Keywords: 4EBP1; Eukaryotic Translation Initiation Factor 4E Binding Protein 1; ATF3; activating transcription factor 3; ATM; Ataxia Telangiectasia Mutated; ATR; Ataxia Telangiectasia and Rad3-Related; ARF; alternative reading frame; BAPTA; 1,2-bis(o-aminophenoxy)e
مقالات ISI (ترجمه نشده)
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Keywords: mTOR; mammalian target of rapamycin; EBI; early brain injury; SAH; subarachnoid hemorrhage; SD; Sprague-Dawley; BBB; blood-brain barrier; aSAH; aneurysmal subarachnoid hemorrhage; ICP; increasing intracranial pressure; CBF; cerebral blood flow; PI3K; phos
Keywords: 4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; aCDase; acid ceramidase; Akt; Akt/protein kinase B; aSMase; acid sphingomyelinase; CalA; calyculin A; CAPP; ceramide activated protein phosphatase; CDase; ceramidase; Cer; ceramide; Des
Keywords: AKT; protein kinase B; ATF4; activating transcription factor 4; cAMP; cyclic adenosine monophosphate; CCL5; (C-C motif) ligand 5; CNS; central nervous system; 4EBP1; 4E (elF4E) binding protein; ECM; extracellular matrix; ERK; p44/p42 extracellular signal-
Keywords: array-based comparative genomic hybridization; cutaneous clear cell myomelanocytic tumor; initiating mutations; mTOR pathway; perivascular epithelioid cell tumor; aCGH; array-based comparative genomic hybridization; MiTF; micro-ophthalmia-associated trans
Keywords: hAECs; human aortic endothelial cells; oxLDL; oxidized low-density lipoprotein; nLDL; native low-density lipoprotein; GPX; glutathione peroxidase; IGF-1; insulin-like growth factor 1; Apoe; apolipoprotein e; ROS; reactive oxygen species; l-NAME; NG-nitro-
eIF4E Phosphorylation in Prostate Cancer
Keywords: eIF4E; eukaryotic translation initiation factor 4E; mTOR; mammalian target of rapamycin; PCa; prostate cancer; Mnk; mitogen activated protein kinase interacting protein kinase; ADT; androgen deprivation therapy; MAPK; mitogen-activated protein kinase; CRP
Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling
Keywords: Plk2; Polo-like kinase 2; TSC; tuberous sclerosis complex; mTOR; mammalian target of rapamycin; p70S6K/S6K; S6: Ribosomal protein S6 kinase; AMPK; AMP-responsive protein kinase; REDD 1; regulated in DNA damage and development 1; 4EBP1; eukaryotic translat
Correlation between telomerase and mTOR pathway in cancer stem cells
Keywords: CSCs; cancer stem cells; mTOR; mammalian target of rapamycin; PI3K; phosphoinositide 3-kinase; AKT; serine/threonine kinase 1; hTERT; human telomerase reverse transcriptase; TERC; telomerase RNA component; GBM; glioblastoma multiforme; TRF1; telomeric rep
Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFα signaling
Keywords: Akt; AKT serine/threonine kinase 1; BCA; bicinchoninic acid; BRAF; B-Raf proto-oncogene, serine/threonine kinas; COX-2; cyclooxygenase-2; CUR; curcumin; CYP3A4; cytochrome P450 3A4; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; eEF2; eukaryotic translati
Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107
Keywords: SA-β gal; senescence-associated beta galactosidase; MTOR; mammalian target of rapamycin; 4EBP1; eIF4E binding protein 1; S6K1; S6 kinase 1; miRNA; microRNA; RISC; RNA-induced silencing complex; UTR; un-translated region; HUVEC; human umbilical vein endot
Binge ethanol exposure induces endoplasmic reticulum stress in the brain of adult mice
Keywords: Alcohol use isorder; Brain damage; Endoplasmic reticulum tress; mTOR signaling; Neurodegeneration; Oxidative stress; ATF6; Activating transcription factor 6; IRE1α; Inositol-requiring kinase.; PERK; Protein kinase RNA-like endoplasmic reticulum kinase.;
Early dietary restriction in rats alters skeletal muscle tuberous sclerosis complex, ribosomal s6 and mitogen-activated protein kinase
Keywords: Muscle, skeletal; Rats; Diet reducing; Fetal growth retardation; TOR serine-threonine kinase; Mitogen-activated protein kinase phosphatases; 4EBP1; 4E binding protein-1; AMP; adenosine monophosphate-activated protein; CON; control; eIF4E; eukaryotic tra
Systemic PTEN-Akt1-mTOR pathway activity in patients with normal tension glaucoma and ocular hypertension: A case series
Keywords: Normal tension glaucoma; Ocular hypertension; PTEN; Akt1; 4EBP1; S6K; mTOR; Mitochondria;
Original ArticleExpression of key mTOR pathway components in pancreatic ductal adenocarcinoma: A multicenter study for clinicopathologic and prognostic significance
Keywords: Pancreatic ductal adenocarcinoma; Prognostic factor; mTOR; 4EBP1; P70S6K; Immunohistochemistry;
Research reportInhibition of AMP-activated protein kinase alleviates focal cerebral ischemia injury in mice: Interference with mTOR and autophagy
Keywords: AMPK; AMP-activated protein kinase; Atg; autophagy related gene; DAP1; death associated protein 1; 4EBP1; eukaryotic initiation factor 4E binding protein 1; FGF; fibroblast growth factor; HIF-1; hypoxia-inducible factor-1; FIP; FAK family kinase-interacti
Nonylphenol induced apoptosis and autophagy involving the Akt/mTOR pathway in prepubertal Sprague-Dawley male rats in vivo and in vitro
Keywords: 4EBP1; eukaryotic translation initiation factor 4E binding protein 1; ABP; androgen binding protein; DAPI; 4â²-6-diamidino-2-phenylindole; DMEM; high-glucose-Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; ER; estrogen receptor; FSH; fo
Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication
Keywords: HBV; Hepatitis B virus; HCC; Hepatocellular carcinoma; HBx; HBV X protein; cccDNA; Covalently closed circular DNA; ORF; Open reading frame; mTORC1; Mammalian target of rapamycin (mTOR) complex 1; TSC2; Tuberous-sclerosis complex-2; AMPK; AMP-activated pro
Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy
Keywords: NRVM; neonatal rat ventricular cardiomyocytes; Class I PI3K; class I phosphoinositide 3-kinase; 4EBP1; 4E binding protein 1; CHOP; C/EBP homologous protein; EF; ejection fraction; FS; fractional shortening; LY02; LY2940002; WT; wild-type; Autophagy; Signa
IGF-I and amino acids effects through TOR signaling on proliferation and differentiation of gilthead sea bream cultured myocytes
Keywords: Sparus aurata; Growth and myogenic factors; 4EBP1; 70S6K; AKT; Myocytes;
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
Keywords: PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig
PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; 4EBP1; eukaryotic translation initiation factor 4E (eIF-4E)-binding protein-1; FOXO; Forkhead box-O class transcription factors; FMRP; Fragile-X mental retardation protein; GSK3β;
p70S6 kinase is a target of the novel proteasome inhibitor 3,3â²-diamino-4â²-methoxyflavone during apoptosis in human myeloid tumor cells
Keywords: AML; acute myeloid leukemia; DD1; 3,3â²-diamino-4â²-methoxyflavone; DNFAA; 2â²,3-dinitroflavone-8-acetic acid; 4EBP1; eukaryotic translation initiation factor 4E binding protein 1; FCS; fetal calf serum; FITC; fluorescein isothiocyanate; LPS; lipopolys
Activation of Gαq subunits up-regulates the expression of the tumor suppressor Fhit
Keywords: GRPR; gastrin-releasing peptide receptor; BK2R; bradykinin type 2 receptor; β2AR; β2 adrenergic receptor; MT1R; melatonin type 1 receptor; CHX; cycloheximide; eIF; eukaryotic initiation factor; 4EBP1; eIF4E binding protein 1; RGS; regulator of G protein
Mechanistic target of rapamycin (mTOR) dependent regulation of thioredoxin interacting protein (TXNIP) transcription in hypoxia
Keywords: Thioredoxin interacting protein; TXNIP; Mechanistic target of rapamycin; mTOR; Eukaryotic initiation factor 4E binding protein; 4EBP1; Hypoxia; Hypoxia-inducible factor; HIF
Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas
Keywords: Chromophobe renal cell carcinoma; mTOR; PTEN; AKT; S6; 4EBP1; HIF-1α
Improved Clearance during Treatment of HPV-Positive Head and Neck Cancer through mTOR Inhibition
Keywords: Ad5 E6/E7; adenovirus 5 expressing HPV-16 E6 and E7; CMI; cell-mediated immunity; CRT; cisplatin/radiation therapy; HNSCC; head and neck squamous cell carcinoma; HPV; human papillomavirus; HPV-; HPV-negative; HPV+; HPV type 16 positive; HTEs; human tonsil
Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine
Keywords: 4EBP1; eukaryotic translation initiation factor 4E binding protein 1; ADRA1D; adrenergic α-1D-receptor; AE; adverse events; ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; SD; Sprague-Dawley; DAG; diacylglycerol; DMARD; disease modifying
Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas
Keywords: Papillary renal cell carcinoma; mTOR; PTEN; AKT; S6; 4EBP1; HIF-1α
A Novel Unstructured Scaffold Based on 4EBP1 Enables the Functional Display of a Wide Range of Bioactive Peptides
Keywords: protein aptamer scaffold; 4EBP1; PCNA; cyclin; Mdm2Trx, thioredoxin A; GFP, green fluorescent protein; SBP, streptavidin-binding peptide; PCNA, proliferating cell nuclear antigen; WT, wild type; β-gal, β-galactosidase; CBD, cyclin-binding domain; Cdk, cyc
Deregulation of mTOR signaling is involved in thymic lymphoma development in Atm−/− mice
Keywords: A-T; ATM; Thymocyte; Thymic lymphoma; c-Myc; mTOR; 4EBP1; Cyclin D1
Chemopreventive efficacy of rapamycin on Peutz–Jeghers syndrome in a mouse model
Keywords: Peutz–Jeghers syndrome; LKB1; Polyposis; Rapamycin; S6; 4EBP1
Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
Keywords: HCC; Hepatocellular carcinoma; VEGF; vascular endothelial growth factor; BEV; Bevacizumab; mTOR; mammalian target-of-rapamycin; p70S6K; p70S6 kinase; RPS6; ribosomal S6 protein; 4EBP1; eukaryotic initiation factor 4E-binding protein 1; RAPA; rapamycin; IP
ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft
Keywords: HCC; hepatocellular carcinoma; RTKIs; tyrosine kinase inhibitors; MAPK; mitogen activated protein kinase; VEGF; vascular endothelial growth factor; mTOR; mammalian target of rapamycin; p70S6K; p70S6 kinase; 4EBP1; eukaryotic initiation factor 4E-binding p
Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells
Keywords: epidermal growth factor receptor; signal transduction; rapamycin; glioblastoma; 4EBP1; AM;