Polymorphisms in androgen signaling pathway predisposing to prostate cancer

► Endogenous androgens have long been considered to be risk factors for prostate cancer. ► Increasing data suggest that PCa develops through a variety of interconnected genes, some of which belong to the androgen pathway. ► New genomic biomarkers will likely make it possible to better estimate the risk of PCa, and distinguish indolent disease from aggressive. ► This data may become important for targeted screening and chemoprevention programs.