Thioredoxin inhibits MPK38-induced ASK1, TGFâβ, and p53 function in a phosphorylation-dependent manner
Keywords: MPK38/MELK; Trx; ASK1; TGF-β; p53; Free radicals;
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Redox signaling in cardiovascular health and disease
Keywords: AngII; angiotensin II; AP-1; activator protein-1; apoA-1; apolipoprotein A-1; Ask1; apoptosis signaling kinase-1; CAD; coronary artery disease; CAMTA; calmodulin-binding transcription activator; CHD; coronary heart disease; CVD; cardiovascular disease; CH
ER stress-induced cell death mechanisms
Keywords: AGE; advanced glycated end-products; ALS; amyotropic lateral sclerosis; AMD; age-related macular degeneration; ARE; antioxidant response elements; ASK1; apoptotic-signaling kinase-1; ATF4; activating transcription factor 4; ATF6; activating transcription
PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats
Keywords: Surgical brain injury; Thrombin; PAR-1; Apoptosis; ASK1; JNK; Bim
Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma
Keywords: IL-6; VEGF; ASK1; Angiogenesis; Osteosarcoma
Rational design of apoptosis signal-regulating kinase 1 inhibitors: Discovering novel structural scaffold
Keywords: Apoptosis signal-regulating kinase 1; ASK1; Inhibitor; Virtual screening; Compound library; Kinase assayASK1, apoptosis signal-regulating kinase 1; AngII, angiotensin II; eNOS, endothelial nitric oxide synthase; ALS, amyotrophic lateral sclerosis; polyQ,
Thioredoxin-mimetic peptides (TXM) reverse auranofin induced apoptosis and restore insulin secretion in insulinoma cells
Keywords: Thioredoxin; Oxidative stress; Diabetes; Insulin secretion; MAPK; Apoptosis; Molecular dynamics; ASK1
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
Keywords: ASK1; Imidazo[1,2-a]pyridine; LLE;
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
Keywords: ASK1; apoptosis signal-regulating kinase 1; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; BAX; Bcl2 associated X protein; BAK; BCL2-antagonist/killer; CHOP; C/EBP-homologous protein; eIF2α; eukaryotic initiation factor
Redox signaling loops in the unfolded protein response
Keywords: AGR2; anterior gradient 2; ARE; antioxidant responsive element; ATF4; activating transcription factor-4; ATF6; activating transcription factor-6; ASK1; apoptosis signal-regulating kinase-1; BI-1; BAX inhibitor-1; BiP; immunoglobulin heavy chain-binding pr
Redox modification of cell signaling in the cardiovascular system
Keywords: AngII; angiotensin II; ASK1; apoptosis signal-regulating kinase 1; BDNF; brain-derived neurotrophic factor; BH4; tetrahydrobiopterin; CaMKII; Ca2+/calmodulin-dependent protein kinase II; cGMP; cyclic guanosine monophosphate; ETC; electron transport chain;
Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase
Keywords: ASK1; apoptosis signal-regulated kinase-1; BSA; bovine serum albumin; BSO; buthionine sulfoximine; BUN; urea nitrogen; CDNB; 1-chloro-2,4-dinitrobenzene; Cr; creatinine; DTNB; 5,5â²-dithiobis (2-nitrobenzotic acid); GPx; glutathione peroxidase; GR; gluta
Proteomic analysis of the soluble and the lysosomal + mitochondrial fractions from rat pancreas: Implications for cerulein-induced acute pancreatitis
Keywords: AAT; α1-antitrypsin; ACN; acetonitrile; AP; acute pancreatitis; ASK1; apoptosis signal-regulating kinase 1; ATP5B; ATP synthase beta chain; CBP; carboxypeptidase; Cer; cerulein; CTRB1; chymotrypsinogen B; L + M; lysosomal + mitochondrial fraction; ST
The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells
Keywords: AE; Aloe-emodin; ASK1; apoptosis signal-regulating kinase 1; ATF; activating transcription factor; CHAC1; cation transport regulator-like protein 1; CHOP; CAAT/enhancer-binding protein-homologous protein; DR5; death receptor 5; eIF2α; eukaryotic initiati
Associate editor: M. PanagiotidisStress management at the ER: Regulators of ER stress-induced apoptosis
Keywords: ASK1; apoptosis signal-regulating kinase 1; ATF; activating transcription factor; BAK; Bcl-2 homologous antagonist/killer; BAX; Bcl-2 associated protein X; BCL-2; B-cell lymphoma 2; BH3; Bcl-2 homology domain 3; BI-1; Bax inhibitor 1; Bim; Bcl-2 interacti
Mercury and selenium interaction in vivo: Effects on thioredoxin reductase and glutathione peroxidase
Keywords: ASK1; apoptosis signal-regulating kinase 1; BSA; bovine serum albumin; Cys; cysteine residue; GC-AFS; gaseous chromatography-atomic fluorescence spectrometry; GPx; glutathione peroxidase; GR; glutathione reductase; GSH; reduced glutathione; GSSG; oxidiz
Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse
Keywords: α-syn; α-synuclein; ASK1; Apoptosis signaling-regulating kinase 1; CMA; Chaperone-mediated autophagy; DAT; Dopamine transporter; ETC; Electron transport chain; iPS; Induced pluripotent stem; LAMP-2A; Lysosome-associated membrane protein 2A; LB; Lewy bod
Identification of novel ASK1 inhibitors using virtual screening
Keywords: ASK1; Virtual screening; Chemical library;
GSK-3β-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock
Keywords: ASK1; GSK-3β; p38; Stability; Endotoxemia
HSP70-mediated control of endothelial cell apoptosis during pre-eclampsia
Keywords: HSP; heat shock protein; Trx; thioredoxin; HSF; heat shock factor; ASK1; apoptosis signal-regulating kinase 1; ROS; reactive oxygen species; MAPKKK; mitogen activated protein kinase kinase kinase; BMI; body mass index; PROM; premature rupture of membrane;
Hydogen peroxide-dependent photocytotoxicity by phloxine B, a xanthene-type food colorant
Keywords: FDA; Food and Drug Administration; PhB; phloxine B; H2O2; hydrogen peroxide; MPO; myeloperoxidase; H2DCF-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; FOX; ferrous ion oxidation-xylenol orange; JNK; cJun-N-terminal kinase; HOCl; hypochlorous acid;
Research ArticleInactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer
Keywords: AIP1; ASK1-interacting protein 1; ASK1; apoptosis signal-regulating kinase 1; CAPRI; Ca2+-promoted Ras inactivator; DAB2IP; disabled homolog 2 interacting protein; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; HCC; hepatocellula
14-3-3 proteins in neurodegeneration
Keywords: TH; tyrosine hydroxylase; 3â²UTR; three prime untranslated region; CSF; cerebrospinal fluid; 2D-PAGE; two-dimensional polyacrylamide gel electrophoresis; PD; Parkinson disease; AD; Alzheimer disease; CJD; Creutzfeldt-Jakob disease; MSA; multiple system a
Apoptosis signal-regulating kinase 1 is an intracellular inducer of p38 MAPK-mediated myogenic signalling in cardiac myoblasts
Keywords: TNFα; H2O2; p38 MAPK; ASK1; Trx; Myogenic differentiation;
Blocking Daxx trafficking attenuates neuronal cell death following ischemia/reperfusion in rat hippocampus CA1 region
Keywords: Cerebral ischemia; Daxx trafficking; Ask1; Fas; NAC; SP600125;
ReviewEndoplasmic reticulum stress in liver disease
Keywords: ATF4; activating transcription factor-4; ATF6; activating transcription factor-6; ATF6β; activating transcription factor-6β; AMP; adenosine monophosphate; ALT; alanine aminotransferase; ASK1; apoptosis signal regulated kinase 1; BI-1; bax inhibitor-1; C
Knockdown of apoptosis signal-regulating kinase 1 modulates basal glycogen synthase kinase-3β kinase activity and regulates cell migration
Keywords: ASK1; GSK-3β; β-Catenin; Axin; Migration
DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex
Keywords: DJ-1; ASK1; Thioredoxin 1; Oxidative stress; Parkinson's disease (PD)
ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells
Keywords: Apoptosis signal-regulating kinase; ASK1; ASK3; MAP3K15; Cell death; Drug target
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates lipopolysaccharide-induced tissue factor expression in pulmonary microvasculature
Keywords: ASK1; Acute lung injury; Tissue factor; Coagulation; Pulmonary microvasculature
Oxidative stress-enhanced SUMOylation and aggregation of ataxin-1: Implication of JNK pathway
Keywords: Polyglutamine diseases; Ataxin-1; SUMO-1; Oxidative stress; JNK; ASK1
Renal Cell Carcinoma Fuhrman Grade and Histological Subtype Correlate With Complete Polymorphic Deletion of Glutathione S-Transferase M1 Gene
Keywords: kidney; carcinoma; renal cell; glutathione transferase; polymorphism; genetic; gene deletion; ASK1; apoptosis signal-regulating kinase 1; GST; glutathione S-transferase; PCR; polymerase chain reaction; RCC; renal cell carcinoma;
Thioredoxin-1 phosphorylated at T100 is needed for its anti-apoptotic activity in HepG2 cancer cells
Keywords: Thioredoxin; Phosphorylation; ASK1; NF-κB
Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia
Keywords: ASK1; apoptosis-sensitive kinase; MAPK; mitogen-activated protein kinase; MAPKK/MKK; MAPK kinase; MAPKKK; MAPKK kinase; JNK; c-Jun N-terminal kinase; ERK; extracellularly regulated kinase; SAPK; stress-activated protein kinase; MEKK; MAPK/ERK kinase; MLK;
Myeloid cell death associated with Toll-like receptor 7/8-mediated inflammatory response. Implication of ASK1, HIF-1alpha, IL-1beta and TNF-alpha
Keywords: Toll-like receptors; Inflammation; Apoptosis; IL-1beta; ASK1; TNF-alpha
Induction of apoptosis by quercetin is mediated through AMPKα1/ASK1/p38 pathway
Keywords: ROS; Quercetin; ASK1; AMPKα1; Apoptosis
Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells
Keywords: Japanese encephalitis virus; Apoptosis; Oxidative stress; ER stress; Thioredoxin; ASK1; ERK1/2; p38 MAPK
Comparative proteome profile during the early period of small-for-size liver transplantation in rats revealed the protective role of Prdx5
Keywords: Comparative proteome; Small-for-size liver transplantation; Oxidative stress; Apoptosis; Regeneration; LDLT; living-donor liver transplantation; IRI; ischemia-reperfusion injury; SFSG; small-for-size liver graft; SFSLT; Small-for-size liver transplantat
Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation
Keywords: Apoptosis; JNK; ASK1; Melanoma; IDO;
Apoptosis signal-regulating kinase 1 regulates the expression of caspase-11
Keywords: Ask1; Caspase-11; LPS; Nox4; TLR4
A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex
Keywords: MAPK; Map kinase; JNK; c-Jun N-terminal kinase; ASK1; apoptosis signal-regulating kinase 1; MKK4; MAPK kinase 4; CD site; common docking site; Arrestin; JNK; Scaffold; MKK4; ASK1; Peptide array;
Lipopolysaccharide triggered TNF-α-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model
Keywords: ASK1; apoptosis signal-regulating kinase 1; α-SMA; α-smooth muscle actin; ASH; alcoholic steatohepatitis; H2O2; hydrogen peroxide; JNK; c-Jun N-terminal kinase; MCD; methionine-choline-deficient; NAC; N-acetyl-l-cysteine; NAFLD; non-alcoholic fatty li
Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress
Keywords: ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; AOX; acyl-coenzyme A oxidase; AP-1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; COL1A1; collagen type 1 α1; COX-2; cyclo-oxygenase 2; CYP2E1; cytochrome P450 2E1; GAPDH; glyce
β-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis
Keywords: β-Arrestins; ASK1; CHIP; Ubiquitination; Apoptosis
Development of a novel fluorescent probe for fluorescence correlation spectroscopic detection of kinase inhibitors
Keywords: Kinase inhibitor; Fluorescence correlation spectroscopy; ASK1; Staurosporine
Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionic acid in the mouse striatum
Keywords: 3-Nitropropionic acid; Oxidative stress; Ask1; Aging; Vulnerability
Ischemic preconditioning suppresses apoptosis of rabbit spinal neurocytes by inhibiting ASK1–14-3-3 dissociation
Keywords: Ischemia reperfusion; Ischemic preconditioning (IPC); Spinal cord; 14-3-3; ASK1
Non-channel functions of connexins in cell growth and cell death
Keywords: ASK1; apoptosis signal-regulating kinase 1; CCN; cysteine rich 61, connective tissue growth factor and nephroblastoma overexpressed; Cx; connexin; Dlgh1; Discs-Large homolog 1; GJIC; gap junctional intercellular communication; NOV; nephroblastoma overexpr
DDTD, an isoflavone derivative, induces cell apoptosis through the reactive oxygen species/apoptosis signal-regulating kinase 1 pathway in human osteosarcoma cells
Keywords: Isoflavone; Osteosarcoma; ASK1; ROS
Methylmercury activates ASK1/JNK signaling pathways, leading to apoptosis due to both mitochondria- and endoplasmic reticulum (ER)-generated processes in myogenic cell lines
Keywords: Methylmercury; Oxidative stress; ASK1; SAPK/JNK; Caspase 12; ER stress