کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2053062 1074254 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons
چکیده انگلیسی

This study was performed to prove our hypothesis that the metabolite(s) of polycyclic aromatic hydrocarbons (PAHs) caused the activation or phosphorylation of p53 via DNA damage to suppress the liver X receptor (LXR)-mediated signal transductions as a probably more direct mechanism. We found that LXR-mediated trans-activation was inhibited by 3-methylchoranthrene (MC) and doxorubicin (Dox) in HepG2 cells carrying wild-type p53, but not in Hep3B cells possessing mutant p53. The exogenous expression of wild-type p53 suppressed the LXR-mediated trans-activation in Hep3B cells. The expression of mRNA for ATP binding cassette A1 was suppressed by MC and Dox in HepG2 cells. The protein expression of retinoid X receptor (RXR), a partner of LXR to form a heterodimer, was suppressed by MC and Dox in HepG2 cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 3, 6 February 2006, Pages 890–893
نویسندگان
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