کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049409 | 1074127 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene](/preview/png/2049409.png)
چکیده انگلیسی
We found that both wild type and Nrf3 (NF-E2-related factor 3) deficient mice are sensitive to BHT single administration exhibiting respiratory distress and considerably lose body weight following treatment. At time of sacrifice, the BHT-treated Nrf3−/− mice had lost significantly more body weight than their WT counterparts. In the lung, transcript levels of the transcription factors Nrf1, Nrf2 and Nrf3 were differentially regulated by BHT treatment. In addition, genes implicated in adipogenesis were repressed following BHT exposure in the white adipose tissue. Together, our data provide the first evidence that BHT exposure not only affects lung function but also leads to impaired adipogenesis in adipocytes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 5, 5 March 2010, Pages 923–928
Journal: FEBS Letters - Volume 584, Issue 5, 5 March 2010, Pages 923–928
نویسندگان
Grégory Chevillard, Zaynab Nouhi, Derjuga Anna, Marilène Paquet, Volker Blank,