Keywords: ARNT، اتمسفر هسته ای AhR; ACOT2, acyl-CoA thioesterase 2; AHR, aryl hydrocarbon receptor; AIP, AHR-interacting protein; ARNT, AHR nuclear translocator; COX4, cytochrome c oxidase subunit 4; CPOX, coproporphyrinogen-III oxidase; CYB5, cytochrome b5; EGFR, epidermal growth factor re
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Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; AhRA, AhR antagonist (CH-223191); ARNT, AhR nuclear translocator; bHLH, basic-helix-loop-helix; CH12.γ2b-3′IghRR, CH12.LX cells stably expressing a 3′IghRR-regulated γ2b transgene; C, LPS alone control; Cyp1A1, cytochrome P
Keywords: ARNT، اتمسفر هسته ای AhR; Collagen; Hypoxia; Xenobiotics; Breast density; Focal adhesion kinase (FAK)AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; DFOM, deferoxamine mesylate salt; ECM, extracellular matrix; FAK, focal adhesion kinase; HD, high density; HIF, hypo
An in silico approach to investigate the source of the controversial interpretations about the phenotypic results of the human AhR-gene G1661A polymorphism
Keywords: ARNT، اتمسفر هسته ای AhR; TCDD, 2,3,7,8-tetrachlorodibenzop-dioxin; FICZ, 6-formylindolo [3,2-b] carbazole; ARNT, AhR nuclear translocator; R, Arginine; AhR, Aryl hydrocarbon receptor; bHLH, Basic helix-loop-helix; K, Lysine; PAS, Per-ARNT-Sim; PTM, Post translational modification
Luteolin suppresses TCDD-induced wasting syndrome in a cultured adipocyte model
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; Arnt, AhR nuclear translocator; C/EBP, CCAAT/enhancer-binding protein; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethylsulfoxide; EGCg, epigallocatechin gallate; GLUT, glucose transporter; MDI, 3-isobutyl-1-methylxa
Triorganotin compounds - ligands for “rexinoid” inducible transcription factors: Biological effects
Keywords: ARNT، اتمسفر هسته ای AhR; 3β-HSD, 3β-hydroxysteroid dehydrogenase; 17β-HSD, 17β-hydroxysteroid dehydrogenase; ABC transporters, ATP binding cassette transporters; AhR, arylhydrocarbon receptor; AhRR, AhRrepressor; AR, androgen receptor; ARNT, AhR nuclear translocator; BaP, benzo-a
The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90
Keywords: ARNT، اتمسفر هسته ای AhR; 17-DMAG, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin, dimethylsulfoxide; 3-MC, 3-methylcholanthrene; AhR, aryl hydrocarbon receptor; Arnt, AhR nuclear translocator; bHLH, basic helix-loop-helix; CYP1A1, cytochrome P450 1A1; DAPI, 4′,6-diamidino-
Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with β-naphthoflavone
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; AhRR, AhR repressor; CYP1A1, cytochrome P450 1 family, member A1; CYP1A2, cytochrome P450 1 family, member A2; CYP1B1, cytochrome P450 1 family, member B1; NQO1, NAD(P)H quinone oxidoreductas
Reduction of CC-chemokine ligand 5 by aryl hydrocarbon receptor ligands
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; BaP, benzo[a]pyrene; CCL, CC-chemokine ligand; FICZ, 6-formylindolo[3,2-b]carbazole; NHEK, normal human epidermal keratinocyte; PAHs, polycyclic aromatic hydrocarbons; PCB, polychlorinated bi
Bilirubin and beyond: A review of lipid status in Gilbert’s syndrome and its relevance to cardiovascular disease protection
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; Arnt, AhR nuclear translocator; BAIF, bile acid independent flow; BDT, bilirubin ditaurate; BMI, body mass index; BW, body weight; CN, Crigler–Najjar; GS, Gilbert’s syndrome; GY, Groningen yellow; HDL, high-density lipoprot
The aryl hydrocarbon receptor ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene regulate distinct genetic networks
Keywords: ARNT، اتمسفر هسته ای AhR; 3-MC, 3-methylcholanthrene; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; ChIP, chromatin immunoprecipitation; CYP1A1, cytrochrome P450 1A1; DES, diethylstilbestrol; EDC, endocrine disruptive chemical; ER, estrogen receptor; ERE, estroge
Sex differences in susceptibility to PAHs is an intrinsic property of human lung adenocarcinoma cells
Keywords: ARNT، اتمسفر هسته ای AhR; AHR, aryl hydrocarbon receptor; AHRR, AHR repressor; ARNT, AHR nuclear translocator; B[a]P, benzo[a]pyrene; CSC, cigarette smoke condensate; CYP, cytochrome P450; ERα, oestrogen receptor α (ESR1); ERβ, oestrogen receptor β (ESR2); PAH, polycyclic aromatic
Chokeberry (Aronia melanocarpa) juice modulates 7,12-dimethylbenz[a]anthracene induced hepatic but not mammary gland phase I and II enzymes in female rats
Keywords: ARNT، اتمسفر هسته ای AhR; ALP, alkaline phosphatase; ALT, alanine aminotransferase; ARNT, AhR nuclear translocator; AST, aspartate aminotransferase; BUN, blood urea nitrogen; ChJ, chokeberry juice; CDNB, 1-chloro-2,4-dinitrobenzene; DMBA, 7,12-dimethylbenz[a]anthracene; DMSO, dime
Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; COX, cyclooxygenase; CYP, cytochrome P450; HRN, hepatic cytochrome P450 reductase null; HRP, horseradish peroxidase; LPO, lactoperoxidase; MDR, multidrug resistance; MPO, myeloperoxidaseAntit
Gender-associated modulation of inducible CYP1A1 expression by andrographolide in mouse liver
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; B6, C57BL/6; D2, DBA/2; EROD, ethoxyresorufin O-deethylase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; 3-MC, 3-methylcholanthrene; P450, cytochrome P450; PAH, polycyclic aromatic hydroc
Developing tools for risk assessment in protected species: Relative potencies inferred from competitive binding of halogenated aromatic hydrocarbons to aryl hydrocarbon receptors from beluga (Delphinapterus leucas) and mouse
Keywords: ARNT، اتمسفر هسته ای AhR; AHR, aryl hydrocarbon (Ah) receptor; ARNT, AHR nuclear translocator; bHLH, basic-helix-loop-helix; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDF, tetrachlorodibenzofuran; PCB, polychlorinated biphenyl; TEF, Toxic Equivalency Factor; TEQ, TCDD equivalent
Polymorphisms and functional differences in aryl hydrocarbon receptors (AhR) in Japanese field mice, Apodemus speciosus
Keywords: ARNT، اتمسفر هسته ای AhR; aa, amino acid(s); AhR, aryl hydrocarbon receptor; AR, androgen receptor; Arnt, AhR nuclear translocator; As-AhR, Apodemus speciosus AhR; As-AhR-TAD, TAD in As-AhR; bHLH, basic helix-loop-helix motif; CYP1A1, cytochrome P450-1A1; DDBJ, DNA data bank of Ja
Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster
Keywords: ARNT، اتمسفر هسته ای AhR; AHR, aryl hydrocarbon receptor; ARNT, AHR nuclear translocator; BAC, bacterial artificial chromosome; DRE, dioxin responsive element; CYP, cytochrome P450; dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin, genomic junction region of Cyp1a1 and Cyp1a2, Cyp1a1_1
Ontogenic expression of hepatic Ahr mRNA is associated with histone H3K4 di-methylation during mouse liver development
Keywords: ARNT، اتمسفر هسته ای AhR; Ahr, aryl hydrocarbon receptor; ARNT, Ahr nuclear translocator; bDNA assay, branched DNA amplification technology; ChIP, chromatin immunoprecipitation; H3K4Me2, histone H3 di-methylation at lysine-4; H3K27Me3, histone H3 tri-methylation at lysine-27; HSP9
Characterization of the pattern of the nongenomic signaling pathway through which TCDD-induces early inflammatory responses in U937 human macrophages
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; cPLA2, cytosolic phospholipase A2; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; COX-2, cyclooxygenase-2; VEGF, vascular endothelial growth factor; 2-APB, 2-aminoethoxydiphenyl borateAhR; TCDD;
The immune phenotype of AhR null mouse mutants: Not a simple mirror of xenobiotic receptor over-activation
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; DC, dendritic cells; DN, double negative; DRE, dioxin responsive element; OVA, ovalbumin; ConA, concanavalin A; PAH, polycyclic aromatic hydrocarbon; TCDD, 2,3,7,8-tetrachloro-dibenzo-p-dioxi
Effect of β-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; 3-MC, 3-methylcholanthrene; βNF, β-naphthoflavone; ARNT, AhR nuclear translocator; XRE, xenobiotic responsive element; CYP, cytochrome P450; Nrf2, nuclear E2-related factor 2; ROS,
A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-κB family
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; COX-2, Cyclooxygenase 2; DC, dendritic cell; DRE, dioxin response element; FICZ, 6-formylindolo[3,2-b]carbazole; IDO, indoleamine-2,3-dioxygenase; IL-8, Interleukin 8; IFN, Interferon; RelBAh
The aryl hydrocarbon receptor is a modulator of anti-viral immunity
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; AhR+/+, AhR wild-type; AhR−/−, AhR deficient; AhRE, AhR response element; Arnt, AhR nuclear translocator; C/EBP-β, CCAAT-enhancer box binding protein beta; CMV, Cytomegalovirus; CTL, cytotoxic T lymphocytes; DC, dendritic c
Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, arylhydrocarbon receptor; AIP, AhR interacting protein; ARNT, AhR nuclear translocator; Apaf1, apoptotic protease-activating factor 1; AREG, amphiregulin; bHLH, basic helix–loop–helix; B(a)P, benzo(a)pyrene; CDK, cyclin-dependent kinase; Cdkn, CDK in
Modulation of TCDD-mediated induction of cytochrome P450 1A1 by mercury, lead, and copper in human HepG2 cell line
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; Cu2+, copper; CYP1A1, cytochrome P450 1A1; Hg2+, mercury; Pb2+, lead; PAHs, polycyclic aromatic hydrocarbons; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxinCytochrome P4501A1; Heavy metals; Aryl h
Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; Arnt, AhR nuclear translocator; CΔ553, AhR deletion construct with C-terminal 553 amino acids deleted; TH-CΔ553, thioredoxin fusion of CΔ553; DRE, dioxin response element; 3MC, 3-methylchloranthrene; PPIase, peptidyl-prolyl
Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; BaP, benzo[a]pyrene; BPDE, BaP-7,8-diol-9,10-epoxide; GST, glutathione S-transferase; HPLC, high-performance liquid chromatography; MROD, methoxyresorufin-O-demethylase; PAH, polycyclic aroma
Involvement of RelB in aryl hydrocarbon receptor-mediated induction of chemokines
Keywords: ARNT، اتمسفر هسته ای AhR; AhR; BAFF; IRF3; Chemokines; Inflammation; Macrophages; TCDDAhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; BAFF, B-cell activating factor; CCL1, CC-chemokine ligand 1; IKK, IκB Kinase; IRF3, interferon γ responsive factor3; TCDD, 2,3,7,8-
Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; B[a]A, benz[a]anthracene; β-NF, β-naphthoflavone; DMSO, dimethylsulfoxide; DRE, Dioxin Responsive Element; EROD, ethoxyresorufin O-deethylase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase;
Microarray analysis of the AHR system: Tissue-specific flexibility in signal and target genes
Keywords: ARNT، اتمسفر هسته ای AhR; AHR, aryl hydrocarbon receptor; AIP, AHR interacting protein; ARNT, AHR nuclear translocator; EST, expressed sequence tags; GEO, Gene Expression Omnibus; HPRT, hypoxanthine phosphoribosyl transferase; MAS4.0/5.0, Affymetrix Microarray Suite 4.0/5.0; MG-U7
β-Naphthoflavone and 3′-methoxy-4′-nitroflavone exert ambiguous effects on Ah receptor-dependent cell proliferation and gene expression in rat liver ‘stem-like’ cells
Keywords: ARNT، اتمسفر هسته ای AhR; 3M4NF, 3′-methoxy-4′-nitroflavone; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; ANF, α-naphthoflavone; BNF, β-naphthoflavone; CYP, cytochrome P450; DRE, dioxin responsive elements; EMSA, electrophoretic mobility shift assay; FITC, fluor
Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons
Keywords: ARNT، اتمسفر هسته ای AhR; ABCA1, ATP binding cassette A1; AHR, aryl hydrocarbon receptor; AR, androgen receptor; ARNT, AHR nuclear translocator; B[a]P, benzo[a]pyrene; CYP, cytochrome P450; DMEM, Dulbecco’s modified Eagle’s medium; Dox, doxorubicin; GR, glucocorticoid receptor; LX
Hypoxic activation of unoccupied estrogen-receptor-alpha is mediated by hypoxia-inducible factor-1 alpha
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; CREB, cyclic AMP-response element binding protein; DBD, DNA binding domain; ER, estrogen receptor; E2, 17-β-estradiol; ERE, estrogen response element; GFP, green fluorescent protein; HIF-1, h
The immune system as a target for environmental chemicals: Xenoestrogens and other compounds
Keywords: ARNT، اتمسفر هسته ای AhR; AhR, aryl hydrocarbon receptor; AM, alveolar macrophage; ANT, anthracene; ARNT, AhR nuclear translocator; APC, antigen-presenting cell; ATII, alveolar type II; BAL, bronchoalveolar lavage; BPA, bisphenol A; BT, butyltin; CBD, chronic beryllium disease; CT