کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
744972 | 894409 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An electrochemical sensor of non-electroactive drug 6-thioguanine based on the dsDNA/AET/Au
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Surface electrochemical method based on dsDNA film modified electrode is applied to a preliminary screening of anticancer drug 6-thioguanine (6-TG). A composite film containing dsDNA was fabricated on 2-aminoethanethiol self-assembled monolayers film modified gold electrode (AET/Au SAMs) by electrostatic adsorption. The two electrochemical probes of [Fe(CN)6]3−/4− and Co(bpy)32+/3+ were used to investigate the interaction between dsDNA and 6-TG. Fluorimetry and UV–vis spectrometry proved further the interaction. The peak currents of the electrochemical probes were linear with the concentrations of 6-TG, a high sensitivity and a low detection limit was obtained, this modified electrode can be used to determine the concentration of 6-TG.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 120, Issue 1, 14 December 2006, Pages 238–244
Journal: Sensors and Actuators B: Chemical - Volume 120, Issue 1, 14 December 2006, Pages 238–244
نویسندگان
Wei Wang, Sheng-Fu Wang, Fen Xie,