دانلود مقالات ISI درباره AD، بیماری آلزایمر + ترجمه فارسی

Evaluation of a technique to identify acetylcholinesterase C-terminal peptides in human serum samples

Keywords: AD، بیماری آلزایمر; AChE, acetylcholinesterase; AD, Alzheimer's disease; PD, Parkinson's disease; MND, motor neuron disease; ACh, acetylcholine; α7-nAChR, alpha 7-nicotinic acetylcholine receptorNeurodegenerative disease; Protein interactions; Acetylcholinesterase; Non-choli

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; ADL, activities of daily living; BPSD, behavioral and psychological symptoms of dementia; DAD, Disability Assessment of Dementia; DLB, Dementia with Lewy Bodies; FAST, Functional Assessment Staging; MMSE, Mini-Mental State Examina

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; ADL, Activities of daily living; BPSD, Behavioral and psychological symptoms of dementia; DAD, Disability Assessment of Dementia; DLB, Dementia with Lewy Bodies; FAST, Functional Assessment Staging; MMSE, Mini-Mental State Examina

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; 3xTgAD, triple transgenic Alzheimer's disease; nonTg, non-transgenic; E2, 17β-estradiol; PDH, pyruvate dehydrogenase; COX, cytochrome c oxidaseMitochondria; Bioenergetics; Reproductive senescence; Alzheimer's disease; Estrogen

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

The potential role of ubiquitin c-terminal hydrolases in oncogenesis

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; BAP1, BRCA1-associated protein-1; CDK, cyclin-dependent kinase; di-Ub, Ub dimers; DUBs, deubiquitinating enzymes; HCF-1, host cell factor 1; hINO80, human Ino80 chromatin-remodeling complex; JAB1, Jun activation domain-binding pro

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease

Keywords: AD، بیماری آلزایمر; estradiol; Aβ; APP; TTR; BACE; Alzheimer's diseaseAβ, amyloid-beta; AD, Alzheimer's disease; APP, amyloid precursor protein; APPCTFs, APP C-terminal fragments; APPim, immature APP; APPm, mature APP; BACE, β-site APP cleaving enzyme; E2, 17 β-estradiol; ID

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

SCA17 repeat expansion: Mildly expanded CAG/CAA repeat alleles in neurological disorders and the functional implications

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; PD, Parkinson's disease; HSPA5, heat shock 70 kDa protein 5; HSPA8, heat shock 70 kDa protein 8; HSPB1, heat shock 27 kDa protein 1; PARK7, Parkinson's disease 7; polyQ, polyglutamine; SCA17, spinocerebellar ataxia type 17; TBH, t

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

ACAT inhibition and amyloid beta reduction

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, beta-Amyloid; APP, Amyloid precursor protein; ACAT, Acyl-coenzyme A: cholesterol acyl-transferase; FC, free cholesterol; CE, cholesteryl ester; ER, endoplasmic reticulum; BBB, blood–brain barrier; Tg, transgenicAlzheimer's dis

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide(1–42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, amyloid β-peptide; MsrA, methionine sulfoxide reductase A; DMSO, dimethylsulfoxide; HFIP, 1,1,1,3,3,3-hexafluoro-2-propanol; Met35, methionine residue in position 35; met-O, methionine sulfoxide; ROS, reactive oxygen species;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Interleukin 6–174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease

Keywords: AD، بیماری آلزایمر; IL-6, interleukin 6; AD, Alzheimer's disease; APP, amyloid precursor protein; VNTR, variable number of tandem repeats; bp, base pairs; SNP, single-nucleotide polymorphism; APOE, apolipoprotein E; CDR, clinical dementia rating scale; CI, confidence interva

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Exacerbation of ischemia-induced amyloid-β generation by diabetes is associated with autophagy activation in mice brain

Keywords: AD، بیماری آلزایمر; Aβ, amyloid-β; AD, Alzheimer's disease; avd, autophagy-like vacuoles containing electron-dense material; CCAO, occlusion of the common carotid artery; DM, diabetes mellitus; EM, electron microscopy; LC3, light chain 3; STZ, streptozotocin; PGL, plasma glu

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; BPSD, behavioral and psychological symptoms of dementia; CHO, Chinese hamster ovary; GTPγS, guanosine-5′-[γ-thio]triphosphate; PCA, p-chloroamphetamine; 5-HT, 5-hydroxytriptamine (serotonin); YKS, yokukansanPartial agonist; Recept

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Transglutaminase 2 expression induced by lipopolysaccharide stimulation together with NO synthase induction in cultured astrocytes

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; APDC, ammonium pyrrolidine-1-carbodithioate; DAN, 2,3-diaminonaphthalene; DMEM, Dulbecco's modified Eagle medium; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; I-κBα, inhibitory subunit α of NF-κB; IL, interleukin; iNOS, induci

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, amyloid β; IL-1, interleukin1; TNF-α, tumor necrosis factor α; iNOS, inducible nitric oxide synthase; COX-2, cyclooxigenase; PPAR-γ, peroxisome proliferator activated receptor γAlzheimer's disease; IL-1; PPAR; TNF; iNOS; COX-2

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by β-amyloid peptides 25–35 in PC12 cells

Keywords: AD، بیماری آلزایمر; GEN, genistein; Aβ, β-amyloid peptides; AD, Alzheimer's disease; GSH/GSSG, reduced glutathione/oxidized glutathione; Nrf2, NF-E2-related factor 2; HO-1, heme oxygenase-1; γ-GCS, γ-glutamylcysteine synthetase; ARE, antioxidant response element; GSH, glutat

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Regional metabolic alteration of Alzheimer's disease in mouse brain expressing mutant human APP-PS1 by 1H HR-MAS

Keywords: AD، بیماری آلزایمر; HR-MAS, high resolution magnetic resonance spinning; APP, amyloid-β precursor protein; WT, wild-type; AD, Alzheimer's disease; TSP, trimethylsilyl-2,2,3,3-tetradeuteropropionic acid; Ala, alanine; GABA, γ-aminobutyric acid; Acet, acetate; NAA, N-acetyl as

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes

Keywords: AD، بیماری آلزایمر; 3xTg-AD, triple transgenic model of Alzheimer's disease; AD, Alzheimer's disease; Aβ, amyloid-β; NTg, non-transgenicAlzheimer's disease; 3xTg-AD; Cognition; Behavior; Motor coordination; Emotionality; Fear and anxiety

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease

Keywords: AD، بیماری آلزایمر; Aβ, amyloid peptide; AD, Alzheimer's disease; ELISA, enzyme-linked immunosorbent assay; MTT, methylthiazoletetrazolium; PBS, phosphate buffered saline; Tris, Tris(hydroxymethyl)amino-methane; LDH, lactate dehydrogenase; BSA, bovine serum albumin; TMB, 3,3

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Quantification of acetylcholine, choline, betaine, and dimethylglycine in human plasma and urine using stable-isotope dilution ultra performance liquid chromatography–tandem mass spectrometry

Keywords: AD، بیماری آلزایمر; ACh, acetylcholine; AD, Alzheimer's disease; AF, amniotic fluid; BHMT, betaine:homocysteine methyltransferase; CSF, cerebrospinal fluid; DMG, dimethylglycine; Hcy, homocysteine; HILIC, hydrophilic interaction liquid chromatography; HPLC, high-performance

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase

Keywords: AD، بیماری آلزایمر; Acetylcholinesterase; Cholinesterase; Cytotoxicity; Flavonoids; UV-VIS spectra; Reversible inhibitionAChE, acetylcholinesterase; BChE, butyrylcholinesterase; AD, Alzheimer's disease; PTCh, propionylthiocholine iodide; ATCh, acetylthiocholine; DTNB, 5,5′-d

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice

Keywords: AD، بیماری آلزایمر; Alzheimer's disease; central nervous system; myelin-derived axon growth inhibitors; neuritic sprouting; amyloid deposition; reticulonAβ, amyloid-β; AD, Alzheimer's disease; APP, amyloid precursor protein; APP tg, APP transgenic; BACE1, beta-site APP cleav

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

Keywords: AD، بیماری آلزایمر; Aβ, amyloid beta; AD, Alzheimer's disease; mPTP, mitochondrial permeability transition pore; cyp D, cyclophilin D; VDAC, voltage-dependent anion channel; ANT, adenine nucleotide translocator; CSA, cyclosporine A; ROS, reactive oxygen speciesAmyloid beta;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2, ε3 and ε4 knock-in mice

Keywords: AD، بیماری آلزایمر; oxysterols; APOE KI mice; Alzheimer's disease; 24-hydroxycholesterol; 27-hydroxycholesterolAβ, amyloid beta; AD, Alzheimer's disease; APOE, apolipoprotein E; BBB, blood–brain barrier; BHT, butylated hydrotoluene; BSTFA, N,O-Bis(trimethylsilyl)trifluoroace

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

High-definition characterization of cerebral β-amyloid angiopathy in Alzheimer's disease

Keywords: AD، بیماری آلزایمر; Aβ, β-amyloid; AD, Alzheimer's disease; CAA, cerebral Aβ angiopathy; MA, brains of AD patients with mild CAA; SA, brains of AD patients with severe CAA; OC, brains of non demented old controls; YC, brains of non demented young controlsCerebral amyloid ang

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Are optimal levels of testosterone associated with better cognitive function in healthy older women and men?

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; AGECAT, Automated Geriatric Examination and Computer Assisted Taxonomy; AR, androgen receptor; BLSA, Baltimore Longitudinal Study of Aging; BP, blood pressure; BMI, body mass index; CV, coefficient of variation; ER, estrogen recep

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Danggui-Shaoyao-San and its active fraction JD-30 improve Aβ-induced spatial recognition deficits in mice

Keywords: AD، بیماری آلزایمر; DSS, Danggui-Shaoyao-San; AD, Alzheimer's disease; Aβ, β-amyloid; LTP, long-term potentiation; i.c.v., intracerebroventricular; PS, population spike; HFS, high frequency stimulusDanggui-Shaoyao-San; JD-30; β-Amyloid; Spatial learning and memory; Long-term

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Systemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes

Keywords: AD، بیماری آلزایمر; 3-NPA, 3-Nitropropionic acid; AD, Alzheimer's disease; GFAP, Glial fibrillary acidic protein; HD, Huntington's disease; MCC, Mitochondrial respiratory chain complex; NeuN, Neuronal nuclei protein; PBS, Phosphate buffered saline; PCD, Programmed cell death

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice

Keywords: AD، بیماری آلزایمر; Aβ, amyloid-β peptide; AD, Alzheimer's disease; ALA, α-linolenic acid; ApoE, apolipoprotein E; APP, amyloid precursor protein; APPsw, APP harbouring the Swedish mutation; ARA, arachidonic acid; BDNF, brain-derived neurotrophic factor; cPLA2, cytosolic pho

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Alanine-to-threonine substitutions and amyloid diseases: Butyrylcholinesterase as a case study

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, amyloid β; BChE, butyrylcholinesterase; DMII, diabetes mellitus type II; FAP, familal amyloid polyneuropathy; NMR, nuclear magnetic resonance; SNP, single nucleotide polymorphism; TTR, transthyretinAlzheimer's disease; Amyloid

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine

Keywords: AD، بیماری آلزایمر; AChE, acetylcholinesterase; HRMS, high resolution mass spectrometry; AD, Alzheimer's disease; CYP, cytochrome P450; AMQ, 7-acetoxy-1-methyl-quinolinium iodide; HMQ, 7-hydroxy-1-methyl-quinolinium productOn-line acetylcholinesterase bioassay; Tacrine; LC–M

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Tooth loss is associated with mild memory impairment in the elderly: The Fujiwara-kyo study

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; MMI, mild memory impairment; MMSE, Mini-Mental State Examination; Recall, three-word delayed recall test; GDS, Geriatric Depression Scale short version; CPI, community periodontal index; MCI, mild cognitive impairment; CRP, plasma

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Electroacupuncture reduces neuroinflammatory responses in symptomatic amyotrophic lateral sclerosis model

Keywords: AD، بیماری آلزایمر; ALS, amyotrophic lateral sclerosis; EA, electroacupuncture; ST36, Zusanli; fALS, familial ALS; hSOD1, human Cu/Zn superoxide dismutase 1; AD, Alzheimer's disease; PD, Parkinson's disease; TNF-α, tumor necrosis factor α; IL, interleukin; IFN, interferon; P

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Different electrophysiological actions of 24- and 72-hour aggregated amyloid-beta oligomers on hippocampal field population spike in both anesthetized and awake rats

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aß, amyloid-beta; LTP, long term potentiation; pSpike, population spike; pEPSP, population excitatory postsynaptic potential; AFM, atomic force microscopy; ACSF, artificial cerebro-spinal fluid; HFIP, hexafluoro-isopropanol; ThT,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Melatonin maintains adult hippocampal neurogenesis and cognitive functions after irradiation

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; AFMK, N1-acetyl-N2-formyl-5-methoxykynuramine; ALS, amyotrophic lateral sclerosis; ARS, acute radiation syndrome; BBB, blood–brain barrier; BDNF, brain-derived neurotropic factor; CSF, cerebrospinal fluid; DCX, doublecortin; DG, d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases

Keywords: AD، بیماری آلزایمر; Aβ, β-amyloid; AD, Alzheimer's disease; APP, β-amyloid precursor protein; BACE, APP-converting enzyme; FMRP, fragile X mental retardation protein; miRNA, microRNA; miRNP, miRNA-containing RNP; mRNA, messenger RNA; PCR, polymerase chain reaction; qRT-PCR,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Okadaic acid (ICV) induced memory impairment in rats: A suitable experimental model to test anti-dementia activity

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; ICV, intracerebroventricular; OKA, okadaic acid; CSF, cerebrospinal fluidOkadaic acid; Oxidative stress; Excitotoxicity; Morris water maze; Memory impairment; Memantine; Donepezil

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

l-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway

Keywords: AD، بیماری آلزایمر; Alzheimer's disease; amyloid beta; l-theanine; calcium; nitric oxide; neuroprotectionAβ, amyloid beta; AD, Alzheimer's disease; DAF-FM DA, 3-amino,4-aminomethyl-2′,7′-difluorescein, diacetate; DMSO, dimethyl sulfoxide; EGTA, (−)-epigallocatechingallate; i

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor

Keywords: AD، بیماری آلزایمر; miRNAs, microRNAs; AD, Alzheimer's disease; TβR II, TGF-β type II receptor; p-Smad2/3, phospho-Smad2/3; Aβ, β-amyloid peptide; NFTs, neurofibrillary tangles; 3′ UTR, 3′-untranslated regions; BACE1, beta-site APP-cleaving enzyme 1; NAV3, neuron navigator 3

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Potential therapeutic effects of curcumin: Relationship to microtubule-associated proteins 2 in Aβ1–42 insult

Keywords: AD، بیماری آلزایمر; Aβ, β-amyloid; AD, Alzheimer's disease; BSA, Bovine Serum Albumin; DMEM, Dulbcco's Modified Eagle Medium; DMSO, dimethyl sulphoxide; IOD, integrated optical density; MAP2, microtubule-associated protein 2; MS, mass spectrometry; MTT, 3-(4,5-Dimethylthiazo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

Keywords: AD، بیماری آلزایمر; PD, Parkinson's disease; PDD, Parkinson's disease with dementia; AD, Alzheimer's disease; α-Syn, α-synuclein; LBs, Lewy bodies; p-Tau, hyperphosphorylated Tau; GSK-3β, glycogen synthase kinase 3β; p-GSK-3β, GSK-3β phosphorylated at Tyr216; IFG, inferior f

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; DS, Down syndrome; (k)bp, (kilo)base pairs; co-IP, co-immunoprecipitation; FTDP-17, frontotemporal dementia with Parkinsonism associated with chromosome 17; hnRNP, heterogeneous nuclear ribonucleoprotein; KH, hnRNPK homology; MAP,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

SP protects cerebellar granule cells against β-amyloid-induced apoptosis by down-regulation and reduced activity of Kv4 potassium channels

Keywords: AD، بیماری آلزایمر; Substance P; Apoptosis; Cerebellar granule cells; Aβ23–35; Voltage-gated K+channels; Kv4.2 and Kv4.3 subunitsAβ, β-amyloid peptide; Akt, serine/threonine protein kinase; AD, Alzheimer's disease; CGCs, cerebellar granule cells; DIV, days in vitro; IKA, fas

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Short-term effects of zinc on acetylcholine metabolism and viability of SN56 cholinergic neuroblastoma cells

Keywords: AD، بیماری آلزایمر; ACh, acetylcholine; AD, Alzheimer's disease; AMPA, α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; ChAT, choline acetyltransferase; DC, differentiated SN56 cells; DMEM, Dulecco Modified Eagle's Medium; FBS, fetal bovine serum; ICDH-NADP, NADP-dependen

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Alpha-tocopherol quinone inhibits beta-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, beta-amyloid peptide; CD, circular dichroism; NO, nitric oxide; DCFH-DA, 2′,7′-dichlorfluorescein-diacetate; α-TQ, RRR-α-tocopherol quinone; α-T, RRR-α-tocopherol; ThT, thioflavin T; HFIP, 1,1,1,3,3,3-hexafluoro-2-propanol; MT

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Molecular dynamics simulations of Aβ fibril interactions with β-sheet breaker peptides

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, amyloid-β; MD, molecular dynamics; RMSD, root mean square deviation; REMD, replica exchange molecular dynamicsAlzheimer's disease; Amyloid-β; Molecular dynamics simulation; Replica exchange molecular dynamics; β-Blocker peptid

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; apoE, apolipoprotein E; Apoe, the apoE gene; APP, amyloid precursor protein; Cer, ceramide; CerPCho, sphingomyelin; CNS, central nervous system; ESI, electrospray ionization; GalCer, galactosylceramides; LDL, low density lipoprote

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; AL, anionic lipids; apoE, apolipoprotein E; APP, amyloid precursor protein; APPsw, APP Swedish mutation K670N/M671L; CDR, clinical dementia rating; CNS, central nervous system; CSF, cerebrospinal fluid; ESI, electrospray ionizatio

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; AICD, APP-intracellular domain; APP, β-amyloid precursor protein; ApoE, apoliprotein E; Aβ, amyloid-β; CTFs, C-terminal fragments; DAPT, N-[N-(3,5-Difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester; FA, formic acid; flAPP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Critical role of interfaces and agitation on the nucleation of Aβ amyloid fibrils at low concentrations of Aβ monomers

Keywords: AD، بیماری آلزایمر; Aβ, amyloid β-peptide; AWI, air–water interface; AD, Alzheimer's disease; IAPP, islet amyloid peptide; CAA, cerebral amyloid angiopathy; cmc, critical micelle concentration; ThT, thioflavin TAmyloid fibril; Amyloidosis; Amyloid β-peptide; Nucleation; Air–

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Candidate anti-Aβ fluorene compounds selected from analogs of amyloid imaging agents

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, β-amyloid protein; AβO, Aβ oligomers; BBB, blood–brain barrier; CR, Congo red; SPR, surface plasmon resonance spectroscopy; EPR, electron paramagnetic resonance spectroscopy; AFM, atomic force microscopy; EM, electron microsco

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه