Proteomic analysis of the soluble and the lysosomal + mitochondrial fractions from rat pancreas: Implications for cerulein-induced acute pancreatitis

► Pancreatic 2DE-analysis during the early phase of experimental acute pancreatitis. ► Subcellular fractionation helps in the identification of new acidic protein changes. ► New described up-regulated proteins: STRAP, serpin B6 and thioredoxin-like 1. ► Overexpressed proteins in the lysosomal + mitochondrial fraction: ATP5B, CTRB1. ► Iodothyronine 5´monodeiodinase decreased in the lysosomal + mitochondrial fraction.