دانلود مقالات ISI درباره Ask1 + ترجمه فارسی

Research articleValproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis

Keywords: Valproic acid; ASK1; Optic neuritis; EAE; Neuroprotection;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of ASK1 signaling by scaffold and adaptor proteins

Keywords: ASK1; Scaffold; Adaptor; MAPK pathway; Protein binding;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Pleiotropic properties of ASK1

Keywords: ASK1; MAPK cascade; Apoptosis; Oxidative stress;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Methylseleninic acid and sodium selenite induce severe ER stress and subsequent apoptosis through UPR activation in PEL cells

Keywords: ER stress; KSHV; Puma; CHOP; Primary effusion lymphoma; Unfolded protein response; ASK1; apoptosis signal-regulated kinase 1; ATF6; activating transcription factor-6; Bim; Bcl-2 interacting mediator of cell death; CHOP; CCAAT/enhancer-binding protein-homo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion

Keywords: AA; Antimycin A; ALL; Allopurinol; ASK1; Apoptosis-signaling kinase 1; DCFH2-DA; 5-(6)-carboxy-2′, 7′-dichlorodihydrofluorescein diacetate; DPI; Diphenyleneiodonium; ERK; Extracellular signal regulated kinase; H2O2; Hydrogen peroxide; JNK; c-Jun-N-ter

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise

Keywords: 8-OHdG; 8-hydroxy-2-deoxyguanosine; ABL1; ABL proto-oncogene 1; AhpC; alkyl hydroperoxide reductase; AKT1; V-Akt murine thymoma viral oncogene homolog 1; APEX1; endonuclease apurinic/apyrimidinic endodeoxyribonuclease 1; ARG1; arginase 1; ARG2; arginase 2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

ASK1 regulates the survival of neuroblastoma cells by interacting with TLX and stabilizing HIF-1α

Keywords: ASK1; apoptosis signal-regulating kinase; NB; neuroblastoma; SP; side population; TLX; Dorosophla tailless homologue; MMP; mitochondrial membrane potential; TLX; ASK1; Neuroblastoma; HIF-1α; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Oxidative and ER stress-dependent ASK1 activation in steatotic hepatocytes and Kupffer cells sensitizes mice fatty liver to ischemia/reperfusion injury

Keywords: HP; hepatocytes; KC; Kupffer cells; I/R; ischemia-reperfusion; OS; oxidant species; PA; palmitic acid; ND; normal diet; HFD; high fat diet; ANOVA; analysis of variance; CD; control diet; JNK; c-Jun N-terminal kinase-1/2; ASK1; Apoptosis signal-regulating

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

SOCS-1 is involved in TNF-α-induced mitochondrial dysfunction and apoptosis in renal tubular epithelial cells

Keywords: TNF-α; tumor necrosis factor-α; CKD; chronic kidney disease; ESRD; end-stage renal disease; SOCS-1; suppressor of cytokine signaling-1; HKCs; human renal tubular epithelial cells; ASK1; apoptosis signal regulating kinase-1; RTEC; renal tubular epithelia

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Baicalein induces cell death in murine T cell lymphoma via inhibition of thioredoxin system

Keywords: Baicalein; Thioredoxin reductase; Cancer stem cells; ASK1; EL4;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Modulation of signaling mechanisms in the heart by thioredoxin 1

Keywords: Akt; protein kinase B; AMPK; Adenosine Monophosphate-activated Protein Kinase; Ang-II; Angiotensin-II; AP1; Activator protein 1 (AP-1); ASK1; Apoptosis Signal-regulating kinase; Atg4; Autophagy related-4; ATP; Adenosine Triphosphate; CDDP; cis-diammine-di

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Interleukin-33 attenuates doxorubicin-induced cardiomyocyte apoptosis through suppression of ASK1/JNK signaling pathway

Keywords: Doxorubicin; Apoptosis; ASK1; JNK; Interleukin-33;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

BH3-only protein BIM: An emerging target in chemotherapy

Keywords: A1; Bcl-2-related protein A1; Apaf-1; Apoptotic protease-activating factor 1; ASK1; Apoptosis Signal Regulated Kinase 1; Bad; Bcl-2 associated agonist of cell death; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; Bcl-2; B-cell l

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death

Keywords: LRRK2; ASK1; MAPK; Neuronal cell death; Phosphorylation;

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2017 سفارش ترجمه

Modifications to the composition of the hyphal outer layer of Aspergillus fumigatus modulates HUVEC proteins related to inflammatory and stress responses

Keywords: AiP; programed cell death 6-interacting protein; AKT; protein kinase B; ASK1; mitogen-activated protein kinase 5; BAD; BLC2-associated agonist of cell death; BAX; BCL2-associated X protein; CD-142; tissue factor; cFOS; FBJ Murine osteosarcoma viral oncoge

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2017 سفارش ترجمه

The regulatory and signaling mechanisms of the ASK family

Keywords: ASK1; ASK2; ASK3; Molecular mechanisms; Stress responses; Signaling mechanisms;

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2017 سفارش ترجمه

Production of recombinant human apoptosis signal-regulating kinase 1 (ASK1) in Escherichia coli

Keywords: ASK1; Apoptosis signal-regulating kinase 1; Recombinant protein; IPTG induction; Auto-induction protocol; ASK1; apoptosis signal-regulating kinase 1; MAPK; mitogen-activated protein kinase; ROS; reactive oxygen species; TNF-α; tumor necrosis factor alpha

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Endophilin-A2-mediated increase in scavenger receptor expression contributes to macrophage-derived foam cell formation

Keywords: Foam cell formation; Scavenger receptor; Endophilin-A2; ASK1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Induced peroxidase and cytoprotective enzyme expressions support adaptation of HUVECs to sustain subsequent H₂O₂ exposure

Keywords: O₂−;  superoxide; H₂O₂; hydrogen peroxide; ROS; reactive oxygen species; DHE; dihydroethidium; EC; endothelial cell; HUVEC; human umbilical vein endothelial cell; eNOS; constitutive nitric oxide synthase; SOD1; superoxide dismutase 1; SOD2; super

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Research ArticleDKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity

Keywords: NAFLD; non-alcoholic fatty liver disease; DKK3; dickkopf-3; HFD; high fat diet; ASK1; apoptosis signal-regulating kinase 1; JNK; c-Jun N-terminal kinases; MAPK; mitogen-activated protein kinase; NC; normal chow; FBG; fasting blood glucose; FINS; fasting s

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

RNAi-mediated silencing of the Arabidopsis thaliana ULCS1 gene, encoding a WDR protein, results in cell wall modification impairment and plant infertility

Keywords: COP1; constitutive photomorphogenic 1; TRIP1; TGF-beta receptor interacting protein 1; FY; flowering time control protein FY; PRL1; protein pleiotropic regulatory locus 1; DCAF1; DDB1-CUL4 associated factor 1; MSI4; multicopy suppressor of IRA1 4; ASK1; A

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations

Keywords: ARE; anti-oxidant response element; ASK1; apoptosis signal regulating kinase 1; ATF4; activating transcription factor 4; ATF6α; activating transcription factor 6α; BI-1; Bax-inhibitor-1; Bim; Bcl-2-interacting mediator of cell death; BiP/GRP78; binding

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Epigallocatechin gallate and mitochondria-A story of life and death

Keywords: ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; ALT; alanine aminotransferase; AMP; adenosine monophosphate; AP-1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; ATP; adenosine triphosphate; Bax; BCL2-Associated X Protein; Bc

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis

Keywords: Trx; thioredoxin; Prx; peroxiredoxin; GPx; glutathione peroxidase; LIP; labile iron pool; MAPK; mitogen activated protein kinases; ASK1; apoptosis signal-regulating kinase 1; JNK; c-Jun NH2-terminal kinase; HUVECs; human umbilical vein endothelial cells;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2016 سفارش ترجمه

Associate Editor: P. MolenaarActivation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1

Keywords: DJ-1; Endogenous antioxidant; Mechanism-oriented therapy; Disease-oriented therapy; ASK1; apoptosis signal regulating kinase; JNK; Jun N-terminal kinase; NQO1; NAD(P)H:quinone oxidoreductase 1; Nrf2; nuclear factor erythroid 2-related factor; p53; tumor p

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation

Keywords: Rheumatoid arthritis; Synovial fibroblasts; ASK1; Thymoquinone; TNF-α; MAP kinase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleSab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

Keywords: ASK1; mitogen-activated protein kinase kinase kinase 5; ATP; Adenosine 5′-triphosphate; Bcl2; B-cell lymphoma 2; BHA; butylated hydroxyanisole; CCCP; Carbonyl cyanide 3-chlorophenylhydrazone; CHOP; DNA-damage-inducible transcript 3; ECAR; extracellular

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one

Keywords: ASK1; apoptosis signal-regulating kinase 1; MAPK; mitogen-activated protein kinase; ER; endoplasmic reticulum; TNF-α; tumor necrosis factor-alpha; AIP-1; ASK1-interacting protein 1; VEGF; vascular endothelial growth factor; Aβ; amyloid beta; CK2; protei

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Complex responses to Si quantum dots accumulation in carp liver tissue: Beyond oxidative stress

Keywords: AOPP; advanced oxidation protein products; ASK1; apoptosis signal-regulating kinase 1; CAT; catalase; CMA; chaperone mediated autophagy; COX-2; cyclooxigenase-2; DAPI; 4,6-diamidino-2-phenylindole; DTDP; 4,4′-dithiodipyridine; EGF; epidermal growth fact

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Redox regulation of metabolic and signaling pathways by thioredoxin and glutaredoxin in NOS-3 overexpressing hepatoblastoma cells

Keywords: ACO; aconitase; ASK1; apoptosis signal-regulating kinase 1; Bcl-2; B-cell lymphoma 2; CaM; calmodulin; CD95; cluster of differentiation 95; DTNB; 5,5-dithio-bis-2-nitrobenzoic acid; ELISA; enzyme-linked immunosorbent assay; GAPDH; glyceraldehyde-3-phospha

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Associate editor: B. TeicherDeubiquitinase inhibition as a cancer therapeutic strategy

Keywords: Cancer therapeutics; Small molecule inhibitors; Proteasome; Deubiquitinase; α,β-unsaturated ketones; Apoptosis; 19S RP; 19S regulatory particle; 20S CP; 20S core particle; ASK1; apoptosis signaling kinase 1; BRCA1; breast cancer type 1 susceptibility pr

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2015 سفارش ترجمه

MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model

Keywords: 6-OHDA; 6-hydroxydopamine; ADAM17; ADAM metallopeptidase domain 17; AMS; 4-acetamido-4′-maleimidylstilbene-2, 2′-disulfonic acid, disodium salt; ASK1; Apoptosis signal-regulating kinase 1; CIB1; Calcium and integrin-binding protein 1; C (in figure); V

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2015 سفارش ترجمه

ASK1 pharmacophore model derived from diverse classes of inhibitors

Keywords: ASK1, apoptosis signal-regulating kinase 1; MAPK, mitogen-activated protein kinase; ROS, reactive oxygen species; ER, endoplasmic reticulum; FCFP4, functional-class fingerprints 4Apoptosis signal-regulating kinase 1; ASK1; Inhibitor; Pharmacophore model

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant

Keywords: ASK1; apoptosis signal-regulating kinase 1; c-IAP1; cellular inhibitor of apoptosis protein 1; DCFH; dichlorodihydrofluorescein; DMSO; dimethyl sulfoxide; Epo; erythropoietin; ERK; extracellular signal-regulated kinase; EpoR; erythropoietin receptor; ET;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line

Keywords: ASK1; signal-regulating kinase 1; FADD; Fas-associated death domain protein; JNK; c-Jun NH2-terminal protein kinase/stress-activated protein kinases; MAPK; mitogen-activated protein kinases; Δψm; mitochondrial transmembrane potential; Rho-123; Rhodamine

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

An overview of mechanisms of redox signaling

Keywords: cAMP; adenosine monophosphate; ASK1; apoptosis signal-regulating kinase-1; P-SNP; cyclic sulfenyl amide; GSH; glutathione (reduced); GSSG; glutathione (oxidized); GPx; glutathione peroxidase(s); GST; glutathione S-transferase(s); GS; glutathione thiyl rad

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Extracellular polysaccharide from Bacillus sp. strain LBP32 prevents LPS-induced inflammation in RAW 264.7 macrophages by inhibiting NF-κB and MAPKs activation and ROS production

Keywords: EPS; Inflammation; NF-κB; MAPKs; ASK1; ROS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats

Keywords: AngII; angiotensin II; AIF; apoptosis inducing factor; ASI; Aortic stiffness index; AP-1; activator protein 1; ASK1; apoptosis signal-regulating kinase 1; Crm1; chromosome region maintenance 1; DAB; 3,3′-diaminobenzidine; DBP; diastolic blood pressure;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Activation of PI3K/Akt pathway limits JNK-mediated apoptosis during EV71 infection

Keywords: Enterovirus 71; PI3K/Akt pathway; JNK; Apoptosis; ASK1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains

Keywords: GPCR; G protein-coupled receptor; JNK; c-Jun NH2-terminal protein kinase; MAPK; mitogen-activated protein kinase; MKK or MAPKK; MAP kinase kinase; MAPKKK; MAP kinase kinase kinase; ASK1; Apoptosis signal-regulating kinase 1, a.k.a. mitogen-activated prote

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival

Keywords: AIF; apoptosis inducing factor; Akt; v-Akt murine thymoma viral oncogene; AP-1; activator protein 1; ARE; antioxidant responsive element; ASK1; apoptosis signal-regulated kinase 1; ATM; ataxia telangiectasia mutated; Duox; Dual oxidase enzymes; DUSP3; dua

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2014 سفارش ترجمه

Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion

Keywords: Ins2; Insulin 2 protein; ER; endoplasmic reticulum; ASK1; apoptosis signal-regulating kinase 1; UPR; unfolded protein response; PERK; protein kinase RNA-like ER kinase; ATF6; activating transcription factor 6; IRE1; inositol-requiring enzyme 1; ERAD; ER-a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells

Keywords: AMPK; AMP-activated protein kinase; ACC; Acetyl-CoA Carboxylase; ASK1; Apoptosis signal regulating kinase 1; ATF6; activating transcription factor 6; CHOP; C/EBP homologous protein; eIF2α; the eukaryotic initiation factor 2α; ELISA; Enzyme-linked immuno

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands

Keywords: TLRs; Toll-like receptors; CpG; unmethylated CpG oligodeoxynucleotides; poly I:C; polyinosinic-polycytidylic acid; NO; nitric oxide; iNOS; inducible nitric oxide synthase; CREB; cAMP response element-binding protein; NFκB; nuclear factor κB; PRRs; pat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Posttranslational modifications of cardiac troponin T: An overview

Keywords: AMI; acute myocardial infarction; ASK1; apoptosis signal-regulating kinase 1; CaMK II; Ca2 +/calmodulin-dependent protein kinase II; cTnT/I/C; cardiac troponin T, I, C; ESRD; end-stage renal disease; GFC; gel filtration chromatography; HF; heart failure;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis

Keywords: AP1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; CBB; Coomassie brilliant blue; DMEM; Dulbecco's modified Eagle's medium; DNCB; dinitrochlorobenzene; DTNB; dithiobisnitrobenzoic acid; GRs; glutathione reductases; HIF-1α; hypoxia-indu

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury

Keywords: Dermorphin; Brain-targeting nanoparticles; RNAi; Ask1; Ischemia/reperfusion injury;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy

Keywords: ATF2; activating transcription factor 2; ASK1; apoptosis signal-regulating kinase 1; CTB; cholera toxin subunit β; IOP; intraocular pressure; MAPK; mitogen-activated protein kinase; RGC; retinal ganglion cell; SC; superior colliculus; Hsp27, Hsp60; Ro320

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه