; succinate-ubiquinone reductase; SDHAF1; succinate-dehydrogenase assembly factor 1; SDHAF2; succinate-dehydrogenase assembly factor 2; SML; sucrose monolaurate; DCIP; 2,6-dichlorophenolindophenol; 3-NP; 3-nitropropionic acid; DTNB; 0
Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis
Keywords: 3-اسید نیتروپروپیونیک; AP; apurinic/apyrimidinic; ARE; antioxidant response element; ATM; ataxia telangiectasia mutated kinase; ATR; Rad3-related kinase; BER; base excision repair; FEN1; flap endonuclease 1; HD; Huntington's disease; MMR; mismatch repair; Nrf2; NF-E2-related
Long-lasting changes in the cochlear K+ recycling structures after acute energy failure
Keywords: 3-اسید نیتروپروپیونیک; SSNHL; sudden sensorineural hearing loss; 3NP; 3-nitropropionic acid; NKCC1; Na-K-Cl cotransporter isoform 1; Cx26; connexin 26; Kir4.1; an inwardly rectifying K+ channel; L-PGDS; lipocalin-type prostaglandin D synthase; ABR; auditory brainstem response;
hMTH1 expression protects mitochondria from Huntington's disease-like impairment
Keywords: 3-اسید نیتروپروپیونیک; HD; Huntington disease; Htt; huntingtin; polyQ; polyglutamine; 3-NP; 3-nitropropionic acid; ROS; Reactive oxygen species; 8-oxodG; 8-hydroxyguanine; DDR; DNA damage response; BER; Base excision repair; DSBs; Double strand breaks; DRP1; Dynamin related pro
Cardioprotective Mechanism of Diazoxide Involves the Inhibition of Succinate Dehydrogenase
Keywords: 3-اسید نیتروپروپیونیک; 16; 3-NPA; 3-nitropropionic acid; 5-HD; 5-hydroxydecanoate; CPG; cardioplegia; DCIP; 2,6-dichloroindophenol; DZX; diazoxide; EDTA-K2; ethylene diamine tetraacetic acid potassium; GLU; glutathione; HEPES; N-[2-hydroxyethyl] piperazine-N-[4-butanesulfonic
Research ReportDownregulation of miR-199a may play a role in 3-nitropropionic acid induced ischemic tolerance in rat brain
Keywords: 3-اسید نیتروپروپیونیک; Brain ischemic tolerance; 3-nitropropionic acid; MiR-199a;