Oscillation of apoptosome formation through assembly of truncated Apaf-1
Keywords: Apaf-1; Programed cell death; Split luciferase complementary assay; Caspase activity; Apoptosis
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BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion
Keywords: AIF; apoptosis inducible factor; AP-1; activator protein-1; AKT; protein kinase B; Apaf-1; apoptosis protease activating factor-1; BAD; Bcl-2-associated death promoter; BCL-2; B-cell lymphoma 2; BCLxL; B-cell lymphoma-extra large; BH3; Bcl-2 homology doma
Angiotensin II-induced mouse hippocampal neuronal HT22 cell apoptosis was inhibited by propofol: Role of neuronal nitric oxide synthase and metallothinonein-3
Keywords: Ang II; angiotensin II; APAF-1; apoptotic protease activating factor-1; AT1R; angiotensin type 1 receptor; AT2R; angiotensin type 2 receptor; Bcl-2; B-cell lymphoma-2; BID; BH3-interacting domain; cIAP-1; cellular inhibitor of apoptosis protein-1; c-FLIP;
Pathophysiology of the hepoxilins
Keywords: AA; arachidonic acid; AMG9810; (2E)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide; Apaf-1; Apoptotic protease activating factor 1; BAPTA; 1,2-Bis(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid; CCCP; carbonyl cya
Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells
Keywords: ALR; AIM2-like receptor; Apaf-1; apoptotic protease activating factor 1; ASC; apoptosis-associated speck-like protein containing a CARD; Bad; Bcl-2-associated death promoter; CLSM; confocal laser scanning microscope; CPF; chlorpyrifos; Cyt c; cytochrome c
Caspase-9 activation and Apaf-1 cleavage by MMP-3
Keywords: Matrix metalloproteinase-3; Apaf-1; Caspase-9; Apoptosis
Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax
Keywords: Apaf-1; Apoptotic protease activating factor 1; cb5; cytochrome b5; polyQ79, polyQ82; polyglutamine repeats containing proteins with 79 or 82 glutamine residues; xbp-1; x-box binding protein 1; FRET; fluorescence resonance energy transfer; Polyglutamine e
The roles of DNA damage-dependent signals and MAPK cascades in tributyltin-induced germline apoptosis in Caenorhabditis elegans
Keywords: ANOVA; analysis of variance; AO; acridine orange; Apaf-1; apoptotic protease-activating factor-1; ASK; apoptosis signal-regulating kinase; BH3; Bcl-2 homology region 3; DAPI; 4â²,6-diamidino-2-phenylindole; DDR; DNA damage response; DMSO; dimethyl sulfox
Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide
Keywords: Apaf-1; apoptosis protease activating factor-1; BSA; bovine serum albumin; BSO; buthionine-[S,R]sulfoximine; CA-AM; calcein-acetoxymethyl ester; CA-Fe; CA-bound iron; CM; conditioned media; DFO; desferrioxamine mesylate; DMSO; dimethyl sulfoxide; DPBS; Du
Associate editor: N. FrossardHeat shock proteins in fibrosis and wound healing: Good or evil?
Keywords: Fibrogenesis; HSP; TGF-β1 signaling; EMT; 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; AP-1; Activator protein 1; Apaf-1; Apoptotic protease-activating factor 1; CHIP; Carboxyl terminus of Hsc70-interacting protein; CsA; Cyclosporine A; ECM; Extrace
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
Acidosis blocks CCAAT/enhancer-binding protein homologous protein (CHOP)- and c-Jun-mediated induction of p53-upregulated mediator of apoptosis (PUMA) during amino acid starvation
Keywords: AAR; amino acid response; Apaf-1; apoptotic protease-activating factor-1; ATF; activating transcription factor; Bcl-2; B cell lymphoma-2; Bax; Bcl-2-associated X protein; Bim; Bcl-2-interacting mediator of cell death; CHOP; CCAAT/enhancer-binding protein
Relevance of signaling molecules for apoptosis induction on influenza A virus replication
Keywords: Akt; v-akt murine thymoma viral oncogene homolog 1; Apaf-1; apoptotic protease activating factor 1; Bax; Bcl-2-associated x protein; Bcl-2; B-cell lymphoma 2; BH; Bcl-2 homology; Caspases; cysteine-aspartic acid protease; DAP3; death-associated protein
Cytotoxicity and modes of action of four Cameroonian dietary spices ethno-medically used to treat Cancers: Echinops giganteus, Xylopia aethiopica, Imperata cylindrica and Piper capense
Keywords: Apaf-1; apoptotic protease activating factor-1; ATP; adenosine triphospahte; CC; column chromatography; DCF; dichlorofluorescein; DCM; dichloromethane; ddH2O; double distilled water; DMSO; dimethylsufoxide; E. giganteus; Echinops giganteus; H2DCF; 2â²,7â
PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins
Keywords: PSAP; presenilin-associated protein; PARP; poly(ADP-ribose) polymerase; Bcl-2; B-cell lymphoma 2; LacZ; β-galactosidase; Z-VAD-fmk; benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone; FADD; Fas-associated death domain; DISC; death-inducing signaling comple
Mitochondrial dysfunction in the hippocampus of rats caused by chronic oxidative stress
Keywords: Apaf-1; apoptosis protease-activating factor; Bcl-2; B-cell lymphoma; BSA; bovine serum albumin; DDC; diethyldithiocarbamate; DNPH; 2,4-dinitrophenylhydrazine; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; eNOS; endothelia
The 5â² untranslated region of Apaf-1 mRNA directs translation under apoptosis conditions via a 5â² end-dependent scanning mechanism
Keywords: IRES; internal ribosome entry site; CITE; cap-independent translation enhancer; Apaf-1; apoptotic peptidase activating factor 1; eIF; eukaryotic initiation factor; ITAF; IRES trans-activating factor; 5â² UTR; 5â² untranslated region; nt; nucleotide; Tra
Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome
Keywords: Ac-LEHD-AFC; N-acetyl-Leu-Glu-His-Asp-(7-amino-4-trifluoromethyl coumarin); Apaf-1; apoptosis protease-activating factor-1; CL; cardiolipin; Cc; cytochrome c; CcO; cytochrome c oxidase; PC9; pro-caspase 9; RNOS; reactive nitrogen/oxygen species; Apoptosom
Caffeate derivatives induce apoptosis in COLO 205 human colorectal carcinoma cells through Fas- and mitochondria-mediated pathways
Keywords: AIF; anti-apoptosis-inducing factor; Apaf-1; anti-apoptotic protease activating factor-1; CAPE; caffeic acid phenylethyl ester; DMSO; dimethylsulphoxide; FLIP; FLICE-inhibitory protein; ÎΨm; mitochondrial membrane potential; MTT; 3-(4,5-dimethylthiazol-
The toxic effects of Aroclor 1254 exposure on the osteoblastic cell line MC3T3-E1 and its molecular mechanism
Keywords: MC3T3-E1 cell; Aroclor 1254; Cell proliferation; Apoptosis; ALP activity; ROS; TRPV6; Apaf-1;
STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1
Keywords: Apoptosis; Bcl-2; Bax; BH3 domain; Apaf-1; Apoptosome
MicroRNA expression profiling of NGF-treated PC12 cells revealed a critical role for miR-221 in neuronal differentiation
Keywords: miRNA; microRNA; 3â²-UTR; 3â²-untranslated region; AD; Alzheimer's diseases; NGF; nerve growth factor; MAPK; mitogen-activated protein kinase; DMEM; Dulbecco's modified Eagle's medium; HS; horse serum; FBS; fetal bovine serum; GEO; Gene Expression
5-epi-Sinuleptolide induces cell cycle arrest and apoptosis through tumor necrosis factor/mitochondria-mediated caspase signaling pathway in human skin cancer cells
Keywords: 5ES; 5-epi-sinuleptolide; 5-Fu; 5-fluorouracil; Apaf-1; apoptotic protease activating factor-1; BCC; basal cell carcinoma; CDK1; cyclin-dependent kinase 1; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethyl sulfoxide; FADD; Fas-associated death domain
Enriching the human apoptosis pathway by predicting the structures of protein-protein complexes
Keywords: AIF; apoptosis-inducing factor, mitochondrion-associated, 1; Apaf-1; apoptotic peptidase activating factor 1; Bax; BCL2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-XL; Bcl-extra large; Bid; BH3 interacting domain death agonist; CASP3; caspase-3; C
Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1α
Keywords: Apaf-1; apoptotic protease activating factor-1; Bcl-2; B cell lymphoma-2; Bcl-xL; B cell lymphoma-extra large; DCFH-DA; 2â²,7â²-dichlorofluorescein-diacetate; ECL; enzyme-linked chemiluminescence; FBS; fetal bovine serum; GAPDH; glyceraldehyde-3-phospha
Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases
Keywords: AD; Alzheimer's disease; AIDS; Acquired Immune Deficiency Syndrome; ALS; amyotrophic lateral sclerosis; APAF-1; apoptotic protease activating factor 1; BUGT; human bilirubin-uridine 5â²-diphosphate-glucuronosyl-transferase; CNS; central nervous system;
STRUCTURAL BIOLOGY OF THE INTRINSIC CELL DEATH PATHWAY: WHAT DO WE KNOW AND WHAT IS MISSING?
Keywords: Apoptosis; Bcl-2; Bax; BH3 domain; Apaf-1; Apoptosome;
Glutathione and modulation of cell apoptosis
Keywords: âΨ; mitochondrial membrane potential; ANT; adenine nucleotide translocase; Apaf-1; apoptotic protease-activating factor-1; ASK-1; apoptosis signal-regulating kinase-1; ATO; arsenic trioxide; AVD; apoptotic volume decrease; BSO; l-buthionine (S,R)-sulfo
Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin
Keywords: Apaf-1; Apoptosis protease-activation factor-1; BSA; Bovine Serum Albumin; CL; cardiolipin; Cc; cytochrome c; CcO; cytochrome c oxidase; CD; Circular Dichroism; DOSY; Diffusion Ordered Spectroscopy; EPR; Electron Paramagnetic Resonance; H2DCF; reduced 2â
Cytotoxic effects of geranyl flavonoid derivatives from the fruit of Artocarpus communis in SK-Hep-1 human hepatocellular carcinoma cells
Keywords: AIF; apoptosis-inducing factor; Apaf-1; apoptotic protease activating factor-1; DMSO; dimethylsulphoxide; IC50; 50% inhibitory concentration; ÎÏm; mitochondria membrane potential; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; PARP;
Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status
Keywords: Apaf-1; apoptosis-protease activating factor-1; BH; Bcl-2 homology domain; CREB; cAMP response element-binding protein; Ct; cycle threshold; GPX1; glutathione peroxidise-1; H2O2; hydrogen peroxide; IAP; inhibitor of apoptosis protein; IFN-γ; interferon-Î
The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis
Keywords: Apaf-1; apoptotic protease-activating factor 1; CcO; cytochrome c oxidase; Cytc; cytochrome c; ÎΨm; mitochondrial membrane potential; EPR; electron paramagnetic resonance; ETC; electron transport chain; OxPhos; oxidative phoshorylation; ROS; reactive ox
Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice
Keywords: AIF; apoptosis-inducing factor; Apaf-1; apoptosis peptidase-activating factor 1; Bax; Bcl-2-associated X protein; Bcl-2; B cell leukemia/lymphoma-2; CuZnSOD; copper-zinc superoxide dismutase; GPx; glutathione peroxidase; GSH; reduced glutathione; GSSG;
Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets?
Keywords: 2 DE; 2D gel electrophoresis; 2DPAGE; 2D polyacrylamide gel electrophoresis; AIF; Apoptosis inducing factor; Apaf-1; Apoptotic protease activating factor 1; APC; Antigen presenting cell; ASK-1; Apoptosis Signal-regulating Kinase 1; Bag; Bcl-2-associated a
Mechanism of tyrosine phosphorylation of procaspase-9 and Apaf-1 in cytosolic fractions of the cerebral cortex of newborn piglets during hypoxia
Keywords: Tyrosine phosphorylation; nNOS; NO; Procaspase-9; Apaf-1; Hypoxia; Newborn
Alix is involved in caspase 9 activation during calcium-induced apoptosis
Keywords: ALG-2; apoptosis-linked gene-2; Alix; ALG-2 interacting protein X; Apaf-1; apototic protease activating factor-1; BHK; baby hamster kidney; DIV; days in vitro; ER; endoplasmic reticulum; RFP; red fluorescent protein; Tg; thapsigargin; ALG-2; Apoptosis; Ce
Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells
Keywords: Aβ; beta-amyloid; AD; Alzheimer's disease; Apaf-1; apoptosis activating factor-1; APP; beta-amyloid precursor protein; ARE; antioxidant responsive element; DCF; 2â²,7â²-dichlorofluorescin; DCFH-DA; 2â²,7â²-dichlorofluorescin diacetate; EB; ethidium b
Differential regulation of caspase-9 by ionizing radiation- and UV-induced apoptotic pathways in thymic cells
Keywords: Apaf-1; apoptosis protease-activating factor; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra long; Bid; BH3 interacting domain death agonist; BSA; bovine serum albumin; CBB; Coomassie brilliant blue; DAPI; 4â²,6-Diamidino-2-phenylindole; DISC; d
The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats
Keywords: Caspase-3; cysteinyl aspartate-specific protease-3; Bcl-2; B-cell leukemia-2; Apaf-1; apoptotic protease activating factor-1; Fas; factor-associated suicide; GABA; γ-aminobutyric acid; PaO2; arterial oxygen pressure; PaCO2; arterial carbon dioxide pressu
Lipid raft connection between extrinsic and intrinsic apoptotic pathways
Keywords: APAF-1; apoptotic protease-activating factor-1; CASMER; clusters of apoptotic signaling molecule-enriched rafts; CTx; cholera toxin; DiOC6(3); 3,3â²-dihexyloxacarbocyanine iodide; DR4; death receptor 4; DR5; death receptor 5; DISC; death-inducing signali
Characterisation of a carp cell line for analysis of apoptosis
Keywords: AO; acridine orange; Apaf-1; apoptosis protease activating factor-1; CLC; carp leucocyte cell line; siRNA; small interfering RNA; UV; ultraviolet; z-VAD.fmk; benzyloxycarbonyl-Val-Ala-Asp(O-me).fluoromethylketone; Apoptosis; CLC; Cyprinus carpio; Macropha
Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection
Keywords: Apoptosis; Mitochondria membrane permeabilization; Caspase; AIF; Apaf-1; Cytochrome c; Retina;
Bacterially expressed recombinant WD40 domain of human Apaf-1
Keywords: Apoptosis; Apoptosome; Apoptotic protease activating factor-1; Apaf-1; WD40 domain
Targeting post-mitochondrial effectors of apoptosis for neuroprotection
Keywords: ABD; ATP-binding domain; AIF; apoptosis-inducting factor; ANT; adenine nucleotide translocase; Antp HD; antennapedia homeodomain; Apaf-1; apoptotic peptidase activating factor 1; BH; Bcl-2 homology; BIR; baculoviral IAP repeat; boc-D-fmk; boc-Asp(OMe)-fmk
Cell death in the injured brain: Roles of metallothioneins
Keywords: ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolyl-propionic acid; Apaf-1; apoptotic protease-activating factor 1; Atg; autophagy gene; Bak; Bcl-2-homologous antagonist/killer; Bax; Bcl-2-associated
Regulation of apoptosis by the redox state of cytochrome c
Keywords: Apaf-1; apoptosis activating factor 1; CARD; caspase recruitment domain; DTT; dithiothreitol, Hsp, heat shock protein; iNOS; inducible nitric oxide synthase, nNOS, neuronal nitric oxide synthase; XIAP; X-chromosome-linked inhibitor of apoptosis; Apoptosom
Polycystin-1 induced apoptosis and cell cycle arrest in G0/G1 phase in cancer cells
Keywords: Apoptosis; Cell cycle; Polycystin-1; Proliferation; Wnt pathway; ADPKD; autosomal dominant polycystic kidney disease; PKD1; polycystic kidney disease gene 1; LRR; leucine-rich repeats; WSC; wall integrity and stress-response component; REJ; receptor for e
Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis
Keywords: Chemoprevention; Resveratrol; Mouse skin tumors; Apoptosis; Mitochondrial pathway; APAF-1;
Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
Keywords: Apaf-1; apoptosis protease-activating factor-1; ROS; reactive oxygen species; ERK; extracellular signal-regulated kinase; NF-κB; nuclear factor-κB; IGFBP; insulin-like growth factor binding protein; PARP; poly(ADP)ribose polymerase; MDM; murine double m
Characterisation of cDNAs of key genes involved in apoptosis in common carp (Cyprinus carpio L.)
Keywords: Common carp (Cyprinus carpio L.); Apoptosis; Apaf-1; Bcl-2; Caspase-8; Mcl-1