کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1219528 1494543 2016 10 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice
ترجمه فارسی عنوان
اثر پیشگیری کننده از روغن کرفس غنی از اسید لینولنیک در برابر آسیب کبدی ناشی از اتانول باعث کاهش التهاب مصنوعی انتونوکسین در موش ها می شود
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موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• α-linolenic acid-rich flaxseed oil alleviates ethanol-induced liver injury.
• Flaxseed oil decreases the elevation of plasma endotoxin level.
• Flaxseed oil ameliorates ethanol-induced intestinal barrier dysfunction.
• Flaxseed oil suppresses gut-derived endotoxin-triggered inflammation in liver.
• This inhibitory effect is associated with blocking TLR4/MyD88/NF-κB signalling.

The effects of α-linolenic acid (ALA)-rich flaxseed oil (FDO) against ethanol-induced liver injury and the probable molecular mechanisms in a mouse model of chronic-plus-single-binge ethanol feeding were evaluated. Mice were fed Lieber-DeCarli ethanol or control liquid diets with corn oil (CNO) or flaxseed oil for 10 days. On day 11, mice are gavaged with a single dose of ethanol or maltose dextrin. Ethanol exposure with CNO caused severe liver injury, inflammation and oxidative stress in liver, which were remarkably ameliorated by FDO. FDO supplementation decreased the elevation of plasma endotoxin level, which might be attributed to ameliorating ethanol-induced intestinal barrier dysfunction via upregulating the expressions of tight junction proteins. Additionally, FDO supplementation suppressed endotoxin-triggered inflammation via blocking TLR4/MyD88/NF-κB cascades in liver. These findings suggest that ALA-rich flaxseed oil may have potential to be developed as an effective agent for ethanol-induced liver injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 23, May 2016, Pages 532–541
نویسندگان
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