Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions

► Carboxycellulose ester dispersions prevent ellagic acid degradation, crystallization. ► Carboxycellulose esters prevent low pH release and recrystallization of ellagic acid. ► HPMCAS strongly enhances ellagic acid solution concentration. ► Dispersion in polymer blends can provide synergistic drug stabilization and release.