کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1983535 1539888 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exploiting the unique regenerative capacity of the liver to underpin cell and gene therapy strategies for genetic and acquired liver disease
ترجمه فارسی عنوان
بهره برداری از ظرفیت بازسازی مجدد کبد به منظور حمایت از سلول ها و استراتژی های ژنتیک برای بیماری های ژنتیکی و کبدی خریداری شده است؟
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

The number of genetic or acquired diseases of the liver treatable by organ transplantation is ever-increasing as transplantation techniques improve placing additional demands on an already limited organ supply. While cell and gene therapies are distinctly different modalities, they offer a synergistic alternative to organ transplant due to distinct architectural and physiological properties of the liver. The hepatic blood supply and fenestrated endothelial system affords relatively facile accessibility for cell and/or gene delivery. More importantly, however, the remarkable capacity of hepatocytes to proliferate and repopulate the liver creates opportunities for new treatments based on emerging technologies. This review will summarise current understanding of liver regeneration, describe clinical and experimental cell and gene therapeutic modalities and discuss critical challenges to translate these new technologies to wider clinical utility.This article is part of a Directed Issue entitled: “Regenerative Medicine: the challenge of translation”.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 56, November 2014, Pages 141–152
نویسندگان
, , , ,