Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture

AMPK and AKT were activated by electroacupuncture treatment, further triggered GLUTs to increase the energy metabolism, and negatively regulated mTOR to induce autophagy and eliminate Aβ deposition, which delayed the cognitive impairments, particularly in learning and memory ability in AD model mice.344