دانلود مقالات ISI درباره APD، مدت زمان بالقوه عمل + ترجمه فارسی

Safety pharmacology in 2010 and beyond: Survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society

Keywords: APD، مدت زمان بالقوه عمل; ADRs, Adverse drug reactions; APD, Action potential duration; eIND, Exploratory Investigational New Drug Application; hERG, Human ether-a-go-go related gene; ICH, International Conference on Harmonization; IUPHAR, International Union of Pharmacological So

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Electrophysiologic basis for the antiarrhythmic actions of ranolazine

Keywords: APD، مدت زمان بالقوه عمل; Antiarrhythmic drug; Atrial fibrillation; Bradyarrhythmia; Electrophysiology; Pharmacology; Ventricular arrhythmia; Ventricular fibrillation; Ventricular tachycardiaAF, atrial fibrillation; AP, action potential; APD, action potential duration; AV, atriove

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Classifying fractionated electrograms in human atrial fibrillation using monophasic action potentials and activation mapping: Evidence for localized drivers, rate acceleration, and nonlocal signal etiologies

Keywords: APD، مدت زمان بالقوه عمل; Alternans; Atrial fibrillation; Fractionation; Monophasic action potential; Spectral analysisAF, atrial fibrillation; AFCL, atrial fibrillation cycle length; APD, action potential duration; CFAE, complex fractionated electrogram; CL, cycle length; CS, cor

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Mechanical Stretch of Atrial Myocyte Monolayer Decreases Sarcoplasmic Reticulum Calcium Adenosine Triphosphatase Expression and Increases Susceptibility to Repolarization Alternans

Keywords: APD، مدت زمان بالقوه عمل; atrial fibrillation; atrial myocyte culture; optical mapping; repolarization alternansAF, atrial fibrillation; APD, action potential duration; APD-ALT, action potential duration alternans; Ca, calcium; Ca-ALT, calcium transient alternans; PR, pacing rate;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Characterization of cardiac repolarization in the Göttingen minipig

Keywords: APD، مدت زمان بالقوه عمل; APD, action potential duration; bpm, beats per minute; CL, cycle length; ECG, electrocardiogram; ISO, isoprenaline; LA, left atrium; LV, left ventricle; MAP, monophasic action potential; MAPD, monophasic action potential duration; QTc, heart rate correcte

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Keeping the rhythm — Pro-arrhythmic investigations in isolated Göttingen minipig hearts

Keywords: APD، مدت زمان بالقوه عمل; APD, action potential duration; AV, Atrio-ventricular; BPM, beats per minute; CPA, N6-Cyclopentyladenosine; EAD, Early after-depolarization; ECG, electrocardiogram; EMw, Electro-Mechanical window; ERP, Effective refractory period; HR, Heart rate; IKr, Rap

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective

Keywords: APD، مدت زمان بالقوه عمل; Cardiac; Ryanodine receptor; Calcium/calmodulin dependent protein kinase II; Calcium; PhosphorylationACE, angiotensin converting enzyme; APD, action potential duration; RyR2, Ryanodine receptor, type 2; CaMKII, Calcium/calmodulin dependent protein kinase

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Impairment of Ubiquitin–Proteasome System by E334K cMyBPC Modifies Channel Proteins, Leading to Electrophysiological Dysfunction

Keywords: APD، مدت زمان بالقوه عمل; UPS, ubiquitin–proteasome system; cMyBPC, cardiac myosin-binding protein C; HCM, hypertrophic cardiomyopathy; APD, action potential duration; Wt, wild type; NRCM, neonatal rat cardiac myocyte; APD90, APD at 90% repolarization; Epi, subepicardial; Endo, su

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2011 سفارش ترجمه

Cellular basis for atrial fibrillation in an experimental model of short QT1: Implications for a pharmacological approach to therapy

Keywords: APD، مدت زمان بالقوه عمل; Arrhythmia; Electrophysiology; Antiarrhythmic drugs; Quinidine; IsoproterenolAF, atrial fibrillation; APD, action potential duration; APD70, action potential duration measured at 70% repolarization; APD90, action potential duration measured at 90% repolar

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Verapamil eliminates the hierarchical nature of activation frequencies from the pulmonary veins to the atria during paroxysmal atrial fibrillation

Keywords: APD، مدت زمان بالقوه عمل; Paroxysmal atrial fibrillation; Verapamil; Dominant frequency; Pulmonary vein; AtriumAF, atrial fibrillation; APD, action potential duration; BP, blood pressure; CL, cycle length; CS, coronary sinus; DAD, delayed after-depolarizations; DF, dominant freque

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Acute dronedarone is inferior to amiodarone in terminating and preventing atrial fibrillation in canine atria

Keywords: APD، مدت زمان بالقوه عمل; Atrial fibrillation; Dronedarone; Amiodarone; Antiarrhythmic agentsAAD, antiarrhythmic drugs; ACh, acetylcholine; AF, atrial fibrillation; AP, action potential; APD, action potential duration; CL, cycle length; DTE, diastolic threshold of excitation; ECG,

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation

Keywords: APD، مدت زمان بالقوه عمل; Familial atrial fibrillation; Genetics; KCNA5 channel; Tyrosine kinase; VariantsAF, atrial fibrillation; APD, action potential duration; CHO, Chinese hamster ovary cells; I-V, current-voltage; KCNA5 (Kv1.5), gene encoding cardiac ultrarapid activating del

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Dual excitation wavelength epifluorescence imaging of transmural electrophysiological properties in intact hearts

Keywords: APD، مدت زمان بالقوه عمل; Optical mapping; Near-infrared; Electrophysiology; Action potential duration; Transmural heterogeneity3D, three-dimensional; AP, action potential; APD, action potential duration; APD80, action potential duration at 80% repolarization; DI, diastolic interv

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Impact of Genetic Discoveries on the Classification of Lone Atrial Fibrillation

Keywords: APD، مدت زمان بالقوه عمل; atrial fibrillation; electrophysiology; geneticsAF, atrial fibrillation; ANP, atrial natriuretic peptide; APD, action potential duration; Cx40, connexin 40; ERP, effective refractory period; LQTS, congenital long QT syndrome

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Genotype-phenotype correlation in tissue models of Brugada syndrome simulating patients with sodium and calcium channelopathies

Keywords: APD، مدت زمان بالقوه عمل; Brugada syndrome; Phase 2 reentry; Epicardium; Premature ventricular complex; Ventricular fibrillationAP, action potential; APD, action potential duration; BS, Brugada syndrome; CL, cycle length; ECG, electrocardiogram; PVC, premature ventricular contract

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability

Keywords: APD، مدت زمان بالقوه عمل; Antiarrhythmic drugs; Atrial remodeling; Electrophysiology; Genetic models; Nav1.5AF, atrial fibrillation; APD, action potential duration; ECG, electrocardiogram; ERP, effective refractory period; LA, left atrium; LQT3, long QT syndrome type 3; LQTS, long

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Synergistic Effect of the Combination of Ranolazine and Dronedarone to Suppress Atrial Fibrillation

Keywords: APD، مدت زمان بالقوه عمل; antiarrhythmic drugs; arrhythmias; electrophysiology; pharmacology; sodium-channel blockersACh, acetylcholine; AF, atrial fibrillation; AP, action potential; APD, action potential duration; CL, cycle length; DAD, delayed afterdepolarization; DTE, diastoli

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

In Humans, Chronic Atrial Fibrillation Decreases the Transient Outward Current and Ultrarapid Component of the Delayed Rectifier Current Differentially on Each Atria and Increases the Slow Component of the Delayed Rectifier Current in Both

Keywords: APD، مدت زمان بالقوه عمل; chronic atrial fibrillation; voltage-dependent potassium channels; electrical remodeling; human myocytes; slow delayed rectifier4-AP, 4-aminopyridine; AF, atrial fibrillation; AP, action potential; APD, action potential duration; ARP, atrial refractory pe

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Early afterdepolarizations and cardiac arrhythmias

Keywords: APD، مدت زمان بالقوه عمل; Afterdepolarization; Arrhythmia; Chaos synchronization; Computer modeling; Nonlinear dynamics; Sudden cardiac death; Systems biology; Torsades de pointes; Triggered activityAP, action potential; APD, action potential duration; DI, diastolic interval; EAD,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

A novel computational model of the human ventricular action potential and Ca transient

Keywords: APD، مدت زمان بالقوه عمل; AP, Action Potential; APD, Action Potential Duration; ECC, Excitation–Contraction Coupling; SL, Subsarcolemma; SR, Sarcoplasmic Reticulum; SERCA, SR Ca-ATPase; NXC, Na–Ca exchanger; TNNP04, ten Tusscher–Noble–Noble–Panfilov model; TP06, ten Tusscher-Panfi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Chronic treatment with anabolic steroids induces ventricular repolarization disturbances: Cellular, ionic and molecular mechanism

Keywords: APD، مدت زمان بالقوه عمل; AAS, anabolic androgenic steroids; DECA, nandrolone decanoate; HRV, heart rate variability; ANS, autonomic nervous system; APD, action potential duration; Ito, transient outward K+ current; APD90, action potential duration at 90% of repolarization; APD30,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Altered Na+Currents in Atrial Fibrillation : Effects of Ranolazine on Arrhythmias and Contractility in Human Atrial Myocardium

Keywords: APD، مدت زمان بالقوه عمل; antiarrhythmia agents; atrial fibrillation; diastolic function; sodium channelsAF, atrial fibrillation; ANOVA, analysis of variance; AP, action potential; APD, action potential duration; HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; INa, Na+c

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Drug induced shortening of the QT/QTc interval: An emerging safety issue warranting further modelling and evaluation in drug research and development?

Keywords: APD، مدت زمان بالقوه عمل; APD, action potential duration; ATP, adenosine triphosphate; CRO, Contract Research Organisation, ECG, electrocardiogram; LVWP, left ventricular wedge preparation; NCE, new chemical entity; QTc, rate corrected QT interval; QT/QTc, QT and/or QTc-interval;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study

Keywords: APD، مدت زمان بالقوه عمل; Fibrosis; Fibroblasts; Conduction; Reentry; VulnerabilityCx, connexin; 3D, three-dimensional; CV, conduction velocity; 2D, two-dimensional; APD, action potential duration; F-M, fibroblast-myocyte; ERP, effective refractory period

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?

Keywords: APD، مدت زمان بالقوه عمل; APD, action potential duration; EAD, early after-depolarisation; hERG, human ether-a-go-go-related gene; HSD-1, 11β-hydroxysteroid dehydrogenase-1; IC50, 50% inhibitory concentration; IKr, rapidly activating delayed inward rectifier potassium channel; IKs

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes

Keywords: APD، مدت زمان بالقوه عمل; AP, Action Potential; APD, Action Potential Duration; APDR, Action Potential Duration Restitution; APD90, Action Potential Duration to 90% of repolarization; DI, Diastolic Interval; endo, endocardial; epi, epicardial; GKs, maximal conductance of IKs; ICaL

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Atrial-Selective Approaches for the Treatment of Atrial Fibrillation

Keywords: APD، مدت زمان بالقوه عمل; AF, atrial fibrillation; AP, action potential; APD, action potential duration; Cx, connexin; DPO, diphenylphosphine oxide; ERP, effective refractory period; IKACh, acetylcholine-regulated potassium current; IKr, rapid delayed-rectifier potassium current;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Ventricular Repolarization Restitution Properties in Patients Exhibiting Type 1 Brugada Electrocardiogram With and Without Inducible Ventricular Fibrillation

Keywords: APD، مدت زمان بالقوه عمل; ANOVA, analysis of variance; APD, action potential duration; ARI, activation recovery interval; BCL, basic drive cycle length; DI, diastolic interval; PES, programmed electrical stimulation; RVA, right ventricular apex; RVOT, right ventricular outflow tra

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Action Potential Dynamics Explain Arrhythmic Vulnerability in Human Heart Failure : A Clinical and Modeling Study Implicating Abnormal Calcium Handling

Keywords: APD، مدت زمان بالقوه عمل; calcium cycling; electrical restitution; ventricular action potentials; computer modeling; conduction velocity; T-wave alternans; sudden cardiac arrestAP, action potential; APD, action potential duration; APD90, action potential duration at 90% repolariza

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Pathophysiology and pharmacology of the cardiac “late sodium current”

Keywords: APD، مدت زمان بالقوه عمل; AP-, anthopleurin; APD, action potential duration; ATX-, anemone toxin; CaM, calmodulin; CaMK, calmodulin kinase; EADs, early afterdepolarizations; ICaL, L-type (dihydropyridine-sensitive) Ca2+ current; INa, sodium current; INaL, late component of INa; IN

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

Keywords: APD، مدت زمان بالقوه عمل; AP, action potential; APD, action potential duration; EAD, early after-depolarization; EAG, ether- à-go-go; ECG, electrocardiogram; HbetaC, Hydroxypropyl beta-cyclodextrins; hERG, human ether-à-go-go-related gene; ICH, International Conference on Harmoniz

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2008 سفارش ترجمه

Prolongation of the QTc Interval Is Seen Uniformly During Early Transmural Ischemia

Keywords: APD، مدت زمان بالقوه عمل; APD, action potential duration; ECG, electrocardiogram; IE, interval editor; LAD, left anterior descending coronary artery; LPC, lysophosphatidylcholine; MUSE, MUSE CV System; STD, ST-segment depression; STE, ST-segment elevation; TWC, T-wave change

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

T-Wave Alternans, Restitution of Human Action Potential Duration, and Outcome

Keywords: APD، مدت زمان بالقوه عمل; APD, action potential duration; DI, diastolic interval; ECG, electrocardiogram/electrocardiography; LV, left ventricle/ventricular; LVEF, left ventricular ejection fraction; MAP, monophasic action potential; RV, right ventricle/ventricular; SCA, sudden ca

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Regulation of cardiac ion channels via non-genomic action of sex steroid hormones: Implication for the gender difference in cardiac arrhythmias

Keywords: APD، مدت زمان بالقوه عمل; Long QT syndrome; Gender; Ion channel; Nitric oxide; eNOS; Sex hormoneAF-1, activation domain-1; AF-2, activation domain-2; AF-3, activation domain-3; APD, action potential duration; AR, androgen receptor; carboxy-PTIO, 2-(4-carboxyphenyl)-4,5-dihydro-4,4

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice

Keywords: APD، مدت زمان بالقوه عمل; APD, action potential duration; AC, adenylyl cyclase; cAMP, cyclic AMP; β-FNA, beta-funaltrexamine; DRG, dorsal root ganglion; GM1, monosialoganglioside; NLX, naloxone; NTX, naltrexone; nor-BNI, nor-binaltorphimine; PKA, protein kinase ANaloxone-evoked hy

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Voltage-gated potassium conductances in Gymnotus electrocytesAB

Keywords: APD، مدت زمان بالقوه عمل; potassium current; potassium channel; A-current; inward rectifier; electric organ dischargeAP, action potential; APD, action potential duration; B. pinnicaudatus, Brachyhypopomus pinnicaudatus; EO, electric organ; EOD, electric organ discharge; G. carapo,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Sarcoplasmic ATP-sensitive potassium channel blocker HMR1098 protects the ischemic heart: Implication of calcium, complex I, reactive oxygen species and mitochondrial ATP-sensitive potassium channel

Keywords: APD، مدت زمان بالقوه عمل; 5HD, 5-hydroxydecanoate; ANT, adenine nucleotide translocator; APD, action potential duration; DTT, dithiothreitol; EDP, left ventricular end diastolic pressure; Glib, glibenclamide; HMR1098, 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenylsulfonyl]-3

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Lipid-lowering therapy with statins, a new approach to antiarrhythmic therapy

Keywords: APD، مدت زمان بالقوه عمل; Statins; Cardiac arrhythmias; Atrial fibrillation; Ventricular tachyarrhythmias; Antiarrhythmic actions; Pleiotropic effectsAF, atrial fibrillation; APD, action potential duration; ApoE-/-, apolipoprotein E-deficient mice; ATP, adenosine triphosphate; [Ca

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2007 سفارش ترجمه

Sodium-Calcium Exchange Initiated by the Ca2+Transient : An Arrhythmia Trigger Within Pulmonary Veins

Keywords: APD، مدت زمان بالقوه عمل; AF, atrial fibrillation; APD, action potential duration; EAD, early afterdepolarization; INCX, inward current sodium-calcium exchange; Na-Ca, sodium-calcium; NCX, sodium-calcium exchange; PV, pulmonary vein

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

An integrated, temporal study of the behavioural, electrophysiological and neuropathological consequences of murine prion disease

Keywords: APD، مدت زمان بالقوه عمل; fAHP, fast after-hyperpolarisation; sAHP, slow after-hyperpolarisation; APD, action potential duration; APH, action potential height; fEPSP, field excitatory post synaptic potential; FV, fibre volley; LTP, long-term potentiation; MRD, maximum rate of depo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Cellular Basis for Trigger and Maintenance of Ventricular Fibrillation in the Brugada Syndrome Model : High-Resolution Optical Mapping Study

Keywords: APD، مدت زمان بالقوه عمل; AP, action potential; APD, action potential duration; APD50, action potential duration measured at 50% repolarization; BCL, basic cycle length; Brugada-ECG, coved-type ST-segment elevation; Delta-Epi interval, interval from the earliest to the latest epic

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

T-Wave Alternans and the Susceptibility to Ventricular Arrhythmias

Keywords: APD، مدت زمان بالقوه عمل; APD, action potential duration; DI, diastolic interval; ECG, electrocardiography; EPS, electrophysiologic study; HCM, hypertrophic cardiomyopathy; ICD, implantable cardioverter-defibrillator; LQTS, long QT syndrome; LV, left ventricular; LVEF, left ventri

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Human ether-a-go-go-related (HERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects

Keywords: APD، مدت زمان بالقوه عمل; 6TM, 6 transmembrane helix; AP, action potential; APD, action potential duration; EAD, early afterdepolarization; ECG, electrocardiogram; HERG, human ether-a-go-go-related gene; IC50, half-maximally inhibitory concentration; IKr, cardiac rapidly activatin

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2006 سفارش ترجمه