Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans
Keywords: آمیلوئید β; Dementia; Mitochondria; mtDNA; Amyloid-β; Oxidative stress;
مقالات ISI آمیلوئید β (ترجمه نشده)
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Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden
Keywords: آمیلوئید β; Alzheimer's disease; Amyloid-β; Dementia; Rabphilin; SNARE complex; Synapse;
Pharmacological characterization of the novel γ-secretase modulator AS2715348, a potential therapy for Alzheimer's disease, in rodents and nonhuman primates
Keywords: آمیلوئید β; Alzheimer's disease; γ-Secretase; Amyloid-β; Cognition;
Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice
Keywords: آمیلوئید β; Montelukast; Cysteinyl leukotriene receptor 1; Amyloid-β; NF-κB; Memory;
Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice
Keywords: آمیلوئید β; AD; Alzheimer's disease; AICD; amyloid precursor protein intracellular domain; ANOVA; analysis of variance; APP; amyloid precursor protein; Aβ; amyloid-β; βFGF; fibroblast growth factor; BrdU; 5-bromo-2-deoxyuridine; DMEM; Dulbecco's modified Eagle m
Cerebrolysin reduces amyloid-β deposits, apoptosis and autophagy in the thalamus and improves functional recovery after cortical infarction
Keywords: آمیلوئید β; Cerebrolysin; Amyloid-β; Apoptosis; Autophagy; Thalamus; Cerebral infarction;
Amyloid β binds procaspase-9 to inhibit assembly of Apaf-1 apoptosome and intrinsic apoptosis pathway
Keywords: آمیلوئید β; Aβ; Amyloid-β; ABAD; alcohol dehydrogenase; ACE; cells treated with 20 μM Aβ42; AD; Alzheimer's disease; C9; caspase-9; Cyto c; cytochrome c; ÎC; caspase-9 lacking the prodomain; HCE; extracts prepared from untreated healthy HeLa cells; MTT; 3-(4, 5
Detection and quantification of plasma amyloid-β by selected reaction monitoring mass spectrometry
Keywords: آمیلوئید β; Aβ; amyloid-β; SRM; selected reaction monitoring; RPLC; reversed-phase liquid chromatography; LOQ; limit of quantification; CSF; cerebrospinal fluid; AD; Alzheimer's disease; APP; amyloid precursor protein; ApoE; apolipoprotein E; ApoJ; apolipoprotein J
Featured ArticleChanges in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease
Keywords: آمیلوئید β; Alzheimer's disease; Amyloid-β; Biomarkers; Diagnosis; Pittsburgh compound B; Positron emission tomography;
Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
Keywords: آمیلوئید β; Alzheimer's Disease; Amyloid-β; BACE-1; Leptin; NF-κB; SIRT1;
Regular ArticleIntranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice
Keywords: آمیلوئید β; Alzheimer disease; 3xTg-AD mice; Intranasal insulin; Brain insulin signaling; Glucose transporters; Synaptic proteins; Amyloid-β;
N-truncation and pyroglutaminylation enhances the opsonizing capacity of Aβ-peptides and facilitates phagocytosis by macrophages and microglia
Keywords: آمیلوئید β; Aβ; amyloid-β; AD; Alzheimer's disease; APP; amyloid precursor protein; BSA; bovine serum albumin; CNS; central nervous system; DAMP; damage-associated molecular pattern; DAPI; 4â²,6-diamidino-2-phenylindole; E. coli; Escherichia coli; EDTA; ethylene
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology
Keywords: آمیلوئید β; Amyloid-β; APP; Tau; Tangles; Insulin resistance; Diabetes;
Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells
Keywords: آمیلوئید β; AMD; amyloid-β; NF-κB; vinpocetine; RPE; inflammasome; cytokine;
Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease
Keywords: آمیلوئید β; Temsirolimus (PubChem CID: 6918289); 3-Methyladenine (PubChem CID: 1673); Alzheimer's disease; Temsirolimus; Autophagy; Amyloid-β; Spatial cognitive deficits;
Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease
Keywords: آمیلوئید β; Alzheimer's disease; Amyloid-β; Niemann-Pick type C disease; NPC1; Tau; Cholesterol; Lipids;
Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D
Keywords: آمیلوئید β; Phosphodiesterase inhibitors; GEBR-7b; APP/PS1; Cognition; BDNF; CREB; Aβ; amyloid-β; AD; Alzheimer's disease; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CREB; cAMP response element-bindin
GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression
Keywords: آمیلوئید β; Aβ; amyloid-β; AD; Alzheimer's disease; Akt; protein kinase B; APP; amyloid precursor protein; BACE1; β-site APP-cleaving enzyme 1; BDNF; brain-derived neurotrophic factor; CGI-S; Clinical Global Impression-Severity scale; CREB; cAMP-response element
Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells
Keywords: آمیلوئید β; Aβ; amyloid-β; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; BACE1; β-site APP-cleaving enzyme-1; BCA; bicinchoninic acid; BSA; bovine serum albumin; CA; carnosic acid; CHAPS; 3-[(3-Cholamidopropyl)
High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia
Keywords: آمیلوئید β; Lewy body-associated disorders; Dementia with Lewy bodies; Alzheimer's disease; Cerebrospinal fluid; Apolipoprotein E; Amyloid-β; Positron emission tomography; Fluorodeoxyglucose-positron emission tomography; Pittsburgh compound B-positron emission
Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction
Keywords: آمیلوئید β; Alzheimer's disease; Astrocytes; Microglia; Microarray; Gene expression; Amyloid-β; Reactive glia;
A systematic review of amyloid-β peptides as putative mediators of the association between affective disorders and Alzheimer׳s disease
Keywords: آمیلوئید β; Amyloid-β; Affective disorder; Alzheimer׳s disease; CSF; Plasma; Biomarkers;
Monitoring and Assessment TechnologyThe critical need for defining preclinical biomarkers in Alzheimer's disease
Keywords: آمیلوئید β; Alzheimer's disease; Alzheimer's Disease Neuroimaging Initiative; Amyloid-β; Apolipoprotein E ε4; Asymptomatic; Cerebrospinal fluid biomarkers; Epigenomics; Metabolomics; Mild cognitive impairment; Neuroimaging biomarkers; Peripheral blood biomarkers; P
Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis
Keywords: آمیلوئید β; Alzheimer's disease; Amyloid-β; Sleep; Diurnal pattern;
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease
Keywords: آمیلوئید β; PERK; elF2α; BACE1; Amyloid-β; ATF4; CREB; Cholinergic neuron; Fear conditioning; Learning and memory; 5XFAD;
NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?
Keywords: آمیلوئید β; Aβ; amyloid-β; cPTIO; 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; DPI; diphenylene iodonium; ERK; extracellular signal-related kinase; HMGB1; high-mobility-group box 1; IFN-γ; interferon-γ; IL; interleukin; iNOS; inducible nitri
Açaà (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro
Keywords: آمیلوئید β; AçaÃ; Amyloid-β; Cyanidin rutinoside; Cyanidin glucoside; Gallic acid; Oxidative stress;
Caspr interaction with Amyloid Precursor Protein reduces amyloid-β generation in vitro
Keywords: آمیلوئید β; Contactin associated protein; Alzheimer's disease; Amyloid-β; Amyloid Precursor Protein; Neurodegenerative disease;
Correlation of Aβ oligomer levels in matched cerebrospinal fluid and serum samples
Keywords: آمیلوئید β; Amyloid-β; Oligomer; Matched serum and CSF; ELISA; Heterophilic antibody;
Formation of non-toxic Aβ fibrils by small heat shock protein under heat-stress conditions
Keywords: آمیلوئید β; AD; Alzheimer's disease; SPs; senile plaques; NFTs; neurofibrillary tangles; CAA; cerebrovascular amyloid angiopathy; Aβ; amyloid-β peptides; sHsp; small heat shock protein; SpHsp16.0; sHsp from fission yeast Schizosaccharomyces pombe; Amyloid-β; Amy
PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
Keywords: آمیلوئید β; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; 4EBP1; eukaryotic translation initiation factor 4E (eIF-4E)-binding protein-1; FOXO; Forkhead box-O class transcription factors; FMRP; Fragile-X mental retardation protein; GSK3β;
Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Aβ1-42 in mice novel object and object location recognition tasks
Keywords: آمیلوئید β; Neuropeptide S; Recognition memory; NMDA; Cholinergic; Amyloid-β; Aβ; amyloid-β; Ach; acetylcholine; AD; Alzheimer disease; DI; discrimination index; i.c.v; intracerebroventricular; i.p; intraperitoneally; NMDAR; N-methyl-d-aspartate receptor; NOR; nov
Protective effects of EphB2 on Aβ1-42 oligomer-induced neurotoxicity and synaptic NMDA receptor signaling in hippocampal neurons
Keywords: آمیلوئید β; Aβ; amyloid-β; AD; Alzheimer's disease; CREB; cAMP response element binding protein; DIV; days in vitro; FBS; fetal bovine serum; hAPP; human amyloid precursor protein; LDH; lactate dehydrogenase; LTP; long-term potentiation; MAPK; mitogen-activated p
Axon degeneration is key component of neuronal death in amyloid-β toxicity
Keywords: آمیلوئید β; Amyloid-β; Nmnat; Axon degeneration; Bcl-xl; Alzheimer's;
Intersite variability of CSF Alzheimer's disease biomarkers in clinical setting
Keywords: آمیلوئید β; Alzheimer's disease; Amyloid-β; Biomarkers; Cerebrospinal fluid; Tau; Variability;
Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms
Keywords: آمیلوئید β; Alzheimer's disease; Drosophila; Copper; Amyloid-β; Neurodegeneration; High-affinity copper importer; Ctr1; DmATP7;
Time course study of Aβ formation and neurite outgrowth disruption in differentiated human neuroblastoma cells exposed to H2O2: Protective role of autophagy
Keywords: آمیلوئید β; AD; Alzheimer's disease; Aβ; Amyloid-β; AO/EB; acridine orange/ethidium bromide; Atg; autophagy related-gene; ECL; electrochemiluminescence; FBS; fetal bovine serum; H2O2; hydrogen peroxide; 3MA; 3-methyladenine; LC3B; microtubule-associated protein l
Amyloid-β oligomer detection by ELISA in cerebrospinal fluid and brain tissue
Keywords: آمیلوئید β; Alzheimer's disease; Amyloid-β; Oligomers; ELISA; Brain tissue; CSF; Heterophilic antibodies;
Involvement of small GTPase RhoA in the regulation of superoxide production in BV2 cells in response to fibrillar Aβ peptides
Keywords: آمیلوئید β; Amyloid-β; BV2; Microglia; RhoA GTPase; Superoxide;
Dose-dependent folic acid and memantine treatments promote synergistic or additive protection against Aβ(25-35) peptide-induced apoptosis in SH-SY5Y cells mediated by mitochondria stress-associated death signals
Keywords: آمیلوئید β; Aβ(25-35); amyloid-β; AD; Alzheimer's disease; AV; annexin-V-FITC; CCCP; carbonyl cyanide 3-chlorophenylhydrazone; COX; cytochrome c oxidase; DCFH-DA; 2â²,7â²-dichlorodihydrofluorescin diacetate; DCF; 2â²,7â²-dichlorofluorescin; FA; folic acid;
Cardiotrophin-1 (CTF1) ameliorates glucose-uptake defects and improves memory and learning deficits in a transgenic mouse model of Alzheimer's disease
Keywords: آمیلوئید β; AD; Alzheimer's disease; Aβ; amyloid-β; CTF1; Cardiotrophin-1; FDG; Fluoro-2-deoxy-d-glucose; GSK-3β; Glycogen synthase kinase-3β; GLUT-1; glucose transporter-1; GLUT-3; glucose transporter-3; PET; positron emission tomography; CTF1; APPswe/PS1dE9; Tr
Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in Aβ production
Keywords: آمیلوئید β; Alzheimer's disease; Oxidative stress; Amyloid-β; DNA methylation; Histone acetylation; Nuclear factor-κB; Specific protein-1; SH-SY5Y cell;
Prazosin, an α1-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease
Keywords: آمیلوئید β; Alzheimer's disease; Amyloid-β; Adrenergic receptors; Inflammation; Prazosin; γ-Secretase; Mouse brain;
Potential therapeutic applications of differentiated induced pluripotent stem cells (iPSCs) in the treatment of neurodegenerative diseases
Keywords: آمیلوئید β; Aβ; amyloid-β; AD; Alzheimer's disease; ALS; amyotrophic Lateral Sclerosis; APP; amyloid precursor protein; BDNF; brain-derived neurotrophic factor; BM-MSCs; bone marrow-derived MSCs; DNA; deoxyribonucleic acid; EBs; embryoid bodies; ESC; embryonic st
Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease
Keywords: آمیلوئید β; Phosphodiesterase inhibitors (PDEIs); Alzheimer's disease (AD); Cognition; CREB; BDNF; APPswe/PS1dE9; Aβ; amyloid-β; AC; adenylate cyclase; AD; Alzheimer's disease; BDNF; brain-derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; cGMP; cyc
Reduction of cerebral Aβ burden and improvement in cognitive function in Tg-APPswe/PSEN1dE9 mice following vaccination with a multivalent Aβ3-10 DNA vaccine
Keywords: آمیلوئید β; Alzheimer's disease; Amyloid-β; DNA vaccine; C3d-p28 molecular adjuvant;
Utilization of a multiple antigenic peptide as a calibration standard in the BAN50 single antibody sandwich ELISA for Aβ oligomers
Keywords: آمیلوئید β; Amyloid-β; Alzheimer's disease; Oligomer; Multiple antigenic peptide; ELISA;
Regular ArticleThe effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes
Keywords: آمیلوئید β; Astrocytes; Amyloid-β; Clearance; Neprilysin; Insulin-degrading enzyme; MMP-9; SCARB1; MARCO; Megalin; LRP2;
Featured ArticleCardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative
Keywords: آمیلوئید β; Alzheimer disease; Vascular risk factors; PiB; Amyloid-β; Cortisol; Blood pressure; Body mass index;
Grey matter volume correlates of cerebrospinal markers of Alzheimer-pathology in Parkinson's disease and related dementia
Keywords: آمیلوئید β; Parkinson's disease; Dementia; Grey matter volume; Magnetic resonance imaging; Cerebrospinal fluid; Ï; Amyloid-β;