دانلود مقالات ISI درباره Akr1C3 + ترجمه فارسی

چالش ها و جهت گیری های آینده تحقیقات مولکولی در سرطان های ریه های مرتبط با آلودگی هوا

Challenges and future direction of molecular research in air pollution-related lung cancers

Keywords: A; adenine; A549; adenocarcinomic human alveolar basal epithelial cells; AKR1C3; Aldo_Keto Reductase; BaP; Benzo(a)pyrene; C; cytosine; CI; Confidence interval; CO; carbon monoxide; CXCL 13; motif chemokine ligand 13; CYP1B1; cytochrome P450 1B1; DKK2; Di

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

آندروژنها و آندومتر: بینش جدید و اهداف جدید

Androgens and endometrium: New insights and new targets

Keywords: Endometrium; Androgen receptor (AR); Decidualisation; Proliferation; Testosterone (T); Dihydrotestosterone (DHT); AKR1C3; SRD5A1; Scarless healing; Endometriosis; Cancer;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

AKR1C3, a crucial androgenic enzyme in prostate cancer, promotes epithelial-mesenchymal transition and metastasis through activating ERK signaling

Keywords: Prostate cancer; Metastasis; Epithelial-to-mesenchymal transition; AKR1C3; ERK; Transcription factor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A

Keywords: PR-104A; DNA adducts; Predictive biomarkers; AKR1C3; P450 oxidoreductase;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C19 steroids as the predominant androgens in prostate cancer

Keywords: UDP; uridine diphosphate; UGT; UDP-glucuronosyltransferases; 17βHSD; 17β-hydroxysteroid dehydrogenase; AKR1C3; 17β-hydroxysteroid dehydrogenase type 5; 11βHSD2; 11β-hydroxysteroid dehydrogenase type 2; SRD5A; 5α-reductase; SRD5A1; 5α-reductase type

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Novel SNPs of WNK1 and AKR1C3 are associated with preeclampsia

Keywords: WNK1; lysine deficient protein kinase 1; ADRB2; β2 adrenergic receptor; NEDD4L; ubiquitin-protein ligase NEDD4-like; KLK1; kallikrein 1; AKR1C3; aldo-keto reductase family1 member C3; SNPs; single nucleotide polymorphisms; CI; confidence interval; OR; od

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment

Keywords: AKR; aldo-keto reductase; CDK; cyclin-dependent kinase; CI; combination index; Dau; daunorubicin; Dau-ol; daunorubicinol; DOX; doxorubicin; DMSO; dimethyl sulfoxide; Fa; fraction affected; HCT116-AKR1C3; cells transfected with pCI_AKR1C3; HCT116-EV; cells

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid

Keywords: Aldo-keto reductase 1C3; AKR1C3; 17β-HSD5; Prostate cancer (PCa); CRPC; Bioisosterism; Scaffold hopping; Inhibitors; X-ray crystallography;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach

Keywords: Aldo-keto reductase 1C3; AKR1C3; 17β-HSD5; Prostate cancer; CRPC; Bioisosterism; Scaffold hopping; Inhibitors; NWCHXFMRNUJDNB-UHFFFAOYSA-N; HZZCFCAKQYBGLE-UHFFFAOYSA-N; YQJHRNZFIOVGQM-UHFFFAOYSA-N; UHUYUGANTDDPEB-UHFFFAOYSA-N; DWGCYTWMYJCZRX-UHFFFAOYSA-N

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells

Keywords: Prostate cancer; 17B-Hydroxysteroid dehydrogenase; AKR1C3; PPAR; Prostaglandins; Bezafibrate

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Aldo-keto reductase 1C3 (AKR1C3) is associated with the doxorubicin resistance in human breast cancer via PTEN Loss

Keywords: AKR1C3; Human breast cancer; DOX resistance; PTEN loss; PTEN/Akt

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model

Keywords: Nrf2/ARE activators; Oxime-bearing coumarins; Antioxidant activity; Cytoprotection; ABCC3; ATP-binding cassette, subfamily C, member 1; AKR1C1; aldo-keto reductase 1 subunit C-1; AKR1C2; aldo-keto reductase 1 subunit C-2; AKR1C3; aldo-keto reductase 1 sub

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro

Keywords: DHEA; dehydroepiandrosterone; DHT; dihydrotestosterone; LHRH; luteinizing hormone releasing hormone; LH; luteinizing hormone; AR; androgen receptor; CRPC; castration resistant prostate cancer; PSA; prostate specific antigen; SRD5A1/2; 5-alpha-reductase is

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors

Keywords: Adion; 4-androstene-3,17-dione; DHO; dihydrooracin; DHO assay; reduction of oracin to DHO assay; DMSO; dimethyl sulfoxide; HPLC; high-performance liquid chromatography; MTT; 3-(4,5-dimethylthiazoyl-2-yl)2,5diphenyl tetrazolium bromide; NADPH; nicotinamide

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Anthracycline resistance mediated by reductive metabolism in cancer cells: The role of aldo-keto reductase 1C3

Keywords: AKR1A1; aldo-keto reductase 1A1; AKR1B1; aldo-keto reductase 1B1; AKR1B10; aldo-keto reductase 1B10; AKR1C3; aldo-keto reductase 1C3; CBR1; carbonyl reductase 1; qRT-PCR; quantitative real-time reverse transcription PCR; UHPLC; ultra-high performance liqu

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and molecular docking studies of novel N-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-based triazoles with potential anticancer activity

Keywords: Isoquinoline; Triazole; Pictet-Spengler reaction; Antiproliferative activity; Molecular docking; AKR1C3;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of proteomic signatures associated with lung cancer and COPD

Keywords: 2D-PAGE; Two dimensional electrophoresis; AKR1B10; Aldo-keto reductase family 1, member B10; AKR1C3; Aldo-keto reductase family 1, member C3; ALDH3A1; Aldehyde dehydrogenase 3 family, member A1; ALDOA; Aldolase A; AMY1A; Alpha 1 amylase; AMY2A; Alpha 2 am

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione

Keywords: 11KA4; 11-ketoandrostenedione; 11KT; 11-ketotestosterone; 11OH-5α-dione; 11β-hydroxy 5α-androstanedione; 11OH-AST; 11β-hydroxyandrosterone; 11OHA4; 11β-hydroxyandrostenedione; 11OHT; 11β-hydroxytestosterone; 11βHSD; 11β-hydroxysteroid dehydrogenas

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2013 سفارش ترجمه

2,3-Diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17β-hydroxysteroid dehydrogenase (AKR1C3)

Keywords: Aldo-keto reductase; AKR1C3; Selective inhibitors; 2,3-Diarylpropenoic acids; CancerDMF, N,N-dimethylformamide; DMSO, dimethyl sulfoxide; ESI, electrospray ionization; HPLC, high-performance liquid chromatography; HRMS, high-resolution mass spectrometry;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Polymorphisms in androgen signaling pathway predisposing to prostate cancer

Keywords: AKR1C3; 3α-hydroxysteroid dehydrogenase; AR; androgen receptor; CNV; copy number variation; CYP; cytochrome P450; DHEA; dehydroepiandrosterone; DHT; dehydrotestosterone; HSD17B; 17β-hydroxysteroid dehydrogenase; HSD3B; hydroxy-δ-5-steroid dehydrogenase

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: Involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt

Keywords: Cadmium; AKR1C3; RPMI-2650 cells; ROS; PI3K/Akt;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Estrogen biosynthesis in human H295 adrenocortical carcinoma cells

Keywords: Human adrenocortical H295 cells; Estrogen biosynthesis; Aromatase; CYP19; 17β-Hydroxysteroid dehydrogenase type 5; AKR1C3; Human adrenal cortex;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Disturbed estrogen and progesterone action in ovarian endometriosis

Keywords: Endometriosis; 17β-Hydroxysteroid dehydrogenases; AKR1C1; AKR1C3; Estrogen- and progesterone-metabolizing enzymes; Estrogen and progesterone receptors

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues

Keywords: DOC; Mineralocorticoid; Inactivation; AKR1C3; Human; Kidney; Colon

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Paracrine-stimulated gene expression profile favors estradiol production in breast tumors

Keywords: AKR1C3; Aromatase; Estrogen; Breast cancer; Breast adipose fibroblast; Epithelial–stromal interaction

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer

Keywords: Green tea; Smoky coal; Lung cancer; OGG1; AKR1C3; GSTM1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه