SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritis
Keywords: Osteoarthritis; Cartilage; Chondrocyte; ADAMTS; SOX9;
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ADAMTS proteases in fertility
Keywords: ADAMTS; Fertility; Ovary; Testis; Fertilisation; Implantation; Pregnancy; PCOS; POF;
The extracellular protease stl functions to inhibit migration of v'ch1 sensory neuron during Drosophila embryogenesis
Keywords: Cell migration; ADAMTS; PNS; stl; Drosophila; Sensory neurons
Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics
Keywords: ADAMTS; ADAMTS-like; Metalloproteinase; Extracellular matrix; Mouse; Knockout; Forward genetics; Reverse genetics; Procollagen; Aggrecanase;
Bone morphogenetic protein-7 antagonizes tumor necrosis factor-α–induced activation of nuclear factor κB and up-regulation of the ADAMTS, leading to decreased degradation of disc matrix macromolecules aggrecan and collagen II
Keywords: BMP-7; TNF-α; NF-κB; ADAMTS; Intervertebral discs
The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis
Keywords: ADAMTS; A disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs; ECM; extracellular matrix; GAG; glycosaminoglycan; HA; hyaluronan; CS; chondroitin sulfate; A disintegrin-like and metalloprotease domain with thrombospondin type 1 m
Ser/Thr-phosphoprotein phosphatases in chondrogenesis: neglected components of a two-player game
Keywords: ADAMTS; A Disintegrin And Metalloproteinase with Thrombospondin Motifs; BMP; bone morphogenic protein; CaMK; Ca2Â +/calmodulin-dependent protein kinase; CaN; calcineurin; CNA, CNB; calcineurin catalytic (A) and regulatory (B) subunits; COX; cyclooxygenase
Hemorrhagin VaH4, a covalent heterodimeric P-III metalloproteinase from Vipera ammodytes ammodytes with a potential antitumour activity
Keywords: Vipera ammodytes ammodytes; Snake venom; Hemorrhagin; Metalloproteinase; Structure; Antitumour; ACN; acetonitrile; ADAM; a disintegrin and metalloproteinase; ADAMTS; ADAM with thrombospondin type-1 motif; BM; basement membrane; BSA; bovine serum albumin;
Regulation of chondrogenesis by protein kinase C: Emerging new roles in calcium signalling
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; ADSC; adipose-derived stem cell; ATP; adenosine triphosphate; BMP; bone morphogenic protein; cAMP; cyclic adenosine monophosphate; COMP; cartilage oligomeric matrix protein; CREB; cAM
ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse
Keywords: ADAMTS; Aggrecanase; Spinal cord injury; Astrocytes;
Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: Differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; ApoB; apolipoprotein B; ApoE; apolipoprotein E; DR3; death receptor 3; ECM; extracellular matrix; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HMDM; human monocyte-derived macroph
VaH3, one of the principal hemorrhagins in Vipera ammodytes ammodytes venom, is a homodimeric P-IIIc metalloproteinase
Keywords: Vipera ammodytes ammodytes; Snake venom; Hemorrhagin; Metalloproteinase; Structure; ADAM; a disintegrin and metalloproteinase; ADAMTS; ADAM with thrombospondin type-1 motif; BM; basal membrane; CR; cysteine-rich; Dis; disintegrin-like; DSF; differential s
Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with tuberculous intervertebral discs and healthy controls
Keywords: MMP; ADAMTS; Spinal tuberculosis; mRNA; Real-time PCR; Intervertebral disc
Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes
Keywords: Chondrocyte; Mechanical stress; RUNX-2; Aggrecanase; ADAMTS; Histone deacetylase inhibitor
Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration
Keywords: Intervertebral disc degeneration; Extracellular matrix; MMPs; ADAMTS; Aging
Modeling ADAMTS13-von Willebrand Factor interaction: Implications for oxidative stress-related cardiovascular diseases and type 2A von Willebrand Disease
Keywords: ADAMTS; A Disintegrin-like And Metalloprotease with ThromboSpondin type I repeats; a.m.u; atomic mass units; CaBS; calcium binding site; M13; the metalloprotease domain of ADAMTS-13; MetSO; methionine sulfoxide; PDB; Protein Data Bank; PN; peroxynitrite;
Zonal differences in meniscus matrix turnover and cytokine response
Keywords: Meniscus; Zonal; MMP; ADAMTS; Aggrecanolysis; Cytokine
Snake venom metalloproteinases: Structure, function and relevance to the mammalian ADAM/ADAMTS family proteins
Keywords: Snake venom metalloproteinase; Disintegrin; MDC protein; ADAM; ADAMTS;
Proteases involved in cartilage matrix degradation in osteoarthritis
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; APC; activated protein C; CITED2; cAMP-responsive element-binding protein/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2; ECM; extracellular matrix; ERK;
Calcium pentosan polysulfate and sodium pentosan polysulfate may be used to treat intervertebral disc degeneration
Keywords: ADAMTS; adamalysin with thrombospondin motifs; CaPPS; calcium pentosan polysulfate; IDD; intervertebral disc degeneration; IL-1; interleukin-1; MMPs; matrix metalloproteinases; NaPPS; sodium pentosan polysulfate; PPS; pentosan polysulfate; TIMPs; inhibito
Structure–activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors
Keywords: Osteoarthritis; Aggrecanase; ADAMTS; Glutamic acid scaffold
Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state
Keywords: Cartilage; Growth plate; ADAMTS; Proteolytic processing; Matrilin;
Emerging roles for ADAMTS5 during development and disease
Keywords: ADAMTS; A Disintegrin-like and Metalloproteinase with Thrombospondin-1 motifs; CSPG; chondroitin sulphate proteoglycan; ECM; extracellular matrix; GAG; glycosaminoglycan; PACE; paired basic amino acid cleaving enzyme; SNP; single nucleotide polymorphism;
The developmental and acute phases of insulin-induced laminitis involve minimal metalloproteinase activity
Keywords: Equine; Laminitis; MMP; Hyperinsulinaemia; Horse; ADAMTS;
Effects of T-2 toxin and selenium on chondrocyte expression of matrix metalloproteinases (MMP-1, MMP-13), α2-macroglobulin (α2M) and TIMPs
Keywords: ECM; extracellular matrix; BMG; bone matrix gelatin; MMPs; matrix metalloproteinases; TIMPs; tissue inhibitors of metalloproteinases; α2M; α2-macroglobulin; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; DME/F12; Dulbecco's Mo
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis
Keywords: OA; osteoarthritis; RA; rheumatoid arthritis; DRG; dorsal root ganglia; MMP; matrix metalloproteinase; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; UTRs; untranslated regions; TLR; Toll-like receptor; NFkB; nuclear factor-kappa
MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; APMA; p-amino-phenyl-mercuric acetate; anti-ARLEIE; an antibody directed against the ARLEIE sequence within aggrecan; CS-2; chondroitin sulfate-2 region; ECM; extracellular matrix; G1
Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells
Keywords: Chondrocyte; Mechanical stress; RUNX-2; ADAMTS; Aggrecanase
C. elegans ADAMTS ADT-2 regulates body size by modulating TGFβ signaling and cuticle collagen organization
Keywords: Body size; ADAMTS; TGFβ; Collagen; Cuticle; C. elegans
Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis
Keywords: Sclerostin; β-catenin; MMPs; ADAMTS; Cartilage; Osteoarthritis
Extracellular proteases in epilepsy
Keywords: ADAM; a disintegrin and metalloproteinase; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; CCI; controlled cortical impact; ECM; extracellular matrix; ECS; electroconvulsive shock; FH; complement inhibitor; GCD; granule cell disper
Potential candidate genomic biomarkers of drug induced vascular injury in the rat
Keywords: A3galt2, alpha 1,3-galactosyltransferase 2; Abca8a, ATP-binding cassette/sub-family A/member 8; Abl2, abelson murine leukemia viral (v-abl) oncogene homolog 2; Actg1, actin, gamma, cytoplasmic 1; Adam9, a disintegrin and metalloproteinase domain 9; Adamts
Modulatory effect of interleukin-1α on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: Role of p38 MAP kinase
Keywords: ADAMTS; a disintegrin and metalloproteinase domain with thrombospondin motifs; CMF; cardiac myofibroblast; DMSO; dimethylsulfoxide; ECM; extracellular matrix; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HSP27; heat shock protein-27; IL-1; intereukin-
10 mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin
Keywords: Aggrecanase; Glucosamine; ADAMTS; Furin; Catabolism
Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage
Keywords: Cartilage; Mechanobiology; Load; IL-1; MMPs; ADAMTS
A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid
Keywords: AEBSF; 4-(2-aminoethyl)-benzenesulfonyl fluoride; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; CS; chondroitin sulfate region; DEAE; diaminoethylcellulose anion; DMEM; Dulbecco's modified Eagle's medium; DMMB; dimethyl-methylene
Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth
Keywords: COMP; cartilage oligomeric matrix protein; ECM1; extracellular matrix protein 1; EGF; epidermal growth factor; ADAMTS; a disintegrin and metalloproteinase with thromospondin motifs; GEP; granulin-epithelin precursor; GST; glutathione S-transferase; PCR;
Removal of O-linked and N-linked oligosaccharides is required for optimum detection of NITEGE neoepitope on ADAMTS4-digested fetal aggrecans: implications for specific N-linked glycan-dependent aggrecanolysis at Glu373-Ala374
Keywords: Aggrecan; NITEGE neoepitope; ADAMTS; Cartilage; Western blot; Neoepitope masking;
Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation
Keywords: ADAMTS; a disintegrin-like and metalloprotease with thrombospondin type 1 repeats; DIC; disseminated intravascular coagulation; IL; interleukin; ISTH; International Society on Thrombosis and Haemostasis; TTP; thrombotic thrombocytopenic purpura; ULvWF; un
Meniscal tissue explants response depends on level of dynamic compressive strain
Keywords: MMP; IL-1; Meniscus; Knee; Osteoarthritis; ADAMTS;
Three-dimensional domain architecture of the ADAM family proteinases
Keywords: ADAM; ADAMTS; Disintegrin metalloproteinases; MDC proteins; Ectodomain shedding
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3
Keywords: ADAM; adamalysin; ADAMTS; adamalysin with thrombospondin motifs; cat; catalytic domain; CysR; cysteine-rich; Dis; disintegrin; LRP; low-density lipoprotein receptor-related protein; MMP; matrix metalloproteinase; N-TIMP; N-terminal domain of TIMP; RAP; re
Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes
Keywords: MMP; matrix-metalloproteinases; ADAMTS; a disintegrin and MMP with thrombospondin motifs; PHCs; primary human chondrocytes; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; JNK; c-Jun NH2-terminal kinase; LPS; lipopolysa
Characterization and regulation of ADAMTS-16
Keywords: ADAMTS; a disintegrin and metalloproteinase domain with thrombospondin motif; MMP; matrix metalloproteinase; RACE; rapid amplification of cDNA ends; TGFβ; transforming growth factor beta; TIMP; tissue inhibitor of metalloproteinases; ADAMTS; Metalloprote
Intra-articular injection of tumor necrosis factor-α in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation
Keywords: Aggrecanase; ADAMTS; Aggrecan; Cartilage; Animal model; Neoepitope
Expression and function of matrix metalloproteinase (MMP)-28
Keywords: ADAMTS; a disintegrin and metalloproteinase domain with thrombospondin motifs; EA; glutamate to alanine mutation; ECM; extracellular matrix; MMP; matrix metalloproteinase; pro-cat; pro and catalytic domains; TIMP; tissue inhibitor of metalloproteinases; W
Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion
Keywords: ADAMTS; a disintegrin-like and metalloprotease with thrombospondin type I motifs; CL; cell lysate; CM; conditioned media; ECM; extracellular matrix; HA; hemagglutinin epitope; MMP; matrix metalloproteinase; PAGE; polyacrylamide gel electrophoresis; PMA; p
Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin-like motifs; CIA; collagen-induced arthritis; COX; cyclooxygenase; FBS; fetal bovine serum; GAPDH; glyceraldehydes-3-phosphate dehydrogenase; IGD; interglobular domain; IL; interleukin; MEK;
Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M
Keywords: Aggrecanase; ADAMTS; MMP; Hyaluronidase; IL-1; TNFα
Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage
Keywords: Aggrecan; ADAMTS; Cytokine-mediated proteolysis; Oncostatin M; Interleukin-1