Keywords: AAV، ویروس مرتبط با adeno; LGT, Lung gene therapy; AAV, Adeno-associated virus; CT, Cycle threshold; DW, Deionized water; GFP, Green fluorescent protein; qPCR, Quantitative polymerase chain reaction; RUL, Right upper lobeAAV; Screening; Gene therapy; Sheep; Lung
مقالات ISI AAV، ویروس مرتبط با adeno (ترجمه نشده)
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Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; AAV2, adeno-associated viral vector serotype 2; AMD, age-related macular degeneration; iPSC, induced pluripotent stem cell; RP, retinitis pigmentosa; RPE, retinal pigment epithelium; VEGF, vascular endothelial growth factor
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; DRG, dorsal root ganglion; ER, endoplasmic reticulum; IR, immunoreactive; NF200, neurofilament 200; NSE, Neuron-Specific Enolase; PB, phosphate buffer; PFA, paraformaldehyde; qRT-PCR, quantitative RT-PCR; RIPA, radioimmunoassa
Keywords: AAV، ویروس مرتبط با adeno; mSC, myelinating Schwann cell; CMV promoter, cytomegalovirus promoter; OPA1, optic atrophy 1; AAV, adeno-associated virus; CAG promoter, cytomegalovirus beta-actin beta-globin promoter; ROI, Region of Interest; OPO, optical parametric oscillatorMyelin; Sc
Keywords: AAV، ویروس مرتبط با adeno; A2ARs, adenosine A2A receptors; AAV, adeno-associated virus; EEG, electroencephalogram; EMG, electromyogram; H1R, histamine H1 receptor; KO, knockout; LH, lateral hypothalamic area; NAc, nucleus accumbens; NREM, non-rapid eye movement; REM, rapid eye move
Keywords: AAV، ویروس مرتبط با adeno; MSC, mesenchymal stem cells; BM, bone marrow; UC, umbilical cord; iPSC, induced pluripotent stem cells; UC-MSC, UC-derived MSC; BM-MSC, BM-derived MSC; NP, nanoparticle; AAV, adeno-associated virus; ASC, adipose-derived stem cells; ZFN, zinc finger nuclea
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; NP, nanoparticles; LCA, Leber’s congenital amaurosis; RPE, retinal pigment epithelium; OS, outer segment; SNP, single nucleotide polymorphism; ERG, electroretinogram; CME, clathrin mediated endocytosis; CvME, caveolae mediated
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; ALS, amyotrophic lateral sclerosis; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ChAT, choline acetyltransferase; CHOP, C/EBP homologous protein; CMAP, compound muscle action potential; CNTF, ciliary neurotrophi
Keywords: AAV، ویروس مرتبط با adeno; LPL, lipoprotein lipase; CNS, central nervous system; TG, triglycerides; AAV, adeno-associated virus; GFP, green fluorescent protein; ANS, autonomic nervous system; RQ, respiratory quotient; SPT, serine palmitoyltransferase; CERS, ceramide synthase; SMPD1
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; AIDS, acquired immunodeficiency syndrome; Apo, B apolipoprotein B; ASS, arginine-succinate synthetase; BM, bone marrow; BMMNCs, bone marrow mononuclear cells; CEHPOB, 4-[(2-carboxyethyl)-hydroxyphosphinyl]-3-oxobutyrate; CoA,
Keywords: AAV، ویروس مرتبط با adeno; HSV-1; Viral vectors; Gene therapy; Retina; Inflammation; IL-6; IL-10HSV, herpes simplex virus; AdV, adenovirus; AAV, adeno-associated virus; NHP, non-human primate; IL, interleukin; TLR, Toll-Like Receptors; pfu, plaque forming units; PR, photoreceptors;
Emotional memory impairments induced by AAV-mediated overexpression of human α-synuclein in dopaminergic neurons of the ventral tegmental area
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; GFP, green fluorescent protein; PD, Parkinson’s disease; SN, substantia nigra; TH, tyrosine hydroxylase; VTA, ventral tegmental area; WT, wild-typeα-Synuclein; Ventral tegmental area; Adeno-associated viral vectors; Memory; Co
Non-coding RNAs as orchestrators of autophagic processes
Keywords: AAV، ویروس مرتبط با adeno; Atg, autophagy related gene; AAV, adeno-associated virus; CryABR120G, αB-crystallin R120G mutation; RNA, ribonucleic acid; DNA, deoxyribonucleic acid; 3-MA, 3 methyladenine; lncRNA, long non-coding RNA; HUVECs, human umbilical vein endothelial cells; HAEC
Comprehensive selection of reference genes for expression studies in meniscus injury using quantitative real-time PCR
Keywords: AAV، ویروس مرتبط با adeno; ACL, anterior cruciate ligament; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; MRI, magnetic resonance imaging; TLDA, TaqMan Low-Density Array; AAV, adeno-associated virus; Crt, relative cycle threshold; Ct, cycle threshold; SD, s
Long-term outcomes of gene therapy for the treatment of Leber's hereditary optic neuropathy
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; BCVA, best corrected visual acuity; CF, counting fingers; ERG, electroretinogram; HM, hand movement; IOP, intraocular pressure; LHON, Leber's hereditary optic neuropathy; MD, mean defect; MtDNA, mitochondrial DNA; ND4, NADH–ub
Stem cell-based therapies for HIV/AIDS
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; Adv, adenovirus; AIDS, acquired immunodeficiency syndrome; AML, acute myelogenous leukemia; BLT, bone marrow/liver/thymus; BCNU, bis-chloroethylnitrosourea; CARs, chimeric antigen receptors; cART, combined antiretroviral thera
Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases
Keywords: AAV، ویروس مرتبط با adeno; 6-OHDA, 6-hidroxydopamine; AAV, adeno-associated virus; AD, Alzheimer's disease; AgRP, agouti-related protein; BDNF, brain-derived neurotrophic factor; CNS, central nervous system; CSF, cerebrospinal fluid; GABA, gamma-aminobutyric acid; HD, Huntington's
Jmjd3 mediates blood–spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; BBB, blood–brain barrier; CNS, central nervous system; ChIP, Chromatin Immunoprecipitation; Cox, cyclooxygenase; GM, gray matter; HDAC, histone deacetylase; MMP, matrix metalloprotease; OGD, oxygen–glucose deprivation;; shRNA,
Emerging Mitochondrial Therapeutic Targets in Optic Neuropathies
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; ADOA, autosomal dominant optic atrophy; Cas 9, CRISPR-associated protein 9; CoQ10, coenzyme Q10; CR, caloric restriction; CRISPR, clustered regularly interspaced short palindromic repeats; E2, 17β-estradiol; ER, estrogen recep
Minimal hepatic glucose-6-phosphatase-α activity required to sustain survival and prevent hepatocellular adenoma formation in murine glycogen storage disease type Ia
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; BW, body weight; ER, endoplasmic reticulum; G6Pase-α, glucose-6-phosphatase-α; G6P, glucose-6-phosphate; G6PC, glucose-6-phosphatase-α gene; G6PT, glucose-6-phosphate transporter; GPE, G6PC promoter and enhancer; GSD-Ia, glyco
Optimization of a multiplex CRISPR/Cas system for use as an antiviral therapeutic
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; CRISPR, clustered regularly interspaced short palindromic repeats; Sau Cas9, Staphylococcus aureus Cas9; sgRNA, single guide RNA; ITRs, inverted terminal repeats; PAM, protospacer adjacent motifAAV multiplex genome editing; CR
Adeno-associated virus mediated gene transfer of Shepherdin inhibits gallbladder carcinoma growth in vitro and in vivo
Keywords: AAV، ویروس مرتبط با adeno; AAV, Adeno-associated virus; AML, acute myeloid leukemia; AGE, agarose gel electrophoresis; CML, chronic myelogenous leukemia; DMSO, dimethyl sulfoxide; FITC, fluorescein isothiocyanate; GBC, gallbladder carcinoma; H&E, Hematoxylin–Eosin; Hsp90, heat shoc
14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson’s disease
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; DA, dopamine; DOPAC, 3,4-dihydroxyphenylacetic acid; eYFP, enhanced yellow fluorescent protein; GFP, green fluorescent protein; HPLC, high performance liquid chromatography; HVA, homovanillic acid; MPTP, 1-methyl-4-phenyl-1,2,
Mitigation of cerebellar neuropathy in globoid cell leukodystrophy mice by AAV-mediated gene therapy
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; BDNF, brain-derived neurotrophic factor; BMT, bone marrow transplantation; CNS, central nervous system; CNTF, ciliary neurotrophic factor; GALC, galactocerebrosidase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GDNF, glia
Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; AMD, age-related macular degeneration; ChR2, channelrhodopsin 2; CNG, cyclic nucleotide-gated channel; CNTF, ciliary neurotrophic factor; GDNF, glial cell derived neurotrophic factor; GFP, green fluorescent protein; ITR, inver
A novel “priming-boosting” strategy for immune interventions in cervical cancer
Keywords: AAV، ویروس مرتبط با adeno; CTL, cytotoxic T-lymphocyte; HPV, human papillomavirus; AAV, adeno-associated virus; rAAV, recombinant AAV; CIN, cervical intraepithelial neoplasm; CMI, cell-mediated immunity; CpG-ODN, CpG oligodeoxynucleotide; TAP, transporter associated with antigen pr
GLT1 overexpression in SOD1G93A mouse cervical spinal cord does not preserve diaphragm function or extend disease
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; C3, 4, 5, cervical spinal cord level 3 (4, 5, etc.); CMAP, compound muscle action potential; eGFP, enhanced green fluorescent protein; GFAP, glial fibrillary acidic protein; GLT1, glutamate transporter-1; NMJ, neuromuscular ju
Regulation of voltage-gated Ca2 + currents by Ca2 +/calmodulin-dependent protein kinase II in resting sensory neurons
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; AIP, autocamtide-2-related inhibitory peptide; CaMKII, calcium/calmodulin-dependent protein kinase II; DMSO, dimethyl sulfoxide; DRG, dorsal root ganglion; EGFP, enhanced GFP; EGTA, ethylene glycol tetraacetic acid; HEPES, 2-[
Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease
Keywords: AAV، ویروس مرتبط با adeno; HT1, Hereditary tyrosinemia type I; FAH, Fumarylacetoacetate hydrolase; NTBC, 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3 cyclohexanedione; FAA, Fumarylacetoacetate; AAV, Adeno-associated virus; SCNT, Somatic cell nuclear transfer; CFTR, Cystic fibrosis tran
The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease
Keywords: AAV، ویروس مرتبط با adeno; 5HIAA, 5-hydroxyindoleacetic acid; 5HT, 5-hydroxytryptamine; AAV, adeno-associated virus; AAV2-GFP, AAV2-green fluorescent protein; AAV2-hIL-10, vector containing cDNA for human interleukin 10; ASP, aspartic acid; cDNA, complementary deoxyribonucleic acid
Hemophilia clinical gene therapy: brief review
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; BP, branch point; FIX, factor IX; hFIX, human factor IX; PP, polypyrimidine tract; PTM, pre-trans-splicing molecule
Channelrhodopsins—Their potential in gene therapy for neurological disorders
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; AMD, age-related macular degeneration; ArchT, archaerhodopsin-T from Halorubrum strain TP009; ChR, channelrhodopsin; ChR1, channelrhodopsin-1; ChR2, channelrhodopsin-2; ChRFR, ChR-fast receiver; ChRWR, ChR-wide receiver; ChRGR
Gene transfer for congestive heart failure: update 2013
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; AC, adenylyl cyclase; AC6, adenylyl cyclase 6; βAR, β-adrenergic receptor; CHF, congestive heart failure; CMV, cytomegalovirus; GRK2, G-protein-coupled receptor kinase 2; LV, left ventricular; IC, intracoronary; SR, sarcoplasm
12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival
Keywords: AAV، ویروس مرتبط با adeno; 12LO, 12-lipoxygenase; AII, Angiotensin II; AAV, adeno-associated virus; Baic, baicalein; CAT, chloramphenicol acetyl transferase; Gfp, green fluorescent protein; HETE, hydroxyeicosatetraenoic acid; MOI, modality of infection; Mp, murine platelet; MCS, mu
Therapeutic intervention for wear debris-induced aseptic implant loosening
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; ASO, antisense oligonucleotide; COX, cyclooxygenase; Dex, dexmethasone; ELVIS, extravasation through leaky vasculature and inflammatory cell-mediated sequestration; EM, erythromycin; FGF-2, fibroblast growth factor-2; FLS, fib
Current strategies for drug delivery to the inner ear
Keywords: AAV، ویروس مرتبط با adeno; BLB, blood labyrinth barrier; AAV, adeno-associated virus; ABR, auditory brainstem response; AIED, autoimmune inner ear disease; BDNF, brain-derived neurotrophic factor; BP, betamethasone phosphate; BBB, blood brain barrier; GDNF, glial-derived neurotroph
Synergistic effects of BDNF and rehabilitative training on recovery after cervical spinal cord injury
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; BDNF, brain-derived neurotrophic factor; CST, corticospinal tract; GFP, green fluorescent protein; NT-3, Neurotrophin 3; p.i., post-injury; RtST, reticulospinal tract; s.c., subcutaneous; SCI, spinal cord injuryReticulospinal
Axon degeneration in Parkinson's disease
Keywords: AAV، ویروس مرتبط با adeno; [3H]TBZOH, tritiated α-dihydrotetrabenazine; 6-OHDA, 6-hydroxydopamine; AAV, adeno-associated virus; AD, Alzheimer's disease; AVs, autophagic vacuoles; DLB, dementia with Lewy Bodies; ILB, incidental Lewy bodies; LB, Lewy body; LRRK2, leucine rich repeat
Arthritis gene therapy and its tortuous path into the clinic
Keywords: AAV، ویروس مرتبط با adeno; AAV, Adeno-associated virus; FDA, Food and drug administration; GFP, Green fluorescent protein; IFN-b, Interferon-beta; IL-1, Interleukin-1; IL-1Ra, Interleukin-1 receptor antagonist; IND, Investigational new drug; MCP, Metacarpophalangeal; OA, Osteoarthr
Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; ACEI, angiotensin converting enzyme inhibitors; AKAP, A-kinase anchoring protein; ARB, angiotensin receptor blockers; BK, large-conductance, Ca2+-activated K+ channel; CaV1.2, L-type Ca2+ channel; CCB, calcium channel blocker;
Gene therapy for retinal disease
Keywords: AAV، ویروس مرتبط با adeno; 661W, murine photoreceptor-derived retinal cell line; AAV, adeno-associated virus; ABCA4, ATP-binding casette, sub-family A, member 4; AIPL1, aryl hydrocarbon receptor interacting protein like-1; ARPE19, retinal pigment epithelia cell line; beta-Pde6, pho
Rodent models of amyotrophic lateral sclerosis
Keywords: AAV، ویروس مرتبط با adeno; AAV, Adeno-associated virus; ALS, Amyotrophic lateral sclerosis; BAC, Bacterial artificial chromosome; ChAT, Choline acetyltransferase; CNS, Central nervous system; cTDP/FUS, Cytoplasmic TDP-43/FUS; CTF, C-terminal fragment; EMG, Electromyography; FALS, F
Gene therapy for the prevention of vein graft disease
Keywords: AAV، ویروس مرتبط با adeno; Ad, adenovirus; AAV, adeno-associated virus; COX-1, cyclooxygenase-1; EC, endothelial cell; ECM, extracellular matrix; eNOS, endothelial nitric oxide synthase; HDAd, helper-dependent adenovirus; HVJ, hemagglutinating virus of Japan; IH, intimal hyperplasi
Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain
Keywords: AAV، ویروس مرتبط با adeno; 3-OMD, 3-methoxy-4-hydroxy-l-phenylalanine; 5-HT, serotonin; 5,7-DHT, 5,7-dihydroxytryptamine; 6-OHDA, 6-hydroxydopamine; AADC, aromatic l-amino acid decarboxylase; AAV, adeno-associated virus; BBB, blood–brain barrier; BH4, 5,6,7,8-tetrahydro-l-biopterin
Adeno-associated virus Rep-mediated targeting of integrase-defective retroviral vector DNA circles into human chromosome 19
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; AAVS1, AAV integration site; EGFP, enhanced green fluorescent protein; FBS, fetal bovine serum; IDRV, integrase-defective retroviral vector; LTR, long terminal repeat; p5IEE, p5 integration efficiency element; RBS, Rep-binding
Identification of the heparin binding site on adeno-associated virus serotype 3B (AAV-3B)
Keywords: AAV، ویروس مرتبط با adeno; HSPG, heparan sulfate proteoglycan; AAV, adeno-associated virus; SOS, sucrose octasulfate; NCS, non-crystallographic symmetry; WT, wild type; ELISA, enzyme-linked immunosorbant assay; GFP, green fluorescent proteinAdeno-associated virus; Heparin; Heparan
Overexpression of insulin like growth factor binding protein 5 reduces liver fibrosis in chronic cholangiopathy
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; Abcb4−/−, ATP-binding cassette, sub-family B member 4; ECM, extracellular matrix; F4/80, EGF-like module containing, mucin-like, hormone receptor-like sequence 1; GFP, green fluorescent protein; GSH, glutathione; GSSG, glutath
Cardiovascular effects of angiotensin II and glutamate in the PVN of Dahl salt-sensitive rats
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; ACE, angiotensin-converting enzyme; AUC, area under the curve; BP, blood pressure; cGMP, guanosine monophosphate; CHF, chronic heart failure; CSF, cerebrospinal fluid; Dahl R, salt resistant; Dahl S, salt sensitive; EO, endoge
Synthetically engineered viruses: Can synthetic chemistry tame the nature?
Keywords: AAV، ویروس مرتبط با adeno; AAV, adeno-associated virus; ABP, arginine-grafted bioreducible polymer; Abs, antibodies; AdV, adenovirus; ATRP, atom transfer radical polymerization; BV, baculovirus; CAR, coxsackie–adenovirus receptors; CCMV, cowpea chlorotic mottle virus; ChNP, chimeri
Prevention of coronary in-stent restenosis and vein graft failure: Does vascular gene therapy have a role?
Keywords: AAV، ویروس مرتبط با adeno; AA, abdominal aorta; AAV, adeno-associated virus; Ad, adenovirus; CA, carotid artery; CABG, coronary artery bypass graft surgery; CAR, coxsackie and adenovirus receptor; CVD, cardiovascular disease; E2F, elongation factor; EC, endothelial cell; ECM, extra