کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
744972 894409 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An electrochemical sensor of non-electroactive drug 6-thioguanine based on the dsDNA/AET/Au
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
An electrochemical sensor of non-electroactive drug 6-thioguanine based on the dsDNA/AET/Au
چکیده انگلیسی

Surface electrochemical method based on dsDNA film modified electrode is applied to a preliminary screening of anticancer drug 6-thioguanine (6-TG). A composite film containing dsDNA was fabricated on 2-aminoethanethiol self-assembled monolayers film modified gold electrode (AET/Au SAMs) by electrostatic adsorption. The two electrochemical probes of [Fe(CN)6]3−/4− and Co(bpy)32+/3+ were used to investigate the interaction between dsDNA and 6-TG. Fluorimetry and UV–vis spectrometry proved further the interaction. The peak currents of the electrochemical probes were linear with the concentrations of 6-TG, a high sensitivity and a low detection limit was obtained, this modified electrode can be used to determine the concentration of 6-TG.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 120, Issue 1, 14 December 2006, Pages 238–244
نویسندگان
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