Keywords: 4-HNE، 4-hydroxynonenal; COPD, chronic obstructive pulmonary disease; HDAC, histone deacetylase; PMA, phorbol 12-myristate 13-acetate; LPS, lipopolysaccharide; GSH, glutathione; qPCR, quantitative polymerase chain reaction; TNFα, tumor necrosis factor α; 4-HNE, 4-hydroxynonenal;
مقالات ISI 4-HNE، 4-hydroxynonenal (ترجمه نشده)
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Keywords: 4-HNE، 4-hydroxynonenal; 2-AG, 2-arachidonylglyceriol; 4-HNE, 4-hydroxynonenal; 4-ONE, 4-oxononenal; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; AA, arachidonic acid; AC, adenocarcinoma; AEA, anandamide; AKT, serine/threonine-specific protein kinase; ALE, advanced lipoxidation-end produ
Keywords: 4-HNE، 4-hydroxynonenal; 2D-GE, two-dimensional gel electrophoresis; 4-HNE, 4-hydroxynonenal; ARP, aldehyde-reactive probe; BHZ, biotin-hydrazide; CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; DMF, dimethyl formammide; DMSO, dimethyl sulfoxide; DNPH, 2,4-dinit
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; ALEs, advanced lipoxidation end products; AGEs, advanced glycation End Products; ECM, extracellular matrix; MMPs, matrix metalloproteases; SMC, smooth muscle cells4-hydroxynonenal; Elastin; Atherosclerosis; Smooth muscle cells; Ex
Keywords: 4-HNE، 4-hydroxynonenal; LDL, low-density-lipoproteins; OxLDL, oxidized low-density-lipoproteins; ROS, reactive oxygen species; PUFAs, polyunsaturated fatty acids; MDA, malondialdehyde; 4-HNE, 4-hydroxynonenal; POVPC,, 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine; AL
Keywords: 4-HNE، 4-hydroxynonenal; Lipid emulsions; Admixtures; Stability; PFAT5; Lipid oxidationALT, alanine amino transferase; Anv, p-anisidine value; AST, aspartate amino transferase; GST, glutathione-S-transferase; 4-HNE, 4-hydroxynonenal; MDA, malondialdehyde; PN, parenteral nutrition
Lysines, Achilles’ heel in alpha-synuclein conversion to a deadly neuronal endotoxin
Keywords: 4-HNE، 4-hydroxynonenal; AGEs, advanced glycation end-products; ALDH, aldehyde dehydrogenases; aS, alpha-synuclein; ALP, autophagic lysosomal pathway; DHA, docosahexaenoic acid; DOPAL, 3,4dihydroxyphenylacetaldehyde; 4-HNE, 4-hydroxynonenal; LBs, Lewy Bodies; MDA, malondialdehyde
Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; AA, antimycin A; A-HNE, alkyne HNE; ECAR, extracellular acidification rate; LDH, lactate dehydrogenase; MnSOD, manganese superoxide dismutase; OCR, oxygen consumption rate; PRP, platelet rich plasma; vWF, von Willebrand Factor; XF
FAT10 suppression stabilizes oxidized proteins in liver cells: Effects of HCV and ethanol
Keywords: 4-HNE، 4-hydroxynonenal; ALT, Alanine Aminotransferase; ChT-like, chymotrypsin like; FAT10, HLA-F adjacent transcript 10; 4-HNE, 4-hydroxynonenal; HCV, hepatitis C virus; IFN, interferon; ISRE, interferon sensitive response element; RT-PCR, realtime polymerase chain reaction; SAM
Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; AP-1, activator protein 1; DMPO, 5,5-dimethyl-2-(8-octanoic acid)-1-pyrroline N-oxide; DNPH, 2,4-dinitrophenylhydrazine; ERK, extracellular signal-regulated kinase; JNK, Jun-N terminal kinase; MAPK, mitogen-activated protein kinas
Dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone in male reproductive health: Implications of differential regulation of human Sertoli cells metabolic profile
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; 7-OH-DHEA, 7-hydroxy-dehydroepiandrosterone; 7-oxo-DHEA, 7-oxo-dehydroepiandrosterone; AP, alkaline phosphatase; DHEA, dehydroepiandrosterone; DHEAS, dehydroepiandrosterone sulfate; DNPHZ, 2,4-dinitrophenylhydrazone; DNPH, 2,4-din
Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; BAL, bronchoalveolar lavage; EMSA, electrophoretic mobility shift assay; iNOS, inducible nitric oxide synthase; NF-κB, nuclear factor-kappa B; SP, surfactant protein; TLR4, toll-like receptor 4; TNFα, tumor necrosis factor-alphaOz
Oxidative stress and adult neurogenesis—Effects of radiation and superoxide dismutase deficiency
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; AA, arachidonic acid; BrdU, bromodeoxyuridine; COX, cyclooxygenase; DHA, docosahexaenoic acid; CNS, central nervous system; CuZnSOD, CuZn containing superoxide dismutase; Dcx, doublecortin; EC-SOD, extracellular superoxide dismuta
p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; ActD, actinomycin D; BAD, Bcl-2 antagonist of cell death; DEN, diethylnitrosamine; H&E, hematoxylin and eosin; HSP27, heat shock protein 27; IL, interleukin; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MP
Antioxidant therapies in traumatic brain and spinal cord injury
Keywords: 4-HNE، 4-hydroxynonenal; TBI, Traumatic brain injury; SCI, Spinal cord injury; ROS, Reactive oxygen species; RNS, Reactive nitrogen species; PN, Peroxynitrite; LP, Lipid peroxidation; MP, Methylprednisolone; CCI, Controlled cortical impact; 4-HNE, 4-hydroxynonenal; 3-NT, 3-Nitrot
Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy
Keywords: 4-HNE، 4-hydroxynonenal; ANOVA, analysis of variance; CA, cinnamaldehyde; CHEM, Chembridge-5861528; DM, diabetes mellitus; DRG, dorsal root ganglion; 4-HNE, 4-hydroxynonenal; IENF, intraepidermal nerve fiber; MG, methylglyoxal; PDN, peripheral diabetic neuropathy; STZ, streptozot
The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages
Keywords: 4-HNE، 4-hydroxynonenal; CL, chemiluminescence; 4-HNE, 4-hydroxynonenal; iNOS, inducible nitric oxide synthase; LPPs, lipid peroxidation products; LPS, lipopolysaccharide; MDA, malondialdehyde; NFκB, nuclear transcription factor; NO, nitric oxide; O2-, superoxide anion radical; O
AKR1B10 induces cell resistance to daunorubicin and idarubicin by reducing C13 ketonic group
Keywords: 4-HNE، 4-hydroxynonenal; AKR1B10, aldo-keto reductase family 1 B10; EGFP, enhanced green fluorescent protein; ESI, electrospray ionization; 4-HNE, 4-hydroxynonenal; HPLC, high-performance liquid chromatography; LC–MS, liquid chromatography–mass spectroscopy; MTT, (3-(4,5-Dimethyl
Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway
Keywords: 4-HNE، 4-hydroxynonenal; AMT, 3-amino-1,2,4-triazole; HSV, human saphenous vein; 4-HNE, 4-hydroxynonenal; HO-1, heme oxygenase-1; IH, neointimal hyperplasia; ROS, reactive oxygen species; SOD, superoxide dismutase; O2•−, superoxideFree radicals; Scavenging enzymes; Catalase; Huma
Intravenous low redox potential saline attenuates FeCl3-induced vascular dysfunction via downregulation of endothelial H2O2, CX3CL1, intercellular adhesion molecule-1, and p53 expression
Keywords: 4-HNE، 4-hydroxynonenal; 3-NT, 3-nitrotyrosine; 4-HNE, 4-hydroxynonenal; DCFDA, 2’,7’-dichlorodihydrofluorescein diacetate; DPI, diphenylene iodonium; HUVEC, human umbilical vein endothelial cell; ICAM-1, intercellular adhesion molecule-1; OCT, optimal cutting temperature; ORP, o
Protective effects and mechanisms of sirtuins in the nervous system
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; Aβ, beta-amyloid; AD, Alzheimer's disease; ADPR, ADP-ribose; ALS, amyotrophic lateral sclerosis; AMPK, AMP-activated protein kinase; APE1, apurinic/apyrimidinic endonuclease-1; APP, amyloid precursor protein; AROS, active regulato
A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma
Keywords: 4-HNE، 4-hydroxynonenal; TBI, traumatic brain injury; FPI, fluid percussion injury; RD, regular diet; iPLA2, independent phospholipase A2; 4-HNE, 4-Hydroxynonenal; FATP, fatty acid transport proteinsRat; Membrane damage; Curcumin; 4-hydoxynonenal; Cognition
Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; A2E, diretinoid pyridinium ethanolamine; HEK, human embryonic kidney; HRP, horseradish peroxidase; LCA, Leber congenital amaurosis; NADPH, nicotinamide adenine dinucleotide phosphate, reduced form; ONH, optic nerve head; ONL, oute
Gene expression profile and cytotoxicity of human bronchial epithelial cells exposed to crotonaldehyde
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; ALDHs, aldehyde dehydrogenases; AKRs, aldo–keto reductases; B[a)P, benzo[a]pyrene; CS, cigarette smoke; FBS, fetal bovine serum; HSPs, heat shock proteins; NNK, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone); PI, Propidium I
Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; BAL, bronchoalveolar lavage; BALF, bronchoalveolar lavage fluid; BMM, bone marrow-derived macrophage; COPD, chronic obstructive pulmonary disease; CSE, cigarette smoke extract; CSF-1, colony-stimulating factor-1; DCFDA, 5-(and-6)-
Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
Keywords: 4-HNE، 4-hydroxynonenal; AMPK, AMP-activated protein kinase; AOX, acyl-CoA oxidase; CYP2E1, cytochrome P4502E1; DHE, dihydroethidine; 4-HNE, 4-hydroxynonenal; GSH, reduced glutathione; IG, intragastric; KO, knockout; KI, knock-in; 3-NT, 3-nitrotyrosine; PPARα, peroxisome prolifer
Biochemical properties of an omega-class glutathione S-transferase of the silkmoth, Bombyx mori
Keywords: 4-HNE، 4-hydroxynonenal; CBB, Coomassie Brilliant Blue R250; CDNB, 1-chloro-2, 4-dinitrobenzene; ECA, ethacrynic acid; GSH, glutathione; GPX, glutathione peroxidase; GST, glutathione S-transferase; 4-HNE, 4-hydroxynonenal; IPTG, isopropyl 1-thio-β-D-galactoside; 4-NPA, 4-nitrophe
Cell sex determines anoikis resistance in vascular smooth muscle cells
Keywords: 4-HNE، 4-hydroxynonenal; ROS, reactive oxygen species; VSMC, vascular smooth muscle cells; MVSMC, male-derived vascular smooth muscle cells; FVSMC, female-derived vascular smooth muscle cells; 4-HNE, 4-hydroxynonenal; FAK, focal adhesion kinase; p-FAK, phosphorylated focal adhesi
Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; AP-1, activator protein 1; ATF, activating transcription factor; CEES, 2-chloroethyl ethyl sulfide; DMPO, 5,5-dimethyl-2-(8-octanoic acid)-1-pyrroline N-oxide; DNPH, 2,4-dinitrophenylhydrazine; ERK, extracellular signal-regulated
Formation of γ-ketoaldehyde–protein adducts during ethanol-induced liver injury in mice
Keywords: 4-HNE، 4-hydroxynonenal; ALT, alanine aminotransferase activity; COX, cyclooxygenase; PBS, phosphate-buffered saline; ROS, reactive oxygen species; TNF-α, tumor necrosis factor α; LGE2, levuglandin E2; iso[4]LGE2, iso[4]levuglandin E2; 4-HNE, 4-hydroxynonenal; MDA, malondialdehyd
NOX and inflammation in the vascular adventitia
Keywords: 4-HNE، 4-hydroxynonenal; AngII, angiotensin II; CVD, cardiovascular diseases; GPX, glutathione peroxidase; 4-HNE, 4-hydroxynonenal; IL-1α, interleukin 1α; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinase; NOS, nitric oxide synthase; PDGF, platelet-derived growth fa
Effect of lipid peroxidation products on the activity of human retinol dehydrogenase 12 (RDH12) and retinoid metabolism
Keywords: 4-HNE، 4-hydroxynonenal; RDH12, retinol dehydrogenase 12; 4-HNE, 4-hydroxynonenal; LRAT, lecithin:retinol acyltransferase; ALDH1A1, aldehyde dehydrogenase 1 family, member A1; GSH, glutathioneRetinoic acid; Retinaldehyde; Retinol; Oxidoreductase; Nonanal; 4-hydroxynonenal
The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice
Keywords: 4-HNE، 4-hydroxynonenal; ROS, reactive oxygen species; UCP, uncoupling protein; ESR, electron spin resonance; UCP3Tg, mice overexpressing human skeletal muscle UCP3; WT, wild type; BSA, bovine serum albumin; TA, tibialis anterior; 4-HNE, 4-hydroxynonenal; DMPO, 5,5-dimethyl-1-pyr
Peroxide-induced cell death and lipid peroxidation in C6 glioma cells
Keywords: 4-HNE، 4-hydroxynonenal; CHD, cyclohexanedione; CHP, cumene hydroperoxide; FBS, foetal bovine serum; HBSS, Hank’s balanced salt solution; 4-HNE, 4-hydroxynonenal; MDA, malondialdehyde; TBA, thiobarbituric acid; TBARS, thiobarbituric acid reactive substances; t-BuOOH, tert-Butyl h
Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells
Keywords: 4-HNE، 4-hydroxynonenal; CYP2E1, cytochrome P450 2E1; CcO, cytochrome c oxidase; DCFDA, 2′,7′-dichlorofluorescein diacetate; DMNA, dimethylnitrosamine; DNPH, dinitrophenol hydrazine; GSH, glutathione; GST, glutathione S-transferase; 4-HNE, 4-hydroxynonenal; LPO, lipid peroxidatio
Increased heart rate variability in mice overexpressing the Cu/Zn superoxide dismutase
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; Ach, acetylcholine; AChE, acetylcholinesterase; ANS, autonomic nervous system; AVB, auriculoventricular block; BuChE, butyryl cholinesterase; CNS, central nervous system; DNA, desoxyribonucleic acid; ECG, electrocardiogram; HF, hi
Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes
Keywords: 4-HNE، 4-hydroxynonenal; PPAR, peroxisome proliferator-activated receptor; DMIX, differentiation mixture; STS, staurosporine; Nrf2, nuclear factor erythroid 2 (NF-E2)-related factor 2; 4-HNE, 4-hydroxynonenal; FA, fatty acidsOxLDL; Adipocytes; Obesity; CD36; Nrf2; PKC
Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation
Keywords: 4-HNE، 4-hydroxynonenal; CK, cytokeratins; DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine; DEAEH, 4,4′-diethylaminoethoxyhexestrol; 4-HNE, 4-hydroxynonenal; MDA, malondialdehyde; MDB, Mallory-Denk bodiesSteatohepatitis; Drugs; Mallory body; Cytokeratin; Transglutaminase; Malondia
Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity
Keywords: 4-HNE، 4-hydroxynonenal; AD, Alzheimer's disease; DCFH-DA, 2,7-dichlorofluorescein diacetate; DMSO, dimethyl sulfoxide; DMEM, Dulbecco's modified Eagle's medium; FBS, fetal bovine serum; Hepes, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; 4-HNE, 4-hydroxynonenal; L-NAME, N
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity
Keywords: 4-HNE، 4-hydroxynonenal; bDNA, branched DNA signal amplification; CDDO-Im, (1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole); DCPIP, 2,6-dichlorophenolindophenol; FeNTA, ferric nitrilotriacetate; 4-HNE, 4-hydroxynonenal; GCLC, glutamate cysteine ligase catalytic subuni
Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives
Keywords: 4-HNE، 4-hydroxynonenal; AGEs, advanced glycoxidation end products; ALEs, advanced lipoxidation end products; DNPH, dinitrophenylhydrazine; 4-HNE, 4-hydroxynonenal; IMAO, MAO inhibitors; LDL, low-density lipoprotein; oxLDL, oxidized LDL; RCCs, reactive carbonyl compounds; ROS, re
Prematurely senescent ARPE-19 cells display features of age-related macular degeneration
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; 8-OHG, 8-hydroxyguanosine; AEBSF, 4-(2-aminoethyl)benzenesulfonyl fluoride; AMD, age-related macular degeneration; Aβ, amyloid β; BRB, blood–retina barrier; CEC, choroidal endothelial cells; ELISA, enzyme-linked immunosorbent assa
Inhibiting pollen reduced nicotinamide adenine dinucleotide phosphate oxidase–induced signal by intrapulmonary administration of antioxidants blocks allergic airway inflammation
Keywords: 4-HNE، 4-hydroxynonenal; Allergy; inflammation; antioxidants; eosinophils; TH2AA, Ascorbic acid; BAL, Bronchoalveolar lavage; H2DCF-DA, 2′-7′-Dihydro-dichlorofluorescein diacetate; 4-HNE, 4-Hydroxynonenal; ID50, Inhibitory dose 50; NAC, N-acetyl cysteine; OVA, Ovalbumin; PAS, Per
Oxidative imbalance in the aging inner ear
Keywords: 4-HNE، 4-hydroxynonenal; AIF, apoptosis-inducing factor; 4-HNE, 4-hydroxynonenal; ROS, reactive oxygen species; SOD2, manganese superoxide dismutase (mitochondrial)Presbycusis; Cochlea; Hair cells; Lipid peroxidation; Protein glutathionylation; Nitrotyrosine; Superoxide dismutase
Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase
Keywords: 4-HNE، 4-hydroxynonenal; ALD, alcoholic liver disease; BSA, bovine serum albumin; 4-HNE, 4-hydroxynonenal; KLH, keyhole lymphet hemocyanin; HMG, 3-hydroxy-3-methylglutaryl; ROS, reactive oxygen species; SDS-PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresisHMG-CoA sy
The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; 13-S-HODE, 13-S-hydroxyoctadecadienoic acid; PPARs, peroxisome proliferator-activated receptors; ROI, reactive oxygen intermediates; MDA, malondialdehyde; LpL, lipoprotein lipase; TTA, tetradecylthioacetic acid; DMEM, Dulbecco's m
Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro
Keywords: 4-HNE، 4-hydroxynonenal; Trx, thioredoxin; TrxR, thioredoxin reductase; Are, autioxidant responsive element; HO-1, heme oxygenase-1; Nrf, nuclear-factor-E2-related factor; 4-HNE, 4-hydroxynonenal; ERG, electroretinogram; ONL, outer nuclear layer; H&E, hematoxylin and eosin; ONH,
Acute ethanol pretreatment increases FAS-mediated liver injury in mice: Role of oxidative stress and CYP2E1-dependent and -independent pathways
Keywords: 4-HNE، 4-hydroxynonenal; ABT, aminobenzotriazole; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CYP2E1, cytochrome P450 2e1; DNPH, 2,4-dinitrophenylhydrazine; GSH, reduced glutathione; GdCl3, gadolinium chloride; HE, hematoxylin-eosin; 4-HNE, 4-hydroxynonenal; I
Adaptive response induced by lipid peroxidation products in cell cultures
Keywords: 4-HNE، 4-hydroxynonenal; β-EPOX-Ch, cholesterol 5β,6β-epoxide; 15d-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2; 4-HNE, 4-hydroxynonenal; HODE, hydroxyoctadecadienoic acid; LysoPC, lysophosphatidylcholine; 7-OHCh, 7-hydroxycholesterol; 6-OHDA, 6-hydroxydopamine; PCOOH, phosphatidylchol
Modulation of cutaneous wound healing by ozone: Differences between young and aged mice
Keywords: 4-HNE، 4-hydroxynonenal; 4-HNE, 4-hydroxynonenal; NFκB, nuclear factor kappa B; P-IκB, phosphorylated inhibitory kappa B alpha; TGFβ, tumor growth factor betaAging; Ozone; Wound healing; TGFβ; NFκB; Lipid peroxidation