دانلود مقالات ISI درباره پراکندگی جامد Amorphous + ترجمه فارسی

Application of hydroxypropyl methylcellulose as a protective agent against magnesium stearate induced crystallization of amorphous itraconazole

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Hydroxypropyl methylcellulose; Dissolution; Downstream processing; Roller compaction; Hydrogen bonding;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

A high-sensitivity HPLC-ELSD method for HPMC-AS quantification and its application in elucidating the release mechanism of HPMC-AS based amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; HPMC-AS; Posaconazole; HPLC-ELSD; Release mechanism;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro

Keywords: پراکندگی جامد Amorphous; Rifapentine (PubChem CID: 6323497); Rifampicin (PubChem CID: 5458213); 3-Formylrifamycin (PubChem CID: 6438444); Hydroxypropylmethylcellulose acetate succinate (PubChem CID: 121950); ASD; amorphous solid dispersion; AUC; area under the curve; CASub; cellu

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Selective synthesis of curdlan ω-carboxyamides by Staudinger ylide nucleophilic ring-opening

Keywords: پراکندگی جامد Amorphous; Curdlan; Regioselective; Chemoselective; Amide; Drug delivery; Amorphous solid dispersion;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Physical stability of API/polymer-blend amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Polymer blends; Thermodynamic model; PC-SAFT; Kwei equation; Phase behavior; Physical stability; Excipients; a; Helmholtz energy (J); Δcp,0,APISL; difference in the solid and liquid heat capacities of the pure API (J/mol K); Î

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of amorphous phase separation and crystallization on the in vitro and in vivo performance of an amorphous solid dispersion

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Bioavailability; Phase separation; Crystallization; IVIVC;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

PermeaLoop™, a novel in vitro tool for small-scale drug-dissolution/permeation studies

Keywords: پراکندگی جامد Amorphous; Dissolution; Permeation; Amorphous solid dispersion; ABT-869; Dynamic; Non-steady state; Non-sink;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

Comparison of two DSC-based methods to predict drug-polymer solubility

Keywords: پراکندگی جامد Amorphous; Solubility; Amorphous solid dispersion; Polymer; Gordon-Taylor; Differential scanning calorimetry (DSC); Flory-Huggins; Decision tree;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

Molecular dynamics, physical and thermal stability of neat amorphous amlodipine besylate and in binary mixture

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Molecular dynamics; Physical stability; Dielectric spectroscopy; Amlodipine besylate; Polyvinyl pyrrolidone-K30;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

From benchtop to pilot scale-experimental study and computational assessment of a hot-melt extrusion scale-up of a solid dispersion of dipyridamole and copovidone

Keywords: پراکندگی جامد Amorphous; Hot-melt extrusion; Simulation; Scale-up; Copovidone; Dipyridamole; Adiabatic; Amorphous solid dispersion;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Oral bioavailability enhancement of β-lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion

Keywords: پراکندگی جامد Amorphous; ASD; amorphous solid dispersion; CSD; crystalline solid dispersion; CCNa; croscarmellose sodium; DSC; differential scanning calorimetry; HPLC; high performance liquid chromatography; HPMC; hydroxypropylmethylcellulose; HPMC-AS; hydroxypropylmethylcellulos

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound-The Venetoclax Story

Keywords: پراکندگی جامد Amorphous; amorphous; absorption, distribution, metabolism, and excretion (ADME); bioavailability; food effect; physiologically based pharmacokinetic modeling; clinical pharmacokinetics; intestinal absorption; passive diffusion/transport; drug interaction; ASD; Amor

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based release retarding materials: Effect of dosage form design

Keywords: پراکندگی جامد Amorphous; ASD; amorphous solid dispersion; ATR; attenuated total reflectance; AUC; area under the curve; BCS; Biopharmaceutic Classification System; CEL; celecoxib; Cmax; maximum concentration, or peak kinetic solubility; CR; controlled release; CRASD; controlled r

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Understanding the generation and maintenance of supersaturation during the dissolution of amorphous solid dispersions using modulated DSC and 1H NMR

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Spray drying; Dissolution; Supersaturation; Drug-polymer interaction; Nuclear magnetic resonance; Crystallization;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Enhanced delivery of fixed-dose combination of synergistic antichagasic agents posaconazole-benznidazole based on amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; Trypanosoma cruzi; Chagas disease; Amorphous solid dispersion; Apparent solubility; Dissolution rate; Fixed-dose combination; Posaconazole (PubChem CID: 468595); Benznidazole (PubChem CID: 31593); Vinylpyrrolidone - vinyl acetate copolymer - PVPVA (Pu

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

Investigating the Impact of Drug Crystallinity in Amorphous Tacrolimus Capsules on Pharmacokinetics and Bioequivalence Using Discriminatory In Vitro Dissolution Testing and Physiologically Based Pharmacokinetic Modeling and Simulation

Keywords: پراکندگی جامد Amorphous; amorphous solid dispersion; bioequivalence; tacrolimus; physiology based pharmacokinetic modeling; dissolution;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Dual mechanism of microenvironmental pH modulation and foam melt extrusion to enhance performance of HPMCAS based amorphous solid dispersion

Keywords: پراکندگی جامد Amorphous; API; active pharmaceutical ingredient; ASD; amorphous solid dispersion; HME; Hot-melt extrusion; HPMCAS; Hydroxypropyl methylcellulose acetate succinate; PAT; Process Analytical Technology; QbD; Quality by Design; Foam melt extrusion; Amorphous solid disp

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Amorphous solid dispersion of cyclosporine A prepared with fine droplet drying process: Physicochemical and pharmacokinetic characterization

Keywords: پراکندگی جامد Amorphous; ASD; amorphous solid dispersion; ASD/CsA; amorphous solid dispersion of cyclosporine A; AUC; area under the curve of blood concentration versus time curve; BA; bioavailability; Cmax; maximum concentration; CsA; cyclosporine A; CV; coefficient of variation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Humidity induced phase transformation of poloxamer 188 and its effect on physical stability of amorphous solid dispersion of AMG 579, a PDE10A inhibitor

Keywords: پراکندگی جامد Amorphous; Hygroscopicity; Poloxamer; Physical stability; Amorphous solid dispersion;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Importance of in vitro dissolution conditions for the in vivo predictability of an amorphous solid dispersion containing a pH-sensitive carrier

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Bioavailability; pH-dependence; Supersaturation; Eudragit; Celecoxib; Polymer;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Experimental observations and dissipative particle dynamic simulations on microstructures of pH-sensitive polymer containing amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Molecular basis; Microstructures; Dissipative particle dynamics;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Impact of Eudragit EPO and hydroxypropyl methylcellulose on drug release rate, supersaturation, precipitation outcome and redissolution rate of indomethacin amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Dissolution rate; Precipitation; Redissolution kinetics;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Water-induced phase separation of miconazole-poly (vinylpyrrolidone-co-vinyl acetate) amorphous solid dispersions: Insights with confocal fluorescence microscopy

Keywords: پراکندگی جامد Amorphous; AAPS; amorphous amorphous phase separation; AFM; atomic force microscopy; ASD; amorphous solid dispersion; CFM; confocal fluorescence microscopy; DSC; differential scanning calorimetry; IR; infrared spectroscopy; LCR; Lorentz contact resonance; PVPVA; pol

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperA comparative assessment of nanocomposites vs. amorphous solid dispersions prepared via nanoextrusion for drug dissolution enhancement

Keywords: پراکندگی جامد Amorphous; Nanocomposites; Amorphous solid dispersion; Nanoextrusion; Spray drying; Nanoparticles; Dissolution;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; PVP; Molecular weight; Amorphous solid dispersion; ​In vitro; Non-sink dissolution; Celecoxib; In vivo; IVIVC;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Influence of PVP/VA copolymer composition on drug-polymer solubility

Keywords: پراکندگی جامد Amorphous; Solubility; Copolymers; Amorphous solid dispersion; Gordon-Taylor; Differential scanning calorimetry (DSC); Flory-Huggins;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; Non-sink dissolution; Amorphous solid dispersion; Bioavailability; Dose-dependence; Polymers; In vitro; In vivo; IVIVC; Supersaturation; Poorly soluble drugs; Solubility enhancement; Celecoxib; PVP; HPMC; PVA

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Research paperPhysicochemical properties of direct compression tablets with spray dried and ball milled solid dispersions of tadalafil in PVP-VA

Keywords: پراکندگی جامد Amorphous; Tadalafil; Amorphous solid dispersion; Spray drying; Ball milling; Direct compression tablets; Dissolution; Supersaturable formulation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Detailed stability investigation of amorphous solid dispersions prepared by single-needle and high speed electrospinning

Keywords: پراکندگی جامد Amorphous; High speed electrospinning; Amorphous solid dispersion; Long-term stability; Raman mapping; Oral drug delivery

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Production of nano-solid dispersions using a novel solvent-controlled precipitation process - Benchmarking their in vivo performance with an amorphous micro-sized solid dispersion produced by spray drying

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Carbamazepine pharmacokinetics; Co-precipitation; Crystalline solid dispersion; Nano-aggregate; Spray drying;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Co amorphous systems: A product development perspective

Keywords: پراکندگی جامد Amorphous; Co amorphous system; Amorphous solid dispersion; Polymers; Miscibility; Phase separation; Stability;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

High speed electrospinning for scaled-up production of amorphous solid dispersion of itraconazole

Keywords: پراکندگی جامد Amorphous; Electrospinning; Itraconazole; Amorphous solid dispersion; Scaling-up; Dissolution enhancement; Continuous nanoformulation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Preparation, characterization and in vivo studies of amorphous solid dispersion of berberine with hydrogenated phosphatidylcholine

Keywords: پراکندگی جامد Amorphous; Berberine; Hydrogenated phosphatidylcholine; Amorphous solid dispersion; Permeability; Intestinal absorption; Bioavailability;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Conversion of solid dispersion prepared by acid-base interaction into free-flowing and tabletable powder by using Neusilin® US2

Keywords: پراکندگی جامد Amorphous; Haloperidol; Weak organic acid; Poorly water-soluble drug; Supersolubilization; Amorphous solid dispersion; Neusilin® US2;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Amorphous solid dispersions of piroxicam and Soluplus®: Qualitative and quantitative analysis of piroxicam recrystallization during storage

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Physical stability; Dissolution; Piroxicam; Soluplus®; Vibrational spectroscopy; Multivariate curve resolution; Principal component analysis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Physical stability of solid dispersions with respect to thermodynamic solubility of tadalafil in PVP-VA

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Tadalafil; Polymer; Physical stability; Crystallization; Thermodynamic solubility;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Optimization of the Büchi B-90 spray drying process using central composite design for preparation of solid dispersions

Keywords: پراکندگی جامد Amorphous; DoE; design of experiment; B-90; Büchi B-90 nano spray dryer; ASDs; amorphous solid dispersions; LF, AS-LF; hypromellose acetate succinate; IT; inlet temperature; FR; air flow rate; AS; polymer concentration; PXRD; powder X-ray diffraction; PLM; polarize

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

The effect of drug and EUDRAGIT® S 100 miscibility in solid dispersions on the drug and polymer dissolution rate

Keywords: پراکندگی جامد Amorphous; CP/MAS; cross polarization/magic-angle spinning; DPH; diphenylhydantoin; ELSD; evaporative light scattering detector; GBM; glibenclamide; PVP; polyvinylpyrrolidone; PXRD; powder X-ray diffraction; SPD; spray-dried sample; S100; Eudragit® S 100; TOSS; tot

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2015 سفارش ترجمه

Hydroxypropyl cellulose stabilizes amorphous solid dispersions of the poorly water soluble drug felodipine

Keywords: پراکندگی جامد Amorphous; Hydroxypropyl cellulose; Hot melt extrusion; Amorphous solid dispersion; Interaction; Stability; Supersaturation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and structure–property evaluation of cellulose ω-carboxyesters for amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; Cellulose ω-carboxyalkanoates; Crystal growth inhibition; Amorphous solid dispersion; Oral drug delivery; Cellulose esters; Cellulose acylation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Amorphous solid dispersion method for improving oral bioavailability of poorly water-soluble drugs

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Differential scanning calorimetry; Fusion method; Solvent evaporation method;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions

Keywords: پراکندگی جامد Amorphous; Ellagic acid; Amorphous solid dispersion; CMCAB; HPMCAS; CAAdP; Cellulose acetate adipate propionate; PVP; Dissolution; Stability; Bioavailability;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Dissolution testing of amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Solubility; Polymer; Molecular weight of polymer; Dissolution; Co-milling

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus®-based solid dispersions

Keywords: پراکندگی جامد Amorphous; Soluplus®; Amorphous solid dispersion; Tablet disintegration; Cloud point depression; Fusion processing; KinetiSol® Dispersing

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Investigation of preparation methods on surface/bulk structural relaxation and glass fragility of amorphous solid dispersions

Keywords: پراکندگی جامد Amorphous; Structural relaxation; Amorphous solid dispersion; Glass fragility; Zero mobility temperature; Stability; Inverse gas chromatography

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Enhanced kinetic solubility profiles of indomethacin amorphous solid dispersions in poly(2-hydroxyethyl methacrylate) hydrogels

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Poly (2-hydroxyethyl methacrylate); Indomethacin; Supersaturation; Kinetic solubility

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Formulation and delivery of improved amorphous fenofibrate solid dispersions prepared by thin film freezing

Keywords: پراکندگی جامد Amorphous; Thin film freezing; Fenofibrate; Amorphous solid dispersion; Supersaturation dissolution; Dosage form development

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization and stability of ternary solid dispersions with PVP and PHPMA

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Hydrogen bonding; Spray drying; Solubility; Flory–Huggins; Free energy of mixing

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Interplay of formulation and process methodology on the extent of nifedipine molecular dispersion in polymers

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Drug–polymer interactions; Formulation; Process technology; Molecular dispersibility

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Is a distinctive single Tg a reliable indicator for the homogeneity of amorphous solid dispersion?

Keywords: پراکندگی جامد Amorphous; Amorphous solid dispersion; Homogeneity; Tg; Confocal Raman microscopy; Hot-melt extrusion

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه