کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2474549 1113147 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Current strategies for drug delivery to the inner ear
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Current strategies for drug delivery to the inner ear
چکیده انگلیسی

For many years, drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of inner ear drug therapy. This paper reviews a number of inner ear drug delivery strategies including systemic, intratympanic, and intracochlear delivery. A focus of this review is the recent advances in intratympanic delivery of medications; approaches utilizing novel biomaterials as well as other recent developments are also discussed. Biotechnology-based approaches, such as gene and stem cell therapy methods are also reviewed. Among the various strategies, local drug delivery approaches including intratympanic and intracochlear drug delivery methods that limit systemic exposure are particularly promising. These inner ear drug delivery systems provide a new opportunity to improve the treatment of inner ear disorders.

This paper reviews recent advances of inner ear drug delivery strategies including systemic, intratympanic and intracochlear delivery, especially intratympanic delivery of medications and its approaches utilizing novel biomaterials and biotechnology. Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 3, Issue 2, April 2013, Pages 86–96
نویسندگان
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