Crotonaldehyde induces autophagy-mediated cytotoxicity in human bronchial epithelial cells via PI3K, AMPK and MAPK pathways
Keywords: Crotonaldehyde; Autophagy; PI3K; AMPK; MAPK;
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Original articleAnti-inflammatory role of Leptin in glial cells through p38 MAPK pathway inhibition
Keywords: AD; alzheimer's disease; AMPK; AMP-activated protein kinase; ATF; ATP protein fusion; BBB; brain blood barrier; CNS; central nervous system; CYT; cytokines; Cyt-c; cytochrome c; IFNγ; interferon-gamma; IL1β; interleukin 1-beta; iNOS; inducible nitric
The role of curcumin in disruption of HIF-1α accumulation to alleviate adipose fibrosis via AMPK-mediated mTOR pathway in high-fat diet fed mice
Keywords: AMPK; AMP-activated protein kinase; BSA; Albumin from bovine serum; DAB; diaminobenzidine; DMEM; dulbecco's modified eagle medium; ECM; extracellular matrix; EWATs; epididymis white adipose tissues; FCCP; Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone
Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice
Keywords: ACC1; acetyl-CoA carboxylase 1; AMPK; AMP-activated protein kinase; BW; body weight; DM; diabetes mellitus; ELISA; enzyme-linked immunosorbent assay; FAS; fatty acidy synthase; FBPase; fructose-1,6-bisphosphatase; FSG; fasting serum glucose; FSI; fasting
Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress
Keywords: ACC; acetyl-CoA carboxylase; Adiponectin R2; adiponectin receptor 2; AFLD; alcoholic fatty liver disease; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ATGL; adipose triglyceride lipase; Bax; Bcl-2-associated X protein; Bcl2; B-cell l
Dissecting the role of AMP-activated protein kinase in human diseases
Keywords: AMPK; Cancer; Type 2 diabetes; Atherosclerosis; Myocardial ischemia; Neurodegenerative disease;
ReviewThe spectraplakins of Caenorhabditis elegans: Cytoskeletal crosslinkers and beyond
Keywords: ABD; actin-binding domain; abf; antibacterial factor related; AC; anchor cell; ACF7; actin crosslinking family protein 7; ALML; anterior lateral microtubule cell; AMPK; AMP-activated protein kinase; B-LINK; basement membrane-LINKage; BM; basement membrane
4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells
Keywords: 4-nonylphenol; Sertoli cells; Autophagy; AMPK; mTOR-p70S6K/4EBP1;
Eicosapentaenoic acid (EPA) vs. Docosahexaenoic acid (DHA): Effects in epididymal white adipose tissue of mice fed a high-fructose diet
Keywords: AKT; protein kinase B; AMPK; AMP-activated protein kinase; aP2; adipocyte protein 2; ATGL; adipose triglyceride lipase; beta3-AR; beta 3-adrenergic receptor; BM; body mass; CD36; cluster of differentiation 36; DHA; docosahexaenoic acid; EPA; eicosapentaen
High-dose metformin (420Â mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis
Keywords: AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; ANOVA; analysis of variance; ATM; ataxia telangiectasia mutated; ATP; adenosine-5â²-triphosphate; CamKK; calcium/calmodulin-dependent
Original ArticleAcetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab
Keywords: ACC; AMPK; Cetuximab; EGFR; HIF-1; Warburg effect;
SVCT-2 determines the sensitivity to ascorbate-induced cell death in cholangiocarcinoma cell lines and patient derived xenografts
Keywords: Ascorbic acid; Cholangiocarcinoma; ROS; SVCT-2; CC; cholangiocarcinoma; AA; ascorbic acid; ROS; reactive oxygen species; SVCT; sodium-dependent vitamin C transporter; NAC; N-acetyl-l-cysteine; CI; combination index; H2AX; histone 2AX; AMPK; adenosine mono
Original ArticleAspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition
Keywords: Aspirin; mTORC1; AMPK; Sorafenib; Proliferation; AMPK; Adenosine 5'-monophosphate (AMP)-activated protein kinase; mTOR; mammalian target of rapamycin; MEF; mouse embryonic fibroblast; TSC2; Tuberous sclerosis 1; NSAID; non-steroidal anti-inflammatory dr
Original ArticleNegative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts
Keywords: Metformin; Sirtuin 1; AMP-activated protein kinase; Cellular senescence; Hepatocellular carcinoma; SIRT1; Sirtuin 1; AMPK; AMP-activated Protein Kinase; TIS; therapy-induced senescence; SA-β-gal; senescence-associated β-galactosidase;
Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis
Keywords: ACM; alcoholic cardiomyopathy; ALDH; aldehyde dehydrogenase; ADH; alcohol dehydrogenase; PKC-β; protein kinase C (PKC)-beta; TCA cycle; tricarboxylic acid; ETC; electron transport chain; RCI; mitochondrial respiratory control index/ratio; FAD+; flavin ad
Antioxidant/antihyperglycemic activity of phenolics from sugarcane (Saccharum officinarum L.) bagasse and identification by UHPLC-HR-TOFMS
Keywords: ROS; reactive oxygen species; 2-NBDG; 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl) amino)-2-deoxyglucose; AKT/PKB; protein kinase B; AMPK; 5â²-AMP-activated protein kinase; GLUT-2; glucose transporter-2; Sugarcane bagasse; Phenolics; Antioxidant; Antidiabete
Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3â²,2â²:3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2â²,3â²:4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of aden
Keywords: AMPK; adenosine 5â²-monophosphate-activated protein kinase; ACC; acetyl CoA carboxylase; ATCC; American Type Culture Collection; CCCP; carbonylcyanide m-chlorophenylhydrazone; dhBBR; dihydroberberine; FBS; fetal calf serum; GC; glucose consumption; GP; g
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway
Keywords: AMPK; 5'-AMP-activated protein kinase; ATF4; activating transcription factor-4; Atg7; autophagy-related protein-7; CHOP; C/EBP homologous protein; CO; carbon monoxide; CORM; CO-releasing molecule; eIF2α; eukaryotic initiation factor-2 alpha; ER; Endoplas
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Transcribing β-cell mitochondria in health and disease
Keywords: β-Cell; Mitochondria; Islets; Genome-wide association study (GWAS); Insulin secretion; Expression quantitative trait locus (eQTL); ATGL; adipocyte triglyceride lipase; AMPK; AMP-dependent protein kinase; COX; Cytochrome c oxidase; CYTB; Cytochrome b; ERR
Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis
Keywords: Obesity; Glucose metabolism; Insulin resistance; KSR2; AMPK;
Anthocyanin-rich mulberry fruit improves insulin resistance and protects hepatocytes against oxidative stress during hyperglycemia by regulating AMPK/ACC/mTOR pathway
Keywords: AMPK; Oxidative stress; Anthocyanin; Insulin resistance; Diabetes;
2-Methoxyestradiol protects against ischemia/reperfusion injury in alcoholic fatty liver by enhancing sirtuin 1-mediated autophagy
Keywords: Chloroquine (PubChem CID: 2719); 2-Methoxyestradiol (PubChem CID: 66414); Sirtinol (PubChem CID: 5717148); AFL; alcoholic fatty liver; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; AST; aspartate aminotransferase; CD; control diet; CQ
Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease
Keywords: Parkinson's disease; Metformin; MPTP; PP2A; BDNF; PD; Parkinson's disease; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; AMPK; 5â²-adenosine mono-phosphate-activated protein kinase; PP2A; protein phosphatase 2A; TH; tyrosine hydroxylase; BDNF; brai
Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase
Keywords: HCC; hepatocellular carcinoma; NCTD; norcantharidin; AA; arachidonic acid; AMPK; 5â² AMP-activated protein kinase; p-AMPK; phosphorylated AMPK; PPP; phosphoprotein phosphatase; PP5; protein phosphatase 5; PI; propidium iodide; TPR; tandem tetratricopepti
Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
Keywords: Adipogenesis; Osteogenesis; Metformin; Diabetes; AMPK; Mesenchymal stem cells;
SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice
Keywords: ALT; Alanine aminotransferase; AMPK; AMP-activated protein kinase; AST; aspartate aminotransferase; ATMs; adipose tissue macrophages; BAT; brown adipose tissue; CT; computed tomographic; DIO; high-fat-diet-induced obese; EGP; endogenous glucose production
High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation
Keywords: AICAR; 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AMPK; AMP-activated protein kinase; AP; alkaline phosphatase; BCAA; branched-chain amino acids; BCKDC; branched-chain alpha-ketoacid dehydrogenase complex; BSA/PBS; bovine serum albumin/phosphat
T-cadherin promotes autophagy and survival in vascular smooth muscle cells through MEK1/2/Erk1/2 axis activation
Keywords: AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; BSA; bovine serum albumin; CQ; chloroquine; EC; endothelial cell; eIF2α; eukaryotic translation initiation factor 2α; ER; endoplasmic reticulum; Erk1/2; extracellular signal-regulated kinase;
Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy
Keywords: GTDF; Adiponectin; Adiponectin receptor; Skeletal muscle atrophy; FoxO; PGC-1α; GTDF; 6-C-β-D-glucopyranosyl-(2S,3S)-(+)-5,7,3â²,4'-tetrahydroxydihydroflavonol; gAd; globular adiponectin; AdipoR; Adiponectin receptor; AMPK; AMP-activated protein kinase
ReviewCaloric restriction - A promising anti-cancer approach: From molecular mechanisms to clinical trials
Keywords: Acetyl-CoA/CoA; acetyl-coenzyme A/Coenzyme A ratio; AMPK; AMP-dependent kinase; APL; autophagolysosome; ATG; autophagy-related gene; ATP/ADP; adenosine triphosphate/adenosine diphosphate ratio; CDK; cyclin-dependent kinase; CR; caloric restriction; CRM; c
Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants
Keywords: Maternal/fetal; Obesity; AMPK; Lipid metabolism; Mesenchymal stem cells;
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)
Keywords: 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration
Keywords: 3MA; 3-methyladenine; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ATP1B2; ATPase Na+/K+ transporting subunit beta 2; BDL; bile duct ligation; Cav1; Caveolin 1; CD31; platelet endothelial cell adhesion molecule-1, PECAM-1; cGMP; cyclic
Methylene blue increases the amount of HSF1 through promotion of PKA-mediated increase in HSF1-p300 interaction
Keywords: AMPK; AMP-activated protein kinase; AS; sodium arsenite; ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; ChIP; chromatin immunoprecipitation; cGI-PDE; cGMP-inhibited phosphodiesterase; cGMP; cyclic guanosine monophosphate; cGS-PDE; cGMP
Oleate induces KATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge
Keywords: ACC; acetyl-CoA carboxylase; AMPK; adenosine 5â²-monophophate-activated protein kinase; AMP-PNP; 5â²-adenylylimidodiphosphate; ARC; arcuate nucleus; CPT1; carnitine palmitolytransferase-1; CSF; cerebrospinal fluid; GE; glucose-excited; GI; glucose-inhib
Voluntary exercise increases adult hippocampal neurogenesis by increasing GSK-3β activity in mice
Keywords: ACSF; artificial cerebrospinal fluid; Akt; PKB- Protein Kinase B; AMP; Adenosine monophosphate; AMPK; 5â²-monophosphate (AMP)-activated protein kinase; ATP; Adenosine triphosphate; BrdU; 5-Bromo-2-deoxyUridine; BSA; bovine serum albumin; cAMP; cyclic AMP
Expression of adenosine 5â²-monophosphate-Activated protein kinase (AMPK) in ovine testis (Ovis aries): In vivo regulation by nutritional state
Keywords: Domestic ruminant; Diet; Steroidogenesis; AMPK; Signal transduction;
Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients
Keywords: AGAT; arginine-glycine amidinotransferase (mostly in the kidney); AMPK; AMP-activated protein kinase; ANT; mitochondrial adenine nucleotide or ATP/ADP carrier of the inner mitochondrial membrane; ATP; adenosine-trisphosphate, the universal energy currency
Estradiol effects on hypothalamic AMPK and BAT thermogenesis: A gateway for obesity treatment?
Keywords: 3 V; third ventricle; ACC; acetyl-CoA carboxylase; AgRP; agouti-related peptide; AMPK; AMP-activated protein kinase; ARC; arcuate nucleus of the hypothalamus; β3-AR; beta3 adrenergic receptor3; BAT; brown adipose tissue; CaMKK2; Ca2 +/calmodulin-depend
AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia
Keywords: VSMCs; vascular smooth muscle cells; PDGF; platelet-derived growth factor; AMPK; AMP-activated protein kinase; ACC; acetyl CoA carboxylase; mTOR; mammalian target of rapamycin; p70S6K; p70 ribosomal protein S6 kinase; S6; S6 ribosomal protein; 4E-BP1; euk
Albiflorin ameliorates obesity by inducing thermogenic genes via AMPK and PI3K/AKT in vivo and in vitro
Keywords: ACC; Acetyl coenzyme A carboxylase; AF; Albiflorin; AKT; Protein kinase B; ALT; Alanine transaminase; AMPK; AMP-activated protein kinase; AP2; Fatty acid-binding protein 4; AST; Aspartate transaminase; BAT; Brown adipose tissue; CD137; Cluster of differen
Autophagy: The spotlight for cellular stress responses
Keywords: HSC70; Heat Shock 70KDa protein; AMPK; AMP-activated protein kinase; ATG; autophagy-related genes; Beclin-1; coiled-coil, myosin-like BCL2-interacting protein; CQ; chloroquine; DNA-PK; DNA-dependent protein kinase; FYVE; Fab1, YOTB, Vac1 and EEA1; GFP; gr
Myotoxicity of statins: Mechanism of action
Keywords: AKT; protein kinase B; AMPK; AMP-activated protein kinase; Bax; Bcl-2-associated X; Bcl-2; B-cell lymphoma 2; BCRP; breast cancer resistance protein; BSEP; bile salt export pump; CaMKII; calmodulin kinase II; CaMKK; Ca2Â +/calmodulin-dependent kinase kina
Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases
Keywords: ADP; adenosine 5â²-diphosphate; AgRP; agouti-related peptide; AMPK; 5â²-AMP-activated protein kinase; ApnA; diadenosine polyphosphate; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATP; adenosine 5â²-triphosphate; BN-PAGE; blue native-p
Nanoformulated copper/zinc superoxide dismutase exerts differential effects on glucose vs lipid homeostasis depending on the diet composition possibly via altered AMPK signaling
Keywords: ACC; Acetyl-coA carboxylase; ACOX1; Acyl-CoA oxidase1; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; DTSSP; 3,3â²-Dithiobis (sulfosuccinimidylpropionate); FABP1; Fatty acid binding protein 1; FASN; Fatty acid synthase; FCCP; Carbonyl c
Ghrelin modulates gene and protein expression of digestive enzymes in the intestine and hepatopancreas of goldfish (Carassius auratus) via the GHS-R1a: Possible roles of PLC/PKC and AC/PKA intracellular signaling pathways
Keywords: Fish; Ghrelin; Sucrase-isomaltase; Aminopeptidase; Trypsin; Lipoprotein lipase; AC; Adenylyl cyclase; AgRP; Agouti-related peptide; AMPK; AMP-activated protein kinase; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's Modified Eagle Medium; [D-Lys3]
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways
Keywords: D-gal; D-galactose; H2S; Hydrogen Sulfide; ROS; Reactive Oxygen Species; CD; Common Deletion; GSH; Glutathione; SOD; Superoxide Dismutase; DMEM; Dulbecco's Modified Eagle Medium; PI3K; Phosphatidylinositol 3-kinase; CaMKKβ; Ca2+/calmodulin-dependent prot
Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover
Keywords: AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; BNIP3; Bcl2/adenovirus E1B 19Â kDa-interacting protein 3; BNIP3-like; (BNIP3L)/NIX; DRP1; dynamin related protein 1; ETC; electron transport chain; FUNDC1; FUN14 domain-containing 1; GABARAP