کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6286535 | 1615395 | 2014 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preconditioning provides neuroprotection in models of CNS disease: Paradigms and clinical significance
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کلمات کلیدی
HbOSbiNOS2VOMPTPOGDNMDAN-methyl-d-aspartateMCAOHspCSDTLRHMGB1BCCAoATA4VOTBI6-Hydroxydopamine6-OHDALPSMSCs3-NPAAβ1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine3-nitropropionic acid - 3-اسید نیتروپروپیونیکROS - ROSTraumatic brain injury - آسیب تروماتیک مغزSurgical brain injury - آسیب مغزی جراحیamyloid-beta - آمیلوئید بتاatmospheres absolute - اتمسفر مطلقcortical spreading depression - افسردگی گسترش کورتکسmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیoxygen/glucose deprivation - اکسیژن / محرومیت گلوکزHyperbaric oxygen - اکسیژن بیش از حدIschemia - ایسکمیAlzheimer's disease - بیماری آلزایمرParkinson's disease - بیماری پارکینسونtyrosine hydroxylase - تیروزین هیدروکسیلازToll-like receptor - تیالآرbilateral common carotid artery occlusion - دو طرفه انسداد شریان کاروتید مشترکDopamine - دوپامینblood brain barrier - سد خونی مغزیBBB - سد خونی مغزیMesenchymal stem cells - سلول های بنیادی مزانشیمیlipopolysaccharide - لیپوپلی ساکاریدNeuroprotection - محافظت نورونی یا محافظت از عصبnitric oxide synthase - نیتریک اکسید سنتازhypoxia/ischemia - هیپوکسیا / ایسکمیHeat shock proteins - پروتئینهای شوک حرارتیPreconditioning - پیش شرط بندیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Preconditioning is a phenomenon in which brief episodes of a sublethal insult induce robust protection against subsequent lethal injuries. Preconditioning has been observed in multiple organisms and can occur in the brain as well as other tissues. Extensive animal studies suggest that the brain can be preconditioned to resist acute injuries, such as ischemic stroke, neonatal hypoxia/ischemia, surgical brain injury, trauma, and agents that are used in models of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Effective preconditioning stimuli are numerous and diverse, ranging from transient ischemia, hypoxia, hyperbaric oxygen, hypothermia and hyperthermia, to exposure to neurotoxins and pharmacological agents. The phenomenon of “cross-tolerance,” in which a sublethal stress protects against a different type of injury, suggests that different preconditioning stimuli may confer protection against a wide range of injuries. Research conducted over the past few decades indicates that brain preconditioning is complex, involving multiple effectors such as metabolic inhibition, activation of extra- and intracellular defense mechanisms, a shift in the neuronal excitatory/inhibitory balance, and reduction in inflammatory sequelae. An improved understanding of brain preconditioning should help us identify innovative therapeutic strategies that prevent or at least reduce neuronal damage in susceptible patients. In this review, we focus on the experimental evidence of preconditioning in the brain and systematically survey the models used to develop paradigms for neuroprotection, and then discuss the clinical potential of brain preconditioning.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 114, March 2014, Pages 58-83
Journal: Progress in Neurobiology - Volume 114, March 2014, Pages 58-83
نویسندگان
R. Anne Stetler, Rehana K. Leak, Yu Gan, Peiying Li, Feng Zhang, Xiaoming Hu, Zheng Jing, Jun Chen, Michael J. Zigmond, Yanqin Gao,