AICAR activates ER stress-dependent apoptosis in gallbladder cancer cells
Keywords: AICAR; ER stress; AMPK; Apoptosis and gallbladder cancer cells;
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The Ca2+/CaMKK2 axis mediates the telbivudine induced upregulation of creatine kinase: Implications for mechanism of antiviral nucleoside analogs' side effect
Keywords: LdT; Telbivudine; HBV; hepatitis B virus; CHB; chronic Hepatitis B; CK; creatine kinase; HSKMCs; human skeletal muscle cells; SOD; superoxide dismutase; MDA; malondialdehyde; LPO; lipid peroxide; ROS; reactive oxygen species; CaMKK2; calmodulin-dependent
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy
Keywords: ABCB6; ATP-binding cassette transporter B6; ABCG2; ATP binding cassette transporter G2; AIF; apoptosis inducing factor; AKT; v-Akt murine thymoma viral oncogene homologue; AMPK; AMP-activated protein kinase; Ang-1; angiotensin 1; ARE; arteether; ARM; arte
Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer
Keywords: ADAM; a disintegrin and metalloproteinase; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; AMPK; adenosine monophosphate activated protein kinase; CD44; cluster of differentiation 44; CD44s; standard CD44; CD44v; CD44 variant isofo
Anti-inflammatory activity of natural stilbenoids: A review
Keywords: AMPK; 5â² adenosine monophosphate-activated protein kinase; AP-1; activator protein 1; CAT; catalase; COX; cyclooxygenase; CRP; C-reactive protein; CSA; cajaninstilbene acid; CYP; cytochrome enzyme; DSS; dextran sulfate sodium; ERK; extracellular signal-
Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice
Keywords: CHMs; Chinese herbal medicines; ATG; autophagy-related proteins; AD; Alzheimer's disease; PD; Parkinson's disease; AMPK; 5â² adenosine monophosphate-activated protein kinase; mTOR; mammalian target of rapamycin; HD; Huntington's disease; HH; hedera
Diet phytochemicals and cutaneous carcinoma chemoprevention: A review
Keywords: Akt; protein kinase B; AMPK; adenosine 5â²-monophosphate (AMP)-activated protein kinase; Ang; angiopoietin; AP-1; activator protein 1; ARE; antioxidant-responsive element; ATF-2; activating transcription factor 2; BCC; basal cell carcinoma; Bcl-2; B-cell
Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment
Keywords: α-SMA; α-smooth muscle actin; AMPK; AMP-activated protein kinase; bHLH; basic Helix-Loop-Helix; DHA; docosahexaenoic acid (22:6n-3); Drp1; dynamin-related protein 1; ECM; extracellular matrix; EMT; epithelial-to-mesenchymal transition; EPA; eicosapentae
Salusin-β mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway
Keywords: Diabetes; Endothelial dysfunction; Endothelial cell; Salusin; AMPK;
Effect of brain-derived neurotrophic factor (BDNF) on hepatocyte metabolism
Keywords: BDNF; Metabolism; Fatty acid oxidation; AMPK; Signaling;
Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis
Keywords: Myostatin; Protein synthesis; eEF2K-eEF2; AMPK;
Targeted mitochondrial uncoupling beyond UCP1 - The fine line between death and metabolic health
Keywords: Energy metabolism; Longevity; Mitochondria; Obesity; Protonophore; Uncoupling protein 1; AMPK; AMP-activated protein kinase; aP2; adipocyte protein 2; ATP; adenosine triphosphate; BAT; brown adipose tissue; CRMP; controlled-released mitochondrial protonop
Metabolic roles of poly(ADP-ribose) polymerases
Keywords: ABCA1; ATP-binding cassette sub-family A member 1; ACACA; acetyl-CoA carboxylase alpha; ACBD3; acyl-CoA binding domain containing 3; ACLY; ATP citrate lyase; ADP; adenosine diphosphate; ADPR; ADP-ribose; AFLD; alcoholic fatty liver disease; AIF; apoptosis
Anti-inflammatory effect of Capuli cherry against LPS-induced cytotoxic damage in RAW 264.7 macrophages
Keywords: Prunus serotina; Capuli cherry; Antioxidant capacity; Oxidative stress; Inflammation; NO; nitric oxide; TNF-α; tumor necrosis factor-α; DW; dry weight; TPC; total phenolic content; GAE; galic acid equivalents; TFC; total flavonoid content; Cateq; catech
Protective effects of gomisin N against hepatic steatosis through AMPK activation
Keywords: Gomisin N; Nonalcoholic fatty liver disease; Lipogenesis; AMP-activated protein kinase; Sterol regulatory element-binding protein 1c; High-fat diet; ACC; Acetyl-CoA carboxylase; AMPK; Adenosine monophosphate (AMP)-activated protein kinase; CPT 1; Carnitin
Modulation of signaling mechanisms in the heart by thioredoxin 1
Keywords: Akt; protein kinase B; AMPK; Adenosine Monophosphate-activated Protein Kinase; Ang-II; Angiotensin-II; AP1; Activator protein 1 (AP-1); ASK1; Apoptosis Signal-regulating kinase; Atg4; Autophagy related-4; ATP; Adenosine Triphosphate; CDDP; cis-diammine-di
Acute fluoride poisoning alters myocardial cytoskeletal and AMPK signaling proteins in rats
Keywords: ACC; Acetyl coA carboxylase; AMPK; 5â²adenosine monophosphate-activated protein kinase; ATP; Adenosine Triphosphate; IF; Intermediate filaments; DAB; 3,3â²-Diaminobenzidine; TMB; 3,3â²,5,5â²-Tetramethylbenzidine; Acute fluoride poisoning; AMPK; Cardia
Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV
Keywords: DPP-IV; dipeptidyl peptidase IV; mg V·kgâ 1; mg Vanadium injected/weight of mice in kg; GLP-1; glucagon-like peptide-1; GIP; glucose-dependent insulinotropic peptide; BEOV; bis(ethylmaltolato)oxovanadium(IV); PTP1B; protein tyrosine phosphatase 1B; P
Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice
Keywords: High glucose; Oxidative stress; Vitamin D; SIRT1/AMPK/IRS1/GLUT4; Glucose metabolism; 1,25(OH)2D3; 1,25-dihydroxyvitamin D3; AKT; serine/threonine protein kinase; AMPK; AMP activated protein kinase; GLUT1; glucose transporter 1; GLUT4; glucose transporter
Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice
Keywords: AMPK; metformin; resveratrol; plantar incision; topical therapeutics;
AMPK activation reduces the number of atheromata macrophages in ApoE deficient mice
Keywords: AMPK; Ccr2; Ly6Chi; Monocyte; Migration; Atherosclerosis;
Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK)
Keywords: Prostate cancer; LNCaP; C42B; Autophagy; AMPK; AEG-1;
PKM2-mediated inhibition of autophagy facilitates Tat's inducing HIV-1 transactivation
Keywords: Tat; Autophagy; PKM2; AMPK;
Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer's disease
Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; ANS; autonomic nervous system; BACE1; beta-site APP-cleaving enzyme 1; BBB; brain blood barrier; CSF; cerebrospinal fluid; DIO; diet-induced obesity; HCD; high calorie diet; H
Honokiol exerts dual effects on browning and apoptosis of adipocytes
Keywords: ACO; peroxisomal acylcoenzyme A oxidase; AMPK; AMP-activated protein kinase; BAT; brown adipose tissue; BAX; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Cidea; gene encoding cell death-inducing DFFA-like effector a; Cited1; gene encoding Cbp/p30
Knockdown of sestrin2 increases pro-inflammatory reactions and ER stress in the endothelium via an AMPK dependent mechanism
Keywords: sesn2; sestrin2; AMPK; AMP-activated protein kinase; HUVEC; human umbilical vein endothelial cells; LPS; lipopolysaccharide; NF-κB; nuclear factor kappa B; ROS; reactive oxygen species; ER; endoplasmic reticulum; ICAM-1; Intercellular Adhesion Molecule 1
Flavonoid derivative (Fla-CN) inhibited adipocyte differentiation via activating AMPK and up-regulating microRNA-27 in 3T3-L1 cells
Keywords: Fla-CN; Anti-obesity; Adipocyte differentiation; MicroRNA-27a/b; AMPK;
The role of the TOR pathway in mediating the link between nutrition and longevity
Keywords: TOR; target of rapamycin; TSC; tuberous sclerosis complex; Rheb; Ras homologue enriched in brain; 4EBP; 4E binding protein; S6K; S6 kinase; PI3K; phosphatidylinositol-3-kinase; Raptor; regulatory-associated protein of mTOR; Deptor; DEP domain-containing m
Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells
Keywords: Osteoblast; Pneumolysin; Autophagy; Sp1; ROS; AMPK; mTOR;
Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation
Keywords: NSCLC; Non small cell lung cancer; CTD; cantharidin; NCTD; norcantharidin; AA; arachidonic acid; AMPK; 5â² AMP activated protein kinase; p-AMPK; phosphorylated AMPK; PP5; protein phosphatase 5; PI; propidium iodide; IHC; immunohistochemistry; PARP; poly
Metformin attenuates ER stress-induced mitochondrial dysfunction
Keywords: AIF; apoptosis inducing factor; AMPK; AMP-activated protein kinase; ASPP2; apoptosis-stimulating protein of p53-2; ADP; adenosine diphosphate; ATP; adenosine triphosphate; CHOP; C/EBP homologous protein; BSA; bovine serum albumin; CRC; calcium retention c
The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices
Keywords: Hippocampus; S1P receptors; Tau phosphorylation; AMPK;
Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells
Keywords: LAT1; L-type amino acid transporter 1; SNAT2; sodium-dependent neutral amino acid transporter 2; 4F2hc; 4F2 heavy chain; AMPK; AMP-activated protein kinase; AICAR; 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; BCAA; branched chain amino acid; mTOR
Cytochrome P450-derived eicosanoids and heart function
Keywords: AA; arachidonic acid; ACS; acute coronary syndrome; ALA; alpha-linolenic acid; AMI; acute myocardial infarction; AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; Ang II; angiotensin II; ANP; atrial natriuretic peptide; BaP; benzo(α)pyrene; BK
Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells
Keywords: AMPK; AMP-activated protein kinase; AO; acridine orange; AVOs; acidic vesicular organelles; FGF-2; fibroblast growth factor 2; Grb2; growth factor receptor binding protein 2; Rab13; Ras-related protein in brain 13; HA; hemagglutinin; HRP; Horseradish pero
The roles of subcellularly located EGFR in autophagy
Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e
Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells
Keywords: ACC; acetyl co-enzyme A carboxylase; AGE; advanced glycation end products; AMPK; 5â² AMP-activated protein kinase; ATG; autophagy related; BAF; bafilomycin; CQ; chloroquine; DMEM; high-glucose Dulbecco's modified Eagle medium; Glo; glyoxalase; GSH; gluta
Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1α pathway
Keywords: AMPK; AMP-activated protein kinase; AraA; adenine 9-β-d-arabinofuranoside; ATP-5β; ATP synthase 5β; Cyt B; cytochrome B; CTRP3; C1q/tumor necrosis factor-related protein-3; FCCP; carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone; H/R; hypoxia-reoxy
Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes
Keywords: 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; AMPK; AMP-activated protein kinase; BSA; bovine serum albumin; ConA; concanavalin A; eEF2; eukaryotic elongation factor 2; eIF; eukaryotic initiation factor; ERK; extracellular-signal-regulated
Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy
Keywords: AMPK; Autophagy; Mitochondriogenesis; NAD+; PGC-1α; SIRT1;
Liqustri lucidi Fructus inhibits hepatic injury and functions as an antioxidant by activation of AMP-activated protein kinase in vivo and in vitro
Keywords: AMPK; LKB1; Ligustri lucidi Fructus; Liver injury; CCl4; ACC; acetyl-CoA carboxylase; AICAR; aminoimidazole-carboxamide-β-d-ribofuranoside; AMPK; AMP-activated protein kinase; FACS; fluorescence-activated cell sorter; GSH; glutathione; H&E; hematoxylin a
Dihydromyricetin prevents obesity-induced slow-twitch-fiber reduction partially via FLCN/FNIP1/AMPK pathway
Keywords: AMPK; Dihydromyricetin; FLCN; FNIP1; Slow fibers;
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
Keywords: AMPK; Cell non-autonomous; FGF21; Healthspan; Klotho; Lifespan; PERK;
Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK
Keywords: SRT1720; Phosphodiesterases; cAMP; AMPK; Sirt1; Epac; Type 2 diabetes; Obesity; Aging; Mitochondria;
Effects of vitamin D and resveratrol on metabolic associated markers in liver and adipose tissue from SAMP8 mice
Keywords: AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; APP; amyloid precursor protein; AUC; area under the curve; ER; endoplasmic reticulum; EPI; epididymal; FFAs; free fatty acids; GRP78; 78Â kDa glucose-regulated protein; GTT; glucose tolerance te
Regulation of GLUT4 activity in myotubes by 3-O-methyl-d-glucose
Keywords: αMEM; α-Minimal essential medium; AICAR; 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK; AMP-activated protein kinase; AS160; Akt substrate of 160 kDa; CB; Cytochalasin B; dGlc; 2-Deoxy-d-glucose; GAPDH; Glyceraldehyde-3-phosphate dehydroge
Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture
Keywords: AD; Alzheimer's disease; EA; electroacupuncture; 18F-FDG; 18F-Fluoro-2-deoxy-D-Glucose; PET; positron emission tomography; AMPK; adenosine monophosphate-activated protein kinase; mTOR; mammalian target of rapamycin; Aβ; amyloid-beta; ThS; Thioflavin stai
In vitro antiglioma action of indomethacin is mediated via AMP-activated protein kinase/mTOR complex 1 signalling pathway
Keywords: Indomethacin; Glioma; Apoptosis; AMPK; mTOR;
Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK
Keywords: I/R; ischemia/reperfusion; OGD/REP; oxygen-glucose deprivation/reperfusion; ROS; reactive oxygen species; Drp-1; dynamin- related protein 1; MFN2; mitofusin-2; HG; high glucose; MCAO; middle cerebral artery occlusion; TTC; triphenyltetrazolium chloride; S
Multifaceted anticancer activity of BH3 mimetics: Current evidence and future prospects
Keywords: A1; Bcl-2-related protein A1; AIF; apoptosis-inducing factor; AKT; protein kinase B; AMPK; 5â²AMP-activated protein kinase; Bad; Bcl-2-associated death promoter; Bak; Bcl-2-associated killer; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl