Keywords: ALD، بیماری کبدی الکلی; α-linolenic acid; Flaxseed oil; Ethanol-induced liver injury; Intestinal barrier function; EndotoxinALA, α-linolenic acid; ALD, alcoholic liver disease; ALP, alkaline phosphatase; ALT, alanine aminotransferase; CNO, corn oil; DHA, docosahexaenoic acid; EP
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Keywords: ALD، بیماری کبدی الکلی; Clinical Profiles; Alcoholic Liver Disease; Asia; Europe; North AmericaADH, alcohol dehydrogenase; AH, alcoholic hepatitis; ALD, alcoholic liver disease; ALDH, aldehyde dehydrogenase; AUD, alcohol use disorder; AUDIT, Alcohol Use Disorders Identification
Keywords: ALD، بیماری کبدی الکلی; ASH, alcoholic steatohepatitis; NASH, non-alcoholic steatohepatitis; NAFLD, non-alcoholic fatty liver disease; ALD, alcoholic liver disease; DAMPs, damage-associated molecular patterns; PAMPs, pathogen-associated molecular patterns; LPS, lipopolysaccharid
Keywords: ALD، بیماری کبدی الکلی; AID, autoimmune liver disease; ALD, alcoholic liver disease; AUROC, area under receiver operator curve; CD, cryptogenic disease; GC, gas chromatography; HBV, hepatitis B virus; HCC, hepatocellular cancer; HCV, hepatitis C virus; ITU, intensive treatment u
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; ASH, alcoholic steatohepatitis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BAL, blood alcohol level; CI, confidence interval; CYP2E1, cytochrome p450 2E1; DNA, deoxyribonucleic acid; HBV, hepatitis B viru
Keywords: ALD، بیماری کبدی الکلی; NASH; Histology; Diagnosis; PrognosisAH, alcoholic hepatitis; ALD, alcoholic liver disease; HCC, hepatocellular carcinoma; IL, interleukin; K, keratin; MIR, microRNA; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis
Keywords: ALD، بیماری کبدی الکلی; Non-infectious liver disease; Alcoholic liver disease; Autoimmune liver disease; Drug-induced liver injury; Non-alcoholic fatty liver diseaseAILD, autoimmune liver disease; ALD, alcoholic liver disease; DILI, drug-induced liver injury; HBV, hepatitis B vi
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; CDT, carbohydrate-deficient transferring; GGT, gamma-glutamyltranspeptidase; HRAR, High Risk Alcoholism Relapse score; LDLT, living donor liver transplantation; MELD, Model for End-Stage Liver Disease scoreliver transplantati
Keywords: ALD، بیماری کبدی الکلی; ACLF, acute-on-chronic liver failure; AD, acute decompensation; ALD, alcoholic liver disease; ALT, alanine transaminase; APASL, Asian Pacific Association for the Study of the Liver; CLD, chronic liver disease; CTP, Child-Turcotte-Pugh; EASL-AASLD, Europea
Diagnosis of HCC for patients with cirrhosis using miRNA profiles of the tumor-surrounding tissue – A statistical model based on stepwise penalized logistic regression
Keywords: ALD، بیماری کبدی الکلی; Adj. p, adjusted p value after Benjamini-Hochberg-correction; ALD, alcoholic liver disease; ALT, alanine transaminase; AP, alkaline phosphatase; AST, aspartate transaminase; CART, Classification And Regression Tree; Ci, cirrhosis; CiT, tumor-associated ci
Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway
Keywords: ALD، بیماری کبدی الکلی; α-SMA, α-smooth muscle actin; AICAR, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AMPK, adenosine monophosphate-activated protein kinase; AST, aspartate aminotransferase; FAS, fatty acid
Mouse and Human Liver Contain Immunoglobulin A–Secreting Cells Originating From Peyer's Patches and Directed Against Intestinal Antigens
Keywords: ALD، بیماری کبدی الکلی; Microbiota; Humoral Response; S1PR1; HepaticAID, activation-induced (cytidine) deaminase; ALD, alcoholic liver disease; BM, bone marrow; BrdU, bromodeoxyuridine; CCR, CC family chemokine receptors; CSR, class-switch recombination; CT, cholera toxin; CXCR,
Liver Transplantation for Alcoholic and Nonalcoholic Fatty Liver Disease: Pretransplant Selection and Posttransplant Management
Keywords: ALD، بیماری کبدی الکلی; Acute Alcoholic Hepatitis; Nonalcoholic steatohepatitis; ObesityACE, angiotensin-converting enzyme; AH, alcoholic hepatitis; ALD, alcoholic liver disease; AUD, alcohol use disorder; BMI, body mass index; CAD, coronary artery disease; CVD, cardiovascular d
Increased DNA methylation in the livers of patients with alcoholic hepatitis
Keywords: ALD، بیماری کبدی الکلی; 5mC, 5-methylcytosine; 5hmC, 5-hydroxymethylcytosine; AH, alcoholic hepatitis; ALD, alcoholic liver disease; DNMTs, DNA methyltransferases; FFPE, formalin-fixed, paraffin-embedded; HCC, hepatocellular carcinoma; MDBs, Mallory–Denk bodies; NASH, non-alcoho
Proangiogenic factors in the development of HCC in alcoholic cirrhosis
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; HIF, hypoxia-induced factor; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; HCC, hepatocellular carcinoma; NLD, non-liver disease; pVHL, Von Hippel-Lindau protein; HIFs, hypoxia-
Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK
Keywords: ALD، بیماری کبدی الکلی; Ad, adenovirus; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AMPK, AMP-activated protein kinase; AST, aspartate aminotransferase; BA, bile acid; BTG2, b-cell translocation gene 2; ChIP, chromatin immunoprecipitation; CHO, cholesterol; CRBN
Role of farnesoid X receptor and bile acids in alcoholic liver disease
Keywords: ALD، بیماری کبدی الکلی; Farnesoid X receptor; Bile acids; Autophagy; Alcoholic liver disease; FoxO3ADH, alcohol dehydrogenase; AF, activation function; AKT, protein kinase B; ALD, alcoholic liver disease; ALT, alanine aminotransferase; ASBT, apical sodium dependent bile acid tra
Protective effect of 1,25-dihydroxyvitamin D3 on ethanol-induced intestinal barrier injury both in vitro and in vivo
Keywords: ALD، بیماری کبدی الکلی; 1,25(OH)2D3, 1,25-dyhydroxy vitamin D3; TJ, tight junction; ALD, alcoholic liver disease; VDR, vitamin D receptor; TEER, transepithelial electrical resistance; FD-4, FITC-Dextran 4000 Da; MLCK, myosin light chain kinase; MLC, myosin light chain; ROS, reac
Saponins isolated from the leaves of Panax notoginseng protect against alcoholic liver injury via inhibiting ethanol-induced oxidative stress and gut-derived endotoxin-mediated inflammation
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BW, body weight; CYP2E1, cytochrome P450 2E1; GSH, glutathione; H2O2, hydrogen peroxide; HO-1, haem oxygenase-1; HPLC, high performance liquid chromatography; HR
Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells
Keywords: ALD، بیماری کبدی الکلی; α-SMA, smooth muscle α-actin; A2AR, adenosine A2A receptor; ALD, alcoholic liver disease; ALF, alcoholic liver fibrosis; ALT, alanine aminotransferase; AST, aspartate transaminase; cAMP, cyclic adenosine monophosphate; C IV, type IV collagen; CREB, cyclic
Myeloperoxidase gene polymorphism predicts fibrosis severity in women with hepatitis C
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; ER, estrogen receptor; GGT, gamma glutamyl transpeptidase; HCV, hepatitis C; HDL, high-density lipoprotein; HIV, human immunodeficiency vir
Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver
Keywords: ALD، بیماری کبدی الکلی; ACC, acyl-CoA carboxylase; ACOX, acyl-CoA oxidase; AFL, alcoholic fatty liver; ALD, alcoholic liver disease; ALT, alanine transaminase; AMPK, AMP-activated protein kinase; AST, aspartate transaminase; CMZ, chlormethiazole; CYP2E1, cytochrome P4502E1; DGAT
Inhibition of NF-κB activation by diethylcarbamazine prevents alcohol-induced liver injury in C57BL/6 mice
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; DEC, diethylcarbamazine; MDA, malondialdehyde; TNF-α, tumor necrosis factor-α; IL-1β, interleukin 1-β; COX-2, cyclooxygenase-2; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; NF-κB, nuclear fa
Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulating in rats
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; ROS, reactive oxygen species; OA, oleanolic acid; EtOH, ethanol; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; TG, triglyceride; ATP, adenosine triphosphate; GSH, glutathione; GSS
Inhibition of Hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; Erk, extracellular-signal-related kinase; JNK, c-Jun-N-terminal kinase; GSK3β, glycogen synthase kinase 3 beta; 4-HNE, 4-hydroxy-2-nonenal; MDM2, ubiquitin ligase murine double minute oncogene 2; NASH, nonalcoholic steatohepa
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population
Keywords: ALD، بیماری کبدی الکلی; ALD, Alcoholic liver disease; ALKP, Alkaline phosphatase; ALT, Alanine transaminase; AST, Aspartate transaminase; Bili (Total), Total bilirubin; BMI, Body mass index; CI, Confidence interval; CTLA4, Cytotoxic-T lymphocyte antigen 4; CYP2E1, Cytochrome P45
Targeting autophagy for the treatment of liver diseases
Keywords: ALD، بیماری کبدی الکلی; APAP, acetaminophen; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AT, alpha-1-antitrypsin; BAF, Bafilomycin A1; CBZ, carbamazepine; CQ, chloroquine; CMA, chaperone-mediated autophagy; 4EBP1, translational initiation factor 4E binding prote
Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease
Keywords: ALD، بیماری کبدی الکلی; AOPP, advanced oxidation protein products; ALD, alcoholic liver disease; BMI, body mass index; CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; ESRD, end stage renal disease; GPx, glutathione peroxidase
Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes – Alcohol dehydrogenase and Cytochrome P450 2E1
Keywords: ALD، بیماری کبدی الکلی; Ac-DEVD-pNA, Ac-DEVD-p-nitroanilide; ADH, alcohol dehydrogenase; ALD, alcoholic liver disease; CYP2E1, Cytochrome P450 2E1; DAB, 3,3′-diaminobenzidine; DTNB, 5′-dithiobis-2-nitrobenzoic acid; DCF-DA, 2′,7′-dichlorofluorescein diacetate; DMEM, Dulbecco’s m
The separate and joint effects of prolonged QT interval and heart rate on mortality
Keywords: ALD، بیماری کبدی الکلی; ACR, albumin-to-creatinine ratio; ALD, alcoholic liver disease; CVD, cardiovascular disease; FPG, fasting plasma glucose; 2hPG, 2 h plasma glucose after a 75-g oral glucose load; HDL-C, HDL cholesterol; ICD-9, International Classification of Disease, Nint
Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; AST, aspartate transaminase; CAT, catalase; GSH, glutathione; HO-1, heme oxygenase-1; LDH, lactate dehydrogenase; MDA, malondialdehyde; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; PBS, phosphate-buffer
Salvia miltiorrhiza Bunge and its active component cryptotanshinone protects primary cultured rat hepatocytes from acute ethanol-induced cytotoxicity and fatty infiltration
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; iNOS, inducible nitric oxide synthase; LPS, lipopolysaccharide; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; ROS, reactive oxygen species; Sm-SF, standardized fraction of Salvia miltiorrhiza; SREBP-1, st
Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA—Revival of a disease-activity marker in autoimmune hepatitis
Keywords: ALD، بیماری کبدی الکلی; ASGPR, asialoglycoprotein receptor; AIH, autoimmune hepatitis; ALD, alcoholic liver disease; ALT, alanine aminotransferase; ANA, anti-nuclear antibody; AST, asparagine aminotransferase; CHAPS, 3[(3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate; BD,
Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: Role of CYP2E1 and TNF-α and activation of JNK and P38 MAP kinase
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CYP2E1, cytochrome P450 2e1; Dex, control dextrose diet; cFLIP, cellular FLICE-like inhibitory protein; EtOH, ethanol diet; GSH, reduced glutathione; HE, hematox
Alcohol induced hepatic fibrosis: Role of acetaldehyde
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; Ac CHO, acetaldehyde; ADH, alcohol dehydrogenase enzyme; ALDH, acetaldehyde dehydrogenase; MEOS, microsomal ethanol-oxidizing system; ROS, reactive oxygen species; HSCs, hepatic stellate cells; PPARγ, peroxisome proliferator-
Oxidative mechanisms in the pathogenesis of alcoholic liver disease
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; ROS, reactive oxygen species; CYP2E1, cytochrome P4502E1; NO, nitric oxide; mtGSH, mitochondrial GSH; MPT, mitochondria permeability transition; NAFLD, non alcoholic fatty liver disease; IRS-1, insulin receptor substrate prot
Decreased expression of peroxiredoxin 6 in a mouse model of ethanol consumption
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; EDC, ethanol-derived calories; 4HNE, 4-hydroxynonenal; IHC, immunohistochemical; 4ONE, 4-oxononenal; PCR, polymerase chain reaction; PRX, peroxiredoxins; ROS, reactive oxygen species; RNS, reactive nitrogen species; SDS-PAGE,
Interaction of osteopontin with neutrophil α4β1 and α9β1 integrins in a rodent model of alcoholic liver disease
Keywords: ALD، بیماری کبدی الکلی; ALD, Alcoholic liver disease; ASH, Alcoholic steatohepatitis; cOPN, cleaved osteopontin; EtOH, Ethanol; LPS, Lipopolysaccharide; OPN, Osteopontin; RGD, arginine–glycine–aspartateChemokine; Chemokinesis; Ethanol; Inflammation; Neutrophils; Steatohepatitis
Myofibroblast – like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenario
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; Ang-1, angiopoietin-1; AP-1, activator protein-1; ASH, alcoholic steatohepatitis; α-SMA, alpha-smooth muscle actin; CLDs, chronic liver diseases; CTGF, connective tissue growth factor; ECM, extra-cellular matrix; EMT, epithel
What fires prometheus?: The link between inflammation and regeneration following chronic liver injury
Keywords: ALD، بیماری کبدی الکلی; aFGF, acidic fibroblast growth factor; ALD, alcoholic liver disease; AFP, alpha-fetoprotein; APC, antigen presenting cells; CTL, cytotoxic T lymphocyte; DC, dendritic cells; dlk, delta-like protein-1; EGF, epidermal growth factor; EGFR, epidermal growth f
Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene
Keywords: ALD، بیماری کبدی الکلی; GST, glutathione transferase; PCR, polymerase chain reaction; CDNB, 1-chloro-2,4-dinitrobenzene; BITC, benzylisothiocyanate; EA, ethacrynic acid; ALD, alcoholic liver disease; ROS, reactive oxygen species; MALDI, matrix assisted laser desorption ionizatio
Complementary and Alternative Medicine in Hepatology: Review of the Evidence of Efficacy
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAM, complementary and alternative medicine; CHC, chronic hepatitis C; FDA, Food and Drug Administration; HBeAg, hepatitis B e antigen; HBV, hepatitis B virus; H
Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; BSA, bovine serum albumin; 4-HNE, 4-hydroxynonenal; KLH, keyhole lymphet hemocyanin; HMG, 3-hydroxy-3-methylglutaryl; ROS, reactive oxygen species; SDS-PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresisHMG-CoA sy
Regenerative capacity differs between micro- and macrovesicular hepatic steatosis
Keywords: ALD، بیماری کبدی الکلی; Steatosis; Microvesicular steatosis; Macrovesicular steatosis; Apoptosis; Proliferation; Regeneration; Alcoholic fatty liver; Nonalcoholic fatty liver; Protein deficiency; PigA, alcohol (group); ALD, alcoholic liver disease; ISEL, in situ end-labelling; N
Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells
Keywords: ALD، بیماری کبدی الکلی; MB, Mallory body; ER, endoplasmic reticulum; K, keratin; GO, glucose oxidase; H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; ALLN, acetyl-leucyl-leucyl-norleucinal; NAC, N-acetyl-cysteine; PBA, 4-phenylbutyrate; ALD, alcoholic liver disease; NASH, n
Utility of a New Model to Diagnose an Alcohol Basis for Steatohepatitis
Keywords: ALD، بیماری کبدی الکلی; ALD, alcoholic liver disease; BMI, body mass index; CDT, carbohydrate deficient transferrin; GGT, γ-glutamyl transferase; IQR, intraquartile range; MCV, mean corpuscular volume; MELD, Model for End State Liver Disease; NAFLD, nonalcoholic fatty liver dise
Diagnosis and management of alcoholic liver disease, a review
Keywords: ALD، بیماری کبدی الکلی; ALD, Alcoholic liver disease; DT, Delirium tremens; AH, Alcoholic hepatitis; DF, Discriminant factor; SBP, Spontaneous bacterial peritonitisAlcoholic liver disease; Cirrhosis; Ascites; Hepatic encephalopathy; Varices
Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: Role of nonoxidative metabolism
Keywords: ALD، بیماری کبدی الکلی; ADH, alcohol dehydrogenase; ALD, alcoholic liver disease; ATP, adenosine triphosphate; FAEE, fatty acid ethyl esters; ELISA, enzyme-linked immunosorbent assay; CYP2E1, cytochrome P450 2E1Ethanol; Fatty acid ethyl esters; HepG2 cells; VA-13 cells; Nonoxida
Metformin Prevents Alcohol-Induced Liver Injury in the Mouse: Critical Role of Plasminogen Activator Inhibitor-1
Keywords: ALD، بیماری کبدی الکلی; ACC, acetyl CoA carboxylase; ALD, alcoholic liver disease; AMPK, AMP kinase; CPT, carnitine palmitoyl-transferase; HGF, hepatic growth factor; MTTP, microsomal triglyceride transfer protein; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic stea
Intrahepatic gene expression in human alcoholic hepatitis
Keywords: ALD، بیماری کبدی الکلی; Cirrhosis; Fibrogenesis; Annexin A2; CD209; Osteopontin‘A’, total log2 intensity; AC, alcoholic cirrhosis; AH, alcoholic hepatitis; ALD, alcoholic liver disease; ES, end-stage ALD; GO, gene ontology; ‘M’, log2 ratio; AS, alcoholic steatosis; MAT1A, methio