کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049377 | 1074126 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cell sex determines anoikis resistance in vascular smooth muscle cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cell sex determines anoikis resistance in vascular smooth muscle cells Cell sex determines anoikis resistance in vascular smooth muscle cells](/preview/png/2049377.png)
چکیده انگلیسی
Sexual dimorphism, detectable in vascular smooth muscle cells freshly isolated from aorta of male and female rats, is associated with a different susceptibility to radiation-induced apoptosis. In this work we investigated the mechanism underlying this difference and discovered that, in comparison with cells from male rats, cells from female rats show adhesion-associated resistance to apoptosis, the so called anoikis resistance. This is apparently due to a more adhering phenotype, characterized by a well organized actin microfilament cytoskeleton and to an increased phosphorylated focal adhesion kinase, and, more importantly, to a higher propensity to undergo survival by autophagy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 21, 3 November 2009, Pages 3448–3454
Journal: FEBS Letters - Volume 583, Issue 21, 3 November 2009, Pages 3448–3454
نویسندگان
Elisabetta Straface, Rosa Vona, Lucrezia Gambardella, Barbara Ascione, Maria Marino, Paola Bulzomi, Silvia Canu, Rita Coinu, Giuseppe Rosano, Walter Malorni, Flavia Franconi,