Blocking Daxx trafficking attenuates neuronal cell death following ischemia/reperfusion in rat hippocampus CA1 region

► JNK inhibitor SP600125 prevents Daxx trafficking from nucleus to cytoplasm. ► Inhibition of JNK prevents Fas-Daxx-Ask1 signal module assembly. ► Fas-Daxx-Ask1 module disassembly leads to decreased Ask1 activation and exerts neuroprotection.