Keywords: PEDV; Papain-like protease; 6-Thioguanine; Noncompetitive inhibition; Alpha coronavirus; AUC; The abbreviations used are analytical ultracentrifugation; CoV; coronavirus; DUB; deubiquitinating; MERS; Middle East respiratory syndrome; βME; β-mercaptoetha
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Keywords: AGA; American Gastroenterological Association; CBC; complete blood count; CI; confidence interval; GRADE; Grading of Recommendations Assessment, Development and Evaluation; IBD; inflammatory bowel disease; RCT; randomized controlled trial; RR; relative ri
Keywords: 6-Thioguanine; Dopamine; Uric acid; Xanthine; Hypoxanthine
Keywords: Genotoxicity; Cobalt compounds; Overall assessment; 2-AA; 2-aminoanthracene; 2NF; 2-nitrofluorene; 4-NOPD; nitro-o-phenylenediamine; 6Â TG; 6-thioguanine; 8-OH-dG; 8-hydroxy-2-deoxyguanosine; 9AA; 9-aminoacridine; AAF; artificial alveolar fluid; B[a]P; be
Keywords: Colon Cancer; Functional Tests; Predisposition; Tumor; 6-TG; 6-thioguanine; CMMRD; constitutional mismatch repair; evMSI; ex vivo microsatellite instability; FAP; familial adenomatous polyposis; gMSI; germline microsatellite instability; IHC; immunohisto
Keywords: 6-Mercaptopurine; 6-Thioguanine; Leukemia; Thiopurine methyltransferase;
Keywords: 6-Thioguanine; Folic acid; ZnO-CuO nanoplates; Voltammetry; Carbon paste electrode
The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress
Keywords: 6-TG; 6-thioguanine; 8-oxoG; 8-oxo-7,8-dihydroguanine; MTH1; MutT Homolog 1; Reactive oxygen species; ROS; 8-oxoguanine (8-oxoG); Genomic instability; MutT homolog; Nucleoside/nucleotide metabolism; Nudix; Oxidative stress;
A SERS substrate of mesoporous g-C3N4 embedded with in situ grown gold nanoparticles for sensitive detection of 6-thioguanine
Keywords: Mesoporous graphitic carbon nitride; SERS; 6-thioguanine; Chemical enhancement; High sensitivity;
A novel “on-off-on” fluorescent sensor for 6-thioguanine and Hg2+ based on g-C3N4 nanosheets
Keywords: g-C3N4 nanosheets; Fluorescence; Sensor; 6-Thioguanine; Mercury;
6-Thioguanine inhibits rotavirus replication through suppression of Rac1 GDP/GTP cycling
Keywords: Rotavirus; 6-Thioguanine; Rac1; Intestinal organoids;
Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes
Keywords: MERS- and SARS-CoV; Papain-like protease; Disulfiram; 6-Thioguanine; Mycophenolic acid; Synergistic inhibition; CoV; coronavirus; Mpro; main protease; DDC; diethyldithiolcarbamate; DUB; deubiquitination; MERS; Middle East respiratory syndrome; βME; β-me
NK cells are biologic and biochemical targets of 6-mercaptopurine in Crohn's disease patients
Keywords: 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; 7-AAD; 7-amino-actinomycin; CD; Crohn's disease; IBD; inflammatory bowel disease; KIR; killer immunoglobulin-like receptor; UC; ulcerative colitis; Caspase; 6-Mercaptopurine; Inflammatory bowel disease; NK cell
Cytosine derivatized diethylenetriaminepentaacetic acid (dtpa) and Eu(III) complexes for selective recognition of 6-Thioguanine
Keywords: Design and synthesis; Double emission peak; Fluorescent probe; 6-Thioguanine; Selective recognition;
Determination of thiopurine S-methyltransferase activity by hydrophilic interaction liquid chromatography hyphenated with mass spectrometry
Keywords: 6-MMP; 6-methylmercaptopurine; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; AZA; azathioprine; Cl-P; 6-chloropurine; DTT; dithiothreitol; IBD; inflammatory bowel diseases; RBC; red blood cells; SAM; S-adenosyl-l-methionine; TGN; thioguanine nucleotides; T
Detection of 6-Thioguanine by surface-enhanced Raman scattering spectroscopy using silver nanoparticles-coated silicon wafer
Keywords: Surface-enhanced Raman scattering; Silver nanoparticles-coated silicon wafer; 6-Thioguanine; Internal standard;
Protein oxidation, UVA and human DNA repair
Keywords: NER; nucleotide excision repair; ROS; reactive oxygen species; UV; ultraviolet; CPD; cyclobutane pyrimidine dimer; 6:4Py:Py; 6:4 pyrimidine:pyrimidone; 1O2; singlet oxygen; 6-TG; 6-thioguanine; Protein oxidation; Reactive oxygen species; Ultraviolet radia
64Cu-ATSM therapy targets regions with activated DNA repair and enrichment of CD133+ cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite
Keywords: 64Cu-ATSM; DNA repair; Nucleic acid antimetabolite; Hypoxia; Internal radiotherapy; 18FDG; [18F]-fluorodeoxyglucose; 5-FU; 5-fluorouracil; 64Cu-ATSM; 64Cu-diacetyl-bis (N4-methylthiosemicarbazone); 6-TG; 6-thioguanine; ANOVA; analysis of variance; ASB9; a
Cytosine derivatized bis(2,2â²-bithienyl)methane molecularly imprinted polymer for selective recognition of 6-thioguanine, an antitumor drug
Keywords: 6-thioguanine; Cytosine; Molecularly imprinted polymer; Capacity measurement; Flow-injection analysis;
Facile colorimetric detection of Hg2+ based on anti-aggregation of silver nanoparticles
Keywords: Silver nanoparticle; Mercury; 6-Thioguanine; Anti-aggregation; Colorimetric sensor;
Electrochemical monitoring of surface confined interaction between 6-Thioguanine and DNA by using single-use graphite electrode
Keywords: 6-Thioguanine; DNA biosensor; Drug–DNA interaction; Pencil graphite electrode; Differential pulse voltammetry
Genotoxicity evaluation of Mequindox in different short-term tests
Keywords: Carbadox; Genotoxicity; Mequindox; Quinoxaline-1; 4-Dioxides; 6-TG; 6-thioguanine; ATCC; American type culture collection; BaP; benzo-[a]-pyrene; CA; chromosomal aberration; CBX; carbadox; CCTCC; China Center for Type Culture Collection; CP; cyclophospham
Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo
Keywords: 6-TG; 6-thioguanine; ATCC; American type culture collection; BaP; benzo-[a]-pyrene; CA; chromosomal aberration; CBX; carbadox; CCTCC; China Center for Type Culture Collection; CP; Cyclophosphamide; CYA; Cyadox; DMEM; Dulbecco's modified Eagle's Medium
Efficacy of drugs used in the treatment of IBD and combinations thereof in acute DSS-induced colitis in mice
Keywords: Dextran sodium sulphate; Colitis; Cyclosporine A; 6-Thioguanine; EP4 agonist; 5-ASA; Combination therapy; IBD;
A density functional theory study on the intramolecular proton transfer in 6-thioguanine and alkali metal cations substituted derivatives (M-TG, MÂ =Â Li+, Na+, K+)
Keywords: 6-Thioguanine; Density functional theory; Transition state; Tautomerization; Intramolecular proton transfer;
Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment
Keywords: 6-MMP; 6-methyl mercaptopurine; AZA; azathioprine; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; 6-TGN; 6-thioguanine nucleotides; TPMT; thiopurine S-methyl transferase; HBI; Harvey-Bradshaw Index; MTLWI; Modified Truelove and Witts Index; 6-Thioguanine;
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2
Keywords: AP site; apurinic/apyrimidinic site; BER; base excision repair; Fpg; formamidopyrimidine [fapy]-DNA glycosylase; HPRT; hypoxanthine phosphoribosyltransferase; IC; immunocomplex; LA QPCR; long amplicon quantitative PCR; Lig IIIα; ligase IIIα; MAF; minor
The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells
Keywords: 6-Mercaptopurine; 6-Thioguanine; Resistance; Leukemia; Microarray; Comparative genomic hybridization;
Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation
Keywords: DNA interstrand crosslinking; 6-Thioguanine; Ultraviolet A; Fanconi anemia;
In vivo 6-thioguanine-resistant T cells from melanoma patients have public TCR and share TCR beta amino acid sequences with melanoma-reactive T cells
Keywords: CE; cloning efficiency; HPRT; hypoxanthine-guanine phosphoribosyltransferase; IMGT; International Immunogenetics Information System; MF; mutant frequency; MT; HPRT-deficient T cells; SCD-T; single-cell derived T cell isolate; TIL(N); tumor-infiltrating
Influences of urea and guanidine hydrochloride on the interaction of 6-thioguanine with bovine serum albumin
Keywords: 6-Thioguanine; Bovine serum albumin; Urea; Guanidine hydrochloride; Fluorescence spectroscopy
Optimización del tratamiento con azatioprina: determinación de la actividad de tiopurina metiltransferasa y las concentraciones de metabolitos tiopurÃnicos
Keywords: Azatioprina; Tiopurina metiltransferasa; 6-tioguanina; 6-metilmercaptopurina; Enfermedad inflamatoria intestinal; Hepatitis autoinmune; Metabolitos tiopurÃnicos; Azathioprine; Thiopurine methyltransferase; 6-thioguanine; 6-methylmercaptopurine; Inflammat
Voltammetric determination of trace quantities of 6-thioguanine based on the interaction with DNA at a mercury electrode
Keywords: 6-Thioguanine; DNA; Intercalation; Electroanalytical method; Clinical analysis
Study on the interaction of 6-thioguanine with bovine serum albumin by spectroscopic techniques
Keywords: 6-Thioguanine; Bovine serum albumin; UV–Vis absorption; Florescence spectroscopy; CD spectra
6-Thioguanine therapy in Crohn′s disease—Observational data in Swedish patients
Keywords: 6-thioguanine; Inflammatory bowel disease; Thiopurine drugs; Drug toxicity
Absence of nodular regenerative hyperplasia after low-dose 6-thioguanine maintenance therapy in inflammatory bowel disease patients
Keywords: Hepatotoxicity; Inflammatory bowel disease; Nodular regenerative hyperplasia; 6-Thioguanine; 6-Thioguaninenucleotides; TPMT
Toxicity of 6-thioguanine: no hepatotoxicity in a series of IBD patients treated with long-term, low dose 6-thioguanine: Some evidence for dose or metabolite level dependent effects?
Keywords: Hepatotoxicity; Inflammatory bowel disease; 6-Thioguanine
Cytostatic drug treatment causes seeding of gene promoter methylation
Keywords: DNA methylation; Drug resistance; 6-Thioguanine; Colorectal cancer; HPRT;
Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light
Keywords: 6-Thioguanine; Ultraviolet light; Photochemistry; Oxidative DNA damage; Antioxidants; Guanine-6-sulfonate; Reactive oxygen species; Rose Bengal; UVA; DNA photoproducts
Chronic liver disease related to 6-thioguanine in children with acute lymphoblastic leukaemia
Keywords: 6-Thioguanine; UK ALL 97/99 clinical trial; Acute lymphoblastic leukaemia; Nodular regenerative hyperplasia; Portal hypertension; Hepatic toxicity; Children
Incidence of Neoplasms in Patients Who Develop Sustained Leukopenia During or After Treatment With 6-Mercaptopurine for Inflammatory Bowel Disease
Keywords: AZA; azathioprine; IBD; inflammatory bowel disease; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; TPMT; thiopurine methyl transferase;
An electrochemical sensor of non-electroactive drug 6-thioguanine based on the dsDNA/AET/Au
Keywords: 6-Thioguanine; DNA; Intercalation; 2-Aminoethanethiol; Screening
Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines
Keywords: 6-Mercaptopurine; 6-Thioguanine; Resistance; Leukemia; Transport
Identification and functional analysis of two rare allelic variants of the thiopurine S-methyltransferase gene, TPMT*16 and TPMT*19
Keywords: TPMT; Genetic polymorphism; Azathioprine; 6-Thioguanine; Deficient methylator; Heterologous expression; RBC; red blood cell; 6-TG; 6-thioguanine; TPMT; thiopurine S-methyltransferase;
Self-assembly of 6-thioguanine and 6-thioguanosine monolayers on the mercury electrode: effects of oxygen and applied potential
Keywords: Self-assembled monolayers (SAMs); 6-thioguanine; 6-thioguanosine; Mercury electrode; Chronoamperometry; Cyclic voltammetry; Open circuit potential measurements;
A multicenter assessment of liver toxicity by MRI and biopsy in IBD patients on 6-thioguanine
Keywords: 6-thioguanine; Nodular regenerative hyperplasia; Immunosuppression; IBD; Hepatotoxicity;
Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes
Keywords: Leukemia; Enzymes; Thiopourine S-methyltransferase; 6-Mercaptopurine; 6-Thioguanine;
Effects of azathioprine and its metabolites on repair mechanisms of the intestinal epithelium in vitro
Keywords: AZA; azathioprine; ELISA; enzyme-linked immunosorbent assay; FACS; fluorescence activated cell scanner; FITC; fluorescein (isothiocyanate form); IBD; inflammatory bowel disease; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; Intestinal epithelium; Prolifera
New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant
Keywords: MMS; methyl methanesulfonate; EMS; ethyl methanesulfonate; MNU; methylnitrosourea; ENU; ethylnitrosourea; CNU; chloroethylnitrosourea; IR; ionizing radiation; MMC; mitomycin C; HR; homologous recombination; HRR; homologous recombinational repair; ROS; rea
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations
Keywords: AO; aldehyde oxidase; AZA; azathioprine; CD; Crohn's disease; DNA; deoxynucleic acid; FDA; Food and Drug Administration; GMPS; guanosine monophosphate synthetase; HPRT; hypoxanthine phosphoribosyl transferase; IBD; inflammatory bowel disease; IBDQ; Inflam