Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; BBB, blood–brain barrier; FCCP, carbonilcyanide p-triflouromethoxyphenylhydrazone; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor E2-related factor 2; OCR, oxygen consumption rate; pMCAO, permanent midd
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Keywords: ARE، عنصر پاسخ antioxidant; ACP, acid phosphatase; ALP, alkaline phosphatase; AR, aldose reductase; ARE, Antioxidant Response Element; CMC, carboxymethylcellulose; DEHP, di-(2-ethylhexyl)phthalate; FSH, follicle-stimulating hormone; FRAP, ferric reducing antioxidant power; GSH, redu
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; BMI, body mass index; CI, confidence interval; CMA, comprehensive meta-analysis; CVD, cardiovascular disease; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; GSH, glutathione; LD
Keywords: ARE، عنصر پاسخ antioxidant; EED, environmental endocrine disruptor; PNP, 4-nitrophenol; DEP, diesel exhaust particles; ROS, reactive oxygen species; GSH, glutathione; GSH-Px, glutathione peroxidase; SOD, superoxide dismutase; CAT, catalase; ARE, antioxidant response element; Nrf2, n
Keywords: ARE، عنصر پاسخ antioxidant; AA, amino-acid; ABCA1, ATP binding cassette transporter A1; ABCB, ATP binding cassette (ABC) transporter; AKI, acute kidney injury; AMI, acute myocardial infarction; ARE, antioxidant response element; ATP, adenosine triphosphate; CHD, coronary heart disea
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; BC, blood collection; BMI, body mass index; CGA, chlorogenic acids; CRP, C-reactive protein; DHFAglcd, dihydroferulic acid glucuronide; FA, ferulic acid; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HO1, heme oxygena
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; EpRE, electrophile response element; GSH, glutathione; Nrf2, nuclear factor erythroid 2-related factor 2; SOD, superoxide dismutase; Trx, thioredoxinAntioxidants; Redox signaling; Glutathione; Peroxidases; Nucleophilic t
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; BSA, bovine serum albumin; DCF, 2′, 7′-dichlorofluorescein; DMSO, dimethyl sulfoxide; FUDR, 5-fluorodeoxyuridine; IPTG, Isopropyl β-D-1-thiogalactopyranoside; NGM, nematode growth medium; ROS, reactive oxygen species; TC
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; GCLM, glutamate–cysteine ligand modifier subunit; HMOX1, heme oxygenase I; IL, interleukin; iNOS, inducible nitric oxide synthase; LPS, lipopolysaccharide; NQO1, NAD(P)H quinone oxidoreductase; Nrf2, nuclear factor eryth
Vitiligo: How do oxidative stress-induced autoantigens trigger autoimmunity?
Keywords: ARE، عنصر پاسخ antioxidant; ROS, reactive oxygen species; UV, ultraviolet; DNA, deoxyribonucleic acid; Nrf2, nuclear factor E2-related factor 2; ARE, antioxidant response element; HO-1, heme oxygenase-1; ER, endoplasmic reticulum; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; APE1, apurinic/
Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; GPx, glutathione peroxidase; HO-1, heme oxygenase 1; MeHg, methylmercury; Nrf2, nuclear factor erythroid 2-related factor 2; PSTK, O-phosphoseryl-tRNA(Sec) kinase; Sec, selenocysteine; SepSecS, O-phosphoseryl-tRNA(Sec) s
Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats
Keywords: ARE، عنصر پاسخ antioxidant; ALT, alanine transaminase; ARE, antioxidant response element; AST, aspartate transaminase; CAS, casein; CAS-C, cholesterol-supplemented casein; GCL, glutamate cysteine ligase; GCLC, glutamate cysteine ligase catalytic subunit; GCLM, glutamate cysteine lig
Paeoniflorin protects Schwann cells against high glucose induced oxidative injury by activating Nrf2/ARE pathway and inhibiting apoptosis
Keywords: ARE، عنصر پاسخ antioxidant; PF, Paeoniflorin; Nrf2, Nuclear Factor-E2-Related Factor 2; DPN, Diabetic Peripheral Neuropathy; ARE, Antioxidant Response Element; Bcl-2, B-Cell CLL/Lymphoma 2; MTT, 3-(4,5-Dimethyl-2-Thiazolyl)-2,5-Diphenyl-2-H-Tetrazolium Bromide; DAPI, 4′,6-Diamidino-
Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation
Keywords: ARE، عنصر پاسخ antioxidant; Nrf1, Nuclear Factor Erythroid-2 Related Factor 1; CNC, cap ‘n’ collar; bZIP, basic leucine zipper; Maf, musculoaponeurotic fibrosarcoma oncogene; ARE, antioxidant response element; EpRE, electrophile responsive element; C/EBP-β, CCAAT Enhancer-binding pr
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; Bach1, BTB and CNC homolog 1; bZip, basic region leucine zipper; ChIP, chromatin immunoprecipitation; CHX, cycloheximide; Crm1, chromosomal region maintenance 1; DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride; FITC,
Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway
Keywords: ARE، عنصر پاسخ antioxidant; ANOVA, analysis of variance; ARE, antioxidant response element; CCK8, Cell Counting Kit-8; CO, carbon monoxide; DAPI, 4′,6-diamino-2-phenylindole; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethylsulfoxide; ERK, extracellular regulated kinase; FBS,
Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells
Keywords: ARE، عنصر پاسخ antioxidant; ARE, Antioxidant Response Element; DNPH, 2,4-Dinitrophenylhydrazine; GAPDH, Glyceraldehyde 3-Phosphate Dehydrogenase; GCL, Glutamate Cysteine Ligase; GST, Glutathione S-Transferase; HDAC, Histone Deacetylase; HO-1, Heme Oxygenase 1; HSP, Heat Shock Protei
The role of heme oxygenase-1 in drug metabolizing dysfunction in the alcoholic fatty liver exposed to ischemic injury
Keywords: ARE، عنصر پاسخ antioxidant; AFL, alcoholic fatty liver; ALT, alanine aminotransferase; ARE, antioxidant response element; AST, aspartate aminotransferase; CD, control diet; CHOP, C/EBP homologous protein; CO, carbon monoxide; CYP, cytochrome P450; ED, ethanol diet; ER, endoplasmic r
Cross-talk between two antioxidants, thioredoxin reductase and heme oxygenase-1, and therapeutic implications for multiple myeloma
Keywords: ARE، عنصر پاسخ antioxidant; AF, Auranofin; AML, Acute myeloid leukemia; ANOVA, Analysis of variance; AP-1, Activator protein-1; ARE, Antioxidant response element; BM, Bone marrow; Btz, Bortezomib; CLL, Chronic lymphocytic leukemia; CML, Chronic myeloid leukemia; CuPP IX, Copper Prot
Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β
Keywords: ARE، عنصر پاسخ antioxidant; ACC, acetyl-CoA carboxylase; AMPK, AMP-activated protein kinase; ARE, antioxidant response element; CaMKK, Ca2 +/calmodulin-dependent protein kinase kinase; DCFH-DA, 2′,7′-dichlorofluorescin diacetate; DN, dominant-negative; ERK, extracellular signal-regu
Redox maintenance and concerted modulation of gene expression and signaling pathways by a nanoformulation of curcumin protects peripheral blood mononuclear cells against gamma radiation
Keywords: ARE، عنصر پاسخ antioxidant; Radiation; Curcumin; Nano; Peripheral blood; Nrf2; BBC38-OHdG, 8-hydroxydeoxyguanosine; ARE, antioxidant response element; CAT, catalase; COX, Cyclooxygenase; DCFH-DA, 2′,7′-dichloro dihydrofluoroscein diacetate; DNC, dendrosomal nanoformulation of curcum
Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2
Keywords: ARE، عنصر پاسخ antioxidant; MG, methyl glyoxal; AKR, aldo-keto reductases; ARE, antioxidant response element; AGE, advanced glycation end products; Nrf2, nuclear factor erythroid 2-related factor 2; NQO1, NAD(P)H:quinone reductases; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetr
Benzo-α-pyrene induced oxidative stress in Caenorhabditis elegans and the potential involvements of microRNA
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; BaP, Benzo-α-pyrene; C. elegans, Caenorhabditis elegans; GCS, gamma-glutamine cysteine synthase; GCS-1, gamma-glutamine cysteine synthase heavy chain; GSH, glutathione; GSTs, glutathione S-transferases; GSS-1, glutathion
Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2: Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line
Keywords: ARE، عنصر پاسخ antioxidant; AKR1C2, aldoketoreductase 1C2; AP-1, activator protein 1; ARE, antioxidant response element; Bach1, BTB and CNC homolog 1; DMEM, Dulbecco's Modified Eagle Medium; DMSO, dimethylsulfoxide; DNCB, 2,4-dinitrochlorobenzene; EC1.5/EC2/EC3, concentration for 1.
Senkyunolide I protects rat brain against focal cerebral ischemia–reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3
Keywords: ARE، عنصر پاسخ antioxidant; I/R, ischemia–reperfusion; tMCAO, transient middle cerebral artery occlusion; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor erythroid 2-related factor 2; ARE, antioxidant response element; MDA, malondialdehyde; SOD, superoxide dismutase
Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice
Keywords: ARE، عنصر پاسخ antioxidant; AKR, aldo-keto reductase; ARE, antioxidant response element; BHA, butylated hydroxyanisole; BQ, tert-butylquinone; β-TrCP, β-transducin repeat-containing protein; GSK-3, glycogen synthase kinase-3; Gapdh, glyceraldehyde-3-phosphate dehydrogenase; GSH, red
Hesperidin protects gentamicin-induced nephrotoxicity via Nrf2/HO-1 signaling and inhibits inflammation mediated by NF-κB in rats
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; CAT, catalase; COX-2, cyclooxygenase-2; ECH, echinoderm microtubule associated; ERK, extracellular signal-regulated kinases; GEN, gentamicin; GST, glutathione-S-transferase; HDN, hesperidin; HO-1, haem oxygenase 1; HRP,
Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: Insights on replicative senescence
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; CA, carnosic acid; CPD, cumulative population doubling; CS, carnosol; FTH1, ferritin heavy chain; GCL, glutamate cysteine ligase; GSH, glutathione; GST-P1, glutathione S-transferase P1; H2O2, hydrogen peroxide; HO-1, hem
Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals
Keywords: ARE، عنصر پاسخ antioxidant; Sepsis; Heme oxygenase; HMGB1; Phosphatidylinositol-3-kinase; Nrf-2AscA, Ascorbic acid; ALT, Alanine aminotransferase; ARE, Antioxidant response element; AST, Aspartate Aminotransferase; CLP, Cecal ligation and puncture; CO, Carbon monoxide; ELISA, Enzyme
Keap1–Nrf2 signalling in pancreatic cancer
Keywords: ARE، عنصر پاسخ antioxidant; AKR1B10, Aldo–keto reductase family 1 b10; ARE, antioxidant response element; Bach1, BTB and CNC homology 1; CNC, Cap ‘n’ collar; Cul3, Cullin-3; ER, endoplasmic reticulum; GCLC, glutamate–cysteine ligase catalytic; HO-1, heme oxygenase 1; Keap1, Kelch-li
Transcription factor Nrf1 is negatively regulated by its O-GlcNAcylation status
Keywords: ARE، عنصر پاسخ antioxidant; AD1, acidic domain 1; ARE, antioxidant response element; bZIP, basic region-leucine zipper; CHX, cycloheximide; CNC, cap’n’collar; EGFP, enhanced green fluorescent protein; ER, endoplasmic reticulum; Glc, glucose; GCLM, glutamate cysteine ligase modifier
Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction
Keywords: ARE، عنصر پاسخ antioxidant; Akt, protein kinase B; ARE, antioxidant response element; BSA, bovine serum albumin; CCA, common carotid artery; cDNA, complementary deoxyribonucleic acid; CGCs, cerebellar granule cells; CNS, central nervous system; DMEM, Dulbecco's modified eagle medium
Modulation of aryl hydrocarbon receptor-regulated enzymes by trimethylarsine oxide in C57BL/6 mice: In vivo and in vitro studies
Keywords: ARE، عنصر پاسخ antioxidant; 4-OHE2, 4-hydroxy estradiol; AhR, aryl hydrocarbon receptor; Aldh3, cytosolic “class 3” aldehyde dehydrogenase; AP-1, activator protein 1; ARE, antioxidant response element; ARNT, aryl hydrocarbon receptor nuclear translocator; AS3MT, arsenic methyltransf
Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents
Keywords: ARE، عنصر پاسخ antioxidant; 1O2, singlet oxygen; AD, Alzheimer׳s disease; ARE, antioxidant response element; Bach1, BTB and CNC homology 1; BTB, broad complex, tramtrack and bric-a-brac; CBP, cAMP response element binding (CREB) protein; CDDO-Me, bardoxolone methyl; COPD, chronic ob
Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention
Keywords: ARE، عنصر پاسخ antioxidant; AD1, Acidic Domain 1; AD2, Acidic Domain 2; AP-1, adaptor protein-1; ARE, Antioxidant Response Element; Bach1, BTB and CNC homolog 1; Bach 2, BTB and CNC homolog 2; BTB, broad complex, tramtrack, bric-a-brac; bZip, basic-leucine zipper; CK2, casein kinase
Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation
Keywords: ARE، عنصر پاسخ antioxidant; AP, apurinic/apyramidinic; ARE, antioxidant response element; CM- H2DCFDA, 5-(and-6) chloromethyl-2′,7′ dichlorodihydrofluorescein diacetate; DSBs, double-strand breaks; EdU, 5-ethynyl-2′-deoxyuridine; GST, glutathione transferase; HO1, heme oxygenase1; K
Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats
Keywords: ARE، عنصر پاسخ antioxidant; ALT, alanine aminotransferase; ALP, alkaline phosphatase; ANOVA, analysis of variance; ARE, antioxidant response element; AST, aspartate aminotransferase; CYP2E1, cytochrome P450 2E1; DHLA, dihydrolipoic acid; ECM, extracellular matrix; ELISA, enzyme-link
Comparison of in vitro tests for antioxidant and immunomodulatory capacities of compounds
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; CAA, cell-based antioxidant activity; GTP-CH1, GTP-cyclohydrolase I; IDO, indoleamine 2,3-dioxygenase; IL-2, interleukine-2; IFN-γ, interferon-gamma; iNOS, inducible nitric oxide synthase; Kyn/Trp, kynurenine to tryptoph
Activation of Nrf2-ARE signal pathway protects the brain from damage induced by epileptic seizure
Keywords: ARE، عنصر پاسخ antioxidant; Nrf2, nuclear factor erythroid 2-related factor 2; ARE, antioxidant response element; SF, sulforaphane; HO-1, heme oxygenase-1; NQO1, NAD(P)H: quinone oxidoreductase-1; MDA, malondialdehyde; GSH, reduced glutathione; ADD, afterdischarge durationNrf2-ARE;
The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; BSA, bovine serum albumin; CI, combination index; DCFH-DA, 2′,7′-dichlorofluorescin diacetate; DMEM, Dulbecco’s modified Eagle medium; DMSO, dimethyl sulfoxide; DPPH, 1,1-Diphenyl-2-picrylhydrazyl; FBS, fetal bovine seru
Baicalein, an active component of Scutellaria baicalensis, protects against lipopolysaccharide-induced acute lung injury in rats
Keywords: ARE، عنصر پاسخ antioxidant; ALI, acute lung injury; ARDS, acute respiratory distress syndrome; ARE, antioxidant response element; BALF, bronchoalveolar lavage fluid; BE, baicalein; CINC-3, cytokine inducible neutrophil chemoattractant-3; CO, carbon monoxide; DHE, dihydroethidium; EL
tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation
Keywords: ARE، عنصر پاسخ antioxidant; AMPK, adenosine monophosphate-activated protein kinase; ARE, antioxidant response element; Baf, bafilomycin A1; BSA, bovine serum albumin; CaMKK2, Calcium/calmodulin-dependent protein kinase kinase 2; CQ, chloroquine; EBSS, amino acid and serum depletion
Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells
Keywords: ARE، عنصر پاسخ antioxidant; Akt, protein kinase B; ARE, antioxidant response element; Erk, extracellular signal-regulated kinase; CBP, CREB-binding protein; CREB, cAMP response-element (CRE) binding protein; CDK, cyclin-dependent kinase; DHE, dihydroethidium; Drp1, dynamin-related p
The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats
Keywords: ARE، عنصر پاسخ antioxidant; ABC, ATP-binding cassette; Mrp1, multidrug resistance protein 1; Nrf2, nuclear factor E2-related factor-2; Keap1, kelch-like ECH-associated protein 1; ARE, antioxidant response element; ROS, reactive oxygen species; GSH, reduced glutathione; GSSG, oxidize
Gene expression changes induced by skin sensitizers in the KeratinoSens™ cell line: Discriminating Nrf2-dependent and Nrf2-independent events
Keywords: ARE، عنصر پاسخ antioxidant; LLNA, local lymph node assay; Nrf2, nuclear factor-erythroid 2-related factor 2; Keap1, Kelch-like ECH-associated protein 1; ARE, antioxidant response element; FCS, fetal calf serum; qRT-PCR, quantitative real time polymerase chain reaction; DMSO, dimethy
The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone
Keywords: ARE، عنصر پاسخ antioxidant; SQSTM1, Sequestosome 1; PDB, Paget's disease of bone; UBA, ubiquitin-associated; ARE, antioxidant response element; KIR, Keap1-interacting region; TPA, 12-O-tetradecanolylphorbol 12-myristae 13-acetate; tBHQ, tert-butylhydroquinonep62; SQSTM1; Ubiquitin;
Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation
Keywords: ARE، عنصر پاسخ antioxidant; ARE, Antioxidant response element; Nrf2, Nuclear factor erythroid 2-like 2; KO, Knockout; WT, Wild-type; P450, Cytochrome P450; NASH, Nonalcoholic steatohepatitis; NAFLD, Nonalcoholic fatty liver disease; co-IP, Co-immunoprecipitationCoumarin 7-hydroxylas
Redox biology of hydrogen sulfide: Implications for physiology, pathophysiology, and pharmacology
Keywords: ARE، عنصر پاسخ antioxidant; ARE, Antioxidant response element; CO, Carbon monoxide; CBS, Cystathionine-β-synthase; CGL, Cystathionine-γ-lyase; CcO, Cytochrome c oxidase; GSH, Glutathione; HSP, Heat shock protein; H2S, Hydrogen sulfide; HIF, Hypoxic inducible factor; IL-1β, Interleuk
Cytochrome P450 2A5 and bilirubin: Mechanisms of gene regulation and cytoprotection
Keywords: ARE، عنصر پاسخ antioxidant; ARE, Antioxidant Response Element; BR, Bilirubin; CHX, Cyclohexamide; CYP, Cytochrome P450; GAPDH, Glyceraldehyde 3-phosphate dehydrogenase; Nrf2, Nuclear factor-E2 p45-related factor 2; POR, NADPH cytochrome P450 oxidoreductase; ROS, Reactive oxygen spec
Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress
Keywords: ARE، عنصر پاسخ antioxidant; ARE, antioxidant response element; CVD, cardiovascular disease; GR, glutathione reductase; HO-1, heme oxygenase-1; Nrf2, nuclear factor (erythroid-derived 2)-like 2; ROS, reactive oxygen species; tBH, tert-butylhydroperoxideNrf2; Phytochemicals; Oxidative