دانلود مقالات ISI درباره بیماری آلزایمر + ترجمه فارسی

A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β; BBB; blood-brain barrier; DFO; deferoxamine; DFP; deferiprone; DFX; deferasirox; Drp1; dynamin-related protein 1; HFe; high-iron diet; Mfn2; mitofusin2; NAC; n-acetyl cysteine;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

The p38 mitogen-activated protein kinase signaling pathway is involved in regulating low-density lipoprotein receptor-related protein 1-mediated β-amyloid protein internalization in mouse brain

Keywords: بیماری آلزایمر; p38 mitogen-activated protein kinase signaling pathway; Beta-amyloid protein; Low-density lipoprotein receptor-related protein 1; Internalization; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Crosstalk pathway inference using topological information and biclustering of gene expression data

Keywords: بیماری آلزایمر; Gene expression analysis; Biclustering; Pathway crosstalk; Topology analysis; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against μ-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble Aβ peptide formation

Keywords: بیماری آلزایمر; Alzheimer's disease; Chalcone; μ-Calpain inhibitor; Cathepsin B inhibitor; Aβ formation; Tau hyperphosphorylation;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies

Keywords: بیماری آلزایمر; DLB; Dementia with Lewy Bodies; AD; Alzheimer's Disease; ADHD; attention deficit hyperactivity disorder; NFTs; neurofibrillary tangles; PM; post mortem delay; RαMHA; R-α-methylhistamine; MMSE; Mini Mental State Examination; UPDRS; Unified Parkinson Di

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Paraoxonases-1, -2 and -3: What are their functions?

Keywords: بیماری آلزایمر; Paraoxonases; Oxidative stress; Anti-inflammatory; Organophosphate; Human disease; AD; Alzheimer's disease; apoE−/−; apolipoprotein E knockout; AREase; arylesterase; Blmh; bleomycin hydrolase; BPHL; biphenyl hydrolase-like protein; CAAD; carotid art

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Astrocytes and lysosomal storage diseases

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; DAMP; danger-associated molecular pattern; GBA; glucocerebrosidase; GFAP; glial fibrillary acidic protein; GLD; globoid cell leukodystrophy; INCL; infantile neuronal ceroid lipofuscinosis; JNCL; juvenile neuronal ceroid lipofusc

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex and hippocampus via NLRP-1 inflammasome activation in male mice

Keywords: بیماری آلزایمر; Glucocorticoids; Locomotor behavior; NLRP1 inflammasome; Neurodegenerative diseases; Neuroinflammation; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25-35) in rats

Keywords: بیماری آلزایمر; ACh; acetylcholine; AChE; acetylcholinesterase; A-Cu-Ag; amino-cupric-silver; AD; Alzheimer's disease; Aβ; β amyloid peptide; ChAT; choline acetyltransferase; CNS; central nervous system; Hc-TeTx; C-terminal domain of tetanus toxin; H&E; Hematoxylin a

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Research reportThe flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ACSF; artificial cerebrospinal fluid; Akt; serine threonine Kinase; APP; amyloid precursor protein; Aβ; β-amyloid; BACE1; β-secretase enzyme; Bai; baicalein; fEPSP; field excitatory postsynaptic potential; GluR1; α-amino-3-h

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

c-Jun-N-terminal kinase 1 is necessary for nicotine-induced enhancement of contextual fear conditioning

Keywords: بیماری آلزایمر; Acetylcholine; Mitogen-activated protein kinase; Hippocampus; Addiction; Alzheimer's disease; Cognition; Genetics;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Neuroscience Forefront ReviewThe complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; CNS; central nervous system; CNTF; ciliary neurotrophic factor; Cx43; connexin 43; DN; dominant negative; EGF; epidermal growth factor; ETC; electron transport chain; GFAP; glial fibrillary ac

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Impaired burrowing is the most prominent behavioral deficit of aging htau mice

Keywords: بیماری آلزایمر; 4R; 4-repeat; AD; Alzheimer's disease; ANOVA; analysis of variance; MAP1A; microtubule-associated protein 1A; mtau−/−; murine tau knockout; NFTs; neurofibrillary tangles; RIPA; radioimmunoassay precipitation; htau; tau knock-out; cognition; behavior

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Estrogen regulates excitatory amino acid carrier 1 (EAAC1) expression through sphingosine kinase 1 (SphK1) transacting FGFR-mediated ERK signaling in rat C6 astroglial cells

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; CNS; central nervous system; DMEM; Dulbecco's modified Eagle's medium; E2; 17β-Estradiol; EAAC1; excitatory amino acid carrier 1; EAATs; excitatory amino acid transporters; EREs; estrogen response elements; FCS; charcoal-st

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ADAM10; a-disintegrin and metalloproteinase 10; APOE; apolipoprotein E; APP; amyloid precursor protein; AQP4; aquaporin-4; Aβ; β-amyloid; BACE1; β-site amyloid precursor protein-cleaving enzyme 1; BBB; blood-brain barrier;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer's disease

Keywords: بیماری آلزایمر; Quercetin; PLGA; Nanoparticles; Amyloid β; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Full length articleGold nanoparticle-capped mesoporous silica-based H2O2-responsive controlled release system for Alzheimer's disease treatment

Keywords: بیماری آلزایمر; Alzheimer's disease; Metal ions; Amyloid-β; Controlled release system; Mesoporous silica nanoparticle;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; AChE; acetylcholinesterase; BuChE; butyrylcholinesterase; Aβ; β-amyloid peptide; BBB; blood-brain barrier; ACh; acetylcholine; MTDL; multitarget-directed ligand; EeAChE; electric eel AChE; CAS; catalytic anionic site; PAS; p

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewGinsenoside Rb1 as a neuroprotective agent: A review

Keywords: بیماری آلزایمر; Alzheimer's disease; Ginseng; Ginsenosides; Neurodegeneration; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; COX4; cytochrome c oxidase subunit IV; EDTA; ethylenediaminetetraacetic acid; FRDA; Friedreich's ataxia; FTH; H-chain ferritin; FtMt; mitochondrial ferritin; G; granule layer; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfon

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer's disease-like cerebral amyloidosis

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; amyloid-beta peptide; APCs; antigen-presenting cells; CAA; cerebral amyloid angiopathy; CP; choroid plexus; CSF; cerebrospinal fluid; DCs; dendritic cells; FI; fluorescence intensity; IFN-γ; interferon gamma; MHC-I, MHC-II

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis

Keywords: بیماری آلزایمر; CALHM1; Calcium homeostasis modulator 1; OR; odds ratio; CI; confidence interval; HWE; Hardy-Weinberg equilibrium; SNP; sing nucleotide polymorphism; Calcium homeostasis modulator 1; Polymorphism; Meta-analysis; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Distribution of PSA-NCAM in normal, Alzheimer's and Parkinson's disease human brain

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; CA1; Cornu Ammonis area 1; CB; cerebellum; CN; Caudate nucleus; DAB; 3,3-diaminobenzidine chromogen; DG; dentate gyrus; EC; entorhinal cortex; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GCL; granule cell layer; GFAP; glial

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Cd; cluster of differentiation; CNS; central nervous system; DIV; days in vitro; DMEM; Dulbecco's Modified Eagle's Medium; E18; embryonic day 18; EAE; experimental autoimmune encephalomyelitis; ELISA; enzyme-linked immunosor

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Optimal digital filters for analyzing the mid-latency auditory P50 event-related potential in patients with Alzheimer's disease

Keywords: بیماری آلزایمر; Event-related potential; P50; Sensory gating; Alzheimer's disease; Digital filter; Filter distortion;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors

Keywords: بیماری آلزایمر; Alzheimer's disease; Anellated xanthines; Caffeine derivatives; Heterocycles; Neurodegenerative disease; Polypharmacology; Parkinson's disease: synthesis; Water-solubility; Xanthines;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors

Keywords: بیماری آلزایمر; Click-chemistry; Monoamine oxidase B; Alzheimer's disease; Irreversible inhibition;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Preliminary evidence of altered steroidogenesis in women with Alzheimer's disease: Have the patients “OLDER” adrenal zona reticularis?

Keywords: بیماری آلزایمر; Alzheimer's disease; Steroid metabolome; Women; GC-MS; RIA; Multivariate statistics;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and evaluation of 8-hydroxyquinolin derivatives substituted with (benzo[d][1,2]selenazol-3(2H)-one) as effective inhibitor of metal-induced Aβ aggregation and antioxidant

Keywords: بیماری آلزایمر; Alzheimer's disease; Multitarget; Organoselenium; GPx-like activity; Antioxidant activity; Aβ aggregation;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

Abolished perineuronal nets and altered parvalbumin-immunoreactivity in the nucleus reticularis thalami of wildtype and 3xTg mice after experimental stroke

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ECM; extracellular matrix; NRT; Nucleus reticularis thalami; NVU; neurovascular unit; PNs; perineuronal nets; TBS; Tris-buffered saline; WFA; Wisteria floribunda agglutinin; cerebral ischemia; animal model; perineuronal net; ext

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2016 سفارش ترجمه

Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer's disease: A post-mortem study with PET radiopharmaceuticals

Keywords: بیماری آلزایمر; 5-HT1A receptor; Alzheimer's disease; F13640; MPPF; PET; Serotonin;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2016 سفارش ترجمه

Common variant in PTK2B is associated with late-onset Alzheimer's disease: A replication study and meta-analyses

Keywords: بیماری آلزایمر; Alzheimer's disease; PTK2B; rs28834970; Association study; Meta-analysis;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

The role of the drebrin/EB3/Cdk5 pathway in dendritic spine plasticity, implications for Alzheimer's disease

Keywords: بیماری آلزایمر; Dendritic spines; Synaptic plasticity; Actin; Microtubules; Drebrin; EB3; ADF/cofilin; Myosin II; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

Neuroprotective effects of ginseng protein on PI3K/Akt signaling pathway in the hippocampus of D-galactose/AlCl3 inducing rats model of Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Ginseng; Neuroprotective; Protein;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

Microtubules in health and degenerative disease of the nervous system

Keywords: بیماری آلزایمر; Microtubule; Neuron; Axon; Dendrite; Katanin; Spastin; Fidgetin; Dynein; Kinesin; Neurodegeneration; Alzheimer's disease; Tau; Tauopathy; Microtubule-associated proteins; Molecular motor proteins; Axonal transport; CAMSAP; Tubulin; Tubulin code; Microtu

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

Micro-RNAs in cognition and cognitive disorders: Potential for novel biomarkers and therapeutics

Keywords: بیماری آلزایمر; Cognitive dysfunctions; miRNA; Biomarkers; Learning and memory; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

Protective effect of recombinant soluble neprilysin against β-amyloid induced neurotoxicity

Keywords: بیماری آلزایمر; Recombinant soluble neprilysin; Protein theraphy; Amyloid beta peptide; Neurotoxicity; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2016 سفارش ترجمه

Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients

Keywords: بیماری آلزایمر; Alzheimer disease; Insulin-like growth factor-1 receptor; Insulin receptor; PSD95; p75 neurotrophin receptor; tyrosine receptor kinase-A; AD; Alzheimer's disease; FBS; fetal bovine serum; HMW; high molecular weight; IGF-1R; insulin-like growth factor-1

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2016 سفارش ترجمه

One of the possible mechanisms of amyloid fibrils formation based on the sizes of primary and secondary folding nuclei of Aβ40 and Aβ42

Keywords: بیماری آلزایمر; Amyloid fibril; Oligomer; Aβ42 peptide; Aβ40 peptide; Alzheimer's disease; Electron microscopy; Size of nucleus; Secondary nucleation;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2016 سفارش ترجمه

Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration

Keywords: بیماری آلزایمر; LRP1; low density lipoprotein receptor related-protein 1; Snx17; Sorting nexin 17; PSD95; postsynaptic density protein 95; Dab-2; disabled homolog 2; ECM; extracellular matrix; RMS; rostral migratory stream; BrdU; 5-bromo-2-deoxyuridine; CPZ; chlorpromazi

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Astrocytes in physiological aging and Alzheimer's disease

Keywords: بیماری آلزایمر; 3xTg-AD; triple transgenic mice model of Alzheimer's disease; AD; Alzheimer's disease; APP; amyloid precursor protein; ATP; adenosine triphosphate; CA1; Cornu Ammonis 1; CNS; Central nervous system; DG; dentate gyrus; GABA; γ-aminobutyric acid; GFAP;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

β-asarone improves learning and memory and reduces Acetyl Cholinesterase and Beta-amyloid 42 levels in APP/PS1 transgenic mice by regulating Beclin-1-dependent autophagy

Keywords: بیماری آلزایمر; Alzheimer's disease; β-asarone; Autophagy; APP/PS1 transgenic mice; PI3K/Akt/mTOR pathway;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

Advances in the development of tau PET radiotracers and their clinical applications

Keywords: بیماری آلزایمر; Tau proteins; Neurofibrillary tangles; Positron emission tomography; Neuroimaging; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

A molecular dynamics study of the BACE1 conformational change from Apo to closed form induced by hydroxyethylamine derived compounds

Keywords: بیماری آلزایمر; Alzheimer's disease; Hydroxyethylamines; GROMACS; BACE1; Flap; Population density;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats

Keywords: بیماری آلزایمر; Seladin-1; Insulin; Alzheimer's disease; Diabetes mellitus; BACE-1;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

Metabolomics approach to explore the effects of Kai-Xin-San on Alzheimer's disease using UPLC/ESI-Q-TOF mass spectrometry

Keywords: بیماری آلزایمر; Alzheimer's disease; Metabolomics; Kai-Xin-San; SYNAPT G2-Si HDMS; Traditional chinese medicine;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Ad-Hepcidin; the recombinated-hepcidin-adenovirus; BBB; brain-blood barrier; BMECs; brain microvascular endothelial cells; DMT1; divalent metal transporter 1; Fpn1; ferroportin 1; GFAAS; graphite furnace atomic absorption spec

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Glutamatergic and central cholinergic dysfunction in the CA1, CA2 and CA3 fields on spatial learning and memory in chronic cerebral ischemia-Induced vascular dementia of rats

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; VaD; vascular dementia; CCI; Chronic Cerebral Global Ischemia; vGluT1; vesicular glutamate transporters type 1; vGluT2; vesicular glutamate transporters type 1; vGluT3; vesicular glutamate transporters type 3; vAChT; vesicular a

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; miRNA-107; BACE1; Aβ; Osthole;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Indandione; Piperazine; Neurotoxicity;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه