
Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways
Keywords: ARE، عنصر پاسخ antioxidant; AMPK, AMP-activated protein kinase; ARE, antioxidant response element; ERK, extracellular signal-regulated kinase; HO-1, heme oxygenase-1; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear erythroid factor 2 (NE-F2)-related factor 2Metformin; Nrf2