AMP kinase promotes Bcl6 expression in both mouse and human T cells
Keywords: T follicular helper cells; Bcl6; AMPK; Metabolism;
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Effect of 6-gingerol on AMPK- NF-κB axis in high fat diet fed rats
Keywords: AMPK; 6-Gingerol; High fat diet; p65; Resistin; Sirtuin 6;
Regulatory mechanism of mineral-balanced deep sea water on hypocholesterolemic effects in HepG2 hepatic cells
Keywords: Mineral-balanced deep sea water; Lipid metabolism; Hypercholesterolemia; HMG-CoA reductase; AMPK;
Protective role of rhapontin in experimental pulmonary fibrosis in vitro and in vivo
Keywords: AMPK; adenosine 5â²-monophosphate (AMP)-activated protein kinase; α-SMA; α smooth muscle actin; BALF; bronchoalveolar lavage fluid; Col I; collagen I; ECM; extracellular matrix; ELISA; enzyme-linked immunosorbent assay; EMT; epithelial-mesenchymal tran
Ludwigia octovalvis extract improves glycemic control and memory performance in diabetic mice
Keywords: LOE; Ludwigia octovalvis extract; AMPK; AMP-activated protein kinase; STZ; streptozotocin; HFD; high fat diet; DR; dietary restriction; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; Glut4; glucose transporter type 4; 2-NBDG; 2-(N-
The emerging role of AMP-activated protein kinase in cholestatic liver diseases
Keywords: AMPK; AMP-activated protein kinase; PSC; primary sclerosing cholangitis; LKB1; Liver Kinase B1; CamKKβ; Ca2+-calmodulin-activated protein kinase beta; ERK1/2; extracellular signal-regulated kinase 1/2; FXR; farnesoid X receptor; BSEP; bile salt export pu
A novel topoisomerase 2a inhibitor, cryptotanshinone, suppresses the growth of PC3 cells without apparent cytotoxicity
Keywords: topo; topoisomerase; VP-16; etoposide; AChE; acetylcholinesterase; STAT 3; signal transducer and activator of transcription 3; AMPK; AMP-activated protein kinase; MTT; 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; FBS; fetal bovine serum; H
Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice
Keywords: Berberine; AMPK; AICAR; CD36; Fatty liver; Fatty acid uptake;
Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy
Keywords: LCD; licoricidin; LCDG; the glycosylated product of licoricidin; AMPK; adenosine 5â²-monophosphate (AMP)-activated protein kinase; Caspase; cysteinyl aspartate specific proteinase; Akt; protein kinase B; mTOR; mammalian target of rapamycin; PGE2; prostag
1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors
Keywords: 1,3-DCP; 1,3-dichloro-2-propanol; ACC; acetyl-CoA carboxylase; AMPK; adenosine 5â²-monophosphate-activated protein kinase; CaMKII; Ca2+/calmodulin (CaM)-dependent protein kinase II; cAMP; cyclic AMP; CPT1; carnitine palmitoyltransferase 1; CREB; cAMP-res
Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes
Keywords: Berberine; High glucose; AMPK; Autophagy; Podocyte;
Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoEâ/â mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
Keywords: PTP1B; Insulin resistance; Interleukin-10; AMPK; Atherosclerosis;
Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma
Keywords: AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AMP; adenosine monophosphate; AMPK; adenosine monophosphate-activated protein kinase; CFSE; carboxyfluorescein succinimidyl ester; G-MDSC; granulocytic myeloid-derived suppressor cell; MDSC; myeloid-de
Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma
Keywords: AMPK; AMP-activated kinase; BRAFi; BRAF inhibitor; ERK; extracellular signal-regulated kinase; ERKi; ERK inhibitor; PGC1α; peroxisome proliferator-activated receptor gamma, coactivator 1-α; MEK; MAPK/ERK kinase; MEKi; MEK inhibitor; mTOR; mechanistic ta
Research reportAntidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression
Keywords: AMPK; AMP-activated protein kinase; BDNF; brain derived neurotrophic factor; CMS; chronic mild stress; CREB; cAMP response element-binding protein; FST; forced swimming test; GSK3β; glycogen synthase kinase-3β; MAOI; monoamine oxidase inhibitors; NARI;
Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes
Keywords: GLUT4; glucose transporter type 4; PI3K; phosphatidylinositol-3 kinase; PKB/Akt; serine/threonine kinase protein kinase B; AMPK; AMP-activated protein kinase; DM; diabetes mellitus; T2DM; type 2 diabetes mellitus; DMEM; Dulbecco's modified Eagle's med
Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway
Keywords: Resveratrol; Osteoarthritis; Autophagy; AMP activated protein kinase; Mammalian target of rapamycin; ADAMTS5; a disintegrin and metalloproteinase with thrombospondin motifs 5; AMPK; AMP activated protein kinase; DMM; destabilization of the medial meniscu
Induction of apoptosis by Moutan Cortex Radicis in human gastric cancer cells through the activation of caspases and the AMPK signaling pathway
Keywords: Moutan Cortex Radicis; Gastric cancer; Apoptosis; Caspase; AMPK;
Hemin Reduces HMGB1 Release by UVB in an AMPK/HO-1-dependent Pathway in Human Keratinocytes HaCaT Cells
Keywords: AMPK; HMGB1; HO-1; ROS; Skin cancer;
Gln223Arg polymorphism in the Caucasian population and Pro1019Pro polymorphism in the Chinese population are risk factors for OSAS: An updated meta-analysis of 1159 subjects
Keywords: ACC; acetyl-CoA carboxylase; AMPK; 5â² adenosine monophosphate-activated protein kinase; CI; confidence intervals; CNKI; Chinese National Knowledge Infrastructure; Grb2; growth factor receptor-bound protein 2; HWE; Hardy-Weinberg equilibrium; IRS; insu
Original articlePhyscion 8-O-β-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1
Keywords: Physcion 8-O-β-glucopyranoside; Breast cancer; Metastasis; DNMT1; Sp1; AMPK;
Proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves regulate lipid metabolism and glucose consumption by activating AMPK pathway in HepG2 cells
Keywords: Proanthocyanidins; Chinese bayberry leaves; Lipid metabolism; Glucose metabolism; AMPK;
Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal
Keywords: Baicalin (PubChem CID: 64982); Scutellarin (PubChem CID: 185617); Baicalin; Scutellarin; Glucose uptake; AMPK; Akt; Adipocytes;
Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway
Keywords: Ischemic stroke; Sirt3; Autophagy; AMPK; mTOR;
The effects of troglitazone on AMPK in HepG2 cells
Keywords: AMPK; Troglitazone; Thiazolidinedione; HepG2; Diabetes; Ser485/491;
Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation
Keywords: AMPK; AMP-activated protein kinase; ATF4; Activating Transcription Factor 4; ATF6; Activating Transcription Factor 6; BAF; Bafilomycin A1; BiP (GRP78); Binding immunoglobulin Protein (78Â kDa glucose regulated protein); BZ; bortezomib; CHOP; C/EBP-Homolog
Diallyl trisulfide induces apoptosis and mitotic arrest in AGS human gastric carcinoma cells through reactive oxygen species-mediated activation of AMP-activated protein kinase
Keywords: DATS; Apoptosis; Mitotic arrest; ROS; AMPK;
Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs
Keywords: AMPK; Metformin; AGE; Inflammatory response; hNSCs;
AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids
Keywords: Exercise; Nociception; Inflammation; Endocannabinoids; AMPK;
Mitochondrial NUDIX hydrolases: A metabolic link between NAD catabolism, GTP and mitochondrial dynamics
Keywords: NAD+; PARP1; NUDIX; AMP; GTP; Mitochondrial dynamics; ADPr; ADP- ribose; ADPrP; ADPr-phosphate; AIF; apoptosis inducing factor; AK3; adenylate kinase 3; AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; ANT; adenine nucleotide translocase;
Cold-inducible protein RBM3 protects neuroblastoma cells from retinoic acid-induced apoptosis via AMPK, p38 and JNK signaling
Keywords: AICAR; 5-Aminoimidazole-4-carboxamide ribonucleotide; AMPK; 5â² AMP-activated protein kinase; DMSO; dimethylsulfoxide; MTT; 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide; PARP; poly (ADP-ribose) polymerase; RA; retinoic acid; RBM3; RNA-bi
Protective effects of wedelolactone on dextran sodium sulfate induced murine colitis partly through inhibiting the NLRP3 inflammasome activation via AMPK signaling
Keywords: WEL; wedelolactone; DSS; dextran sulfate sodium; UC; ulcerative colitis; COX-2; cyclooxygenase-2; iNOS; Inducible nitric oxide synthase; MAPK; mitogen activated protein kinase; DAI; disease activity index; MPO; myeloperoxidase; AP; alkaline phosphatase; I
Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice
Keywords: NAFLD; non-alcoholic fatty liver disease; WAT; white adipose tissue; ND; normal diet; HD; high-fat diet; RP; red paprika-supplemented diet; CS; capsanthin-supplemented diet; TG; triacylglycerol; TC; total cholesterol; HDL; high-density lipoprotein; NEFA;
Anti-tumorigenic and anti-angiogenic effects of natural conifer Abies sibirica terpenoids in vivo and in vitro
Keywords: AMPK; 5â² adenosine monophosphate-activated protein kinase; CD31; cluster of differentiation 31; DMEM; Dulbecco's modified eagle medium; DMSO; dimethyl sulfoxide; FACS; fluorescence-activated cell sorting; FBS; fetal bovine serum; GAPDH; glyceraldehyde
Berberine modulates amyloid-β peptide generation by activating AMP-activated protein kinase
Keywords: Alzheimer's disease; Berberine; AMP-activated protein kinase; Amyloid-β; β-site APP cleaving enzyme-1; AD; Alzheimer's disease; Aβ; Amyloid-β; APP; Amyloid precursor protein; AMPK; AMP-activated protein kinase; BACE1; β-site APP cleaving enzyme-1; β
Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance
Keywords: Ilexgenin A; AMPK; Lipolysis; Inflammation; Hepatic gluconeogenesis;
β-ecdysterone from Cyanotis arachnoidea exerts hypoglycemic effects through activating IRS-1/Akt/GLUT4 and IRS-1/Akt/GLUT2 signal pathways in KK-Ay mice
Keywords: β-EC; β-ecdysterone; ALT; alanine aminotransferase; AMPK; (AMP)-activated protein kinase; DM; diabetes mellitus; FBG; fasting blood glucose; FFA; free fatty acid; GLUT4; insulin-responsive glucose transporter 4; HDL-C; high density lipoprotein cholester
Histidine-alleviated hepatocellular death in response to 4-hydroxynonenal contributes to the protection against high-fat diet-induced liver injury
Keywords: 4-HNE; 4-hydroxynonenal; ALT; alanine aminotransferase; AML-12 hepatocyte; alpha mouse liver-12 hepatocyte; AMPK; AMP-activated protein kinase; DCFH-DA; 2,7-dichloro-dihydro-fluorescein diacetate; DMEM; Dulbecco's Modified Eagle Medium; DMEM/F-12; Dulb
Crotonaldehyde induces autophagy-mediated cytotoxicity in human bronchial epithelial cells via PI3K, AMPK and MAPK pathways
Keywords: Crotonaldehyde; Autophagy; PI3K; AMPK; MAPK;
Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2Â +
Keywords: Akt; protein kinase B; AMPK; AMP-activated protein kinase; BAPTA-AM; 1,2-bis(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid acetoxymethyl ester; DMEM; Dulbecco's modified Eagle's medium; EGTA; ethylene glycol tetraacetic acid; ER; endoplasmic reticu
Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase
Keywords: AMPK; mTORC1; eEF2K; eEF2; Compound 991; Translation;
Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression
Keywords: AMPK; AMP - activate kinase alpha 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; CHK2; checkpoint kinase 2; CHK1; checkpoint kinase 1; CDK; cyclin-dependent kinase; CDKN2A; cyclin dependent kinase inhibitor 2A;
Original articleAnti-inflammatory role of Leptin in glial cells through p38 MAPK pathway inhibition
Keywords: AD; alzheimer's disease; AMPK; AMP-activated protein kinase; ATF; ATP protein fusion; BBB; brain blood barrier; CNS; central nervous system; CYT; cytokines; Cyt-c; cytochrome c; IFNγ; interferon-gamma; IL1β; interleukin 1-beta; iNOS; inducible nitric
α-Pyrrolidinononanophenone provokes apoptosis of neuronal cells through alterations in antioxidant properties
Keywords: AMC; 7-amido-4-methylcoumarin; AMPK; AMP kinase; BSO; DL-buthionine-(S,R)-sulfoximine; DCFH-DA; 6-carboxy-2â²,7â²-dichloro-dihydrofluorescein diacetate-di(acetoxymethylester); DEM; diethylmaleate; DMF; N,N-dimethylformamide; DPBS; Dulbecco's phosphate
Sauchinone exerts anticancer effects by targeting AMPK signaling in hepatocellular carcinoma cells
Keywords: Sauchinone; Apoptosis; Anti-cancer; AMPK; Hepatocellular carcinoma;
Expression of recombinant SnRK1 in E. coli. Characterization of adenine nucleotide binding to the SnRK1.1/AKINβγ-β3 complex
Keywords: SnRK1; Snf1 related kinase 1; AMPK; AMP activated kinase; SNF1; Sucrose non fermenting 1; CBS; cystathionine β-synthase; SnAK2; SnRK1-activating kinase 2; Arabidopsis thaliana; CBS motifs; Nucleotide binding; SnRK1 complexes; Phosphorylation;
Original ArticlemicroRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression
Keywords: Pancreatic cancer; microRNA-7; Autophagy; Aerobic glycolysis; Cancer metabolism; AMPK; AMP-activated protein kinase; ATG; autophagy-related gene; ciRS-7; circular RNA sponge for miR-7; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; H&E
The protective effect of the active components of ERPC on diabetic peripheral neuropathy in rats
Keywords: DPN; diabetic peripheral neuropathy; PKC; protein kinase C; TCM; traditional Chinese medicine; MNCV; motor nerve conduction velocity; AGE; advanced glycation end products; RAGE; receptor of advanced glycation end products; NF-κB; nuclear factor-κB; MDA;
Liraglutide relieves myocardial damage by promoting autophagy via AMPK-mTOR signaling pathway in zucker diabetic fatty rat
Keywords: Liraglutide; Diabetic cardiomyopathy; Autophagy; AMPK;
Metformin: Insights into its anticancer potential with special reference to AMPK dependent and independent pathways
Keywords: Metformin; Cancer; mTORC1 inhibition; AMPK; Preclinical evidence; Clinical trials;