|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|1384569||1500603||2017||11 صفحه PDF||سفارش دهید||دانلود رایگان|
• Nicotine has been loaded into composite sodium alginate based films and wafers for nicotine replacement therapy (NRT).
• Magnesium aluminium silicate and sodium alginate helped stabilise the nicotine within the formulations and enhanced drug recovery.
• The films and wafers showed different physical properties which affected their functional characteristics for an ideal buccal NRT.
Composite wafers and films comprising HPMC and sodium alginate (SA) were formulated for nicotine (NIC) replacement therapy via the buccal route. Magnesium aluminium silicate (MAS) was added in different concentration ratios (0.25, 0.5, 0.75) to stabilize NIC and its effect on mechanical properties, internal and surface morphology, physical form, thermal properties, swelling, mucoadhesion, drug content and release behaviour of the formulations was investigated. MAS changed the physico-mechanical properties of the composite formulations causing a decrease in mechanical hardness, collapsed wafer pores, increased roughness of film surface, increase in crystallinity and decreased mucoadhesion of the wafers. However, MAS increased swelling in both films and wafers as well as interaction between NIC and SA, which increased drug-loading capacity. Further, MAS resulted in rapid and slow release of NIC from wafers and films respectively. The results suggest that the ideal formulation for the stabilization of NIC in the composite formulations was MAS 0.25.
Journal: Carbohydrate Polymers - Volume 155, 2 January 2017, Pages 78–88