Keywords: AO، آکاردین نارنجی; AO, acridine orange; 9AA, 9-amino acridine; HHb, human hemoglobin; UV, ultra violet; CD, circular dichroism; FTIR, Fourier transform infrared spectroscopy; ITC, isothermal titration calorimetryAcridine dyes; Dye–protein association; Spectroscopy; Calorime
مقالات ISI AO، آکاردین نارنجی (ترجمه نشده)
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Keywords: AO، آکاردین نارنجی; ER, endoplasmic reticulum; UPR, Unfolded Protein Response; AO, acridine orange; LC3, microtubule-associated protein 1 light chain 3; ERAD, ER associated degradation; XBP1, X-box binding protein 1; IRE1, inositol-requiring enzyme-1; PERK, pancreatic eIF2 k
Keywords: AO، آکاردین نارنجی; Anti-cancer; Drug resistance-reversing effects; Membrane-disruption; Peptides5-Fu, 5-fluorouracil; ADM, adriamycin; AMPs, antimicrobial peptides; AO, acridine orange; DMSO, dimethyl sulfoxide; EB, ethidium bromide; FBS, fetal bovine serum; FITC, fluoresce
Keywords: AO، آکاردین نارنجی; Annexin V–FITC, Recombinant annexin V conjugated to fluorescein isothiocyanate; AO, Acridine orange; APAF-1, Apoptosis activating factor-1; ATM, Ataxia telangiectasia mutated gene; ATR, Attainable total reflectance; BAX, BCL-2 associated X protein; BCL-2,
Keywords: AO، آکاردین نارنجی; AO, acridine orange; CaP, caudal primary; DNP, 2,4-dinitrophenol; FCCP, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; GCL, ganglion cell layer; hpf, hours post-fertilization; INL, inner nuclear layer; L, lens; N, neural tube; N, notochord; PL, pho
Keywords: AO، آکاردین نارنجی; AO, acridine orange; CA, chromosomal aberrations; CBMN, cytokinesis-block micronucleus assay; DMSO, dimethyl sulfoxide; EtBr, ethidium bromide; GSH, glutathione; GPx, glutathione peroxidise; HLP, haloperidol; HPBL, human peripheral blood lymphocyte; LMP,
Keywords: AO، آکاردین نارنجی; ADSA, axisymmetric drop shape analysis; UV–vis, ultraviolet-visible; DRUV, diffuse reflectance at the UV–vis; PDT, photodynamic therapy; GPI, glycosylphosphatidylinositol; SDS, sodium dodecylsulfate; AO, acridine orange; TNAP, tissue-nonspecific alkaline
The cytotoxic and pro-apoptotic effects of phenylephrine on corneal stromal cells via a mitochondrion-dependent pathway both in vitro and in vivo
Keywords: AO، آکاردین نارنجی; AIF, apoptosis-inducing factor; ANOVA, analysis of variance; AO, acridine orange; CCT, central corneal thickness; Cyt. c, cytochrome c; DMEM/F12 medium, Dulbecco’s modified Eagle medium Ham’s nutrient mixture F-12 (1:1); DMSO, dimethyl sulfoxide; EB, ethi
TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo
Keywords: AO، آکاردین نارنجی; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer; CGs, cardiac glycosides; SJ, Streptocaulon juventas; MTT, 3-(4,5-dimethylibiazol-2-yl)-2,5-diphenyl-tetrazolium bromide; AO, acridine orange; PI, propidium iodide; i.v., intravenous; LTXA9,
UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma
Keywords: AO، آکاردین نارنجی; UA, ursolic acid (3b-hydroxy-urs-12-en-28-oic acid); 2-DG, 2-deoxy-d-glucose; GK, glucokinase; GLUT1, glucose transporter 1; AO, acridine orange; DAPI, 4, 6-diamidino-2-phenylindole; PI, propidium iodide; TBDMSCl, tert-butyl dimethyl chlorosilane; 2MP, 2-
Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice
Keywords: AO، آکاردین نارنجی; AO, acridine orange; AP, apical; BL, basolateral; BW, body weight; CAT, catalase; DHA, docosahexaenoic acid; EB, ethidium bromide; EPA, eicosapentaenoic acid; GSH, glutathione; PL, phospholipids; PUFAs, polyunsaturated fatty acids; ROS, reactive oxygen sp
Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway
Keywords: AO، آکاردین نارنجی; α-SMA, α-smooth muscle actin; ALT, alanine aminotransferase; AMPK, AMP-activated protein kinase; AST, aspartate aminotransferase; AO, acridine orange; AVO, acidic vesicular organelles; CCl4, carbon tetrachloride; DCFH-DA, 2′,7′-dichlo-rofluore-scein diace
Synthesis and characterisation of morin reduced gold nanoparticles and its cytotoxicity in MCF-7 cells
Keywords: AO، آکاردین نارنجی; AO, acridine orange; AuNPs, gold nanoparticles; ctAuNPs, citrate reduced AuNPs; DDSA, dodecenyl succinic acid; DMEM, Dulbecco’s modified Eagles medium; DLS, dynamic light scattering; DMSO, Dimethylsulphoxide; EGCG, epigallocatechin gallate; EtBr, ethidium
Critical roles for nitric oxide and ERK in the completion of prosurvival autophagy in 4OHTAM-treated estrogen receptor-positive breast cancer cells
Keywords: AO، آکاردین نارنجی; 4OHTAM, 4-hydroxytamoxifen; AO, acridine orange; DAF-FAM, 4-Amino-5-methylamino-2',7'-difluorofuorescein diacetate; DHE, dihydroethidium; ERK, extracelluar signal-regulated kinase; ER, estrogen receptor; HO-1, heme oxygenase-1; eNOS, endothelial nitric ox
Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol
Keywords: AO، آکاردین نارنجی; AOH, alternariol; AO, acridine orange; AMPK, AMP-activated protein kinase; ATM, ataxia telangiectasia mutated; SA-β-Gal, senescence-associate-β-galactosidase; BSA, bovine serum albumin; ConA, concanamycin A; CQ, chloroquine; DMEM, Dulbecco’s modified eagl
Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells
Keywords: AO، آکاردین نارنجی; AIF, apoptosis inducing factor; ABTS, 2, 2′-Azino-di-3-ethylbenzthiazoline sulfonate (6) diammonium salt; AO, acridine orange; BH, Bcl-2 homology; CDK, cyclindependent kinase; DiOC6, 3,3′-dihexyloxacarbocyanine iodide; DMSO, dimethylsulfoxide; HRP, horser
Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells
Keywords: AO، آکاردین نارنجی; AO, acridine orange; AI, apoptotic index; AP-1, activated protein-1; CI, combination index; BL EthOH, Ethanolic extract of Leaf; DCFH2-DA, 2,7-dichlorofluorescein diacetate; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulphoxide; EB, ethidium
Comparative toxicity and apoptosis induced by diorganotins in rat pheochromocytoma (PC12) cells
Keywords: AO، آکاردین نارنجی; AIF, apoptosis-inducing factor; Apaf-1, apoptotic protease activation factor 1; AO, acridine orange; Cyt c, cytochrome c; DCF, dichlorofluorescein; DCFH, dichlorofluorescein; DCFH-DA, 2′,7′-dichlorofluorescein-diacetate; DMEM, Dulbecco’s modified Eagle’s
TNF-α-stimulated macrophages protect A549 lung cells against iron and oxidation
Keywords: AO، آکاردین نارنجی; AMs, alveolar macrophages; AMC, 7-amino-4-methyl-coumarin; AO, acridine orange; DFO, deferoxamine; ELF, epithelial lining fluid; GAPDH, glycerylaldehyde-3-phosphate dehydrogenase; γ-GCS, γ-glutamylcysteine synthetase; GO, glucose oxidase; GSH, reduced glu
Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma
Keywords: AO، آکاردین نارنجی; RSV, Resveratrol, 3,4′,5-trihydroxy-trans-stilbene; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; DAPI, 4′,6-diamidino-2-phenylindole; MDC, monodansylcadaverine; 3-MA, 3-methyladenine; AVOs, autophagic vacuoles; AO, acridine orange; Z
Cardamonin exerts potent activity against multiple myeloma through blockade of NF-κB pathway in vitro
Keywords: AO، آکاردین نارنجی; AO, acridine orange; Bcl-2, B-cell lymphoma-2; Bcl-xL, B-cell lymphoma-xL; CCK-8, Cell Counting Kit-8 assay kit; EB, ethidium bromide; cIAP, cellular inhibitor of apoptosis; ECL, enhanced chemiluminescenece; IκBα, Ikappa-B alpha; IKK, IκB kinase; MM, mult
Synthesis, characterization, cytotoxicity, apoptotic inducing activity, cellular uptake, interaction of DNA binding and antioxidant activity studies of ruthenium(II) complexes
Keywords: AO، آکاردین نارنجی; APIP, 2-(2-aminophenyl)imidazo[4,5-f][1,10]phenanthroline; HAPIP, 2-(2-hydroxyl-5-aminophenyl)imidazo[4,5-f][1,10]phenanthroline; CT DNA, calf thymus DNA; bpy, 2,2′-bipyridine; AO, acridine orange; EB, ethidium bromide; DMSO, dimethylsulfoxide; RPMI, Rosw
CD40-mediated cell death requires TRAF6 recruitment
Keywords: AO، آکاردین نارنجی; AO, acridine orange; AP-1, activator protein-1; APCs, antigen presenting cells; AV, annexin V; db, disulfide bond; ERK, extracellular signal-regulated kinase; Jak3, Janus kinase 3; JNK, c-Jun NH2-terminal kinase; LMP, lysosomal membrane permeabilization;
N1-(quinolin-2-ylmethyl)butane-1,4-diamine, a polyamine analogue, attenuated injury in in vitro and in vivo models of cerebral ischemia
Keywords: AO، آکاردین نارنجی; AIF, apoptosis inducing factor; AO, acridine orange; CNS, central nerver system; CNQX, 6-cyano-7-nitroquinoxaline-2,3-dione; DCF-DA, 2′,7′-dichlorofluorescein diacetate; DMEM, Dulbecco's modified eagle's medium; EB, ethidium bromide; Glu, glumate; GSH-px,
Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization
Keywords: AO، آکاردین نارنجی; AhR, aryl hydrocarbon receptor; AO, acridine orange; Ac-DEVD-AMC, acetyl-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin; AMC, 7-amino-4-methylcoumarin; C11, C11-BODIPY581/591 or 4,4-difluoro-5-(4-phenyl-1,3,butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoic
Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes
Keywords: AO، آکاردین نارنجی; AO, acridine orange; DHE, dihydroethidium; EtBr, ethidium bromide; 2-OH-E+, 2-hydroxyethidium; FITC, fluorescein isothiocyanate; GSH, glutathione (reduced); GSSG, glutathione (oxidized); HPLC, high-performance liquid chromatography; JC-1, 5,5′,6,6′-tetrac
Anticancer drug 5-fluorouracil induces reproductive and developmental defects in Caenorhabditis elegans
Keywords: AO، آکاردین نارنجی; 5-FU, 5-fluorouracil; AO, acridine orange; BER, base excision repair; DAPI, 4′6-diamidino-2-phenylindole; DDR, DNA damage response; DPD, dihydropyrimidine dehydrogenase; FdUMP, fluorodeoxyuridine monophosphate; FdUTP, fluorodeoxyuridine triphosphate; FUMP
UV-B overexposure induces programmed cell death in a BY-2 tobacco cell line
Keywords: AO، آکاردین نارنجی; AO, acridine orange; DAPI, 4′,6-diamidino-2-phenylindole; FDA, fluorescein diacetate; PBS, phosphate buffered saline; PI, propidium iodide; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; UV-B, ultraviolet B; UV-C, ultraviolet CProgra
Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution
Keywords: AO، آکاردین نارنجی; AO, acridine orange; B[a]P, benzo[a]pyrene; CI, confidence interval; c-PAHs, carcinogenic polycyclic aromatic hydrocarbons; CYP1A1, cytochrome P-450 1A1; detDFI, detectable DFI; DFI, DNA fragmentation index; dsDNA, double strand DNA; EPHX1, epoxide hydrol
Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones
Keywords: AO، آکاردین نارنجی; CQ, chloroquine; IC50, half-maximum inhibitory concentration; ROS, reactive oxygen species; FP IX, ferri/ferroprotoporphyrin IX; IDC, intraerythrocytic developmental cycle; GSH, reduced glutathione; GSSG, glutathione disulphide; AO, acridine orange; EtBr,
Autophagy induction by the 30–100 kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species
Keywords: AO، آکاردین نارنجی; AIAI, autophagy-inducing AN ingredient; AN, areca nut; ANE, areca nut extract; AO, acridine orange; BQ, betel quid; BQE, betel quid extract; CE81T/VGH, human esophageal carcinoma cells; CMT415, primary culture of normal human oral fibroblasts; IC50, 50% i
TNF-alpha preserves lysosomal stability in macrophages: A potential defense against oxidative lung injury
Keywords: AO، آکاردین نارنجی; AMs, alveolar macrophages; AMC, 7-amino-4-methyl-coumarin; AO, acridine orange; ELF, epithelial lining fluid; EPR, electron paramagnetic resonance; GAPDH, glycerylaldehyde-3-phosphate dehydrogenase; γ-GCS, γ-glutamylcystein synthetase; GO, glucose oxidase
Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112
Keywords: AO، آکاردین نارنجی; AO, acridine orange; DiFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate; DiFMU, 6,8-difluoro-4-methylumbelliferone; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; dox, doxycycline; DTT, dithiothreitol; EB, Ethidium bromide; EGF, epid
Inhibition of LPS-induced apoptosis in differentiated-PC12 cells by new triazine derivatives through NF-κB-mediated suppression of COX-2
Keywords: AO، آکاردین نارنجی; Alzheimer's disease; COX-2; LPS; NF-κB; PC12 cells; 1,2,4-triazine derivativesAD, Alzheimer's disease; ANN, artificial neural network; AO, acridine orange; BBB, blood–brain barrier; CNS, central nervous system; CSBP, plasma protein binding ratio; COX, cyc
Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: Mediation by the mitochondrial pathway
Keywords: AO، آکاردین نارنجی; AO, acridine orange; EAF, EPEC adherence factor; FASL, FAS ligand; FBS, fetal bovine serum; FITC, fluorescein isothiocyanate; LB, lysogeny broth; MIB, mitochondrial isolation buffer; MRS, de Man-Rogosa-Sharp broth; PBS, phosphate buffered saline; RT, room
Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications
Keywords: AO، آکاردین نارنجی; 5-FU, 5-fluorouracil; AFM, atomic force microscopy; AO, acridine orange; BMP, 2-bone morphogenetic protein-2; BSA, bovine serum albumin; CaP, calcium phosphate; CdSe, cadmium selenide; CMC, carboxymethyl chitin; DA, degree of acetylation; DD, degree of de
Sperm head defects and disturbances in spermatozoal chromatin and DNA integrities in idiopathic infertile subjects: Association with cigarette smoking
Keywords: AO، آکاردین نارنجی; AO, acridine orange; ROS, reactive oxygen species; DFI, DNA fragmentation index; SCSA, sperm chromatin structure assay; FCM, flow cytometry; LPO, lipid peroxidation; TBARS, malondialdehyde; SOD, superoxide dismutase; CAT, catalase; GSH, reduced glutathion
Plasmodium falciparum: Development and validation of a measure of intraerythrocytic growth using SYBR Green I in a flow cytometer
Keywords: AO، آکاردین نارنجی; Als, Alsever’s solution; ANOVA, multifactrial analysis of variance; AO, acridine orange; CQ, chloroquine; CRPMI, basal medium; EC50, concentrations inhibiting schizont formation by 50%; FCM, flow cytometry; FSC, forward scatter; GFS, a growth-promoting fr
Radiomodifying and anticlastogenic effect of Zingerone on Swiss albino mice exposed to whole body gamma radiation
Keywords: AO، آکاردین نارنجی; AO, acridine orange; FCS, fetal calf serum; MN, micronuclei; PCE, polychromatic erythrocytes; NCE, normochromatic erythrocytes; ROS, reactive oxygen species; ZO, ZingeroneZingerone; Radioprotection; Micronuclei; Lipid peroxidation
Cholesterol secoaldehyde induces apoptosis in H9c2 cardiomyoblasts through reactive oxygen species involving mitochondrial and death receptor pathways
Keywords: AO، آکاردین نارنجی; AO, acridine orange; BSO, dl-buthionine sulfoximine; C3I, caspase-3 inhibitor; C8I, caspase-8 inhibitor; C9I, caspase-9 inhibitor; ChSeco, cholesterol secoaldehyde or 3β-hydroxy-5-oxo-5,6-secocholestan-6-al; CM-H2DCFDA, 5-(and-6)-chloromethyl-2′,7′-dichlo
Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells
Keywords: AO، آکاردین نارنجی; Ac-DEVD-AMC, acetyl-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin; AO, acridine orange; BH, Bcl-2 homology; CPT, 20-S-camptothecin lactone; EF, error factor; ER, endoplasmic reticulum; FC, fold change; iTRAQ, isobaric tag for relative and absolute quantitation
Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis
Keywords: AO، آکاردین نارنجی; AO, acridine orange; DMSO, dimethylsulfoxide; DPH, 1,6-diphenyl-1,3,5-hexatriene; FLICA, fluorochrome-labelled inhibitor of caspases; 7KC, 7-Ketocholesterol; MC540, merocyanine 540; 3MA, 3-methyladenine; MDC, monodansylcadaverine; NR, Nile Red; PDK-1, 3′P
Anti-clastogenic effect of magnolol on benzo(a)pyrene-induced clastogenicity in mice
Keywords: AO، آکاردین نارنجی; B(a)P, benzo(a)pyrene; IQ, 2-amino-3-methylimidazo[4,5-f]quinoline; Glu-P-2, 2-aminodipyrido[1,2-a:3′,2′-d]imidazole; 2AA, 2-aminoanthracene; DMBA, 7,12-dimethylbenz[a]anthracene; AO, acridine orange; UGT, UDP-glucuronosyltransferase; GST, glutathione-S-t
Cytotoxic effects of crotamine are mediated through lysosomal membrane permeabilization
Keywords: AO، آکاردین نارنجی; Toxin; Crotamine; Lysosome; Cellular uptake; Cell-penetrating peptides; Highly proliferative cells; Protease; CytotoxicityCPP, Cell penetrating peptide; AO, Acridine orange; CHO, Chinese hamster ovary; Cy3-crotamine, Cy3-conjugated crotamine; FITC-crotami
Oxidative stress causes a decline in lysosomal integrity during hypothermic incubation of rat hepatocytes
Keywords: AO، آکاردین نارنجی; AO, acridine orange; C11-BODIPY, 4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid; DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride, hydrate; DFO, desferrioxamine mesylate; DPD, 2,2′-dipyridyl; FITC-DFO, fluoresc
The herb medicine formula “Yang Wei Kang Liu” improves the survival of late stage gastric cancer patients and induces the apoptosis of human gastric cancer cell line through Fas/Fas ligand and Bax/Bcl-2 pathways
Keywords: AO، آکاردین نارنجی; YWKLF, formula “Yang Wei Kang Liu”; Sub-F1, Sub-Formula 1; Sub-F2, Sub-Formula 2; Sub-F3, Sub-Formula 3; AgNORs, argyrophilic nucleolar organizer regions; AO, acridine orange; Δ ψm, mitochondrial membrane potential.Herb medicine; Serum pharmacology; Apopt
Central role of mitochondria and p53 in PUVA-induced apoptosis in human keratinocytes cell line NCTC-2544
Keywords: AO، آکاردین نارنجی; ANG, Angelicin; AO, acridine orange; 5-MOP, 5-methoxypsoralen; 8-MOP, 8-methoxypsoralen; Δψmt, mitochondrial potential; HBSS, Hank's balanced salt solution; HE, hydroethidine; ICL, interstrand cross-link; MDM2, murine double minute; NAO, 10-N-nonyl-acridi
Roles of basic residues and salt-bridge interaction in a vacuolar H+-pumping pyrophosphatase (AVP1) from Arabidopsis thaliana
Keywords: AO، آکاردین نارنجی; AO, acridine orange; DCCD, dicyclohexylcarbodiimide; EGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid; PVDF, polyvinylidiene difluoride; TMD, transmembrane domainArabidopsis thaliana; AVP1; Proton pump; V-PPase; Salt bridge; Site-d
Morphological study on apoptosis Hela cells induced by soyasaponins
Keywords: AO، آکاردین نارنجی; TEM, transmission electron microscope; CLSM, confocal laser scanning microscope; FCS, fetal calf serum; DMSO, dimethyl sulphoxide; AO, acridine orange; EB, ethidium bromide; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PBS, phosphate
Proteomic changes of PC12 cells treated with proteasomal inhibitor PSI
Keywords: AO، آکاردین نارنجی; ACN, acetonitrile; AO, acridine orange; AR, aldose reductase; 2-D DIGE, 2-dimensional difference gel electrophoresis; 2-DE, two-dimensional electrophoresis; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulphoxide; DTT, dithiothreitol; EB, ethi