کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2581009 1561642 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advanced lipoxidation end-products
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Advanced lipoxidation end-products
چکیده انگلیسی

Chemical and nonenzymatic molecular modifications induced by reactive carbonyl species (RCS) generated by peroxidation of membrane phospholipids acyl chains play a dual role as signaling molecules and as mediators of the aging process. Cytotoxic effects of RCS are due to their capacity to react with cellular constituents, forming advanced lipoxidation end-products (ALEs). Reactive carbonyl compounds are stable and can diffuse within or even escape from the cell and attack targets far from the site of formation. The consequent loss of function and structural integrity of modified biomolecules can have a wide range of downstream functional consequences and may be the cause of subsequent cellular dysfunctions and tissue damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 192, Issues 1–2, 30 June 2011, Pages 14–20
نویسندگان
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