Keywords: مهار کننده آلوستریک; IKKβ inhibitor; NF-κB; Reumatoid arthritis; Allosteric inhibitor
مقالات ISI مهار کننده آلوستریک (ترجمه نشده)
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Keywords: مهار کننده آلوستریک; ERK2, extra-cellular signal-regulated kinase 2; STAT3, hepatic signal transducer and activator of transcription 3; 5-IOD, 5′-iodotubercidin; PEP, designed peptide inhibitor; pNA, p-nitroanilineERK2; Allosteric inhibitor; In silico screening; Crystal struc
Keywords: مهار کننده آلوستریک; Fructose-1,6-bisphosphatase inhibitor; Diabetes; Allosteric inhibitor; Indole derivative
Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation
Keywords: مهار کننده آلوستریک; Constrained peptide; EGFR; Allosteric inhibitor; Kinase dimerization; Stapled peptide;
Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice
Keywords: مهار کننده آلوستریک; PTP1B inhibitor; Diabetes; Obesity; Allosteric inhibitor; db/db mouse; EDTA; ethylenediaminetetraacetic acid; FBS; fetal bovine serum; GLUT4; glucose transporter type 4; GPDH; glycerol-3-phosphate dehydrogenase; HbA1c; hemoglobin A1c; HFD; high-fat diet;
Breathing new life into West Nile virus therapeutics; discovery and study of zafirlukast as an NS2B-NS3 protease inhibitor
Keywords: مهار کننده آلوستریک; West nile virus; NS2B-NS3 protease; Zafirlukast; Allosteric inhibitor; Serine protease;
The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity
Keywords: مهار کننده آلوستریک; TrkA; Juxtamembrane region; Allosteric inhibitor; Crystal structure; Tyrosine kinase inhibitor;
ReviewBinding of small molecules at interface of protein-protein complex - A newer approach to rational drug design
Keywords: مهار کننده آلوستریک; Hot spots; Protein interfaces; Druggability; Orthosteric inhibitor; Allosteric inhibitor; Interfacial binding inhibitor;
Whole-cell biopanning with a synthetic phage display library of nanobodies enabled the recovery of follicle-stimulating hormone receptor inhibitors
Keywords: مهار کننده آلوستریک; Allosteric inhibitor; Recombinant antibody production; cAMP-dependent signaling; GPCR; Phage display;
Sphingosine kinase 1 (SK1) allosteric inhibitors that target the dimerization site
Keywords: مهار کننده آلوستریک; SK; sphingosine kinase; S1P; sphingosine-1-phosphate; PKC-α; protein kinase C alpha; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinositol kinase; CKII; casein kinase II; EGFR; epidermal growth factor receptor; sphingosine kinase 1; alloster
Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction
Keywords: مهار کننده آلوستریک; HIV-1 integrase; Allosteric inhibitor; LEDGF/p75; Dimerization; 3-Hydroxypicolinamide;
Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models
Keywords: مهار کننده آلوستریک; Fibroblast growth factor receptor 2; Allosteric inhibitor; Alofanib; RPT835; Preclinical studies;
Effect of allosteric molecules on structure and drug affinity of HIV-1 protease by molecular dynamics simulations
Keywords: مهار کننده آلوستریک; HIV-1 protease; Inhibitor; Allosteric inhibitor; Molecular dynamics simulation; Binding free energy;
Allosteric inhibitors of calpains: Reevaluating inhibition by PD150606 and LSEAL
Keywords: مهار کننده آلوستریک; PEF; penta-EF-hand; FRET; fluorescence resonance energy transfer; Allosteric inhibitor; Calcium-activated protease; Calpain; Penta-EF-hand; PD150606; Enzyme kinetics;
Insight into the structural mechanism for PKBα allosteric inhibition by molecular dynamics simulations and free energy calculations
Keywords: مهار کننده آلوستریک; PKB/Akt; protein kinase B; MD; molecular dynamics; PI3K; phosphatidylinostiol-3-kinase; PDK1; 3â²-phosphoinositide-dependent kinase-1; PTEN; phosphatase and tensin homolog; MM/PBSA; molecular mechanics/Poisson Boltzmann surface area; MM/GBSA; molecular m
Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase
Keywords: مهار کننده آلوستریک; Fructose-1; 6-Bisphosphatase inhibitor; Allosteric inhibitor; Indole; Diabetes
Discovery and characterization of novel allosteric FAK inhibitors
Keywords: مهار کننده آلوستریک; Focal adhesion kinase; Allosteric inhibitor; Slow dissociation; CancerFAK, focal adhesion kinase; ATP, adenosine 5′-triphosphate; DMSO, dimethyl sulfoxide; DTT, DL-dithiothreitol; EDTA, ethylenediamine-N,N,N′,N′-tetraacetic acid; MgCl2, magnesium chloride
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
Keywords: مهار کننده آلوستریک; JKRPMFOXHVVOBW-UHFFFAOYSA-N; MIPLGURQVCDRMI-UHFFFAOYSA-N; Hepatitis C virus; NS5b polymerase; Allosteric inhibitor; Macrocycle;
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
Keywords: مهار کننده آلوستریک; Hepatitis C virus; NS5b polymerase; Allosteric inhibitor; Macrocycle;
Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors
Keywords: مهار کننده آلوستریک; Glycogen phosphorylase; Glycogen phosphorylase inhibitor; 3,4-Dihydro-2-quinolone; Allosteric inhibitor; Dimer interface; X-ray crystallography; Physical properties; DMPK properties; Solubility; Plasma protein binding; Oxidative cyclisation; Thienopyrrole
Structure–activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter
Keywords: مهار کننده آلوستریک; N-Benzyl GBR analogue synthesis; SAR; Allosteric inhibitor; DAT, SERT, NET transporters; Cocaine treatment agent
Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors
Keywords: مهار کننده آلوستریک; Hepatitis; Replication; RNA polymerase; Nucleoside; Non-nucleoside inhibitor; Membrane protein complex; Allosteric inhibitor; Cell fractionation; NS5B; Replicase;